{"id":"https://openalex.org/W2604077333","doi":"https://doi.org/10.3892/ol.2017.5928","title":"HIF-1\u03b1 acts as a molecular target for simvastatin cytotoxicity in B16.F10 melanoma cells cultured under chemically induced hypoxia","display_name":"HIF-1\u03b1 acts as a molecular target for simvastatin cytotoxicity in B16.F10 melanoma cells cultured under chemically induced hypoxia","publication_year":2017,"publication_date":"2017-03-27","ids":{"openalex":"https://openalex.org/W2604077333","doi":"https://doi.org/10.3892/ol.2017.5928","mag":"2604077333","pmid":"https://pubmed.ncbi.nlm.nih.gov/28521491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5431316"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2017.5928","doi":"https://doi.org/10.3892/ol.2017.5928","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2017.5928","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2017.5928/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/ol.2017.5928/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075340410","display_name":"Emilia Lic\u0103rete","orcid":"https://orcid.org/0000-0003-1190-6003","observed_orcids":["https://orcid.org/0000-0003-1190-6003"]},"institutions":[{"id":"https://openalex.org/I3125347698","display_name":"Babe\u0219-Bolyai University","ror":"https://ror.org/02rmd1t30","country_code":"RO","type":"education","lineage":["https://openalex.org/I3125347698"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Emilia Licarete","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]},{"raw_affiliation_string":"Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048417448","display_name":"Alina Ses\u0103rman","orcid":"https://orcid.org/0000-0002-7491-9955","observed_orcids":["https://orcid.org/0000-0002-7491-9955"]},"institutions":[{"id":"https://openalex.org/I3125347698","display_name":"Babe\u0219-Bolyai University","ror":"https://ror.org/02rmd1t30","country_code":"RO","type":"education","lineage":["https://openalex.org/I3125347698"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Alina Sesarman","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]},{"raw_affiliation_string":"Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083377960","display_name":"Valentin Florian Rauca","orcid":"https://orcid.org/0000-0002-5879-9308","observed_orcids":["https://orcid.org/0000-0002-5879-9308"]},"institutions":[{"id":"https://openalex.org/I3125347698","display_name":"Babe\u0219-Bolyai University","ror":"https://ror.org/02rmd1t30","country_code":"RO","type":"education","lineage":["https://openalex.org/I3125347698"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Valentin Florian Rauca","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061590676","display_name":"Lavinia Lupu\u0163","orcid":"https://orcid.org/0000-0003-3815-0170","observed_orcids":["https://orcid.org/0000-0003-3815-0170"]},"institutions":[{"id":"https://openalex.org/I3125347698","display_name":"Babe\u0219-Bolyai University","ror":"https://ror.org/02rmd1t30","country_code":"RO","type":"education","lineage":["https://openalex.org/I3125347698"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Lavinia Luput","raw_affiliation_strings":["Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027719379","display_name":"Laura P\u0103tra\u0219","orcid":"https://orcid.org/0000-0002-6981-3881","observed_orcids":["https://orcid.org/0000-0002-6981-3881"]},"institutions":[{"id":"https://openalex.org/I3125347698","display_name":"Babe\u0219-Bolyai University","ror":"https://ror.org/02rmd1t30","country_code":"RO","type":"education","lineage":["https://openalex.org/I3125347698"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Laura Patras","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]},{"raw_affiliation_string":"Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043390427","display_name":"Manuela Banciu","orcid":"https://orcid.org/0000-0003-2556-4008","observed_orcids":["https://orcid.org/0000-0003-2556-4008"]},"institutions":[{"id":"https://openalex.org/I3125347698","display_name":"Babe\u0219-Bolyai University","ror":"https://ror.org/02rmd1t30","country_code":"RO","type":"education","lineage":["https://openalex.org/I3125347698"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Manuela Banciu","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]},{"raw_affiliation_string":"Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400006 Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I3125347698"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3125347698"],"apc_list":null,"apc_paid":null,"fwci":0.6475,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.60413799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"5","first_page":"3942","last_page":"3950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.18799999356269836,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.972000002861023},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cobalt-chloride","display_name":"cobalt chloride","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9539999961853027},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.6110000014305115},{"id":"https://openalex.org/keywords/anticancer-drug-combination","display_name":"anticancer drug