{"id":"https://openalex.org/W2603778043","doi":"https://doi.org/10.1182/blood.v126.23.442.442","title":"S6K1 Regulates Self-Renewal of Leukemia Initiating Cells and Normal Hematopoietic Stem Cells","display_name":"S6K1 Regulates Self-Renewal of Leukemia Initiating Cells and Normal Hematopoietic Stem Cells","publication_year":2015,"publication_date":"2015-12-03","ids":{"openalex":"https://openalex.org/W2603778043","doi":"https://doi.org/10.1182/blood.v126.23.442.442","mag":"2603778043"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v126.23.442.442","doi":"https://doi.org/10.1182/blood.v126.23.442.442","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.442.442","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025331824","display_name":"Joydeep Ghosh","orcid":"https://orcid.org/0000-0003-2497-964X","observed_orcids":["https://orcid.org/0000-0003-2497-964X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joydeep Ghosh","raw_affiliation_strings":["Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103109746","display_name":"Anindya Chatterjee","orcid":"https://orcid.org/0000-0003-4584-5990","observed_orcids":["https://orcid.org/0000-0003-4584-5990"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anindya Chatterjee","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054139346","display_name":"Baskar Ramdas","orcid":"https://orcid.org/0009-0006-2206-5720","observed_orcids":["https://orcid.org/0009-0006-2206-5720"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Baskar Ramdas","raw_affiliation_strings":["Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008673953","display_name":"Michihiro Kobayashi","orcid":"https://orcid.org/0000-0001-6065-6026","observed_orcids":["https://orcid.org/0000-0001-6065-6026"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michihiro Kobayashi","raw_affiliation_strings":["Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102586377","display_name":"Peilin Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peilin Ma","raw_affiliation_strings":["Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351183","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0003-4878-9111","observed_orcids":["https://orcid.org/0000-0003-4878-9111"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":["Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070365550","display_name":"David R. Plas","orcid":"https://orcid.org/0000-0001-7568-1400","observed_orcids":["https://orcid.org/0000-0001-7568-1400"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Plas","raw_affiliation_strings":["University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035841414","display_name":"Reuben Kapur","orcid":"https://orcid.org/0000-0003-2225-1700","observed_orcids":["https://orcid.org/0000-0003-2225-1700","https://orcid.org/0009-0008-1025-5126"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reuben Kapur","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008673953","https://openalex.org/A5054139346","https://openalex.org/A5070365550","https://openalex.org/A5102586377","https://openalex.org/A5103109746"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I63135867"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36780849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"23","first_page":"442","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.27390000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.11540000140666962,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s6k1","display_name":"S6K1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/leukemia-initiating-cells","display_name":"leukemia-initiating cells","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mll-af9-fusion","display_name":"MLL-AF9 fusion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/raptors","display_name":"raptors","score":0.7639999985694885},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/serial-transplantation","display_name":"serial