{"id":"https://openalex.org/W2603499432","doi":null,"title":"MODELING OF SINGLE CHANNEL AND WHOLE CELL CURRENT MEASUREMENTS WITH APPLICATION TO CALCIUM CHANNELS (NEURON, BIOPHYSICS, MARKOVIAN MODELS)","display_name":"MODELING OF SINGLE CHANNEL AND WHOLE CELL CURRENT MEASUREMENTS WITH APPLICATION TO CALCIUM CHANNELS (NEURON, BIOPHYSICS, MARKOVIAN MODELS)","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2603499432","mag":"2603499432"},"language":"en","primary_location":{"id":"pmh:oai:repository.rice.edu:1911/15942","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1911/15942&quot;&gt;https://hdl.handle.net/1911/15942&lt;/a&gt;.","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059314323","display_name":"David L. Wilson","orcid":"https://orcid.org/0000-0001-9763-1463","observed_orcids":["https://orcid.org/0000-0001-9763-1463"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David L. Wilson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9763-1463","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059314323"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.9509999752044678},{"id":"https://openalex.org/keywords/single-channel-recording","display_name":"single-channel recording","score":0.5709999799728394},{"id":"https://openalex.org/keywords/parameter-identifiability","display_name":"parameter identifiability","score":0.7900000214576721},{"id":"https://openalex.org/keywords/maximum-likelihood-estimation","display_name":"maximum likelihood estimation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/low-pass-filtering","display_name":"low-pass filtering","score":0.5210000276565552},{"id":"https://openalex.org/keywords/channel-inactivation","display_name":"channel inactivation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/recovery-from-inactivation","display_name":"recovery from inactivation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/calcium-accumulation","display_name":"calcium accumulation","score":0.5249999761581421},{"id":"https://openalex.org/keywords/model-discrimination","display_name":"model discrimination","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.487813264131546},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45457005500793457},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4371701180934906},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.41905301809310913},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3352554440498352},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3274345397949219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2520633339881897},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09903350472450256},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.06651708483695984}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:repository.rice.edu:1911/15942","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1911/15942&quot;&gt;https://hdl.handle.net/1911/15942&lt;/a&gt;.","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:scholarship.rice.edu:1911/15942","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1911/15942","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2603499432","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.rice.edu/handle/1911/15942","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983243544","https://openalex.org/W2047446161","https://openalex.org/W2292894628","https://openalex.org/W2104179937","https://openalex.org/W3081581070","https://openalex.org/W1508819982","https://openalex.org/W2162517871","https://openalex.org/W2105393278","https://openalex.org/W1988806663","https://openalex.org/W1976344531"],"abstract_inverted_index":{"Modern":[0],"measurements":[1,50,119],"of":[2,8,26,35,65,91,100,160,206,221,282,331],"membrane,":[3],"ionic":[4],"channel":[5,30,86,115,201,277,317],"molecules":[6],"consist":[7],"whole":[9,110,241],"cell":[10,111,242],"current":[11,19],"relaxations":[12,243],"obtained":[13,108],"using":[14,199,301],"various":[15],"voltage":[16],"pulse":[17,248],"protocols,":[18,249],"noise":[20,222],"power":[21],"spectra":[22],"from":[23,51,97,109,211,245,255,273],"small":[24],"numbers":[25],"channels,":[27],"and":[28,38,55,68,163,172,186,218,223,250,258,275,292,314,334,343,348],"single":[29,85,114,200,216,276,316],"intervals":[31],"in":[32,127],"the":[33,61,66,84,89,92,95,132,137,150,158,182,194,204,219,240,288,308,315,329],"form":[34],"waiting,":[36],"closed,":[37],"open":[39,162,171],"time":[40],"histograms.":[41],"A":[42,280],"state-variable":[43],"description":[44],"was":[45,57,178,190,284],"developed":[46,73,179],"for":[47,74,83,180,232,295,311,321,340],"predicting":[48],"these":[49,78],"Markovian":[52],"state":[53],"models,":[54],"it":[56,251],"used":[58],"to":[59,104,129,270,345],"analyze":[60],"parameter":[62,332],"identifiability":[63],"properties":[64],"models":[67,101,230,263,283],"measurements.":[69,116,195],"Computer":[70],"programs":[71],"were":[72,102,120,141,155,264,268,299,307],"estimating":[75],"model":[76,237,297],"parameters;":[77],"included":[79,203],"maximum":[80],"likelihood":[81],"estimation":[82,333],"data.":[87],"In":[88],"case":[90],"Ca":[93],"channel,":[94],"parameters":[96],"a":[98,207,215,235,337],"variety":[99],"found":[103,198],"be":[105],"faster":[106],"when":[107],"rather":[112],"than":[113],"The":[117],"latter":[118],"low":[121],"pass":[122],"filtered":[123,212],"at":[124],"1":[125],"kHz":[126],"order":[128],"reliably":[130],"detect":[131],"(TURN)":[133],"1/2":[134],"picoamp":[135],"openings;":[136],"errors":[138,197],"that":[139,286,328],"resulted":[140],"elucidated":[142],"by":[143,157],"running":[144],"Monte":[145],"Carlo":[146],"simulated":[147],"channels":[148,213],"through":[149],"threshold":[151],"detection":[152],"algorithm.":[153],"Intervals":[154],"distorted":[156,184],"absence":[159],"brief":[161],"closed":[164,173],"times":[165],"as":[166,168],"well":[167],"falsely":[169],"prolonged":[170],"times.":[174],"An":[175],"analytical":[176],"technique":[177],"computing":[181],"resulting":[183,244],"histograms,":[185],"after":[187],"correction":[188],"there":[189],"reasonable":[191],"agreement":[192],"between":[193],"Other":[196],"simulations":[202],"appearance":[205],"bimodal":[208],"amplitude":[209,217],"distribution":[210],"having":[214],"effects":[220],"finite":[224],"record":[225],"length":[226],"recording.":[227],"Of":[228],"six":[229],"considered":[231],"describing":[233],"activation,":[234],"4-state":[236],"best":[238],"fit":[239],"simple,":[246],"short":[247],"also":[252],"predicted":[253],"results":[254,342],"2-pulse":[256,309],"protocols":[257],"temperature":[259],"experiments.":[260],"Some":[261],"inactivation":[262,274,313],"eliminated":[265],"because":[266],"they":[267],"unable":[269],"simulate":[271],"recover":[272],"failure":[278],"traces.":[279],"family":[281],"suggested":[285],"describes":[287],"present":[289],"experimental":[290],"results,":[291],"possible":[293],"tests":[294,306],"future":[296],"discrimination":[298],"evaluated":[300],"simulation.":[302],"Two":[303],"relatively":[304],"insensitive":[305],"test":[310],"\"coupled\"":[312],"Hi-Lo":[318],"sort":[319],"method":[320],"determining":[322],"Ca-accumulation-dependent":[323],"processes.":[324],"It":[325],"is":[326,336],"concluded":[327],"combination":[330],"simulation":[335],"useful":[338],"tool":[339],"interpreting":[341],"helping":[344],"plan":[346],"experiments":[347],"analyses.":[349]},"counts_by_year":[],"updated_date":"2026-09-05T08:02:43.246662","created_date":"2017-04-07T00:00:00"}
