{"id":"https://openalex.org/W2602864067","doi":"https://doi.org/10.1002/jcp.25663","title":"Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A 2A Receptor Involvement","display_name":"Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A 2A Receptor Involvement","publication_year":2017,"publication_date":"2017-03-03","ids":{"openalex":"https://openalex.org/W2602864067","doi":"https://doi.org/10.1002/jcp.25663","mag":"2602864067","pmid":"https://pubmed.ncbi.nlm.nih.gov/27791262"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.25663","doi":"https://doi.org/10.1002/jcp.25663","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.25663","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065256219","display_name":"Francesca Veronesi","orcid":"https://orcid.org/0000-0002-6750-9376","observed_orcids":["https://orcid.org/0000-0002-6750-9376"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesca Veronesi","raw_affiliation_strings":["Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Via Di Barbiano, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Via Di Barbiano, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050730849","display_name":"Dante Dallari","orcid":"https://orcid.org/0000-0002-0595-5477","observed_orcids":["https://orcid.org/0000-0002-0595-5477"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dante Dallari","raw_affiliation_strings":["Conservative Orthopedic Surgery and Innovative Techniques Ward, Rizzoli Orthopedic Institute, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conservative Orthopedic Surgery and Innovative Techniques Ward, Rizzoli Orthopedic Institute, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068456851","display_name":"Giacomo Sabbioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Sabbioni","raw_affiliation_strings":["Conservative Orthopedic Surgery and Innovative Techniques Ward, Rizzoli Orthopedic Institute, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conservative Orthopedic Surgery and Innovative Techniques Ward, Rizzoli Orthopedic Institute, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025911765","display_name":"Chiara Carubbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Carubbi","raw_affiliation_strings":["Conservative Orthopedic Surgery and Innovative Techniques Ward, Rizzoli Orthopedic Institute, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conservative Orthopedic Surgery and Innovative Techniques Ward, Rizzoli Orthopedic Institute, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081110911","display_name":"L\u00facia Martini","orcid":"https://orcid.org/0000-0001-5765-4839","observed_orcids":["https://orcid.org/0000-0001-5765-4839"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Martini","raw_affiliation_strings":["Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Via Di Barbiano, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Via Di Barbiano, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024706525","display_name":"Milena Fini","orcid":"https://orcid.org/0000-0002-3732-3570","observed_orcids":["https://orcid.org/0000-0002-3732-3570"]},"institutions":[{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Milena Fini","raw_affiliation_strings":["Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Via Di Barbiano, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Via Di Barbiano, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065256219"],"corresponding_institution_ids":["https://openalex.org/I4210121742"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.5203,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.42241379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"232","issue":"9","first_page":"2299","last_page":"2307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.3483999967575073,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.11400000005960464,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polydeoxyribonucleotide","display_name":"polydeoxyribonucleotide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/musculoskeletal-tissue-regeneration","display_name":"musculoskeletal regeneration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/skin-regeneration","display_name":"skin regeneration","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.925000011920929},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.996999979019165},{"id":"https://openalex.org/keywords/tendon-regeneration","display_name":"tendon regeneration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8880000114440918},{"id":"https://openalex.org/keywords/inflammation-reduction","display_name":"inflammation reduction","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7395471930503845},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7307245135307312},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7118324637413025},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5104702711105347},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5048351883888245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4587053060531616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36111435294151306},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3570607900619507},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3485340476036072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3243885934352875},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20188528299331665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12693020701408386},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.09475144743919373}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009141","descriptor_name":"Musculoskeletal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009141","descriptor_name":"Musculoskeletal