{"id":"https://openalex.org/W2604189752","doi":"https://doi.org/10.1080/13510002.2017.1308910","title":"Sodium arsenite-induced cardiovascular and renal dysfunction in rat via oxidative stress and protein kinase B (Akt/PKB) signaling pathway","display_name":"Sodium arsenite-induced cardiovascular and renal dysfunction in rat via oxidative stress and protein kinase B (Akt/PKB) signaling pathway","publication_year":2017,"publication_date":"2017-04-02","ids":{"openalex":"https://openalex.org/W2604189752","doi":"https://doi.org/10.1080/13510002.2017.1308910","mag":"2604189752","pmid":"https://pubmed.ncbi.nlm.nih.gov/28366046","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8900624"},"language":"en","primary_location":{"id":"doi:10.1080/13510002.2017.1308910","doi":"https://doi.org/10.1080/13510002.2017.1308910","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13510002.2017.1308910","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13510002.2017.1308910?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/13510002.2017.1308910?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043404389","display_name":"Ademola Adetokunbo Oyagbemi","orcid":"https://orcid.org/0000-0002-8996-8610","observed_orcids":["https://orcid.org/0000-0002-8996-8610"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Ademola Adetokunbo Oyagbemi","raw_affiliation_strings":["Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-8996-8610","affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017250336","display_name":"Temidayo Olutayo Om\u00f3b\u00f2w\u00e1l\u00e9","orcid":"https://orcid.org/0000-0002-9486-2861","observed_orcids":["https://orcid.org/0000-0002-9486-2861"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Temidayo Olutayo Omobowale","raw_affiliation_strings":["Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-9486-2861","affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110551794","display_name":"Ebunoluwa Rachael Asenuga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ebunoluwa Racheal Asenuga","raw_affiliation_strings":["Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Benin, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Benin, Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072451697","display_name":"Grace Onyeche Ochigbo","orcid":"https://orcid.org/0000-0003-1489-5848","observed_orcids":["https://orcid.org/0000-0003-1489-5848"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Grace Onyeche Ochigbo","raw_affiliation_strings":["Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035252339","display_name":"Abiola Olumuyiwa Adejumobi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Abiola Olumuyiwa Adejumobi","raw_affiliation_strings":["Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043078523","display_name":"Adeolu Alex Adedapo","orcid":"https://orcid.org/0000-0003-3003-7579","observed_orcids":["https://orcid.org/0000-0003-3003-7579"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Adeolu Alex Adedapo","raw_affiliation_strings":["Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074800822","display_name":"Momoh Audu Yakubu","orcid":"https://orcid.org/0000-0002-6072-2473","observed_orcids":["https://orcid.org/0000-0002-6072-2473"]},"institutions":[{"id":"https://openalex.org/I48205209","display_name":"Texas Southern University","ror":"https://ror.org/05ch0aw77","country_code":"US","type":"education","lineage":["https://openalex.org/I48205209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Momoh Audu Yakubu","raw_affiliation_strings":["Department of Environmental and Interdisciplinary Sciences, COSET, Texas Southern University, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-6072-2473","affiliations":[{"raw_affiliation_string":"Department of Environmental and Interdisciplinary Sciences, COSET, Texas Southern University, Houston, TX, USA","institution_ids":["https://openalex.org/I48205209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043404389"],"corresponding_institution_ids":["https://openalex.org/I181631907"],"apc_list":{"value":1625,"currency":"GBP","value_usd":1993},"apc_paid":{"value":1625,"currency":"GBP","value_usd":1993},"fwci":1.2868,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.74911574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"22","issue":"6","first_page":"467","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.13449999690055847,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-arsenite","display_name":"sodium arsenite","score":0.9950000047683716},{"id":"https://openalex.org/keywords/arsenic-toxicity","display_name":"arsenic toxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9120000004768372},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.847000002861023},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.6620000004768372},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2779495234","wikidata":"https://www.wikidata.org/wiki/Q419586","display_name":"Sodium arsenite","level":3,"score":0.7884654998779297},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7474008202552795},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.682545006275177},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6670976877212524},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.6156686544418335},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5892268419265747},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.5866301655769348},{"id":"https://openalex.org/C172507514","wikidata":"https://www.wikidata.org/wiki/Q730249","display_name":"Arsenic toxicity","level":3,"score":0.5812938213348389},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5455682873725891},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5141029953956604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5111587643623352},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.4897890090942383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47811856865882874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4650508165359497},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.442238450050354},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4002174735069275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2990354597568512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2657396197319031},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.1769353151321411},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13868671655654907},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017670","descriptor_name":"Sodium Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018053","descriptor_name":"Arsenites","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/13510002.2017.1308910","doi":"https://doi.org/10.1080/13510002.2017.1308910","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13510002.2017.1308910","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13510002.2017.1308910?