{"id":"https://openalex.org/W2603744264","doi":null,"title":"Diminished cerebrovascular reserve in the cerebral white matter of elderly individuals with leukoaraiosis","display_name":"Diminished cerebrovascular reserve in the cerebral white matter of elderly individuals with leukoaraiosis","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2603744264","mag":"2603744264"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/73143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/73143","pdf_url":"https://utoronto.scholaris.ca/bitstreams/45be7669-d56b-4272-bb97-ad4bbf43cdfc/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/45be7669-d56b-4272-bb97-ad4bbf43cdfc/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065429959","display_name":"Kevin Sam","orcid":"https://orcid.org/0000-0002-1030-752X","observed_orcids":["https://orcid.org/0000-0002-1030-752X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kevin Sam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065429959"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cerebrovascular-reserve","display_name":"cerebrovascular reserve","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cerebrovascular-reactivity","display_name":"cerebrovascular reactivity","score":0.968999981880188},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.8799999952316284},{"id":"https://openalex.org/keywords/normal-appearing-white-matter","display_name":"normal-appearing white matter","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.4970000088214874},{"id":"https://openalex.org/keywords/carbon-dioxide-reactivity","display_name":"carbon dioxide reactivity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/white-matter-injury","display_name":"white matter injury","score":0.699999988079071},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"diffusion MRI","score":0.640999972820282},{"id":"https://openalex.org/keywords/perfusion-mri","display_name":"perfusion MRI","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.47600001096725464},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5889999866485596},{"id":"https://openalex.org/keywords/white-matter-ischemia","display_name":"white matter ischemia","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2776191500","wikidata":"https://www.wikidata.org/wiki/Q2123166","display_name":"Leukoaraiosis","level":4,"score":0.9531227350234985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5522333979606628},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5514053106307983},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4338645935058594},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41919374465942383},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.1552906334400177},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1188163161277771}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/73143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/73143","pdf_url":"https://utoronto.scholaris.ca/bitstreams/45be7669-d56b-4272-bb97-ad4bbf43cdfc/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2603744264","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/73143/3/Sam_Kevin_201606_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/73143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/73143","pdf_url":"https://utoronto.scholaris.ca/bitstreams/45be7669-d56b-4272-bb97-ad4bbf43cdfc/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2603744264.pdf","grobid_xml":"https://content.openalex.org/works/W2603744264.grobid-xml"},"referenced_works_count":131,"referenced_works":["https://openalex.org/W61629541","https://openalex.org/W128151115","https://openalex.org/W204247669","https://openalex.org/W578813473","https://openalex.org/W1497608667","https://openalex.org/W1508621167","https://openalex.org/W1520572285","https://openalex.org/W1549213315","https://openalex.org/W1567524252","https://openalex.org/W1602635229","https://openalex.org/W1822779864","https://openalex.org/W1839080396","https://openalex.org/W1873795627","https://openalex.org/