{"id":"https://openalex.org/W2602943319","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.128.4","title":"Placental Megalin and Cubilin Expression is Associated with Markers of Vitamin D Status but Not Fetal Bone Growth During Adolescent Pregnancy","display_name":"Placental Megalin and Cubilin Expression is Associated with Markers of Vitamin D Status but Not Fetal Bone Growth During Adolescent Pregnancy","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2602943319","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.128.4","mag":"2602943319"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.128.4","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.128.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.128.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003624984","display_name":"Corrie Marie Whisner","orcid":"https://orcid.org/0000-0003-3888-6348","observed_orcids":["https://orcid.org/0000-0003-3888-6348"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corrie M Whisner","raw_affiliation_strings":["Division of Nutritional Sciences, Cornell University, Ithaca, NY","School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nutritional Sciences, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026126690","display_name":"Carrie E. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie E Thomas","raw_affiliation_strings":["Division of Nutritional Sciences, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nutritional Sciences, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091197879","display_name":"Kimberly O O'Brien","orcid":"https://orcid.org/0000-0002-0954-1706","observed_orcids":["https://orcid.org/0000-0002-0954-1706"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly O O'Brien","raw_affiliation_strings":["Division of Nutritional Sciences, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nutritional Sciences, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.606,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.7444192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cubilin","display_name":"cubilin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vitamin-d-status","display_name":"vitamin D status","score":0.8980000019073486},{"id":"https://openalex.org/keywords/teenage-pregnancy","display_name":"adolescent pregnancy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9430000185966492},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fetal-bone-growth","display_name":"fetal bone growth","score":0.8040000200271606},{"id":"https://openalex.org/keywords/placental-gene-expression","display_name":"placental gene expression","score":0.703000009059906},{"id":"https://openalex.org/keywords/neonatal-vitamin-d-status","display_name":"neonatal vitamin D status","score":0.5640000104904175},{"id":"https://openalex.org/keywords/heel-ultrasound","display_name":"heel ultrasound","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7620627880096436},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.6233752965927124},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6125813126564026},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5571234822273254},{"id":"https://openalex.org/C153639570","wikidata":"https://www.wikidata.org/wiki/Q906435","display_name":"Vitamin D-binding protein","level":3,"score":0.5513673424720764},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.5084077715873718},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.5041826963424683},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.48188644647598267},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.4714337885379791},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.44656282663345337},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.40388941764831543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3688478469848633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.358174592256546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14973509311676025},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.09329771995544434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.128.4","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.128.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.128.