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8900624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8900624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Rep","raw_type":"Text"},{"id":"pmid:28366046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28366046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox report : communications in free radical research","raw_type":"Journal Article"},{"id":"pmh:oai:digitalscholarship.tsu.edu:facpubs-1222","doi":null,"is_oa":false,"landing_page_url":"https://digitalscholarship.tsu.edu/facpubs/212","pdf_url":null,"source":{"id":"https://openalex.org/S4377196639","display_name":"Digital Scholarship - Texas Southern University (Texas Southern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I48205209","host_organization_name":"Texas Southern University","host_organization_lineage":["https://openalex.org/I48205209"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1080/13510002.2017.1308910","doi":"https://doi.org/10.1080/13510002.2017.1308910","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13510002.2017.1308910","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13510002.2017.1308910?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2604189752.pdf","grobid_xml":"https://content.openalex.org/works/W2604189752.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W952491933","https://openalex.org/W1506043065","https://openalex.org/W1516423097","https://openalex.org/W1523119366","https://openalex.org/W1553130581","https://openalex.org/W1581414347","https://openalex.org/W1674731755","https://openalex.org/W1750690213","https://openalex.org/W1964612566","https://openalex.org/W1979376504","https://openalex.org/W1987739207","https://openalex.org/W2000922007","https://openalex.org/W2011630342","https://openalex.org/W2016586100","https://openalex.org/W2034327183","https://openalex.org/W2055376998","https://openalex.org/W2060194897","https://openalex.org/W2060292931","https://openalex.org/W2073495046","https://openalex.org/W2073562334","https://openalex.org/W2082737026","https://openalex.org/W2082946732","https://openalex.org/W2096795975","https://openalex.org/W2102029805","https://openalex.org/W2103527486","https://openalex.org/W2123733967","https://openalex.org/W2125032250","https://openalex.org/W2266929960","https://openalex.org/W2315717810","https://openalex.org/W2341645158","https://openalex.org/W2346969849","https://openalex.org/W2355509766","https://openalex.org/W2570425584"],"related_works":["https://openalex.org/W4406177768","https://openalex.org/W2758437082","https://openalex.org/W4388048936","https://openalex.org/W1974173442","https://openalex.org/W2000922007","https://openalex.org/W2042303541","https://openalex.org/W2086349015","https://openalex.org/W2951731008","https://openalex.org/W7161390772","https://openalex.org/W2346969849"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Arsenic":[1],"is":[2,7,22],"a":[3,129,157],"ubiquitous":[4],"element":[5],"that":[6],"widely":[8],"distributed":[9],"in":[10,99,107,116,122,132,159],"the":[11,25,39,58,123,127,133,160,163],"environment":[12],"to":[13,37,56,70,149,171,182],"which":[14],"man":[15],"and":[16,32,49,76,95,102,111,173,192],"animals":[17],"are":[18],"exposed.":[19],"Cardiovascular":[20],"disease":[21],"one":[23],"of":[24,27,41,60,62,87,162,189,194],"aftermaths":[26],"chronic":[28],"arsenic":[29,153,172,183],"exposure-related":[30],"morbidity":[31],"mortality.":[33],"This":[34],"study":[35,53],"sought":[36],"investigate":[38],"possibility":[40],"reversal":[42],"from":[43],"arsenic-induced":[44],"cardio-renal":[45,185],"toxicity":[46,186],"following":[47,140,169],"exposure":[48,170],"subsequent":[50],"withdrawal.":[51,88,154],"The":[52],"also":[54],"seeks":[55],"understand":[57],"mechanism":[59],"action":[61],"this":[63,174],"reversal.":[64],"METHODS:":[65],"Rats":[66],"were":[67,120],"orally":[68],"exposed":[69],"sodium":[71],"arsenite":[72],"at":[73],"10,":[74],"20":[75],"40":[77],"mg/kg":[78],"daily":[79],"for":[80],"4":[81,85],"weeks":[82,86],"followed":[83],"by":[84,178],"RESULTS:":[89],"generation":[90],"but":[91],"decrease":[92],"total":[93],"thiol":[94],"reduced":[96],"glutathione":[97,117],"levels":[98],"both":[100],"cardiac":[101,124],"renal":[103,134],"tissues.":[104,125],"Furthermore,":[105],"increases":[106,115],"superoxide":[108],"dismutase,":[109],"glutathione-S-transferase":[110],"catalase":[112],"with":[113],"significant":[114,130],"peroxidase":[118],"activities":[119],"observed":[121],"On":[126],"contrary,":[128],"reduction":[131,158],"antioxidant":[135,143],"enzyme":[136],"activity":[137],"was":[138,175],"recorded":[139],"exposure.":[141],"Also,":[142],"defense":[144],"system":[145],"did":[146],"not":[147,176],"return":[148],"apparent":[150],"values":[151],"after":[152],"Immunohistochemistry":[155],"revealed":[156],"expression":[161],"pro-survival":[164],"protein-protein":[165],"kinase":[166],"B":[167],"(Akt/PKB)":[168],"reversed":[177],"withdrawal":[179],"Discussion:":[180],"Exposure":[181],"caused":[184],"via":[187],"induction":[188],"oxidative":[190],"stress":[191],"down-regulation":[193],"Akt/PKB":[195],"expressions.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-14T00:00:00"}
