{"id":"https://openalex.org/W2603222001","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e18112","title":"An analysis of target-specific patient resource utilization in NSCLC clinical trials.","display_name":"An analysis of target-specific patient resource utilization in NSCLC clinical trials.","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W2603222001","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e18112","mag":"2603222001"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.30.15_suppl.e18112","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e18112","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.e18112","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087234749","display_name":"Neeta Somaiah","orcid":"https://orcid.org/0000-0002-0146-7732","observed_orcids":["https://orcid.org/0000-0002-0146-7732"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neeta Somaiah","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102964486","display_name":"George R. Simon","orcid":"https://orcid.org/0000-0002-3894-0773","observed_orcids":["https://orcid.org/0000-0002-3894-0773"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George R. Simon","raw_affiliation_strings":["Hollings Cancer Center, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hollings Cancer Center, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"15_suppl","first_page":"e18112","last_page":"e18112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/molecularly-targeted-agents","display_name":"molecularly targeted agents","score":0.843999981880188},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/vegfr-tyrosine-kinase-inhibitors","display_name":"VEGFR inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.4339999854564667},{"id":"https://openalex.org/keywords/trial-accrual","display_name":"trial accrual","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8417130708694458},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6758320927619934},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48597466945648193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3911358714103699}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2012.30.15_suppl.e18112","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e18112","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.e18112","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131157630","https://openalex.org/W1992785925","https://openalex.org/W2069926674","https://openalex.org/W3182048312","https://openalex.org/W3000010538","https://openalex.org/W4410861008","https://openalex.org/W2020631337","https://openalex.org/W2088955344","https://openalex.org/W2898148905","https://openalex.org/W3080570544"],"abstract_inverted_index":{"e18112":[0],"Background:":[1],"A":[2,78],"plethora":[3],"of":[4,17,23,37,59,117,123,145,168,232,255,279,286],"targeted":[5,18,28,83,256],"agents":[6,19,29,84,159,169,219,257,281],"are":[7,40,92,140,160,183],"currently":[8,52,161],"being":[9,30],"evaluated":[10,31,193,260],"in":[11,45,85,151,194,211],"patients":[12,95,124,150,205],"with":[13,198,276],"NSCLC.":[14],"The":[15,35,57,165,252],"number":[16,22,122,167,254,278],"exceeds":[20],"the":[21,46,50,65,111,115,121,233,241,284,287,290],"targets":[24,39,147,272],"leading":[25],"to":[26,42,63,110,126,208,228,258,264],"many":[27],"against":[32],"similar":[33],"targets.":[34,251],"identification":[36],"new":[38,271],"likely":[41],"increase":[43],"exponentially":[44],"near":[47],"future":[48],"given":[49],"numerous":[51],"ongoing":[53,129],"molecular":[54,146],"profiling":[55],"efforts.":[56],"objective":[58],"this":[60],"analysis":[61],"is":[62,172,247],"estimate":[64],"target-specific":[66],"patient":[67,293],"resource":[68,245],"utilization":[69,246],"and":[70,104,114,128,177,187,200,273,289],"its":[71],"impact":[72,291],"on":[73,269,292],"routine":[74],"clinical":[75,86,152,163],"care.":[76,294],"Methods:":[77],"comprehensive":[79],"search":[80,102],"for":[81,134,226],"molecularly":[82],"testing":[87],"that":[88,191],"have":[89,222],"accrued":[90],"or":[91,207],"accruing":[93,148],"NSCLC":[94,132,136,149,204,227],"were":[96,107,192],"performed":[97],"by":[98],"using":[99],"publically":[100],"available":[101],"engines":[103],"databases.":[105],"Agents":[106],"grouped":[108],"according":[109],"primary":[112],"target":[113,171,221,262],"phase":[116,130,195],"development.":[118],"We":[119],"computed":[120],"allocated":[125],"completed":[127],"III":[131,196],"trials":[133],"advanced":[135],"alone.":[137],"Results:":[138],"There":[139,182],"more":[141,216,237],"than":[142,217],"30":[143],"categories":[144],"trials.":[153],"By":[154],"conservative":[155],"estimates,":[156],"approximately":[157],"215":[158],"undergoing":[162],"testing.":[164],"median":[166],"per":[170,220,261],"7":[173,184],"(range":[174],"2":[175,218],"(HIF-1\u03b1":[176],"PDGFR\u03b1)":[178],"\u2013":[179],"24":[180],"(EGFR)).":[181],"EGFR":[185],"inhibitors":[186,190],"10":[188],"VEGFR":[189],"trials;":[197],"36,093":[199],"20,313":[201],"stage":[202],"IV":[203],"enrolled":[206,210],"be":[209,236,259,265],"these":[212,275],"trials,":[213],"respectively.":[214],"No":[215],"been":[223],"FDA":[224],"approved":[225],"date.":[229],"Further":[230],"details":[231],"analyses":[234],"will":[235],"comprehensively":[238],"presented":[239],"at":[240],"meeting.":[242],"Conclusions:":[243],"Patient":[244],"unevenly":[248],"distributed":[249],"across":[250],"optimal":[253,280],"remains":[263],"defined.":[266],"More":[267],"emphasis":[268],"identifying":[270],"targeting":[274],"limited":[277],"may":[282],"accelerate":[283],"advancement":[285],"field":[288]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2017-04-07T00:00:00"}