{"id":"https://openalex.org/W2602736757","doi":"https://doi.org/10.1186/s13045-017-0441-z","title":"Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis","display_name":"Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis","publication_year":2017,"publication_date":"2017-03-21","ids":{"openalex":"https://openalex.org/W2602736757","doi":"https://doi.org/10.1186/s13045-017-0441-z","mag":"2602736757","pmid":"https://pubmed.ncbi.nlm.nih.gov/28327179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5361845"},"language":"en","primary_location":{"id":"doi:10.1186/s13045-017-0441-z","doi":"https://doi.org/10.1186/s13045-017-0441-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-017-0441-z","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-017-0441-z","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-017-0441-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066279331","display_name":"Ying\u2010Jan Wang","orcid":"https://orcid.org/0000-0003-3169-2495","observed_orcids":["https://orcid.org/0000-0003-3169-2495"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Jan Wang","raw_affiliation_strings":["Department of Biomedical Informatics, Asia University, Taichung, Taiwan","Department of Environmental and Occupational Health, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan","Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Department of Environmental and Occupational Health, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100994096","display_name":"Jing-Fang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jing-Fang Lin","raw_affiliation_strings":["Department of Environmental and Occupational Health, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103935041","display_name":"Li-Hsin Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Hsin Cheng","raw_affiliation_strings":["The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090715275","display_name":"Wen\u2010Tsan Chang","orcid":"https://orcid.org/0000-0001-5622-8299","observed_orcids":["https://orcid.org/0000-0001-5622-8299"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Tsan Chang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029273603","display_name":"Y. H. Kao","orcid":"https://orcid.org/0000-0001-7803-9384","observed_orcids":["https://orcid.org/0000-0001-7803-9384"]},"institutions":[{"id":"https://openalex.org/I4210091198","display_name":"E-Da Hospital","ror":"https://ror.org/00eh7f421","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091198"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Hsien Kao","raw_affiliation_strings":["Department of Medical Research, E-Da Hospital, 82445, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, E-Da Hospital, 82445, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210091198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017662619","display_name":"Ming\u2010Min Chang","orcid":"https://orcid.org/0000-0002-6537-2249","observed_orcids":["https://orcid.org/0000-0002-6537-2249"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Min Chang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111521413","display_name":"Bour-Jr Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I56019348","display_name":"Chia Nan University of Pharmacy and Science","ror":"https://ror.org/02834m470","country_code":"TW","type":"education","lineage":["https://openalex.org/I56019348"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bour-Jr Wang","raw_affiliation_strings":["Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan","Department of Environmental and Occupational Health, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan","institution_ids":["https://openalex.org/I56019348"]},{"raw_affiliation_string":"Department of Environmental and Occupational Health, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210158999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113658251","display_name":"Hung-Chi Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hung-Chi Cheng","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan. hungchi@mail.ncku.edu.tw","The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan. hungchi@mail.ncku.edu.tw","Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan. hungchi@mail.ncku.edu.tw","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan. hungchi@mail.ncku.edu.tw","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5113658251"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":4.0119,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.94126679,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"72","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.49630001187324524,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.49630001187324524,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.16689999401569366,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.12370000034570694,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pterostilbene","display_name":"pterostilbene","score":1.0},{"id":"https://openalex.org/keywords/fibronectin-assembly","display_name":"fibronectin