{"id":"https://openalex.org/W2603560873","doi":"https://doi.org/10.1161/jaha.116.005257","title":"An NPPB Promoter Polymorphism Associated With Elevated N\u2010Terminal pro\u2013B\u2010Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality","display_name":"An NPPB Promoter Polymorphism Associated With Elevated N\u2010Terminal pro\u2013B\u2010Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality","publication_year":2017,"publication_date":"2017-03-25","ids":{"openalex":"https://openalex.org/W2603560873","doi":"https://doi.org/10.1161/jaha.116.005257","mag":"2603560873","pmid":"https://pubmed.ncbi.nlm.nih.gov/28341776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5533018"},"language":"en","primary_location":{"id":"doi:10.1161/jaha.116.005257","doi":"https://doi.org/10.1161/jaha.116.005257","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.116.005257","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1161/jaha.116.005257","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002826830","display_name":"Sara Bretschger Seidelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara B. Seidelmann","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","Division of Cardiovascular Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MA","Sara B. Seidelmann Cardiovascular Division, Brigham and Women's Hospital, Boston, MA Division of Cardiovascular Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Cardiovascular Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Sara B. Seidelmann Cardiovascular Division, Brigham and Women's Hospital, Boston, MA Division of Cardiovascular Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015556779","display_name":"Orly Vardeny","orcid":"https://orcid.org/0000-0002-6387-1351","observed_orcids":["https://orcid.org/0000-0002-6387-1351"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orly Vardeny","raw_affiliation_strings":["Departments of Pharmacy and Medicine, University of Wisconsin\u2010Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacy and Medicine, University of Wisconsin\u2010Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010456790","display_name":"Brian Lee Claggett","orcid":"https://orcid.org/0000-0002-4215-9218","observed_orcids":["https://orcid.org/0000-0002-4215-9218","https://orcid.org/0009-0009-1748-4340"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Claggett","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","Brian Claggett Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Brian Claggett Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065660599","display_name":"Bing Yu","orcid":"https://orcid.org/0000-0003-4818-1077","observed_orcids":["https://orcid.org/0000-0003-4818-1077"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Yu","raw_affiliation_strings":["Epidemiology, Human Genetics &amp; Environmental Sciences, UTHealth School of Public Health, Houston, TX","Bing Yu Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, Human Genetics &amp; Environmental Sciences, UTHealth School of Public Health, Houston, TX","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Bing Yu Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Houston, TX","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038371805","display_name":"Amil M. Shah","orcid":"https://orcid.org/0000-0003-1056-4451","observed_orcids":["https://orcid.org/0000-0003-1056-4451"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amil M. Shah","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","Amil M. Shah Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Amil M. Shah Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052604218","display_name":"Christie Mitchell Ballantyne","orcid":"https://orcid.org/0000-0002-6432-1730","observed_orcids":["https://orcid.org/0000-0002-6432-1730"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christie M. Ballantyne","raw_affiliation_strings":["Methodist DeBakey Heart Center, Baylor College of Medicine, Houston, TX","Christie M. Ballantyne Methodist DeBakey Heart Center, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Methodist DeBakey Heart Center, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Christie M. Ballantyne Methodist DeBakey Heart Center, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026446943","display_name":"Elizabeth Selvin","orcid":"https://orcid.org/0000-0001-6923-7151","observed_orcids":["https://orcid.org/0000-0001-6923-7151","https://orcid.org/0000-0002-3539-2070"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Selvin","raw_affiliation_strings":["The Johns Hopkins Institute for Clinical and Translational Research, Baltimore, MD","Elizabeth Selvin The Johns Hopkins Institute for Clinical and Translational Research, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Institute for Clinical and Translational Research, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Elizabeth Selvin The Johns Hopkins Institute for Clinical and Translational Research, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052863636","display_name":"Calum