{"id":"https://openalex.org/W2602408024","doi":null,"title":"Attenuation of Cardiac Fibrillation Vulnerability by n-3 Polyunsaturated Fatty Acids in a Rat Model of Cardiomyopathy","display_name":"Attenuation of Cardiac Fibrillation Vulnerability by n-3 Polyunsaturated Fatty Acids in a Rat Model of Cardiomyopathy","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2602408024","mag":"2602408024"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/68065","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/68065","pdf_url":"https://utoronto.scholaris.ca/bitstreams/082843b2-7f5c-49d9-a15b-049e1db2d7f1/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/082843b2-7f5c-49d9-a15b-049e1db2d7f1/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086847707","display_name":"Lily Zou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lily Zou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086847707"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.10100000351667404,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9610000252723694},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.972000002861023},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"ventricular fibrillation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/isoproterenol-induced-cardiomyopathy","display_name":"isoproterenol-induced cardiomyopathy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6859999895095825},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9610000252723694},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.7897477149963379},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.6842796802520752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6411522626876831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6016998291015625},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5806435346603394},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5733422636985779},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.5404603481292725},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5384741425514221},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3291514217853546},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.26118534803390503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20552781224250793},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.13997456431388855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11075747013092041}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/68065","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/68065","pdf_url":"https://utoronto.scholaris.ca/bitstreams/082843b2-7f5c-49d9-a15b-049e1db2d7f1/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2602408024","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/68065","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/68065","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/68065","pdf_url":"https://utoronto.scholaris.ca/bitstreams/082843b2-7f5c-49d9-a15b-049e1db2d7f1/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2602408024.pdf","grobid_xml":"https://content.openalex.org/works/W2602408024.grobid-xml"},"referenced_works_count":283,"referenced_works":["https://openalex.org/W20074729","https://openalex.org/W60084911","https://openalex.org/W84521899","https://openalex.org/W101847764","https://openalex.org/W116012272","https://openalex.org/W121941273","https://openalex.org/W574413806","https://openalex.org/W630136860","https://openalex.org/W1259067619","https://openalex.org/W1493851469","https://openalex.org/W1512521218","https://openalex.org/W1522393179","https://openalex.org/W1560062315","https://openalex.org/W1579904080","https://openalex.org/W1598829273","https://openalex.org/W1614828697","https://openalex.org/W1689569903","https://openalex.org/W1787497562","https://openalex.org/W1802953485","https://openalex.org/W1850077490","https://openalex.org/W1889002087","https://openalex.org/W1902677963","https://openalex.org/W1910629691","https://openalex.org/W1916800720","https://openalex.org/W1943326237","https://openalex.org/W1946138107","https://openalex.org/W1946799893","https://openalex.org/W1966849708","https://openalex.org/W1968339647","https://openalex.org/W1969244298","https://openalex.org/W1971208911","https://openalex.org/W1971623493","https://openalex.org/W1972813728","https://openalex.org/W1973154574","https://openalex.org/W1973320574","https://openalex.org/W1973896710","https://openalex.org/W1974941153","https://openalex.org/W1976052678","https://openalex.org/W1977159309","https://openalex.org/W1977385197","https://openalex.org/W1981797363","https://openalex.org/W1982430428","https://openalex.org/W1982983732","https://openalex.org/W1983132802","https://openalex.org/W1983531379","https://openalex.org/W1983716025","https://openalex.org/W1983880756","https://openalex.org/W1984117401","https://openalex.org/W1984364985","https://openalex.org/W1984385535","https://openalex.org/W1985792770","https://openalex.org/W1985807437","https://openalex.org/W1986111942","https://openalex.org/W1986222699","https://openalex.org/W1986637