transplantation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.621999979019165},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.5149999856948853},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7134091854095459},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6521384716033936},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6043416857719421},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6036826968193054},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5890641212463379},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.579033374786377},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.5600491762161255},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.4810514748096466},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.46805375814437866},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.42656466364860535},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3569062054157257},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33489060401916504},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15792685747146606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v126.23.442.442","doi":"https://doi.org/10.1182/blood.v126.23.442.442","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.442.442","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6902732499","https://openalex.org/W2409479260","https://openalex.org/W2127259700","https://openalex.org/W2597817312","https://openalex.org/W2943578965","https://openalex.org/W2547556544","https://openalex.org/W3129753562","https://openalex.org/W2983414429","https://openalex.org/W2433883710","https://openalex.org/W4400618560"],"abstract_inverted_index":{"Abstract":[0],"The":[1,152,471],"mixed-lineage":[2],"leukemia":[3,34,91,189],"(MLL)":[4],"gene":[5],"is":[6,150,162],"required":[7],"for":[8,59],"the":[9,87,96,126,146,215,248,253,318,330,414,440,458,534],"maintenance":[10],"of":[11,19,31,40,68,76,89,108,128,142,148,157,166,168,174,178,186,198,217,250,258,264,292,332,351,372,383,389,396,416,442,461,474,498,504,509,513,536,582,593,609,611,617,626,630,643],"adult":[12,32],"hematopoietic":[13,65,235,278],"stem":[14,279],"cells":[15,93,236,282,340,355,551,563,621],"(HSCs)":[16],"and":[17,36,52,105,171,184,205,213,256,276,280,284,295,308,320,343,394,422,432,484,614,628],"regulation":[18],"progenitor":[20,281],"population.":[21],"Translocations":[22],"in":[23,28,37,43,61,73,101,195,234,252,274,315,386,405,418,430,466,493,501,520,538,575,586,619,623,632,635],"MLL":[24,69,97],"have":[25,54,246],"been":[26,55,229],"detected":[27],"approximately":[29,38],"5-10%":[30],"acute":[33,41,187],"patients":[35,79],"70%":[39],"leukemias":[42],"infants.":[44],"Various":[45],"genes,":[46],"including":[47],"AF4,":[48],"AF5,":[49],"AF9,":[50],"ELL":[51],"ENL":[53],"identified":[56],"as":[57,374,376,447,605],"partners":[58],"translocation":[60],"MLL-rearranged":[62],"leukemia.":[63,98],"In":[64,119,135,242,323],"cells,":[66],"expression":[67],"fusion":[70,240,272],"proteins":[71],"result":[72],"a":[74,102,163,176,261,406,606],"block":[75],"differentiation.":[77],"AML":[78,259,354,620],"who":[80,347],"successfully":[81,129],"undergo":[82],"treatment":[83,111],"but":[84,191,457],"relapse":[85],"suggest":[86],"importance":[88],"targeting":[90],"initiating":[92],"(LICs)":[94],"within":[95,409],"LICs":[99,122,613],"remain":[100],"quiescent":[103],"state":[104],"are":[106,123],"capable":[107],"survival":[109,316],"despite":[110],"with":[112,339,561],"chemotherapeutic":[113],"agents":[114],"or":[115,556],"targeted":[116],"molecular":[117],"inhibitors.":[118],"mouse":[120],"models,":[121],"defined":[124,448],"by":[125,449],"capability":[127],"propagating":[130],"disease":[131,139,627],"upon":[132],"serial":[133],"transplantation.":[134],"order":[136,324],"to":[137,231,325,360,527,598,645],"prevent":[138],"relapse,":[140],"identification":[141],"molecules,":[143],"which":[144,398],"regulate":[145],"self-renewal":[147,167,331,610,637],"LICs,":[149,333],"essential.":[151],"phosphatidylinositol":[153],"3-kinase":[154],"(PI3K)-Akt-mechanistic":[155],"target":[156],"rapamycin":[158],"complex1":[159],"(mTORC1)":[160],"pathway":[161,391],"key":[164],"regulator":[165,608],"both":[169,293,392,612],"HSCs":[170,429,445,588,596,633],"LICs.":[172],"Deletion":[173],"Raptor,":[175],"subunit":[177],"mTORC1,":[179],"does":[180],"not":[181,438],"affect":[182],"initiation":[183,220],"progression":[185,255],"myeloid":[188,480],"(AML),":[190],"Raptor":[192],"deficiency":[193,436,629],"results":[194,385,622,634],"delayed":[196,624],"propagation":[197,257,625],"AML.":[199,310,349],"Upon":[200],"its":[201],"activation,":[202],"mTORC1":[203,378,397],"phosphorylates":[204],"activates":[206],"p70":[207],"ribosomal":[208],"protein":[209,224],"S6":[210],"kinase":[211],"(S6K1)":[212],"inhibits":[214],"activity":[216],"eukaryote":[218],"translation":[219],"factor":[221],"4E":[222],"binding":[223],"1":[225],"(4E-BP1).":[226],"S6K1":[227,251,265,328,352,364,384,401,417,435,467,494,499,537,568,594,604,618,631],"has":[228],"shown":[230],"be":[232,403],"hyperactivated":[233],"expressing":[237,367],"oncogenic":[238],"MLL-AF9":[239,271,299,368],"protein.":[241],"our":[243,601],"study,":[244],"we":[245,334,424,541],"assessed":[247],"role":[249,415,535],"initiation,":[254],"using":[260],"genetic":[262],"model":[263],"knockout":[266],"mice":[267,338,469,525,558],"(S6K1-/-).":[268],"We":[269],"expressed":[270],"oncoprotein":[273],"WT":[275,294,319,342,431,555],"S6K1-/-":[277,296,321,344,433,524,557],"(HSC/Ps)":[283],"transplanted":[285,335,560],"them":[286],"into":[287,564],"lethally":[288,336,565],"irradiated":[289,337,566],"recipients.":[290,322,567],"Recipients":[291,350],"HSC/Ps":[297,366],"bearing":[298],"displayed":[300,571],"high":[301],"white":[302],"blood":[303],"cell":[304,514],"(WBC)":[305],"count,":[306],"splenomegaly":[307],"developed":[309,348],"There":[311],"was":[312,517,584],"no":[313],"difference":[314],"between":[317],"determine":[326,413],"whether":[327],"regulates":[329],"from":[341,523,529,548,553,590],"primary":[345],"recipients":[346,577,592],"deficient":[353,365,468,495,569,595],"survived":[356],"significantly":[357,464,491,518],"longer":[358],"compared":[359,526,597],"controls":[361],"(n=17/group,":[362],"p<0.001).":[363,579],"showed":[369],"reduced":[370,387,465,492,502,572],"activation":[371,388],"Akt":[373],"well":[375],"decreased":[377,519,636],"activity,":[379],"suggesting":[380],"that":[381,400],"deletion":[382],"PI-3K-Akt-mTORC1":[390],"upstream":[393],"downstream":[395],"indicates":[399],"might":[402],"involve":[404],"feedback":[407],"loop":[408],"this":[410],"pathway.":[411],"To":[412,532],"normal":[419],"HSC":[420],"development":[421],"maintenance,":[423],"analyzed":[425],"bone":[426,549],"marrow":[427,550],"derived":[428,522,552],"mice.":[434,496],"did":[437],"alter":[439],"frequency":[441],"long":[443],"term":[444],"(LT-HSCs)":[446],"CD150+":[450],"CD48-":[451],"Lin-":[452],"Sca1+":[453],"c-Kit+":[454],"surface":[455],"markers,":[456],"absolute":[459,472],"number":[460,473],"LT-HSCs":[462,505,521,528,547,570],"were":[463,489,559],"(p<0.02).":[470],"multipotent":[475],"progenitors":[476,481,486],"(MPPs)":[477],"(p<0.001),":[478],"common":[479],"(CMPs)":[482],"(p<0.01)":[483,488],"megakaryocyte-erythroid":[485],"(MEPs)":[487],"also":[490],"Deficiency":[497,616],"resulted":[500],"quiescence":[503],"(p<0.05).":[506],"Expression":[507,580],"level":[508,581],"p21,":[510],"an":[511],"inhibitor":[512],"cycle":[515],"progression,":[516],"control":[530],"group.":[531],"study":[533,602],"HSCs'":[539],"function,":[540],"performed":[542],"competitive":[543],"repopulation":[544],"assay.":[545],"Sorted":[546],"either":[554],"competitor":[562],"repopulating":[573],"ability":[574],"secondary":[576,591],"(n=9-10/group,":[578],"p21":[583],"downregulated":[585],"donor-derived":[587],"isolated":[589],"control.":[599],"Overall,":[600],"establishes":[603],"critical":[607],"HSCs.":[615],"potential.":[638],"Disclosures":[639],"No":[640],"relevant":[641],"conflicts":[642],"interest":[644],"declare.":[646]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-04-07T00:00:00"}