{"id":"https://openalex.org/W2603316729","doi":null,"title":"Modulation of oxidative stress and inflammation using a grape seed derived polyphenol","display_name":"Modulation of oxidative stress and inflammation using a grape seed derived polyphenol","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2603316729","mag":"2603316729"},"language":"en","primary_location":{"id":"pmh:oai:scholar.sun.ac.za:10019.1/100193","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/100193","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059075942","display_name":"Kelly Shirley Petersen-Ross","orcid":"https://orcid.org/0000-0003-2887-6568","observed_orcids":["https://orcid.org/0000-0003-2887-6568"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kelly Shirley Petersen-Ross","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2887-6568","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059075942"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.18310000002384186,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9660000205039978},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8080000281333923},{"id":"https://openalex.org/keywords/high-intensity-interval-training","display_name":"high-intensity interval training","score":0.8769999742507935},{"id":"https://openalex.org/keywords/acute-exercise","display_name":"acute exercise","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8119999766349792},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cd66b","display_name":"CD66b","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.3970000147819519},{"id":"https://openalex.org/keywords/sedentary-lifestyle","display_name":"sedentary lifestyle","score":0.6389999985694885},{"id":"https://openalex.org/keywords/polyphenol-supplementation","display_name":"polyphenol supplementation","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.8005561828613281},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.761005163192749},{"id":"https://openalex.org/C2776971262","wikidata":"https://www.wikidata.org/wiki/Q5597007","display_name":"Grape seed extract","level":3,"score":0.5463108420372009},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5246639251708984},{"id":"https://openalex.org/C3019171606","wikidata":"https://www.wikidata.org/wiki/Q10978","display_name":"Grape seed","level":2,"score":0.4807279407978058},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4227164089679718},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.40207111835479736},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3329569697380066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3323447108268738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27301469445228577},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2217296063899994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20878008008003235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.059672266244888306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.056116312742233276},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholar.sun.ac.za:10019.1/100193","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/100193","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2603316729","doi":null,"is_oa":false,"landing_page_url":"https://scholar.sun.ac.za:443/handle/10019.1/100193","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W139379903","https://openalex.org/W604196653","https://openalex.org/W1140116790","https://openalex.org/W1575454059","https://openalex.org/W1915196633","https://openalex.org/W1916774421","https://openalex.org/W1920486352","https://openalex.org/W1925167593","https://openalex.org/W1971637037","https://openalex.org/W1974526050","https://openalex.org/W1980149585","https://openalex.org/W1987652249","https://openalex.org/W2008869160","https://openalex.org/W2013204959","https://openalex.org/W2015011680","https://openalex.org/W2015486163","https://openalex.org/W2016135974","https://openalex.org/W2017523055","https://openalex.org/W2022970298","https://openalex.org/W2025993106","https://openalex.org/W2042685638","https://openalex.org/W2042890040","https://openalex.org/W2044159907","https://openalex.org/W2047330128","https://openalex.org/W2048195638","https://openalex.org/W2050315287","https://openalex.org/W2054972774","https://openalex.org/W2060814375","https://openalex.org/W2066503688","https://openalex.org/W2067305246","https://openalex.org/W2070415934","https://openalex.org/W2081044480","https://openalex.org/W2085128107","https://openalex.org/W2091388938","https://openalex.org/W2093090727","https://openalex.org/W2101861123","https://openalex.org/W2105025177","https://openalex.org/W2114556905","https://openalex.org/W2120049814","https://openalex.org/W2122696263","https://openalex.org/W2125121177","https://openalex.org/W2145129819","https://openalex.org/W2146453376","https://openalex.org/W2152124253","https://openalex.org/W2156427429","https://openalex.org/W2159082795","https://openalex.org/W2160541327","https://openalex.org/W2170313716","https://openalex.org/W2170416289","https://openalex.org/W2194294353","https://openalex.org/W2197281791","https://openalex.org/W2213513919","https://openalex.org/W2228886912","https