{"id":"https://openalex.org/W2604262893","doi":null,"title":"Bioengineering Human Scaffold-free Cartilage Constructs Using Paediatric Auricular Tissue","display_name":"Bioengineering Human Scaffold-free Cartilage Constructs Using Paediatric Auricular Tissue","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2604262893","mag":"2604262893"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/70213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70213","pdf_url":"https://utoronto.scholaris.ca/bitstreams/321c5654-cbaa-4eb6-9867-f52e9294cb10/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/321c5654-cbaa-4eb6-9867-f52e9294cb10/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110321094","display_name":"Pedram Akbari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pedram Akbari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110321094"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11866","display_name":"Reconstructive Facial Surgery Techniques","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/auricular-cartilage","display_name":"auricular cartilage","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cartilage-tissue-engineering","display_name":"cartilage tissue engineering","score":0.7409999966621399},{"id":"https://openalex.org/keywords/micromass-culture","display_name":"micromass culture","score":0.9330000281333923},{"id":"https://openalex.org/keywords/chondrogenic-induction","display_name":"chondrogenic induction","score":0.8479999899864197},{"id":"https://openalex.org/keywords/external-ear-reconstruction","display_name":"external ear reconstruction","score":0.8669999837875366},{"id":"https://openalex.org/keywords/auricular-deformity","display_name":"ear deformity","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.8323637247085571},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6995497345924377},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.49880552291870117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4498499929904938},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.43315589427948},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3610459268093109}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/70213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70213","pdf_url":"https://utoronto.scholaris.ca/bitstreams/321c5654-cbaa-4eb6-9867-f52e9294cb10/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2604262893","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/70213","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/70213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70213","pdf_url":"https://utoronto.scholaris.ca/bitstreams/321c5654-cbaa-4eb6-9867-f52e9294cb10/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323654","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2604262893.pdf","grobid_xml":"https://content.openalex.org/works/W2604262893.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W392640108","https://openalex.org/W564522898","https://openalex.org/W638605339","https://openalex.org/W1483986747","https://openalex.org/W1493693710","https://openalex.org/W1513605181","https://openalex.org/W1520384293","https://openalex.org/W1524146716","https://openalex.org/W1539872251","https://openalex.org/W1916928829","https://openalex.org/W1963514599","https://openalex.org/W1963573052","https://openalex.org/W1964940632","https://openalex.org/W1971243659","https://openalex.org/W1971278836","https://openalex.org/W1971491691","https://openalex.org/W1973944296","https://openalex.org/W1974128523","https://openalex.org/W1974867264","https://openalex.org/W1978619076","https://openalex.org/W1979312095","https://openalex.org/W1980701446","https://openalex.org/W1981899336","https://openalex.org/W1982646609","https://openalex.org/W1982890975","https://openalex.org/W1983370727","https://openalex.org/W1984876438","https://openalex.org/W1986024374","https://openalex.org/W1988635537","https://openalex.org/W1992801092","https://openalex.org/W1994472758","https://openalex.org/W1994627481","https://openalex.org/W2000720459","https://openalex.org/W2001705654","https://openalex.org/W2002001684","https://openalex.org/W2008177303","https://openalex.org/W2008239595","https://openalex.org/W2009701841","https://openalex.org/W2013436619","https://openalex.org/W2013969954","https://openalex.org/W2016802198","https://openalex.org/W2017676959","https://openalex.org/W2018028722","https://openalex.org/W2018345631","https