assembly","score":0.8539999723434448},{"id":"https://openalex.org/keywords/akt-erk-signaling","display_name":"AKT/ERK signaling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lewis-lung-carcinoma","display_name":"Lewis lung carcinoma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pi3k-inhibition","display_name":"PI3K inhibition","score":0.7419999837875366},{"id":"https://openalex.org/keywords/erk-inhibition","display_name":"ERK inhibition","score":0.9210000038146973},{"id":"https://openalex.org/keywords/stilbenoids","display_name":"stilbenoids","score":0.8109999895095825},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6069999933242798},{"id":"https://openalex.org/keywords/lung-colonization","display_name":"lung colonization","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C2781196776","wikidata":"https://www.wikidata.org/wiki/Q2908011","display_name":"Pterostilbene","level":3,"score":0.8401676416397095},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6517510414123535},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5547995567321777},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5499529242515564},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.5387080907821655},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5320937037467957},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5227001905441284},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.49489277601242065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4728070795536041},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.46554693579673767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4288055896759033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.382579505443573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3724013566970825},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21606630086898804},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17717725038528442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14218637347221375},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12145769596099854},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13045-017-0441-z","doi":"https://doi.org/10.1186/s13045-017-0441-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-017-0441-z","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-017-0441-z","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},{"id":"pmid:28327179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28327179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5361845","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5361845/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hematol Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b9ce3ce9c9fb4aa2ba0d3b30785c424f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b9ce3ce9c9fb4aa2ba0d3b30785c424f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13045-017-0441-z","doi":"https://doi.org/10.1186/s13045-017-0441-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-017-0441-z","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-017-0441-z","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1052468712","display_name":null,"funder_award_id":"MOST 105-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G1074125387","display_name":"(103CA1037) Development of Cancer Pericellular Fibronectin-Targeted Anti-Metastatic Protein Drugs, Cruise Drug-Delivery Systems, and Anti-Metastatic Cancer Vaccines (II)","funder_award_id":"MOST104-2325-B006-001","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4474485137","display_name":"The Role of Autophagy and Its Related Regulatory Pathways Induced by Metal-Based Nanoparticles in Inflammation and Nanotoxicity","funder_award_id":"MOST105-2320-B006-021","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G456520585","display_name":null,"funder_award_id":"MOST-103","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G521541656","display_name":null,"funder_award_id":"2320-B-006","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6453099304","display_name":"(103CA1037) Development of Cancer Pericellular Fibronectin-Targeted Anti-Metastatic Protein Drugs, Cruise Drug-Delivery Systems, and Anti-Metastatic Cancer Vaccines (I)","funder_award_id":"MOST103-2325-B006-009","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2602736757.pdf","grobid_xml":"https://content.openalex.org/works/W2602736757.