{"id":"https://openalex.org/W2602632053","doi":null,"title":"The Role of Rac and Filamin A in Osteoclast Function and Osteoclast Heterogeneity","display_name":"The Role of Rac and Filamin A in Osteoclast Function and Osteoclast Heterogeneity","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2602632053","mag":"2602632053"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/70804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70804","pdf_url":"https://utoronto.scholaris.ca/bitstreams/3b7d8525-f346-459c-ac5d-fd390fd581af/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/3b7d8525-f346-459c-ac5d-fd390fd581af/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083100060","display_name":"Stephanie R. Goldberg","orcid":"https://orcid.org/0000-0001-9895-3798","observed_orcids":["https://orcid.org/0000-0001-9895-3798"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephanie R. Goldberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9895-3798","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083100060"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/rac-gtpase","display_name":"Rac GTPase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/filamin-a","display_name":"filamin A","score":0.921999990940094},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8740000128746033},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.7350000143051147},{"id":"https://openalex.org/keywords/mechanical-properties-of-bone","display_name":"bone mechanical properties","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bone-turnover","display_name":"bone turnover","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.9325897693634033},{"id":"https://openalex.org/C20563397","wikidata":"https://www.wikidata.org/wiki/Q410803","display_name":"Filamin","level":4,"score":0.6982231140136719},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.51836758852005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2551576495170593},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25513988733291626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15889617800712585},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.07015568017959595},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.0575927197933197},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/70804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70804","pdf_url":"https://utoronto.scholaris.ca/bitstreams/3b7d8525-f346-459c-ac5d-fd390fd581af/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2602632053","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/70804","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/70804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70804","pdf_url":"https://utoronto.scholaris.ca/bitstreams/3b7d8525-f346-459c-ac5d-fd390fd581af/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2602632053.pdf","grobid_xml":"https://content.openalex.org/works/W2602632053.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W14371590","https://openalex.org/W103535723","https://openalex.org/W197156706","https://openalex.org/W1245164586","https://openalex.org/W1500690807","https://openalex.org/W1523599202","https://openalex.org/W1551387535","https://openalex.org/W1595293335","https://openalex.org/W1623233150","https://openalex.org/W1805858026","https://openalex.org/W1964180143","https://openalex.org/W1964527550","https://openalex.org/W1967464005","https://openalex.org/W1967502057","https://openalex.org/W1971589882","https://openalex.org/W1971960449","https://openalex.org/W1972516366","https://openalex.org/W1975024491","https://openalex.org/W1976691466","https://openalex.org/W1977271471","https://openalex.org/W1977830503","https://openalex.org/W1978418436","https://openalex.org/W1980178339","https://openalex.org/W1984046567","https://openalex.org/W1986997195","https://openalex.org/W1987660468","https://openalex.org/W1990963067","https://openalex.org/W1993612260","https://openalex.org/W1994596418","https://openalex.org/W1998111806","https://openalex.org/W1998837503","https://openalex.org/W1999365762","https://openalex.org/W2000647744","https://openalex.org/W2003843696","https://openalex.org/W2006915056","https://openalex.org/W2007660746","https://openalex.org/W2007925869","https://openalex.org/W2012300995","https://openalex.org/W2013207691","https://openalex.org/W2015866089","https://openalex.org/W2017055730","https://openalex.org/W2018073425","https://openalex.org/W2019199377","https://openalex.org/W2019374720","https://openalex.org/W2021100604","https://openalex.org/W2021571622","https://openalex.org/W2023071036","https://openalex.org/W2023640846","https://openalex.org/W2027810531","https://openalex.org/W2030734416","https://openalex.org/W2036125852","https://openalex.org/W2036256326","https://openalex.org/W2043805472","https://openalex.org/W2055502077","https://openalex.org/W2056810908","https://openalex.org/W2057258584","https://openalex.org/W2058761057","https://openalex.org/W2059324975","https://openalex.org/W2062519237","https://openalex.org/W2064797437","https://openalex.org/W2065770578","https://openalex.org/W2066