{"id":"https://openalex.org/W2603489261","doi":null,"title":"A study of translation regulation in cancer by application of ribosome profiling","display_name":"A study of translation regulation in cancer by application of ribosome profiling","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2603489261","mag":"2603489261"},"language":"en","primary_location":{"id":"pmh:oai:cora.ucc.ie:10468/3646","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10468/3646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401150","display_name":"Cork Open Research Archive (University College Cork, Ireland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210141138","host_organization_name":"APC Microbiome Institute","host_organization_lineage":["https://openalex.org/I4210141138"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10468/3646","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004205742","display_name":"Ioanna Tzani","orcid":"https://orcid.org/0000-0002-3282-8553","observed_orcids":["https://orcid.org/0000-0002-3282-8553","https://orcid.org/0000-0001-8224-4241"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ioanna Tzani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3282-8553","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004205742"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"249","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.3862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.734000027179718},{"id":"https://openalex.org/keywords/ribosome-profiling","display_name":"ribosome profiling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7730000019073486},{"id":"https://openalex.org/keywords/n-terminal-extension","display_name":"N-terminal extension","score":0.824999988079071},{"id":"https://openalex.org/keywords/proteoforms","display_name":"proteoforms","score":0.8230000138282776},{"id":"https://openalex.org/keywords/polyamine-pathway","display_name":"polyamine pathway","score":0.6610000133514404},{"id":"https://openalex.org/keywords/merkel-cell-carcinoma","display_name":"Merkel cell carcinoma","score":0.6880000233650208},{"id":"https://openalex.org/keywords/merkel-cell-polyomavirus","display_name":"Merkel cell polyomavirus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/small-t-antigen","display_name":"small T antigen","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cap-dependent-translation","display_name":"cap-dependent translation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hallmarks-of-cancer","display_name":"cancer hallmarks","score":0.6610000133514404},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C182325514","wikidata":"https://www.wikidata.org/wiki/Q7322425","display_name":"Ribosome profiling","level":5,"score":0.678655207157135},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6448277235031128},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.58749920129776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5428436398506165},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3733230233192444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3666604161262512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2673896551132202},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.18212658166885376},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.1388009488582611},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09135013818740845}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:cora.ucc.ie:10468/3646","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10468/3646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401150","display_name":"Cork Open Research Archive (University College Cork, Ireland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210141138","host_organization_name":"APC Microbiome Institute","host_organization_lineage":["https://openalex.org/I4210141138"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2603489261","doi":null,"is_oa":false,"landing_page_url":"https://cora.ucc.ie/handle/10468/3646?show=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:cora.ucc.ie:10468/3646","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10468/3646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401150","display_name":"Cork Open Research Archive (University College Cork, Ireland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210141138","host_organization_name":"APC Microbiome Institute","host_organization_lineage":["https://openalex.org/I4210141138"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1539489658","https://openalex.org/W1591311438","https://openalex.org/W1668594850","https://openalex.org/W1771918025","https://openalex.org/W1944327053","https://openalex.org/W1964912188","https://openalex.org/W1980645073","https://openalex.org/W1982475399","https://openalex.org/W1988302863","https://openalex.org/W1997847498","https://openalex.org/W2005620028","https://openalex.org/W2008410413","https://openalex.org/W2012359139","https://openalex.org/W2024144538","https://openalex.org/W2024751967","https://openalex.org/W2025071373","https://openalex.org/W2026487666","https://openalex.org/W2032448102","https://openalex.org/W2037313242","https://openalex.org/W2040138014","https://openalex.org/W2043986644","https://openalex.org/W2044767031","https://openalex.org/W2045022080","https://openalex.org/W2045348184","https://openalex.org/W2052543720","https://openalex.org/W2053486980","https://openalex.org/W2058426472","https://openalex.org/W2058977593","https://openalex.org/W2061136057","https://openalex.org/W2063795380","https://openalex.org/W2068138304","https://openalex.org/W2068345721","https://openalex.org/W2068427129","https://openalex.org/W2069257471","https://openalex