combination","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.8560316562652588},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7758586406707764},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.7606881260871887},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7030511498451233},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6894148588180542},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6594049334526062},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.623404860496521},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5876755118370056},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5416865944862366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4215569496154785},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41109564900398254},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37567830085754395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34199249744415283},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32130134105682373},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24907410144805908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18845608830451965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1631239950656891},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/ol.2017.5928","doi":"https://doi.org/10.3892/ol.2017.5928","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2017.5928","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2017.5928/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4283767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5431316","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5431316","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5431316","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"},{"id":"pmid:28521491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28521491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ol.2017.5928","doi":"https://doi.org/10.3892/ol.2017.5928","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2017.5928","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2017.5928/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1679186985","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G3548584378","display_name":null,"funder_award_id":"POSDRU/159/1.5/S/133391","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"}],"funders":[{"id":"https://openalex.org/F4320315989","display_name":"National Authority for Scientific Research and Innovation","ror":null},{"id":"https://openalex.org/F4320323444","display_name":"Autoritatea National\u0103 pentru Cercetare Stiintific\u0103","ror":"https://ror.org/03padf885"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2604077333.pdf","grobid_xml":"https://content.openalex.org/works/W2604077333.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1500106869","https://openalex.org/W1547961512","https://openalex.org/W1576012697","https://openalex.org/W1889409859","https://openalex.org/W1963092557","https://openalex.org/W1967920215","https://openalex.org/W1971660417","https://openalex.org/W1972495045","https://openalex.org/W1973891793","https://openalex.org/W1988377666","https://openalex.org/W1992102289","https://openalex.org/W2001348339","https://openalex.org/W2018554367","https://openalex.org/W2019784830","https://openalex.org/W2022369905","https://openalex.org/W2025974453","https://openalex.org/W2031468048","https://openalex.org/W2035816919","https://openalex.org/W2037841577","https://openalex.org/W2042784458","https://openalex.org/W2046440427","https://openalex.org/W2047423258","https://openalex.org/W2068647210","https://openalex.org/W2073493869","https://openalex.org/W2075219064","https://openalex.org/W2087688280","https://openalex.org/W2091068407","https://openalex.org/W2098547698","https://openalex.org/W2106925175","https://openalex.org/W2107236288","https://openalex.org/W2107893047","https://openalex.org/W2109120201","https://openalex.org/W2116715687","https://openalex.org/W2118291530","https://openalex.org/W2121001769","https://openalex.org/W2121385812","https://openalex.org/W2123049006","https://openalex.org/W2125289626","https://openalex.org/W2130522035","https://openalex.org/W2150048971","https://openalex.org/W2161129080","https://openalex.org/W2162121911","https://openalex.org/W2261170609","https://openalex.org/W2580449060"],"related_works":["https://openalex.org/W7162011049","https://openalex.org/W2888328083","https://openalex.org/W4402736192","https://openalex.org/W2046440427","https://openalex.org/W4289877076","https://openalex.org/W7097500437","https://openalex.org/W2792562552","https://openalex.org/W2391233698","https://openalex.org/W2062235476","https://openalex.org/W1979247766"],"abstract_inverted_index":{"Our":[0],"previous":[1],"studies":[2],"reported":[3],"that":[4,86,208],"one":[5],"of":[6,10,14,27,32,36,59,69,80,115,119,123,129,141,143,166,180,216],"the":[7,11,28,33,37,45,66,87,102,120,126,139,155,159,176,213],"main":[8,177],"mechanisms":[9],"antitumor":[12],"activity":[13],"simvastatin":[15],"(SIM)":[16],"in":[17,71,150,186,203,218],"B16.F10":[18,60,103,151],"murine":[19],"melanoma":[20,73,92],"cells":[21,61,74,93,153],"was":[22,131],"associated":[23],"with":[24,62,205],"strong":[25,98],"suppression":[26],"constitutive":[29,67,127,214],"cell":[30,104],"production":[31,68,149,185],"\u03b1":[34],"subunit":[35],"heterodimeric":[38],"transcription":[39],"factor":[40,42],"hypoxia-inducible":[41],"(HIF)-1.":[43],"Thus,":[44],"present":[46,160],"study":[47,161],"aimed":[48],"to":[49,106,138,175,211],"broaden":[50],"this":[51,81,144,181],"finding":[52],"under":[53],"hypoxic":[54,187],"conditions":[55],"induced":[56],"by":[57,77,134],"incubation":[58],"cobalt":[63],"chloride,":[64],"when":[65],"HIF-1\u03b1":[70,130,184,217],"these":[72,191],"is":[75],"amplified":[76],"inducible":[78,121],"expression":[79,122,128,215],"factor.":[82],"The":[83],"data":[84,192],"demonstrated":[85],"SIM":[88,167,201],"antiproliferative":[89],"effects":[90,165],"on":[91,101,146,168,183,200],"were":[94],"mediated":[95],"mainly":[96],"via":[97],"suppressive":[99],"actions":[100],"capacity":[105],"support":[107],"tumor":[108,169,188],"angiogenesis":[109],"and":[110],"inflammation,":[111],"as":[112],"a":[113,116],"result":[114],"high":[117],"inhibition":[118],"HIF-1\u03b1.":[124],"However,":[125],"not":[132],"affected":[133],"SIM,":[135],"probably":[136],"due":[137],"lack":[140],"effect":[142],"statin":[145,182],"nuclear":[147],"factor-\u03baB":[148],"cancer":[152],"at":[154],"concentration":[156],"tested.":[157],"Additionally,":[158],"noted":[162],"slight":[163],"reducing":[164],"oxidative":[170],"stress,":[171],"which":[172],"may":[173],"contribute":[174],"inhibitory":[178],"action":[179],"cells.":[189],"Collectively,":[190],"are":[193,209],"valuable":[194],"for":[195],"future":[196],"anticancer":[197],"strategies":[198],"based":[199],"administration":[202],"combination":[204],"cytotoxic":[206],"drugs":[207],"able":[210],"counteract":[212],"tumors.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}