A. MacRae","orcid":"https://orcid.org/0000-0001-5181-2664","observed_orcids":["https://orcid.org/0000-0001-5181-2664"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calum A. MacRae","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","Calum A. MacRae Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Calum A. MacRae Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044048476","display_name":"Eric Boerwinkle","orcid":"https://orcid.org/0000-0001-8813-0544","observed_orcids":["https://orcid.org/0000-0001-8813-0544"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Boerwinkle","raw_affiliation_strings":["Epidemiology, Human Genetics &amp; Environmental Sciences, UTHealth School of Public Health, Houston, TX","Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX","Eric Boerwinkle Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Houston, TX Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, Human Genetics &amp; Environmental Sciences, UTHealth School of Public Health, Houston, TX","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Eric Boerwinkle Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health, Houston, TX Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054830306","display_name":"Scott David Solomon","orcid":"https://orcid.org/0000-0003-3698-9597","observed_orcids":["https://orcid.org/0000-0003-3698-9597"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott D. Solomon","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","Scott D. Solomon Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Scott D. Solomon Cardiovascular Division, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054830306"],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":{"value":3810,"currency":"USD","value_usd":3810},"fwci":3.4406,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.92775802,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"6","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4641000032424927,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4641000032424927,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.25850000977516174,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.23280000686645508,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nppb","display_name":"NPPB","score":0.6930000185966492},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.8100000023841858},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8999999761581421},{"id":"https://openalex.org/keywords/antihypertensive-medication-use","display_name":"antihypertensive medication use","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.8130000233650208},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6190000176429749},{"id":"https://openalex.org/keywords/atherosclerosis-risk-in-communities-study","display_name":"Atherosclerosis Risk in Communities Study","score":0.8519999980926514},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6639999747276306},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.382999986410141},{"id":"https://openalex.org/keywords/black-and-white-populations","display_name":"black and white populations","score":0.5260000228881836},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9584981799125671},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.8005784749984741},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6275110244750977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6000229120254517},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46864718198776245},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.44884192943573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27434343099594116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21050500869750977},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17245420813560486},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.15507620573043823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/jaha.116.005257","doi":"https://doi.org/10.1161/jaha.116.005257","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.116.005257","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5533018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5533018","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Heart Assoc","raw_type":"Text"},{"id":"pmid:28341776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28341776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c42f4f2028ad44f9a79724154e19e8eb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c42f4f2028ad44f9a79724154e19e8eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 4 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1161/jaha.116.005257","doi":"https://doi.org/10.1161/jaha.116.005257","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.116.005257","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8799999952316284}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5196008120","display_name":"Research and Mentoring in the Clinical Epidemiology of Type 2 Diabetes","funder_award_id":"K24DK106414","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6406125805","display_name":"Diabetes and Prediabetes in Older Adults in