://openalex.org/W2018516449","https://openalex.org/W2019467756","https://openalex.org/W2021842516","https://openalex.org/W2022322050","https://openalex.org/W2025247123","https://openalex.org/W2030140788","https://openalex.org/W2033533236","https://openalex.org/W2034876159","https://openalex.org/W2035814409","https://openalex.org/W2037960738","https://openalex.org/W2039284873","https://openalex.org/W2041351774","https://openalex.org/W2041381481","https://openalex.org/W2044383840","https://openalex.org/W2046125987","https://openalex.org/W2047403480","https://openalex.org/W2047652836","https://openalex.org/W2048621583","https://openalex.org/W2049401674","https://openalex.org/W2049973324","https://openalex.org/W2050582548","https://openalex.org/W2055593386","https://openalex.org/W2057948940","https://openalex.org/W2060397124","https://openalex.org/W2064481190","https://openalex.org/W2069122966","https://openalex.org/W2070821632","https://openalex.org/W2070952973","https://openalex.org/W2071554551","https://openalex.org/W2071575323","https://openalex.org/W2074123147","https://openalex.org/W2077128213","https://openalex.org/W2078538052","https://openalex.org/W2079246198","https://openalex.org/W2080803003","https://openalex.org/W2080922285","https://openalex.org/W2081138623","https://openalex.org/W2082091542","https://openalex.org/W2082427520","https://openalex.org/W2083882414","https://openalex.org/W2085711413","https://openalex.org/W2086269269","https://openalex.org/W2086407300","https://openalex.org/W2088307350","https://openalex.org/W2089753144","https://openalex.org/W2092197856","https://openalex.org/W2097340765","https://openalex.org/W2097454781","https://openalex.org/W2103649635","https://openalex.org/W2104799329","https://openalex.org/W2108582427","https://openalex.org/W2113094049","https://openalex.org/W2114704594","https://openalex.org/W2119331267","https://openalex.org/W2121510728","https://openalex.org/W2122180971","https://openalex.org/W2123760352","https://openalex.org/W2129685860","https://openalex.org/W2130744701","https://openalex.org/W2133588934","https://openalex.org/W2135222543","https://openalex.org/W2141598500","https://openalex.org/W2150568780","https://openalex.org/W2152190782","https://openalex.org/W2160445739","https://openalex.org/W2162715820","https://openalex.org/W2164042225","https://openalex.org/W2169014673","https://openalex.org/W2210423983","https://openalex.org/W2312715336","https://openalex.org/W2325846435","https://openalex.org/W2328591743","https://openalex.org/W2337939639","https://openalex.org/W2409708846","https://openalex.org/W2412387599","https://openalex.org/W2415697301","https://openalex.org/W2415729894","https://openalex.org/W2910513247","https://openalex.org/W4299564257","https://openalex.org/W4323873710"],"related_works":["https://openalex.org/W2556270239","https://openalex.org/W1483986747","https://openalex.org/W2304898488","https://openalex.org/W7168428726","https://openalex.org/W4389609143","https://openalex.org/W1973944296","https://openalex.org/W3024091758","https://openalex.org/W3092461348","https://openalex.org/W2503727178","https://openalex.org/W2913205671"],"abstract_inverted_index":{"Currently,":[0],"patients":[1],"with":[2,17,71],"external":[3,19],"ear":[4,20],"deformities":[5],"rely":[6],"on":[7],"hyaline":[8],"cartilage":[9,33,63,81,87],"grafts":[10],"or":[11],"silicone":[12],"prosthesis":[13],"to":[14],"provide":[15],"them":[16],"adequate":[18],"reconstruction.":[21],"Scaffold-free":[22],"auricular":[23,58,62,86],"tissue":[24],"engineering":[25],"provides":[26],"a":[27,52],"means":[28],"of":[29],"creating":[30],"patient":[31],"specific":[32],"constructs":[34,59,82],"solely":[35],"using":[36,60],"their":[37],"own":[38],"cells,":[39],"ensuring":[40],"biocompatibility,":[41],"long":[42],"term":[43],"stability,":[44],"and":[45,91],"reduced":[46],"morbidity.":[47],"Here,":[48],"we":[49],"have":[50],"developed":[51],"simple":[53],"method":[54],"for":[55,74],"generating":[56],"scaffold-free":[57],"paediatric":[61,85],"remnants.":[64],"High":[65],"cell":[66],"density":[67],"micromass":[68],"cultures":[69],"treated":[70],"chondrogenic":[72],"medium":[73],"prolonged":[75],"periods":[76],"result":[77],"in":[78],"mechanically":[79],"stable":[80],"resembling":[83],"native":[84],"mechanically,":[88],"histologically,":[89],"immunohistochemically,":[90],"biochemically.":[92]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-04-14T00:00:00"}