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G387473168","display_name":null,"funder_award_id":"2012\u201067012\u201019815","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W438694630","https://openalex.org/W111006225","https://openalex.org/W2164260862","https://openalex.org/W961315634","https://openalex.org/W4403351541","https://openalex.org/W2588371709","https://openalex.org/W4389007952","https://openalex.org/W2761214342","https://openalex.org/W2076443833","https://openalex.org/W2622177892"],"abstract_inverted_index":{"Megalin":[0,299,379],"and":[1,10,29,50,63,71,76,102,123,128,148,154,179,189,199,206,227,234,242,254,256,267,275,287,300,315,333,338,346,363,376,416,427],"cubilin":[2,51,301,331,347,417],"are":[3],"highly":[4],"expressed":[5],"in":[6,14,52,94,106,195,308,389],"the":[7,24],"human":[8],"placenta":[9,251],"may":[11],"be":[12],"involved":[13],"modulating":[15],"maternal\u2010fetal":[16],"25(OH)D":[17,163],"status.":[18,431],"Few":[19],"studies":[20],"have":[21],"focused":[22],"on":[23],"expression":[25,47,253,290,302,332,381,413],"of":[26,39,48,55,69,280,319,414,420],"these":[27],"transporters":[28],"associations":[30,249,326],"with":[31,58,67,264,294,307,354,386,405],"vitamin":[32,60,73,429],"D\u2010related":[33],"outcomes":[34],"during":[35,119],"pregnancy.":[36],"The":[37],"purpose":[38],"this":[40],"study":[41,97,117],"was":[42,82,184,210,260,382],"to":[43,99,115,247,424],"characterize":[44],"placental":[45,187,330],"transcript":[46,252,289,380],"megalin":[49,198,288,345,415],"a":[53,95,261,278],"cohort":[54,263],"pregnant":[56,87],"adolescents":[57,88],"suboptimal":[59],"D":[61,74,168,359,373,410,430],"status":[62,75],"evaluate":[64],"their":[65],"relationships":[66],"markers":[68],"maternal":[70,101,121,255,320,355,375,397,426],"neonatal":[72],"fetal":[77,103,130,257,310,370,377,428],"bone":[78,104,124,322],"growth.":[79],"Placental":[80],"tissue":[81,188],"obtained":[83,138],"at":[84,139,158,399],"delivery":[85,149,159],"from":[86,186],"(n=86;":[89],"age":[90],"\u226418":[91],"y)":[92],"enrolled":[93],"longitudinal":[96],"designed":[98],"assess":[100,248],"health":[105],"Rochester,":[107],"New":[108],"York.":[109],"During":[110],"pregnancy,":[111],"teens":[112,270,404],"completed":[113,222],"up":[114],"three":[116],"visits":[118],"which":[120],"anthropometrics":[122],"quality":[125],"(heel":[126],"ultrasound)":[127],"standard":[129],"biometry":[131],"measures":[132,318],"(sonography)":[133],"were":[134,160,193,221,236,245,291,303,327,350],"obtained.":[135],"Maternal":[136],"serum":[137,356],"mid\u2010gestation":[140],"(MG;":[141],"26.2":[142],"\u00b1":[143,151],"3.5":[144],"gestational":[145],"weeks":[146],"(GW))":[147],"(39.9":[150],"1.2":[152],"GW)":[153],"cord":[155,390],"blood":[156,391],"collected":[157],"analyzed":[161],"for":[162,238],"(Diasorin":[164],"assay),":[165,172],"1,25(OH)":[166,357,371,408],"2":[167,358,372,409],"(thymus":[169],"receptor":[170],"binding":[171],"PTH":[173,387,398],"(ELISA),":[174,176],"NTX":[175],"osteoprotegerin":[177],"(ELISA)":[178],"osteocalcin":[180],"(RIA)":[181],"concentrations.":[182],"RNA":[183],"extracted":[185],"real\u2010time":[190],"PCR":[191],"reactions":[192],"performed":[194],"triplicate":[196],"using":[197,223],"cubilin\u2010specific":[200],"primers":[201],"(sequence":[202,216],"ID":[203,217],"numbers":[204],"NM_004525.2":[205],"NM_001081.3,":[207],"respectively).":[208],"Beta\u2010actin":[209],"used":[211,237,246],"as":[212,272],"an":[213],"endogenous":[214],"control":[215],"NM_001101.2).":[218],"Non\u2010parametric":[219],"comparisons":[220],"Wilcoxon":[224],"rank":[225],"sums":[226],"Chi\u2010square":[228],"statistics,":[229],"while":[230],"two\u2010sample":[231],"t":[232],"tests":[233],"ANOVA":[235],"parametric":[239],"comparisons.":[240],"Pearson":[241],"Spearman":[243],"correlations":[244],"between":[250,329],"characteristics.":[258],"This":[259],"diverse":[262],"53":[265],"(61.6%)":[266],"33":[268],"(38.4%)":[269],"self\u2010reporting":[271],"African":[273],"American":[274],"Caucasian,":[276],"respectively;":[277],"total":[279],"24":[281],"(27.9%)":[282],"reported":[283],"being":[284],"Hispanic.":[285],"Cubilin":[286],"positively":[292],"correlated":[293],"one":[295],"another":[296],"(r=0.294,":[297],"p=0.006).":[298],"not":[304,369,396],"significantly":[305,351],"associated":[306,353,385],"utero":[309],"growth,":[311],"infant":[312],"birth":[313],"weight":[314],"length,":[316],"or":[317,374,401,433],"heel":[321],"quality.":[323],"Significant":[324],"positive":[325],"observed":[328],"1\u2010alpha":[334],"hydroxylase":[335],"(r=0.251,":[336],"p<0.030)":[337],"24\u2010hydroxylase":[339],"(r=0.254,":[340],"p=0.028)":[341],"mRNA":[342,348,418],"expression.":[343],"Both":[344],"levels":[349],"negatively":[352,384],"(r=":[360,392],"\u22120.359,":[361],"p=0.007":[362],"r=":[364],"\u22120.299,":[365],"p=0.027,":[366],"respectively)":[367],"but":[368,395],"25(OH)D.":[378],"also":[383],"concentrations":[388],"\u22120.444,":[393],"p=0.026)":[394],"MG":[400],"delivery.":[402],"Pregnant":[403],"lower":[406],"circulating":[407],"had":[411],"greater":[412],"suggestive":[419],"prenatal":[421],"regulatory":[422],"mechanisms":[423],"maintain":[425],"Support":[432],"Funding":[434],"Information":[435],"Funded":[436],"by":[437],"USDA/NIFA":[438],"Grant":[439],"No.":[440],"2012\u201067012\u201019815":[441]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-04-07T00:00:00"}