W1919291000","https://openalex.org/W1927563061","https://openalex.org/W1952172696","https://openalex.org/W1964224738","https://openalex.org/W1971852160","https://openalex.org/W1972609121","https://openalex.org/W1974948363","https://openalex.org/W1978949387","https://openalex.org/W1982486040","https://openalex.org/W1983112713","https://openalex.org/W1983602360","https://openalex.org/W1986159654","https://openalex.org/W1986424054","https://openalex.org/W1988129374","https://openalex.org/W1990870045","https://openalex.org/W1994157973","https://openalex.org/W1995205013","https://openalex.org/W1996022954","https://openalex.org/W1996470432","https://openalex.org/W1997639314","https://openalex.org/W1997882069","https://openalex.org/W1998787359","https://openalex.org/W2003902517","https://openalex.org/W2003929217","https://openalex.org/W2004006028","https://openalex.org/W2008809070","https://openalex.org/W2009586997","https://openalex.org/W2011689297","https://openalex.org/W2014376103","https://openalex.org/W2019161608","https://openalex.org/W2019642924","https://openalex.org/W2020400960","https://openalex.org/W2024434386","https://openalex.org/W2026781040","https://openalex.org/W2027180565","https://openalex.org/W2031288206","https://openalex.org/W2034028717","https://openalex.org/W2042422091","https://openalex.org/W2042522004","https://openalex.org/W2042698075","https://openalex.org/W2043782309","https://openalex.org/W2045693909","https://openalex.org/W2046235958","https://openalex.org/W2046627153","https://openalex.org/W2050297923","https://openalex.org/W2051031104","https://openalex.org/W2054988239","https://openalex.org/W2055615567","https://openalex.org/W2056022329","https://openalex.org/W2056856515","https://openalex.org/W2060419273","https://openalex.org/W2060467175","https://openalex.org/W2062298663","https://openalex.org/W2063001897","https://openalex.org/W2063238201","https://openalex.org/W2064496873","https://openalex.org/W2065085069","https://openalex.org/W2065852918","https://openalex.org/W2066495740","https://openalex.org/W2068074389","https://openalex.org/W2073094519","https://openalex.org/W2073748140","https://openalex.org/W2077328502","https://openalex.org/W2081061369","https://openalex.org/W2082785212","https://openalex.org/W2085829822","https://openalex.org/W2086499847","https://openalex.org/W2087242089","https://openalex.org/W2087653213","https://openalex.org/W2090843523","https://openalex.org/W2090971379","https://openalex.org/W2091857690","https://openalex.org/W2094344877","https://openalex.org/W2094822743","https://openalex.org/W2095287737","https://openalex.org/W2100809123","https://openalex.org/W2105202736","https://openalex.org/W2107595357","https://openalex.org/W2107741047","https://openalex.org/W2110859952","https://openalex.org/W2111256015","https://openalex.org/W2111605497","https://openalex.org/W2114629294","https://openalex.org/W2117140276","https://openalex.org/W2118411978","https://openalex.org/W2122919389","https://openalex.org/W2124659271","https://openalex.org/W2125358722","https://openalex.org/W2125672808","https://openalex.org/W2127871601","https://openalex.org/W2128070813","https://openalex.org/W2130630814","https://openalex.org/W2132813432","https://openalex.org/W2133188899","https://openalex.org/W2134172803","https://openalex.org/W2136451283","https://openalex.org/W2136590470","https://openalex.org/W2136626157","https://openalex.org/W2137850467","https://openalex.org/W2142658473","https://openalex.org/W2144914358","https://openalex.org/W2146689212","https://openalex.org/W2147599271","https://openalex.org/W2148751712","https://openalex.org/W2148992333","https://openalex.org/W2151752381","https://openalex.org/W2156574403","https://openalex.org/W2159172202","https://openalex.org/W2160475191","https://openalex.org/W2161480852","https://openalex.org/W2163234334","https://openalex.org/W2163904986","https://openalex.org/W2165503283","https://openalex.org/W2166711387","https://openalex.org/W2170621670","https://openalex.org/W2172154123