574904","https://openalex.org/W2066646366","https://openalex.org/W2067718592","https://openalex.org/W2068456508","https://openalex.org/W2072231974","https://openalex.org/W2072654899","https://openalex.org/W2073614445","https://openalex.org/W2077955101","https://openalex.org/W2078868696","https://openalex.org/W2081636793","https://openalex.org/W2082050404","https://openalex.org/W2083251543","https://openalex.org/W2085939052","https://openalex.org/W2093252878","https://openalex.org/W2098095516","https://openalex.org/W2102312968","https://openalex.org/W2102783132","https://openalex.org/W2103040045","https://openalex.org/W2108063837","https://openalex.org/W2112880618","https://openalex.org/W2114726696","https://openalex.org/W2117403796","https://openalex.org/W2122367477","https://openalex.org/W2123297082","https://openalex.org/W2139440574","https://openalex.org/W2139987446","https://openalex.org/W2141814030","https://openalex.org/W2142820105","https://openalex.org/W2144656400","https://openalex.org/W2148244700","https://openalex.org/W2153149830","https://openalex.org/W2154991399","https://openalex.org/W2160546595","https://openalex.org/W2162212747","https://openalex.org/W2163895773","https://openalex.org/W2170480807","https://openalex.org/W2170555117","https://openalex.org/W2170812873","https://openalex.org/W2172023589","https://openalex.org/W2333102461","https://openalex.org/W2337636949","https://openalex.org/W2412061207","https://openalex.org/W2475583140","https://openalex.org/W4239395424","https://openalex.org/W4241776582"],"related_works":["https://openalex.org/W2041050215","https://openalex.org/W2131050500","https://openalex.org/W2554911891","https://openalex.org/W4362606493","https://openalex.org/W3211902708","https://openalex.org/W1978418436","https://openalex.org/W2481005871","https://openalex.org/W2030497695","https://openalex.org/W2562562823","https://openalex.org/W1977461892"],"abstract_inverted_index":{"Osteoclasts":[0],"are":[1],"multinucleated":[2],"cells":[3],"that":[4,17,29,50,103,137],"resorb":[5],"bone":[6,128,168,210,220,230,238,261,278],"and":[7,36,95,109,131,201,219,226,239,253],"carry":[8],"out":[9],"their":[10],"function":[11,25,52],"via":[12],"a":[13],"dynamic":[14],"actin":[15,32,78],"cytoskeleton":[16,33],"is":[18,53],"regulated":[19],"by":[20],"Rho":[21,23,87],"GTPases.":[22],"GTPases":[24,88],"as":[26,121,123,180],"molecular":[27],"switches":[28],"regulate":[30,90],"the":[31,178,188,207,224,254,270],"in":[34,75,124,170,174,203,244,251],"osteoclasts":[35,76,106,183,218,257],"many":[37],"other":[38],"cell":[39],"types.":[40],"A":[41,82],"Rac":[42],"GTPase":[43],"validation":[44],"experiment":[45],"was":[46,98,135],"used":[47,214],"to":[48,72,89,114,157,181,215,236,265,274],"prove":[49],"osteoclast":[51,91],"best":[54],"characterized":[55],"through":[56],"three-dimensional":[57],"(3-D)":[58],"volumetric":[59],"analysis":[60],"of":[61,67,209,249,256,272],"resorption":[62,198],"pits":[63],"(Rpits).":[64],"The":[65,165,195,242],"success":[66],"this":[68,101],"method":[69,200],"prompted":[70],"us":[71],"measure":[73],"Rpits":[74,112],"lacking":[77],"binding":[79],"protein":[80],"Filamin":[81],"(FLNA),":[83],"which":[84,192],"interacts":[85],"with":[86,148,206],"formation":[92],"(osteoclastogenesis":[93],"(OCG))":[94],"function.":[96],"It":[97],"observed":[99],"using":[100],"technique":[102],"FLNA-knock-out":[104],"(KO)":[105,140],"were":[107,142,154,213,263],"smaller":[108],"produced":[110],"shallower":[111],"compared":[113,235],"WT":[115,162],"osteoclasts.":[116],"Using":[117],"an":[118],"osteoporosis":[119,146,196],"model":[120],"well":[122],"vivo":[125,204,252],"techniques":[126,205],"measuring":[127],"material,":[129],"structural":[130],"mechanical":[132,211],"properties,":[133],"it":[134],"demonstrated":[136],"FLNA":[138,175,250],"knockout":[139],"bones":[141,153],"protected":[143],"from":[144,191,259],"post-menopausal":[145],"associated":[147],"estrogen":[149],"depletion.":[150],"FLNA-KO":[151],"cortical":[152,163],"also":[155],"found":[156],"be":[158],"more":[159,267],"ductile":[160],"than":[161],"bones.":[164],"discrepancy":[166],"between":[167,223],"behavior":[169],"vertebrae":[171],"vs.":[172],"femora":[173],"mice":[176],"triggered":[177],"question":[179],"whether":[182,217],"behave":[184],"differently":[185],"depending":[186],"on":[187],"skeletal":[189],"site":[190],"they":[193],"originated.":[194],"model,":[197],"pit":[199],"aforementioned":[202],"exception":[208],"properties":[212],"determine":[216],"turnover":[221,233],"differed":[222],"cranial":[225],"appendicular":[227],"skeletons.":[228],"Calvarial":[229],"displayed":[231],"higher":[232],"rates":[234],"long":[237],"mandibular":[240],"bone.":[241],"novel":[243],"vitro":[245],"3-D":[246],"method,":[247],"characterization":[248],"assessment":[255],"arising":[258],"different":[260],"locations":[262],"executed":[264],"provide":[266],"insight":[268],"into":[269],"development":[271],"pharmacotherapeutics":[273],"better":[275],"manage":[276],"pathological":[277],"loss.":[279]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-04-07T00:00:00"}