{"id":"https://openalex.org/W2603394063","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.8560","title":"Y90-ibritumomab tiuxetan (Y90-IT) and high-dose melphalan as conditioning regimen before autologous stem cell transplantation (ASCT) for elderly patients with lymphoma in relapse or resistant to chemotherapy: A feasibility trial (SAKK 37/05).","display_name":"Y90-ibritumomab tiuxetan (Y90-IT) and high-dose melphalan as conditioning regimen before autologous stem cell transplantation (ASCT) for elderly patients with lymphoma in relapse or resistant to chemotherapy: A feasibility trial (SAKK 37/05).","publication_year":2013,"publication_date":"2013-05-20","ids":{"openalex":"https://openalex.org/W2603394063","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.8560","mag":"2603394063"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.15_suppl.8560","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.8560","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.8560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022825869","display_name":"Mich\u00e8le Voegeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091012","display_name":"Kantonsspital Baselland","ror":"https://ror.org/00b747122","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210091012"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michele Voegeli","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik, Liestal, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik, Liestal, Switzerland","institution_ids":["https://openalex.org/I4210091012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103271749","display_name":"St\u00e9phanie Rondeau","orcid":"https://orcid.org/0000-0002-3514-3461","observed_orcids":["https://orcid.org/0000-0002-3514-3461"]},"institutions":[{"id":"https://openalex.org/I4210148109","display_name":"Swiss Group For Clinical Cancer Research","ror":"https://ror.org/04rtrpb08","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210148109"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephanie Rondeau","raw_affiliation_strings":["SAKK - Swiss Group for Clinical Cancer Research, Coordinating Center, Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAKK - Swiss Group for Clinical Cancer Research, Coordinating Center, Berne, Switzerland","institution_ids":["https://openalex.org/I4210148109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047925939","display_name":"Simona Berardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148109","display_name":"Swiss Group For Clinical Cancer Research","ror":"https://ror.org/04rtrpb08","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210148109"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Simona Berardi","raw_affiliation_strings":["SAKK - Swiss Group for Clinical Cancer Research, Coordinating Center, Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAKK - Swiss Group for Clinical Cancer Research, Coordinating Center, Berne, Switzerland","institution_ids":["https://openalex.org/I4210148109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013803774","display_name":"Erika Lerch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Erika Lerch","raw_affiliation_strings":["IOSI (Oncology Institute of Southern Switzerland), Bellinzona, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOSI (Oncology Institute of Southern Switzerland), Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4404532900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063994503","display_name":"Luciano Wannesson","orcid":"https://orcid.org/0000-0002-5902-0757","observed_orcids":["https://orcid.org/0000-0002-5902-0757"]},"institutions":[{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luciano Wannesson","raw_affiliation_strings":["IOSI (Oncology Insitute of Southern Switzerland), Bellinzona, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOSI (Oncology Insitute of Southern Switzerland), Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4404532900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043426460","display_name":"Thomas Pabst","orcid":"https://orcid.org/0000-0002-6055-5257","observed_orcids":["https://orcid.org/0000-0002-6055-5257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Pabst","raw_affiliation_strings":["Institute of Medical Oncology, Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Oncology, Berne, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053675875","display_name":"Jochen Rentschler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jochen Rentschler","raw_affiliation_strings":["Universit\u00e4tsspital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsspital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073648048","display_name":"Mario J. Bargetzi","orcid":"https://orcid.org/0000-0002-2519-6754","observed_orcids":["https://orcid.org/0000-0002-2519-6754"]},"institutions":[{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mario Bargetzi","raw_affiliation_strings":["Kantonsspital Aarau, Aarau, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kantonsspital Aarau, Aarau, Switzerland","institution_ids":["https://openalex.org/I4210161075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113785262","display_name":"Lorenz M. Jost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148932","display_name":"Kantonsspital Baselland Standort Bruderholz","ror":"https://ror.org/04eyn1y36","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210148932"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lorenz M. Jost","raw_affiliation_strings":["Kantonsspital Bruderholz, Bruderholz, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kantonsspital Bruderholz, Bruderholz, Switzerland","institution_ids":["https://openalex.org/I4210148932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079761251","display_name":"Nicolas Ketterer","orcid":"https://orcid.org/0009-0003-8593-5242","observed_orcids":["https://orcid.org/0009-0003-8593-5242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Ketterer","raw_affiliation_strings":["Hirslanden Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hirslanden Lausanne, Lausanne, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055969947","display_name":"Angelika Bischof Delaloye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Angelika Bischof Delaloye","raw_affiliation_strings":["Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045311601","display_name":"Michele E. G. Ghielmini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michele