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W945969252","https://openalex.org/W1581536859","https://openalex.org/W1707828128","https://openalex.org/W1965839750","https://openalex.org/W1975507419","https://openalex.org/W1982408819","https://openalex.org/W1988886961","https://openalex.org/W1994190235","https://openalex.org/W1994317594","https://openalex.org/W2000368193","https://openalex.org/W2006104542","https://openalex.org/W2015509667","https://openalex.org/W2017900948","https://openalex.org/W2023046316","https://openalex.org/W2023151687","https://openalex.org/W2028714796","https://openalex.org/W2031935322","https://openalex.org/W2032800126","https://openalex.org/W2043880395","https://openalex.org/W2045701552","https://openalex.org/W2049854103","https://openalex.org/W2060115924","https://openalex.org/W2062464922","https://openalex.org/W2071555402","https://openalex.org/W2076908665","https://openalex.org/W2083218851","https://openalex.org/W2096224160","https://openalex.org/W2097565006","https://openalex.org/W2103339837","https://openalex.org/W2112123578","https://openalex.org/W2115868128","https://openalex.org/W2118610654","https://openalex.org/W2121244179","https://openalex.org/W2134655779","https://openalex.org/W2140813472","https://openalex.org/W2143143107","https://openalex.org/W2144272048","https://openalex.org/W2148902207","https://openalex.org/W2151089147","https://openalex.org/W2156444438","https://openalex.org/W2156936527","https://openalex.org/W2168645747","https://openalex.org/W2171313040","https://openalex.org/W2235523093","https://openalex.org/W2266814182","https://openalex.org/W2267810789","https://openalex.org/W2278001291","https://openalex.org/W2291506065","https://openalex.org/W2306446750","https://openalex.org/W2337542937","https://openalex.org/W2915478882","https://openalex.org/W4211214747"],"related_works":["https://openalex.org/W7136030859","https://openalex.org/W2887269873","https://openalex.org/W2271258050","https://openalex.org/W2084296110","https://openalex.org/W2023151687","https://openalex.org/W3191913182","https://openalex.org/W2076480857","https://openalex.org/W2567266080","https://openalex.org/W2142282326","https://openalex.org/W1971134531"],"abstract_inverted_index":{"BACKGROUND:":[0],"Polymeric":[1],"fibronectin":[2],"(polyFN)":[3],"assembled":[4],"on":[5,31,173,240],"suspended":[6,43,55,97,133,151,241],"breast":[7],"cancer":[8,23,33,44,78,113,259],"cells":[9,45,60,79,99,135,222,243,260],"is":[10],"required":[11],"for":[12],"metastasis.":[13,24,114,246],"Conceivably,":[14],"drugs":[15],"that":[16,204],"target":[17],"such":[18],"polyFN":[19,38,62,94,127,171,238],"may":[20],"fight":[21],"against":[22,112],"While":[25],"stilbene":[26],"analogs":[27],"trigger":[28],"pro-apoptotic":[29],"effect":[30],"attached":[32],"cells,":[34,153],"whether":[35,74,86],"they":[36],"prevent":[37],"assembly":[39,95,128,172,239],"and":[40,118,129,145,166,218,223,244,253,263],"metastasis":[41,75,131,190,211,219,256],"of":[42,61,76,101,108,132,220,257],"via":[46],"an":[47,137],"apoptosis-independent":[48,138,262],"manner":[49],"remains":[50],"unexplored.":[51],"METHODS:":[52],"We":[53,84,103],"depleted":[54],"Lewis":[56],"lung":[57,77,130,189,216,255,258],"carcinoma":[58],"(LLC)":[59],"by":[63,182,193],"silencing":[64],"the":[65,105,121,169,183,225,231],"endogenous":[66],"FN":[67],"expression":[68],"or":[69],"pterostilbene":[70],"(PS)":[71],"to":[72,92],"examine":[73],"could":[80],"thus":[81],"be":[82],"suppressed.":[83],"investigated":[85],"PS":[87,111,119,235,247],"regulates":[88],"AKT-ERK":[89],"signaling":[90],"axis":[91],"suppress":[93],"in":[96,136,150,209,230,250,261],"LLC":[98,134,152,174,221,242],"independently":[100],"apoptosis.":[102],"tested":[104],"therapeutic":[106],"effects":[107,178],"orally":[109,207],"administered":[110,208],"RESULTS:":[115],"Both":[116],"FN-silencing":[117],"among":[120],"three":[122],"stilbenoids":[123],"indeed":[124],"significantly":[125,214],"reduced":[126,162,224],"manner.":[139],"Mechanistically,":[140],"PS-induced":[141],"AKT":[142],"phosphorylation":[143,148],"(pAKT)":[144],"suppressed":[146,236],"ERK":[147,184],"(pERK)":[149],"whereas":[154],"pretreatment":[155,177],"with":[156,199],"a":[157],"PI3K":[158],"inhibitor,":[159],"LY294002,":[160,194],"effectively":[161],"pAKT,":[163],"rescued":[164],"pERK,":[165],"consequently":[167],"reversed":[168],"PS-suppressed":[170,188],"cells;":[175],"these":[176],"were":[179],"then":[180],"overturned":[181],"inhibitor":[185],"U0126.":[186,200],"Indeed,":[187],"was":[191,196],"counteracted":[192],"which":[195],"further":[197],"overruled":[198],"Finally,":[201],"we":[202],"found":[203],"PS,":[205],"when":[206],"experimental":[210],"assays,":[212],"both":[213,251],"prevented":[215],"colonization":[217],"already":[226],"established":[227],"tumor":[228],"growth":[229],"mouse":[232],"lungs.":[233],"CONCLUSIONS:":[234],"AKT/ERK-regulated":[237],"pulmonary":[245],"possesses":[248],"potency":[249],"preventing":[252],"treating":[254],"apoptosis-dependent":[264],"manners,":[265],"respectively.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-04-07T00:00:00"}