035","https://openalex.org/W1987335225","https://openalex.org/W1987393255","https://openalex.org/W1988209263","https://openalex.org/W1988808111","https://openalex.org/W1994788779","https://openalex.org/W1995979123","https://openalex.org/W1996062140","https://openalex.org/W1997046781","https://openalex.org/W1997189950","https://openalex.org/W1998083759","https://openalex.org/W1998329763","https://openalex.org/W1998430513","https://openalex.org/W1998591849","https://openalex.org/W1998623046","https://openalex.org/W1999195942","https://openalex.org/W1999911479","https://openalex.org/W2000221802","https://openalex.org/W2002389910","https://openalex.org/W2002750215","https://openalex.org/W2003494755","https://openalex.org/W2005214015","https://openalex.org/W2011375737","https://openalex.org/W2012326631","https://openalex.org/W2013041263","https://openalex.org/W2013355377","https://openalex.org/W2016856943","https://openalex.org/W2017179259","https://openalex.org/W2017459402","https://openalex.org/W2019417598","https://openalex.org/W2020894855","https://openalex.org/W2021120787","https://openalex.org/W2021602855","https://openalex.org/W2024047496","https://openalex.org/W2025275528","https://openalex.org/W2027593393","https://openalex.org/W2028064478","https://openalex.org/W2029788612","https://openalex.org/W2030845966","https://openalex.org/W2031150814","https://openalex.org/W2032834672","https://openalex.org/W2033870874","https://openalex.org/W2034516527","https://openalex.org/W2034786923","https://openalex.org/W2035265358","https://openalex.org/W2035489586","https://openalex.org/W2035547713","https://openalex.org/W2037714257","https://openalex.org/W2038827664","https://openalex.org/W2038843437","https://openalex.org/W2043659211","https://openalex.org/W2044563880","https://openalex.org/W2044819266","https://openalex.org/W2045799069","https://openalex.org/W2045914318","https://openalex.org/W2049519185","https://openalex.org/W2049635468","https://openalex.org/W2049767734","https://openalex.org/W2049817344","https://openalex.org/W2050688237","https://openalex.org/W2050708996","https://openalex.org/W2051221402","https://openalex.org/W2051626126","https://openalex.org/W2051822015","https://openalex.org/W2052773632","https://openalex.org/W2053777538","https://openalex.org/W2055038470","https://openalex.org/W2055143941","https://openalex.org/W2055217106","https://openalex.org/W2057010969","https://openalex.org/W2057046598","https://openalex.org/W2057198069","https://openalex.org/W2058744110","https://openalex.org/W2058878434","https://openalex.org/W2059812555","https://openalex.org/W2065161217","https://openalex.org/W2065873192","https://openalex.org/W2066166072","https://openalex.org/W2066229820","https://openalex.org/W2067026685","https://openalex.org/W2067199548","https://openalex.org/W2069492752","https://openalex.org/W2071544160","https://openalex.org/W2071755201","https://openalex.org/W2072132290","https://openalex.org/W2074334843","https://openalex.org/W2078472811","https://openalex.org/W2079183773","https://openalex.org/W2079418868","https://openalex.org/W2080543940","https://openalex.org/W2080660202","https://openalex.org/W2080671193","https://openalex.org/W2080915708","https://openalex.org/W2081336606","https://openalex.org/W2083693664","https://openalex.org/W2086257379","https://openalex.org/W2086847901","https://openalex.org/W2087878463","https://openalex.org/W2088666701","https://openalex.org/W2088742606","https://openalex.org/W2092474731","https://openalex.org/W2093983853","https://openalex.org/W2094522836","https://openalex.org/W2094981066","https://openalex.org/W2095073323","https://openalex.org/W2095471709","https://openalex.org/W2095715381","https://openalex.org/W2096296897","https://openalex.org/W2096961774","https://openalex.org/W2097841516","https://openalex.org/W2098291803","https://openalex.org/W2099130395","https://openalex.org/W2099831545","https://openalex.org/W2099859189","https://openalex.org/W2101165462","https://openalex.org/W2103010344","https://openalex.org/W2104630488","https://openalex.org/W2105395125","https://openalex.org/W2105510976","https://openalex.org/W2106649982","https://openalex.org/W2106761396","https://openalex.org/W2107359871","https://openalex.org/W2107714800","https://openalex.org/W2108955518","https://openalex.org/W2109446152","https://openalex.org/W2109738640","https://openalex.org/W2110427976","https://openalex.org/W2112299903","https://openalex.org/W2114066901","https://openalex.org/W2114775432","https://openalex.org/W2114969501","https://openalex.org/W2116091611","https://openalex.org/W2117264363","https://openalex.org/W2117661203","https://openalex.org/W2117994717","https://openalex.org/W2118212225","https://openalex.org/W2118574591","https://openalex.org/W2118784425","https://openalex.org/W2119277398","https://openalex.org/W2119400775","https://openalex.org/W2119458801","https://openalex.org/W2120386224","https://openalex.org/W2120739418","https://openalex.org/W2120795994","https://openalex.org/W2121912757","https://openalex.org