System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009141","descriptor_name":"Musculoskeletal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011089","descriptor_name":"Polydeoxyribonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043683","descriptor_name":"Receptors, Adenosine A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.25663","doi":"https://doi.org/10.1002/jcp.25663","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.25663","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:27791262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27791262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326075","display_name":"Regione Emilia-Romagna","ror":"https://ror.org/02k57f568"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1487238564","https://openalex.org/W1560312555","https://openalex.org/W1573984805","https://openalex.org/W1583648900","https://openalex.org/W1879284022","https://openalex.org/W1890616234","https://openalex.org/W1932683163","https://openalex.org/W1963532936","https://openalex.org/W1973519172","https://openalex.org/W1973856775","https://openalex.org/W1977846159","https://openalex.org/W1980188952","https://openalex.org/W1983659112","https://openalex.org/W1985755569","https://openalex.org/W1995572536","https://openalex.org/W2012189513","https://openalex.org/W2023117905","https://openalex.org/W2032501755","https://openalex.org/W2035107225","https://openalex.org/W2041196654","https://openalex.org/W2047996987","https://openalex.org/W2052707775","https://openalex.org/W2054848055","https://openalex.org/W2062269302","https://openalex.org/W2065865316","https://openalex.org/W2068104869","https://openalex.org/W2069585671","https://openalex.org/W2070896812","https://openalex.org/W2073665284","https://openalex.org/W2075551405","https://openalex.org/W2077169520","https://openalex.org/W2077546211","https://openalex.org/W2083633975","https://openalex.org/W2086541144","https://openalex.org/W2094344379","https://openalex.org/W2105387584","https://openalex.org/W2115902703","https://openalex.org/W2117658331","https://openalex.org/W2124167914","https://openalex.org/W2139451045","https://openalex.org/W2154540514","https://openalex.org/W2155587700","https://openalex.org/W2157888591","https://openalex.org/W2163807300","https://openalex.org/W2212825578","https://openalex.org/W2263378377","https://openalex.org/W2341652811","https://openalex.org/W2465861059","https://openalex.org/W4246006373"],"related_works":["https://openalex.org/W3048084631","https://openalex.org/W2899276400","https://openalex.org/W4210712837","https://openalex.org/W7203639304","https://openalex.org/W2610140566","https://openalex.org/W4411255023","https://openalex.org/W4413336945","https://openalex.org/W2760111318","https://openalex.org/W4407745445","https://openalex.org/W4409076323"],"abstract_inverted_index":{"Polydeoxyribonucleotides":[0],"(PDRNs)":[1],"are":[2,41,177,210,236],"low":[3],"molecular":[4],"weight":[5],"DNA":[6],"molecules":[7],"of":[8,56,73,78,83,97,171,216,221,230,242],"natural":[9],"origin":[10],"that":[11],"stimulate":[12],"cell":[13,155],"migration":[14],"and":[15,22,27,38,61,75,104,163,166,183,224,244],"growth,":[16,156],"extracellular":[17],"matrix":[18],"(ECM)":[19],"protein":[20],"production,":[21],"reduce":[23],"inflammation.":[24],"Most":[25],"preclinical":[26],"clinical":[28,62,120,135,144,149,198],"studies":[29,63,99,235],"on":[30,36,49,109],"tissue":[31,157],"regeneration":[32,51,82,205],"with":[33,186],"PDRNs":[34,153,176,209,243],"focused":[35],"skin,":[37],"only":[39],"few":[40],"about":[42],"musculoskeletal":[43,84],"tissues.":[44,85],"Starting":[45],"from":[46,213],"an":[47],"overview":[48],"skin":[50,110,204],"studies,":[52],"through":[53,168],"the":[54,65,71,81,123,169,191,201,228,240,247],"analysis":[55],"in":[57,59,80,92,112,115,129,132,139,197],"vitro,":[58,113,130,140],"vivo,":[60,116,133],"(1990\u20132016),":[64],"present":[66],"review":[67],"aimed":[68],"at":[69],"defining":[70],"effects":[72],"PDRN":[74,192,248],"their":[76],"mechanisms":[77],"action":[79],"This":[86],"would":[87],"also":[88],"help":[89],"future":[90],"researches":[91],"this":[93],"area.":[94],"A":[95,173,231],"total":[96],"29":[98],"were":[100,108],"found":[101],"by":[102],"PubMed":[103],"www.webofknowledge.com":[105],"searches:":[106],"20":[107],"(six":[111],"six":[114],"one":[117,134,141],"vitro/vivo,":[118,142],"seven":[119],"studies),":[121,136,145],"while":[122,200],"other":[124],"nine":[125],"regarded":[126],"bone":[127],"(one":[128,138,148],"two":[131,143],"cartilage":[137],"or":[146],"tendon":[147,184],"study)":[150],"tissues":[151],"regeneration.":[152],"improved":[154],"repair,":[158],"ECM":[159],"proteins,":[160],"physical":[161],"activity,":[162],"reduced":[164],"pain":[165],"inflammation,":[167],"activation":[170,229],"adenosine":[172],"2A":[174,232],"receptor.":[175,233],"currently":[178],"used":[179,196],"for":[180,203],"bone,":[181],"cartilage,":[182],"diseases,":[185],"a":[187,214,219],"great":[188],"variability":[189],"regarding":[190],"dosage":[193,202],"to":[194,218,238,245],"be":[195],"practice,":[199],"is":[206],"well":[207],"established.":[208],"usually":[211],"administered":[212],"minimum":[215],"three":[217],"maximum":[220],"five":[222],"times":[223],"they":[225],"act":[226],"trough":[227],"Further":[234],"advisable":[237],"confirm":[239],"effectiveness":[241],"standardize":[246],"dose.":[249],"J.":[250],"Cell.":[251],"Physiol.":[252],"232:":[253],"2299\u20132307,":[254],"2017.":[255],"\u00a9":[256],"2016":[257],"Wiley":[258],"Periodicals,":[259],"Inc.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}