.org/W2069844653","https://openalex.org/W2070634275","https://openalex.org/W2071804506","https://openalex.org/W2071849521","https://openalex.org/W2074517075","https://openalex.org/W2075231959","https://openalex.org/W2079517684","https://openalex.org/W2084104403","https://openalex.org/W2101084790","https://openalex.org/W2101804908","https://openalex.org/W2102050179","https://openalex.org/W2102992903","https://openalex.org/W2109535551","https://openalex.org/W2109672343","https://openalex.org/W2112089152","https://openalex.org/W2114837243","https://openalex.org/W2117163223","https://openalex.org/W2122329254","https://openalex.org/W2127986230","https://openalex.org/W2128085251","https://openalex.org/W2137356940","https://openalex.org/W2138113666","https://openalex.org/W2145502099","https://openalex.org/W2145583354","https://openalex.org/W2152974197","https://openalex.org/W2153532854","https://openalex.org/W2155533012","https://openalex.org/W2155552623","https://openalex.org/W2161810908","https://openalex.org/W2168138973","https://openalex.org/W2171819173","https://openalex.org/W2272073213","https://openalex.org/W2765633603"],"related_works":["https://openalex.org/W108928143","https://openalex.org/W7100582683","https://openalex.org/W2067706446","https://openalex.org/W2038169765","https://openalex.org/W1601034887","https://openalex.org/W4408245670","https://openalex.org/W4388451321","https://openalex.org/W1486138253","https://openalex.org/W4388107320","https://openalex.org/W2076826746"],"abstract_inverted_index":{"Cancer":[0],"is":[1,11,74,193,310],"the":[2,20,30,87,90,105,146,153,164,176,186,200,272,285,331,377],"name":[3],"given":[4],"to":[5,18,56,85,175,195,243,250,345,365,375],"diverse":[6],"diseases,":[7],"whose":[8],"common":[9],"characteristic":[10],"uncontrolled":[12],"cell":[13,68,388],"proliferation.":[14],"In":[15,80,247],"an":[16,149,248],"effort":[17,249],"rationalise":[19],"complexity":[21],"of":[22,41,47,89,104,113,133,148,163,167,178,189,199,203,229,254,282,284,325,380],"cancer":[23,57],"Hanahan":[24],"and":[25,50,70,72,93,108,131,141,160,206,256,288,301,319,382],"Weinberg":[26],"(2000,":[27],"2011)":[28],"proposed":[29,344],"hallmarks":[31,46],"that":[32,36,370],"comprise":[33],"biological":[34],"capabilities":[35],"enable":[37],"tumour":[38,48,155,315,351],"development.":[39],"Dysregulation":[40],"molecular":[42,211,361],"pathways":[43],"underlie":[44],"these":[45,326],"progression":[49],"their":[51,134,257],"study":[52,173,359],"has":[53,62,295],"been":[54,343],"central":[55,64,297],"biology.":[58],"The":[59,234,336],"PI3K/AKT/mTOR":[60],"pathway":[61,92,107,239,287],"a":[63,116,227,266,296,311,347,367],"role":[65,88,209,298,349],"in":[66,77,96,152,171,210,226,237,265,271,299,350],"translation,":[67],"growth":[69],"proliferation":[71],"it":[73],"frequently":[75],"dysregulated":[76],"various":[78,102],"cancers.":[79],"this":[81,168,172,191,204,238,360],"work":[82,99,138,275],"we":[83,261,363],"aimed":[84,364],"elucidate":[86,207],"PI3K":[91,106],"protein":[94,109,124],"synthesis":[95],"cancer.":[97,306],"Our":[98],"focused":[100],"on":[101,123,139,259,280,386],"levels":[103],"synthesis,":[110,125],"with":[111,182,219,316],"application":[112],"ribosome":[114,142,263,384],"profiling;":[115],"powerful":[117],"technique,":[118],"which":[119],"provides":[120],"genome-wide":[121],"information":[122],"by":[126,330,353],"capturing":[127],"actively":[128],"translating":[129],"ribosomes":[130],"sequencing":[132],"associated":[135],"transcripts.":[136],"Previous":[137],"bioinformatics":[140],"profiling":[143,264,385],"data":[144],"suggested":[145],"presence":[147],"N-terminal":[150,183],"extension":[151],"well-studied":[154],"suppressor":[156],"PTEN.":[157],"Mutational":[158],"analysis":[159],"further":[161,251],"investigation":[162],"5\u2019":[165],"leader":[166],"gene":[169,205],"performed":[170],"led":[174],"discovery":[177,192],"previously":[179,267,290],"uncharacterized":[180,291],"proteoforms":[181],"extensions.":[184],"Given":[185],"physiological":[187,230],"importance":[188],"PTEN":[190],"expected":[194],"broaden":[196],"our":[197,277],"understanding":[198],"translational":[201,245,292],"regulation":[202,253,281],"its":[208,302],"pathology.":[212],"Polyamines":[213],"are":[214,240,328],"ubiquitous":[215],"small":[216,337],"basic":[217],"molecules":[218],"known":[220],"but":[221,313],"not":[222],"well":[223],"defined":[224],"roles":[225],"range":[228],"processes,":[231],"including":[232],"translation.":[233,357],"enzymes":[235,283],"involved":[236],"themselves":[241],"subject":[242],"extensive":[244],"regulation.":[246],"characterize":[252],"polyamines":[255],"effect":[258],"translation":[260],"applied":[262,383],"established":[268],"system":[269,369],"available":[270],"lab.":[273],"This":[274],"confirmed":[276],"previous":[278],"knowledge":[279],"polyamine":[286],"identified":[289],"events.":[293],"Translation":[294],"physiology":[300],"aberrations":[303],"can":[304],"cause":[305],"Merkel":[307,332],"Cell":[308,333],"Carcinoma":[309],"rare":[312],"aggressive":[314],"poor":[317],"prognosis":[318],"increasing":[320],"incident":[321],"rates.":[322],"Approximately":[323],"80%":[324],"cancers":[327],"induced":[329],"Polyomavirus":[334],"(MCV).":[335],"T":[338],"(sT)":[339],"viral":[340],"antigen":[341],"had":[342],"have":[346],"causal":[348],"initiation":[352],"affecting":[354],"cap":[355],"dependent":[356],"To":[358],"interaction":[362],"develop":[366],"model":[368],"inducibly":[371],"expresses":[372],"MCV":[373],"sT":[374],"imitate":[376],"initial":[378],"steps":[379],"tumourigenesis":[381],"metastatic":[387],"lines.":[389]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-04-07T00:00:00"}