{"id":"https://openalex.org/W2602808394","doi":"https://doi.org/10.1200/jco.2017.35.4_suppl.239","title":"Early obesity and risk of cholangiocarcinoma in the United States.","display_name":"Early obesity and risk of cholangiocarcinoma in the United States.","publication_year":2017,"publication_date":"2017-02-01","ids":{"openalex":"https://openalex.org/W2602808394","doi":"https://doi.org/10.1200/jco.2017.35.4_suppl.239","mag":"2602808394"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.4_suppl.239","doi":"https://doi.org/10.1200/jco.2017.35.4_suppl.239","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.4_suppl.239","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068626603","display_name":"Akram S. Shalaby","orcid":"https://orcid.org/0009-0008-8394-2963","observed_orcids":["https://orcid.org/0009-0008-8394-2963"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akram Shalaby","raw_affiliation_strings":["GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054771911","display_name":"Milind M. Javle","orcid":"https://orcid.org/0000-0001-9158-0941","observed_orcids":["https://orcid.org/0000-0001-9158-0941"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milind M. Javle","raw_affiliation_strings":["Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012936802","display_name":"Rachna T. Shroff","orcid":"https://orcid.org/0000-0003-0066-2672","observed_orcids":["https://orcid.org/0000-0003-0066-2672"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachna T. Shroff","raw_affiliation_strings":["GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007566329","display_name":"Ahmed Abousamra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed OS Abousamra","raw_affiliation_strings":["GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089093200","display_name":"Reham Abdel\u2010Wahab","orcid":"https://orcid.org/0000-0002-5432-5068","observed_orcids":["https://orcid.org/0000-0002-5432-5068"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reham Abdel-Wahab","raw_affiliation_strings":["Clinical Oncology Department, Assiut University, Assiut, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology Department, Assiut University, Assiut, Egypt;","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109069003","display_name":"Vijayashri Rallapalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijayashri Rallapalli","raw_affiliation_strings":["GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336695","display_name":"Donghui Li","orcid":"https://orcid.org/0000-0002-7542-0662","observed_orcids":["https://orcid.org/0000-0002-7542-0662"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donghui Li","raw_affiliation_strings":["GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115883202","display_name":"Manal M. Hassan","orcid":"https://orcid.org/0000-0002-8413-449X","observed_orcids":["https://orcid.org/0000-0002-8413-449X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manal Hassan","raw_affiliation_strings":["GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"4_suppl","first_page":"239","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cancer-risk-factors","display_name":"cancer risk factors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/viral-hepatitis","display_name":"viral hepatitis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8379999995231628},{"id":"https://openalex.org/keywords/family-history-of-cancer","display_name":"family history of cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/risk-model","display_name":"risk model","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9145801663398743},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6910398006439209},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6695404052734375},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6300567388534546},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5196848511695862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5149534344673157},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5011794567108154},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4773252606391907},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4482566714286804},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4311886131763458},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.4153997004032135},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.326751708984375},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.05815035104751587},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