E. G. Ghielmini","raw_affiliation_strings":["IOSI (Oncology Institute of Southern Switzerland), Bellinzona, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOSI (Oncology Institute of Southern Switzerland), Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4404532900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"15_suppl","first_page":"8560","last_page":"8560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibritumomab-tiuxetan","display_name":"ibritumomab tiuxetan","score":0.9290000200271606},{"id":"https://openalex.org/keywords/high-dose-melphalan","display_name":"high-dose melphalan","score":0.8820000290870667},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.9120000004768372},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9150000214576721},{"id":"https://openalex.org/keywords/relapsed-lymphoma","display_name":"relapsed lymphoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cd20-positive-lymphoma","display_name":"CD20-positive lymphoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/myeloablation","display_name":"myeloablation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/feasibility","display_name":"feasibility","score":0.5789999961853027},{"id":"https://openalex.org/keywords/stem-cell-mobilization","display_name":"stem cell mobilization","score":0.6930000185966492},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/complete-response-rate","display_name":"complete response rate","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9168815612792969},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.7986183762550354},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.6855342984199524},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5265234708786011},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.5198915004730225},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.514065146446228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4996960163116455},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4716799855232239},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.46833157539367676},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.45399364829063416},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.4524111747741699},{"id":"https://openalex.org/C2779968505","wikidata":"https://www.wikidata.org/wiki/Q416507","display_name":"ThioTEPA","level":4,"score":0.4411260783672333},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.37898507714271545},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.09572362899780273}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.15_suppl.8560","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.8560","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.8560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6978147483","https://openalex.org/W1989615427","https://openalex.org/W2914867471","https://openalex.org/W2980845492","https://openalex.org/W2591005337","https://openalex.org/W7097453354","https://openalex.org/W2949215664","https://openalex.org/W1986313461","https://openalex.org/W2219419824","https://openalex.org/W2134642572"],"abstract_inverted_index":{"8560":[0],"Background:":[1],"Standard":[2],"conditioning":[3,56,279],"regimens":[4],"for":[5,58,172,176,190,283],"ASCT":[6,282],"are":[7],"often":[8],"not":[9,175,228],"tolerated":[10],"by":[11,95,112],"elderly":[12,27,59],"patients.":[13,60],"Single":[14],"agent":[15],"high-dose":[16,50],"melphalan":[17,51,96,123,272],"has":[18],"been":[19],"shown":[20],"to":[21,83,118],"be":[22,80],"safe":[23,276],"and":[24,38,52,103,111,142,169,183,221,244,254,269,277],"active":[25],"in":[26,40,72,124,135],"patients":[28,153,179,187,226,250,256,284],"with":[29,65,105,126],"multiple":[30],"myeloma.":[31],"Y90-IT":[32,53,93,129,268],"is":[33,274],"a":[34,55,106,252,275],"well-tolerated":[35],"lymphoma":[36,71],"treatment":[37,182,200,230],"feasible":[39,278],"the":[41,120,181],"transplantation":[42],"setting.":[43],"We":[44],"therefore":[45],"investigated":[46],"this":[47],"combination":[48,125,265],"of":[49,90,122,210,232,240],"as":[54],"regimen":[57,88,280],"Methods:":[61],"Patients":[62],"\u226565":[63,285],"years":[64,160],"relapsed":[66],"or":[67,74,198],"chemotherapy":[68,78],"resistant":[69],"CD20-positive":[70],"PR":[73],"CR":[75,143],"after":[76,147,261],"salvage":[77],"could":[79],"enrolled":[81],"prior":[82],"stem":[84],"cell":[85],"mobilization.":[86],"Myeloablation":[87],"consisted":[89],"standard":[91,127],"dose":[92,128,267,271],"followed":[94],"at":[97],"escalating":[98],"doses":[99],"(100,":[100],"140,":[101],"170":[102],"200mg/m2,":[104],"3+3":[107],"phase":[108],"I":[109],"design)":[110],"ASCT.":[113],"The":[114,264,287],"primary":[115],"objective":[116],"was":[117,158,165,170],"identify":[119],"MTD":[121],"(as":[130],"defined":[131],"<":[132],"1":[133],"DLT":[134,193],"3":[136,197,246],"patients);":[137],"secondary":[138],"endpoints":[139],"were":[140,154,184,188,257],"toxicity":[141,173],"rate":[144],"100":[145,259],"days":[146,260],"transplantation.":[148,262],"Results:":[149],"Between":[150],"2006-2012":[151],"twenty":[152],"included.":[155],"Median":[156],"age":[157],"72":[159],"(range":[161],"66-77).":[162],"One":[163],"patient":[164],"considered":[166],"retrospectively":[167],"ineligible":[168],"evaluable":[171,189],"but":[174],"DLT.":[177,191],"Thirteen":[178],"received":[180],"transplanted.":[185],"Eleven":[186],"No":[192],"occurred.":[194],"Non-hematological":[195],"grade":[196,245],"higher":[199],"related":[201],"adverse":[202],"events":[203],"were:":[204],"infection":[205],"(n=6,":[206],"including":[207],"2":[208,255],"cases":[209],"febrile":[211],"neutropenia),":[212],"diarrhea":[213],"(n=3),":[214,235],"mucositis,":[215],"anorexia,":[216],"viral":[217],"hepatitis,":[218],"hypokalemia,":[219],"dehydration":[220],"multi-organ":[222],"failure":[223,234,242],"(n=1).":[224,248],"Seven":[225,249],"did":[227],"start":[229],"because":[231],"mobilization":[233],"progressive":[236],"disease":[237],"(n=2),":[238],"worsening":[239],"cardiac":[241],"(n=1)":[243],"dyspnea":[247],"achieved":[251],"CR/CRu":[253],"stable":[258],"Conclusions:":[263],"ofstandard":[266],"high":[270],"(200mg/m2)":[273],"before":[281],"years.":[286],"results":[288],"show":[289],"promising":[290],"activity.":[291],"Clinical":[292],"trial":[293],"information:":[294],"NCT00392691.":[295]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2017-04-07T00:00:00"}