/W2122004333","https://openalex.org/W2122143586","https://openalex.org/W2123273468","https://openalex.org/W2123694602","https://openalex.org/W2124281590","https://openalex.org/W2125112011","https://openalex.org/W2125248064","https://openalex.org/W2126889659","https://openalex.org/W2127611201","https://openalex.org/W2127661519","https://openalex.org/W2128264631","https://openalex.org/W2128761672","https://openalex.org/W2128788220","https://openalex.org/W2129034209","https://openalex.org/W2129447883","https://openalex.org/W2130527455","https://openalex.org/W2130735505","https://openalex.org/W2131098465","https://openalex.org/W2131133480","https://openalex.org/W2132487687","https://openalex.org/W2132505348","https://openalex.org/W2134286592","https://openalex.org/W2134674592","https://openalex.org/W2135720009","https://openalex.org/W2136260720","https://openalex.org/W2136604276","https://openalex.org/W2136780483","https://openalex.org/W2137334802","https://openalex.org/W2139391492","https://openalex.org/W2142347023","https://openalex.org/W2142493353","https://openalex.org/W2143717300","https://openalex.org/W2144258092","https://openalex.org/W2147506318","https://openalex.org/W2149256612","https://openalex.org/W2149342776","https://openalex.org/W2151074096","https://openalex.org/W2151350236","https://openalex.org/W2152748654","https://openalex.org/W2153722087","https://openalex.org/W2154061926","https://openalex.org/W2155924708","https://openalex.org/W2156253779","https://openalex.org/W2156256007","https://openalex.org/W2159070515","https://openalex.org/W2160411766","https://openalex.org/W2160775239","https://openalex.org/W2162521391","https://openalex.org/W2163718496","https://openalex.org/W2164224373","https://openalex.org/W2164355930","https://openalex.org/W2164825231","https://openalex.org/W2165006299","https://openalex.org/W2166154572","https://openalex.org/W2166326216","https://openalex.org/W2167075471","https://openalex.org/W2168332652","https://openalex.org/W2168526937","https://openalex.org/W2169126536","https://openalex.org/W2169152183","https://openalex.org/W2169679878","https://openalex.org/W2169804106","https://openalex.org/W2170174040","https://openalex.org/W2171160325","https://openalex.org/W2172011106","https://openalex.org/W2177769559","https://openalex.org/W2192223169","https://openalex.org/W2256772852","https://openalex.org/W2259128162","https://openalex.org/W2313067803","https://openalex.org/W2313203550","https://openalex.org/W2315032898","https://openalex.org/W2320349116","https://openalex.org/W2320772820","https://openalex.org/W2324030005","https://openalex.org/W2335140980","https://openalex.org/W2395480375","https://openalex.org/W2408256685","https://openalex.org/W2410013566","https://openalex.org/W2413541045","https://openalex.org/W2414153828","https://openalex.org/W2461915730","https://openalex.org/W2518574064","https://openalex.org/W2972087099"],"related_works":["https://openalex.org/W2624346301","https://openalex.org/W2121395599","https://openalex.org/W1522393179","https://openalex.org/W2130654433","https://openalex.org/W2124281590","https://openalex.org/W2335513525","https://openalex.org/W2081149970","https://openalex.org/W1939670273","https://openalex.org/W2151350236","https://openalex.org/W1998430513"],"abstract_inverted_index":{"Ventricular":[0],"fibrillation":[1,5],"(VF)":[2],"and":[3,57,65,116],"atrial":[4],"are":[6],"major":[7],"health":[8],"concerns.":[9],"Current":[10],"therapies":[11],"do":[12],"not":[13,137],"treat":[14],"the":[15,30,48,51,66,85,105,118,140],"structural":[16,33,68,121,148],"remodeling":[17],"that":[18,94],"underlies":[19],"many":[20],"arrhythmic":[21],"conditions.":[22],"N-3":[23],"polyunsaturated":[24],"fatty":[25],"acids":[26,55,59],"(PUFAs)":[27],"may":[28],"prevent":[29],"formation":[31],"of":[32,43,82,87,120,125,133,146],"remodeling.":[34,69,122,149],"Therefore,":[35],"we":[36],"sought":[37],"to":[38],"develop":[39],"a":[40],"rat":[41,71],"model":[42,72,132],"cardiomyopathy,":[44,134],"followed":[45],"by":[46,75],"characterizing":[47],"individual":[49],"effect":[50],"n-3":[52,88],"PUFAs,":[53,89],"docosahexaenoic":[54],"(DHA)":[56],"eicosapentaenoic":[58],"(EPA)":[60],"in":[61,113,130],"preventing":[62],"VF":[63,102,114,141],"vulnerability":[64,103,115,142],"associated":[67],"The":[70,123],"was":[73],"developed":[74],"superimposing":[76],"hypertension":[77],"with":[78],"repeated":[79],"bolus":[80],"injections":[81],"isoproterenol.":[83],"In":[84],"absence":[86],"spontaneously":[90],"hypertensive":[91],"rats":[92],"(SHRs)":[93],"received":[95],"isoproterenol":[96],"for":[97],"8":[98],"weeks":[99],"had":[100],"higher":[101],"than":[104],"control":[106],"SHRs.":[107],"DHA":[108],"partially":[109],"attenuated":[110],"this":[111,126,131],"increase":[112],"reduced":[117,139],"quantity":[119],"results":[124],"study":[127],"suggested":[128],"that,":[129],"DHA,":[135],"but":[136],"EPA":[138],"manifested":[143],"through":[144],"attenuation":[145],"arrhythmia-promoting":[147]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}