.4_suppl.239","doi":"https://doi.org/10.1200/jco.2017.35.4_suppl.239","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.4_suppl.239","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385563388","https://openalex.org/W2052145855","https://openalex.org/W1966949368","https://openalex.org/W2162451445","https://openalex.org/W2606245383","https://openalex.org/W3165656548","https://openalex.org/W3031194228","https://openalex.org/W1992462510","https://openalex.org/W2100221589","https://openalex.org/W2357595506"],"abstract_inverted_index":{"239":[0],"Background:":[1],"In":[2,160,250],"the":[3,6,16,21,28,33,46,51,77,224,236,351],"United":[4],"States,":[5],"incidence":[7,30],"of":[8,25,31,53,72,80,91,100,138,265,278,323,353],"intrahepatic":[9],"cholangiocarcinoma":[10],"(ICC)":[11],"has":[12,41],"been":[13,43],"increasing":[14,29],"over":[15],"last":[17],"few":[18],"decades.":[19],"Despite":[20],"public":[22],"health":[23],"problem":[24],"obesity":[26,38,73,299,324],"and":[27,39,70,127,131,144,227,246,262,281],"ICC,":[32],"relationship":[34,67],"between":[35,68],"early":[36,291,297],"adulthood":[37,298],"ICC":[40,69,169,196,234,288,306,320,327],"never":[42],"examined":[44],"in":[45,195,286,307],"American":[47],"population.":[48],"Methods:":[49],"At":[50],"University":[52],"Texas":[54],"MD":[55,103],"Anderson":[56,104],"Cancer":[57],"Center":[58],"we":[59,162],"conducted":[60],"a":[61,190,301,316,331],"case-control":[62],"study":[63],"aimed":[64],"at":[65,102,148,223],"examining":[66],"history":[71,264],"after":[74],"controlling":[75],"for":[76,135,198,305,319],"potential":[78],"confounding":[79],"several":[81],"risk":[82,136,197,303,328,332],"factors.":[83],"Cases":[84],"were":[85,94,133,171,267],"patients":[86,101,130,167,289],"with":[87,168,204,233,270,290,325,342],"pathologically":[88],"confirmed":[89],"diagnosis":[90],"ICC.":[92,271,355],"Controls":[93],"healthy":[95,175],"subjects":[96],"recruited":[97,163],"from":[98,157],"spouses":[99],"who":[105,170],"had":[106],"cancers":[107],"other":[108,326,343],"than":[109],"liver":[110,139,312],"or":[111,275],"gastrointestinal.":[112],"Each":[113],"case":[114],"was":[115,155,178,189,216,230,241,283],"frequency":[116],"matched":[117],"to":[118,173,202,336,349],"4":[119],"controls":[120,132],"by":[121],"age":[122],"(\u00b1":[123],"5":[124],"years),":[125],"sex,":[126],"race.":[128],"Case":[129],"interviewed":[134],"factors":[137,329],"cancer.":[140],"A":[141],"self-reported":[142],"weight":[143],"body":[145,181],"size":[146],"pictogram":[147],"ages":[149],"20,":[150],"30,":[151],"40,":[152],"50,":[153],"60":[154],"obtained":[156],"each":[158],"participant.":[159],"2016":[161],"63":[164],"newly":[165],"diagnosed":[166],"compared":[172,201],"252":[174],"controls.":[176],"Obesity":[177,222],"defined":[179],"as":[180],"mass":[182],"index":[183],"(BMI)":[184],"\u2265":[185],"30.0.":[186],"Results:":[187],"There":[188],"significant":[191,302,317],"3":[192],"fold":[193],"increase":[194],"obese":[199],"individuals":[200],"those":[203],"normal":[205],"weight.":[206],"The":[207],"estimated":[208,237],"odds":[209],"ratio":[210],"(OR),":[211],"95%;":[212],"confidence":[213],"interval":[214],"(CI)":[215],"3.3":[217],"(1.3-9.1);":[218],"P":[219],"=":[220],".02.":[221],"mid-20s,":[225],"mid-30s,":[226],"mid-":[228],"40s":[229],"significantly":[231,268,284],"associated":[232,269],"risk;":[235],"OR":[238],"(95%":[239],"CI)":[240],"7.3":[242],"(2.8-19.7),":[243],"7":[244],"(2.4-20.9),":[245],"4.8":[247],"(2-11.4),":[248],"respectively.":[249],"addition,":[251],"viral":[252],"hepatitis,":[253],"heavy":[254],"alcohol":[255],"use":[256],"(":[257],">":[258],"40":[259],"ml":[260],"ethanol/day),":[261],"family":[263],"cancer":[266],"Underlying":[272],"radiological,":[273],"pathological,":[274],"clinical":[276],"evidence":[277],"steatosis,":[279],"fibrosis,":[280],"cirrhosis":[282],"observed":[285],"25%":[287],"obesity.":[292],"Conclusions:":[293],"We":[294],"concluded":[295],"that":[296],"is":[300,346],"factor":[304,318],"USA":[308],"where":[309],"underlying":[310],"fatty":[311],"diseases":[313],"can":[314],"be":[315],"progression.":[321],"Integration":[322],"into":[330],"model":[333],"may":[334],"lead":[335],"identify":[337],"high-risk":[338],"individuals.":[339],"Future":[340],"collaboration":[341],"US":[344],"institutions":[345],"highly":[347],"warranted":[348],"highlight":[350],"mechanism":[352],"obesity-induced":[354]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-04-07T00:00:00"}