://openalex.org/W2228906515","https://openalex.org/W2277742836","https://openalex.org/W2283876366","https://openalex.org/W2315512556","https://openalex.org/W2338246215","https://openalex.org/W2406581144"],"related_works":["https://openalex.org/W2810800641","https://openalex.org/W2567059590","https://openalex.org/W2623682025","https://openalex.org/W4304774413","https://openalex.org/W4406785700","https://openalex.org/W7098561090","https://openalex.org/W2885975802","https://openalex.org/W2365520480","https://openalex.org/W4394890047","https://openalex.org/W2080075664"],"abstract_inverted_index":{"ENGLISH":[0],"ABSTRACT:":[1],"Oxidative":[2,172,265],"stress":[3,378,417],"and":[4,64,76,113,140,155,181,184,205,220,236,258,285,314,321,341,390,418],"inflammation":[5,389],"are":[6,25],"intricately":[7],"interlinked,":[8],"especially":[9],"in":[10,73,116,176,210,223,296,327,376,410],"the":[11,31,54,77,86,144,208,246,278,401],"context":[12],"of":[13,56,79,88,101,119,218,248,267,308,326,339,344,357,403,421],"ageing/accelerated":[14],"ageing,":[15],"as":[16,18,27,42,44,61,189,301,303],"well":[17,43,302],"several":[19],"chronic":[20,114],"disease":[21],"states,":[22],"where":[23],"they":[24],"implicated":[26],"aetiological":[28],"factors.":[29],"In":[30,143,240,311],"past":[32],"decade":[33],"polyphenols":[34,387],"have":[35],"been":[36,71],"investigated":[37],"for":[38,212,245],"their":[39,297],"potent":[40],"anti-oxidant":[41,63,97],"anti-inflammatory":[45,65,99,364],"properties.":[46],"Previous":[47],"research":[48],"by":[49,393],"our":[50],"group":[51,146],"has":[52,70],"highlighted":[53],"potential":[55,96],"a":[57,102,147,226,233,337],"grape":[58,103,385],"seed-derived":[59,104,386],"polyphenol":[60,105,209,329],"both":[62,347],"modality.":[66],"However,":[67],"no":[68],"data":[69],"generated":[72],"human":[74,132],"models":[75,118],"mechanism(s)":[78],"action":[80],"is":[81],"still":[82],"largely":[83],"unknown.":[84],"Thus":[85],"aim":[87],"this":[89,293],"study":[90],"was":[91,150,174,229,294,333],"to":[92,162,167,225,349],"more":[93,395],"comprehensively":[94],"investigate":[95],"or":[98,379],"mechanisms":[100],"(PCO)":[106],"on":[107,272],"acute":[108,169],"(as":[109,115],"found":[110],"with":[111,207,336],"exercise)":[112],"ageing)":[117],"oxidative":[120,170,284,377,391,416],"stress.":[121,171],"After":[122],"obtaining":[123],"ethical":[124],"clearance,":[125],"blood":[126],"samples":[127],"were":[128,194,243,269],"obtained":[129],"from":[130,134,201],"healthy":[131],"subjects":[133,316],"two":[135],"different":[136],"groups":[137],"(aged":[138],"(n=7)":[139],"young":[141,145,202,289,315],"(n=14).":[142],"further":[148],"distinction":[149],"made":[151],"between":[152],"sedentary":[153,290],"(n=8)":[154],"fit":[156,203],"individuals":[157],"(n=6)":[158],"whom":[159],"we":[160],"exposed":[161],"an":[163,363],"HIIT":[164],"exercise":[165,200,369],"intervention":[166,370],"induce":[168,373],"status":[173,266],"assessed":[175,188],"plasma":[177,185,309],"using":[178,232],"validated":[179],"photometric":[180],"colorimetric":[182],"assays":[183],"myeloperoxidase":[186],"(MPO)":[187],"baseline":[190],"inflammatory":[191,286],"indicator.":[192],"Neutrophils":[193],"isolated":[195],"at":[196],"rest":[197],"(and":[198],"after":[199,323],"subjects)":[204],"treated":[206,219],"vitro":[211,328],"1":[213,324],"hour.":[214],"The":[215,274,331,353,368],"chemokinetic":[216,319],"capacity":[217,250,322],"control":[221],"neutrophils":[222,242,268,358,404],"response":[224],"chemotactic":[227],"signal":[228],"then":[230],"determined":[231],"Dunn":[234],"chamber":[235],"live":[237],"cell":[238],"imaging.":[239],"addition,":[241],"analysed":[244],"expression":[247,343],"functional":[249],"markers":[251],"(intracellular":[252],"MPO,":[253],"Fc\u03b3":[254],"Receptor":[255],"IIIb":[256],"(CD16)":[257],"CEACAM":[259],"8":[260],"(CD66b))":[261],"via":[262],"flow":[263],"cytometry.":[264],"also":[270,334],"performed":[271],"isolates.":[273],"results":[275],"indicate":[276],"that":[277,360,384],"aged":[279,313],"population":[280],"had":[281,317,362],"significantly":[282],"worse":[283],"profiles":[287],"than":[288],"controls":[291],"-":[292,346],"evident":[295],"conjugated":[298],"dienes":[299],"content":[300,356],"decreased":[304],"ferric":[305],"reducing":[306],"ability":[307],"(FRAP).":[310],"neutrophils,":[312],"increased":[318,342],"accuracy":[320],"hour":[325],"treatment.":[330],"treatment":[332],"associated":[335],"shedding":[338],"CD16":[340],"CD66b":[345],"linked":[348],"improved":[350],"neutrophil":[351,397],"motility.":[352,398],"intracellular":[354],"MPO":[355],"indicated":[359],"PCO":[361],"effect":[365],"across":[366],"groups.":[367],"did":[371],"not":[372],"measurable":[374],"changes":[375],"inflammation.":[380,422],"We":[381],"therefore":[382],"concluded":[383],"modulate":[388],"responses":[392],"facilitating":[394],"efficient":[396],"This":[399],"decreases":[400],"number":[402],"required":[405],"per":[406],"response,":[407],"effectively":[408],"resulting":[409],"less":[411,415],"secondary":[412],"tissue":[413],"damage,":[414],"faster":[419],"resolution":[420]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}