ARIC","funder_award_id":"R01DK089174","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8482525456","display_name":"A Community Zebrafish Resource for Modeling GWAS Biology","funder_award_id":"R24OD017870","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000879491","display_name":"Noninvasive Cardiovascular Imaging Research Training Program","funder_award_id":"T32HL094301","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1683012326","https://openalex.org/W1967986324","https://openalex.org/W1976644985","https://openalex.org/W1985848888","https://openalex.org/W1998011994","https://openalex.org/W1998527603","https://openalex.org/W2010527366","https://openalex.org/W2010783692","https://openalex.org/W2021723069","https://openalex.org/W2035300663","https://openalex.org/W2069722675","https://openalex.org/W2089283827","https://openalex.org/W2090318936","https://openalex.org/W2096401598","https://openalex.org/W2106464473","https://openalex.org/W2113570961","https://openalex.org/W2113698123","https://openalex.org/W2120535556","https://openalex.org/W2124528949","https://openalex.org/W2127816057","https://openalex.org/W2131036882","https://openalex.org/W2140775548","https://openalex.org/W2154560680","https://openalex.org/W2155817807","https://openalex.org/W2157752701","https://openalex.org/W2166719143","https://openalex.org/W2287701530","https://openalex.org/W2606269269","https://openalex.org/W2731507867","https://openalex.org/W4238868571","https://openalex.org/W4242416368"],"related_works":["https://openalex.org/W2939701487","https://openalex.org/W2087373251","https://openalex.org/W7154373116","https://openalex.org/W3001183226","https://openalex.org/W2090318936","https://openalex.org/W1998527603","https://openalex.org/W2114747484","https://openalex.org/W2074555606","https://openalex.org/W4379535117","https://openalex.org/W7095506873"],"abstract_inverted_index":{"Background":[0],"Elevated":[1],"B\u2010type":[2],"natriuretic":[3],"peptide":[4],"(":[5,35,143,267],"BNP":[6,33,98,128,290],")":[7],"levels":[8,55,99,286],"are":[9],"associated":[10,117,152,233,283],"with":[11,50,70,80,118,130,136,153,197,201,234,284],"heart":[12],"failure":[13],"and":[14,56,59,67,106,184,225,255,298,301],"increased":[15,256,302],"mortality":[16,237],"in":[17,27,38,44,140,204,278],"the":[18,28,32,41,111,131,198,229,279],"general":[19],"population.":[20],"We":[21],"investigated":[22],"rs198389,":[23],"a":[24,119,214],"functional":[25],"variant":[26],"promoter":[29,281],"region":[30],"of":[31,63,125,217,246,259,265,287],"gene":[34],"NPPB":[36,280],"),":[37],"patients":[39,69],"from":[40,262],"Atherosclerosis":[42],"Risk":[43],"Communities":[45],"Study":[46],"to":[47],"investigate":[48],"associations":[49],"N\u2010terminal":[51],"pro\u2010BNP":[52],"(NT\u2010pro":[53],"BNP)":[54],"outcomes.":[57],"Methods":[58],"Results":[60],"A":[61],"total":[62],"11":[64],"361":[65],"black":[66],"white":[68],"rs198389":[71,275],"genotyping":[72],"attended":[73],"visit":[74,93,109],"1":[75],"(aged":[76],"45\u201364":[77],"years;":[78],"1987\u20131989),":[79],"follow\u2010up":[81,216],"visits":[82,103],"occurring":[83],"every":[84],"3":[85],"years":[86,264],"(visit":[87],"2\u2013visit":[88],"4,":[89,105],"1990\u20131999),":[90],"followed":[91],"by":[92],"5":[94],"(2011\u20132013).":[95],"NT":[96,126,288],"\u2010pro":[97,127,289],"were":[100,221],"measured":[101],"at":[102],"2,":[104,110],"5.":[107],"At":[108],"GG":[112,149,230],"genotype":[113,133,150,200,231],"(frequency":[114,134],"18%)":[115],"was":[116,151,232],"41%":[120],"higher":[121],"mean":[122],"plasma":[123],"level":[124],"compared":[129,196],"AA":[132,199,271],"34%),":[135],"intermediate":[137,202],"values":[138,203],"observed":[139],"AG":[141,205],"s":[142],"P":[144,161,169,182,194,268],"=4.2\u00d710":[145],"\u221252":[146],").":[147],"The":[148,274],"reduced":[154,294],"systolic":[155],"blood":[156,164,295],"pressure":[157,165],"(\u22121.6":[158],"mm":[159,167],"Hg,":[160,168],"=0.006),":[162],"diastolic":[163],"(\u22121":[166],"=0.003),":[170],"antihypertension":[171],"medication":[172],"use":[173],"(odds":[174,186],"ratio,":[175,187,239,250],"0.85;":[176],"95%":[177,189,241,252],"CI":[178,190],",":[179,191],"0.74\u20130.97":[180],"[":[181,193],"=0.02]),":[183],"hypertension":[185,297],"0.81;":[188],"0.72\u20130.92":[192],"=0.002])":[195],"s.":[206,272],"These":[207],"relationships":[208],"persisted":[209],"throughout":[210,291],"subsequent":[211],"visits.":[212],"After":[213],"median":[215],"23":[218],"years,":[219],"there":[220],"4031":[222],"deaths.":[223],"With":[224],"without":[226],"covariate":[227],"adjustment,":[228],"modestly":[235],"lower":[236],"(hazard":[238,249],"0.86;":[240],"CI,":[242,253],"0.78\u20130.95),":[243],"primarily":[244],"reflective":[245],"cardiovascular":[247,299],"death":[248],"0.75;":[251],"0.61\u20130.92),":[254],"residual":[257],"lifespan":[258],"8":[260],"months":[261],"50":[263],"age":[266],"=0.02)":[269],"versus":[270],"Conclusions":[273],"G":[276],"allele":[277],"is":[282],"elevated":[285],"adult":[292],"life,":[293],"pressure,":[296],"mortality,":[300],"lifespan.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-07T00:00:00"}
