{"id":"https://openalex.org/W2604154828","doi":"https://doi.org/10.1111/micc.12372","title":"Cdc42 regulates branching in angiogenic sprouting in vitro","display_name":"Cdc42 regulates branching in angiogenic sprouting in vitro","publication_year":2017,"publication_date":"2017-04-05","ids":{"openalex":"https://openalex.org/W2604154828","doi":"https://doi.org/10.1111/micc.12372","mag":"2604154828","pmid":"https://pubmed.ncbi.nlm.nih.gov/28376260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5505782"},"language":"en","primary_location":{"id":"doi:10.1111/micc.12372","doi":"https://doi.org/10.1111/micc.12372","is_oa":false,"landing_page_url":"https://doi.org/10.1111/micc.12372","pdf_url":null,"source":{"id":"https://openalex.org/S111876535","display_name":"Microcirculation","issn_l":"1073-9688","issn":["1073-9688","1549-8719"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microcirculation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5505782","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101640582","display_name":"Duc-Huy T. Nguyen","orcid":"https://orcid.org/0000-0003-0805-8103","observed_orcids":["https://orcid.org/0000-0003-0805-8103"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duc\u2010Huy T. Nguyen","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083753621","display_name":"Lin Gao","orcid":"https://orcid.org/0000-0002-1781-4671","observed_orcids":["https://orcid.org/0000-0002-1781-4671"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Gao","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084054380","display_name":"Alec Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alec Wong","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100609547","display_name":"Christopher S. Chen","orcid":"https://orcid.org/0000-0003-2445-8449","observed_orcids":["https://orcid.org/0000-0003-2445-8449"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher S. Chen","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston, MA, USA","Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2445-8449","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100609547"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984","https://openalex.org/I44142251","https://openalex.org/I79576946"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":0.8934,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.70532521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":1.0},{"id":"https://openalex.org/keywords/angiogenic-sprouting","display_name":"angiogenic sprouting","score":0.9959999918937683},{"id":"https://openalex.org/keywords/branching-morphogenesis","display_name":"branching morphogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.8640000224113464},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7789999842643738},{"id":"https://openalex.org/keywords/collective-migration","display_name":"collective migration","score":0.5730000138282776},{"id":"https://openalex.org/keywords/single-cell-migration","display_name":"single-cell migration","score":0.8830000162124634},{"id":"https://openalex.org/keywords/filopodia","display_name":"filopodia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tip-cells","display_name":"tip cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/vascular-structure","display_name":"vascular architecture","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.9373033046722412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7216558456420898},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7205687761306763},{"id":"https://openalex.org/C2778241760","wikidata":"https://www.wikidata.org/wiki/Q1057052","display_name":"Sprouting","level":2,"score":0.657785952091217},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5525993704795837},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5005090236663818},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44454970955848694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43007558584213257},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.41221147775650024},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1852504014968872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1728856861591339},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13104015588760376},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.10657823085784912},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032701","descriptor_name":"Biomimetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/micc.12372","doi":"https://doi.org/10.1111/micc.12372","is_oa":false,"landing_page_url":"https://doi.org/10.1111/micc.12372","pdf_url":null,"source":{"id":"https://openalex.org/S111876535","display_name":"Microcirculation","issn_l":"1073-9688","issn":["1073-9688","1549-8719"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microcirculation","raw_type":"journal-article"},{"id":"pmid:28376260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28376260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microcirculation (New York, N.Y. : 1994)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4974366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5505782","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5505782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5505782","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Microcirculation","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4974366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5505782","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2673717269","display_name":"Using micropost arrays to measure traction forces during dendritic cell motility","funder_award_id":"R01GM104287","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G730080929","display_name":"Local Regulation of Angiogenesis by Microenvironment","funder_award_id":"R01EB000262","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W146073455","https://openalex.org/W1595817144","https://openalex.org/W1968680922","https://openalex.org/W1977245174","https://openalex.org/W1984042890","https://openalex.org/W2020410964","https://openalex.org/W2030609555","https://openalex.org/W2071199281","https://openalex.org/W2084112564","https://openalex.org/W2086452068","https://openalex.org/W2086919152","https://openalex.org/W2088390218","https://openalex.org/W2100537036","https://openalex.org/W2102748451","https://openalex.org/W2109067831","https://openalex.org/W2112251383","https://openalex.org/W2113837682","https://openalex.org/W2120859231","https://openalex.org/W2120909571","https://openalex.org/W2134033760","https://openalex.org/W2145013849","https://openalex.org/W2153593459","https://openalex.org/W2160422029","https://openalex.org/W2163579392","https://openalex.org/W2166639482","https://openalex.org/W2221895040","https://openalex.org/W2269409612","https://openalex.org/W2278684209"],"related_works":["https://openalex.org/W2800292831","https://openalex.org/W2047779091","https://openalex.org/W3009493537","https://openalex.org/W2054034043","https://openalex.org/W2086452068","https://openalex.org/W2343541706","https://openalex.org/W2566545260","https://openalex.org/W4379744593","https://openalex.org/W2064026527","https://openalex.org/W3160401938"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1],"morphogenetic":[2,115,187],"events":[3,43,142],"that":[4,123,153,182],"occur":[5],"during":[6,189],"angiogenic":[7,27,95,118,190],"sprouting":[8,28,191],"involve":[9],"several":[10],"members":[11],"of":[12,16,24,38,53,66,94,111,117,126,134,147,161,171,197],"the":[13,21,36,51,85,109,114,145,169,195,198],"Rho":[14],"family":[15],"GTPases,":[17],"including":[18],"Cdc42.":[19],"However,":[20],"precise":[22],"roles":[23,52],"Cdc42":[25,54,99,112,127,155,166,183],"in":[26,44,55,58,68,87,159,174],"have":[29],"been":[30],"difficult":[31],"to":[32,35,40,49,89,139],"elucidate":[33],"owing":[34],"lack":[37],"models":[39],"study":[41],"these":[42,148],"vitro.":[45],"Here,":[46],"we":[47,97],"aim":[48],"identify":[50],"branching":[56,141],"morphogenesis":[57],"angiogenesis.":[59],"METHODS:":[60],"Using":[61],"a":[62,76,90,102],"3D":[63],"biomimetic":[64],"model":[65],"angiogenesis":[67],"vitro,":[69],"where":[70],"endothelial":[71,135,175],"cells":[72],"were":[73],"seeded":[74],"inside":[75],"cylindrical":[77],"channel":[78,86],"within":[79],"collagen":[80],"gel":[81],"and":[82,107,192],"sprouted":[83],"from":[84],"response":[88],"defined":[91],"biochemical":[92],"gradient":[93],"factors,":[96],"inhibited":[98],"activity":[100],"with":[101],"small":[103],"molecule":[104],"inhibitor":[105],"ML141":[106],"examined":[108],"effects":[110,130],"on":[113,131],"processes":[116,188],"sprouting.":[119],"RESULTS:":[120],"We":[121,150],"find":[122],"partial":[124],"inhibition":[125],"had":[128],"minimal":[129],"directional":[132],"migration":[133,158],"cells,":[136],"but":[137],"led":[138],"fewer":[140],"without":[143],"affecting":[144],"length":[146],"branches.":[149],"also":[151,167],"observed":[152],"antagonizing":[154],"reduced":[156],"collective":[157],"favor":[160],"single":[162],"cell":[163],"migration.":[164],"Additionally,":[165],"regulated":[168],"initiation":[170],"filopodial":[172],"extensions":[173],"tip":[176],"cells.":[177],"CONCLUSIONS:":[178],"Our":[179],"findings":[180],"suggest":[181],"can":[184],"affect":[185],"multiple":[186],"ultimately":[193],"impact":[194],"architecture":[196],"vasculature.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-14T00:00:00"}