","https://openalex.org/W2409344231","https://openalex.org/W2416735615"],"related_works":["https://openalex.org/W2506724805","https://openalex.org/W2047576632","https://openalex.org/W2051426766","https://openalex.org/W2539797428","https://openalex.org/W1968058101","https://openalex.org/W2061601951","https://openalex.org/W2460521385","https://openalex.org/W2111605497","https://openalex.org/W2312371306","https://openalex.org/W4401575619"],"abstract_inverted_index":{"The":[0,135,150,201,303],"cerebral":[1,170],"white":[2,73,90,122,130,237,254,286,325],"matter":[3,74,91,111,123,131,255,287,326],"contains":[4],"millions":[5],"of":[6,14,25,47,66,86,103,112,117,137,158,168,185,188,214,220,227,284,305,324],"fibers":[7,27,53],"that":[8,75,210],"serve":[9],"to":[10,37,44,71,88,105,128,142,172,192,194,203,218,252,315],"connect":[11],"different":[12],"regions":[13],"the":[15,51,63,72,89,101,109,113,118,129,138,166,169,186,189,212,215,236,270,281,306,322],"brain":[16,30,228],"and":[17,126,156,262,301,328],"supports":[18],"sophisticated":[19],"information":[20],"processing.":[21],"A":[22],"sudden":[23],"loss":[24,46],"these":[26],"in":[28,34,55,146,208,224,235,249,260,269,312,336],"a":[29,35,38,56,82,147,183,195,292,330],"region":[31],"as":[32,199],"seen":[33],"stroke":[36],"large":[39,106],"blood":[40,67,124,159,174,221],"vessel,":[41],"can":[42,76,206],"lead":[43],"severe":[45],"function":[48],"especially":[49],"when":[50,289],"affected":[52],"are":[54],"strategic":[57],"location.":[58],"Little":[59],"is":[60,133,141,182,247,278,309],"known":[61],"about":[62],"fine":[64],"network":[65],"vessels":[68,107,125],"supplying":[69,108],"nutrition":[70],"become":[77],"diseased":[78],"with":[79,272,280],"age,":[80],"producing":[81],"very":[83],"similar":[84],"pattern":[85],"injury":[87,104,127,288,327,335],"termed":[92],"\"leukoaraiosis\".":[93],"Considerable":[94],"research":[95,140],"has":[96,243],"been":[97,267],"carried":[98],"out":[99],"studying":[100],"effects":[102],"gray":[110],"brain.":[114],"However,":[115],"understanding":[116],"relationship":[119,145],"between":[120],"dysfunctional":[121],"itself":[132],"limited.":[134],"purpose":[136],"present":[139,151],"study":[143],"this":[144,241],"unique":[148],"way.":[149],"work":[152],"will":[153],"use":[154],"MRI":[155,264,294],"manipulation":[157],"carbon":[160],"dioxide":[161],"(CO2)":[162],"levels":[163],"for":[164,333],"mapping":[165],"capacity":[167],"vasculature":[171,191,216],"control":[173],"flow,":[175],"i.e.":[176],"assessing":[177],"cerebrovascular":[178],"reactivity":[179],"(CVR).":[180],"CVR":[181,246,277],"measure":[184],"response":[187,202,308],"arterial":[190],"respond":[193],"vasoactive":[196],"stimulus,":[197],"such":[198],"CO2.":[200],"vasodilatory":[204],"stimuli":[205],"fail":[207],"diseases":[209],"affect":[211],"integrity":[213],"leading":[217],"interruption":[219],"supply,":[222],"resulting":[223],"varying":[225],"degrees":[226],"injury,":[229],"including":[230],"slowly":[231],"progressive":[232],"ischemic":[233],"demyelination":[234],"matter.":[238],"Research":[239],"within":[240],"thesis":[242,318],"demonstrated":[244],"that:":[245],"reduced":[248],"leukoaraiosis":[250,313],"compared":[251,314],"normal-appearing":[253],"(NAWM);":[256],"(2)":[257],"Cross-sectionally,":[258],"abnormalities":[259],"diffusion":[261],"perfusion":[263],"metrics":[265],"have":[266],"observed":[268],"NAWM":[271],"steal":[273],"physiology;":[274],"(3)":[275],"Reduced":[276],"associated":[279],"subsequent":[282],"development":[283],"visible":[285],"subjects":[290],"completed":[291],"follow-up":[293],"scan":[295],"separated":[296],"12-months":[297],"apart":[298],"from":[299],"baseline":[300],"(4)":[302],"speed":[304],"vascular":[307],"also":[310],"abnormal":[311],"NAWM.":[316],"This":[317],"provides":[319],"insight":[320],"into":[321],"mechanism":[323],"highlights":[329],"novel":[331],"method":[332],"predicting":[334],"susceptible":[337],"individuals.":[338]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-04-07T00:00:00"}
