{"id":"https://openalex.org/W2602396445","doi":"https://doi.org/10.1016/j.jsbmb.2017.03.019","title":"GPER blockers as Nox downregulators: A new drug class to target chronic non-communicable diseases","display_name":"GPER blockers as Nox downregulators: A new drug class to target chronic non-communicable diseases","publication_year":2017,"publication_date":"2017-03-23","ids":{"openalex":"https://openalex.org/W2602396445","doi":"https://doi.org/10.1016/j.jsbmb.2017.03.019","mag":"2602396445","pmid":"https://pubmed.ncbi.nlm.nih.gov/28343901"},"language":"en","primary_location":{"id":"doi:10.1016/j.jsbmb.2017.03.019","doi":"https://doi.org/10.1016/j.jsbmb.2017.03.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsbmb.2017.03.019","pdf_url":null,"source":{"id":"https://openalex.org/S168421034","display_name":"The Journal of Steroid Biochemistry and Molecular Biology","issn_l":"0960-0760","issn":["0960-0760","1879-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The Journal of Steroid Biochemistry and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jsbmb.2017.03.019","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049615698","display_name":"Matthias R. Meyer","orcid":"https://orcid.org/0000-0003-3206-3244","observed_orcids":["https://orcid.org/0000-0003-3206-3244"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I2799963127","display_name":"Triemli Hospital","ror":"https://ror.org/03kpdys72","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799963127","https://openalex.org/I4405256532"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Matthias R. Meyer","raw_affiliation_strings":["Institute of Primary Care, University of Zurich, Switzerland; Division of Cardiology, Triemli City Hospital, Zurich, Switzerland. Electronic address: matthias.meyer@triemli.zuerich.ch","Division of Cardiology, Triemli City Hospital, Zurich, Switzerland","Institute of Primary Care, University of Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Primary Care, University of Zurich, Switzerland; Division of Cardiology, Triemli City Hospital, Zurich, Switzerland. Electronic address: matthias.meyer@triemli.zuerich.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I2799963127"]},{"raw_affiliation_string":"Division of Cardiology, Triemli City Hospital, Zurich, Switzerland","institution_ids":["https://openalex.org/I2799963127"]},{"raw_affiliation_string":"Institute of Primary Care, University of Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060993179","display_name":"Matthias Barton","orcid":"https://orcid.org/0000-0002-8200-4341","observed_orcids":["https://orcid.org/0000-0002-8200-4341"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Matthias Barton","raw_affiliation_strings":["Molecular Internal Medicine, University of Zurich, Zurich, Switzerland. Electronic address: barton@access.uzh.ch","Molecular Internal Medicine, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Internal Medicine, University of Zurich, Zurich, Switzerland. Electronic address: barton@access.uzh.ch","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Molecular Internal Medicine, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049615698","https://openalex.org/A5060993179"],"corresponding_institution_ids":["https://openalex.org/I202697423","https://openalex.org/I2799963127"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.2821,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.27641956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"176","issue":null,"first_page":"82","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.2565999925136566,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-estrogen-receptor","display_name":"G protein-coupled estrogen receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.859000027179718},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ligand-independent-activation","display_name":"ligand-independent receptor activation","score":0.753000020980835},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5180000066757202},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8140000104904175},{"id":"https://openalex.org/keywords/non-communicable-diseases","display_name":"non-communicable diseases","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2776061955","wikidata":"https://www.wikidata.org/wiki/Q18038565","display_name":"NOX1","level":4,"score":0.8373492956161499},{"id":"https://openalex.org/C166471694","wikidata":"https://www.wikidata.org/wiki/Q18268232","display_name":"GPER","level":5,"score":0.7310964465141296},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6436771154403687},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.5750534534454346},{"id":"https://openalex.org/C2779546753","wikidata":"https://www.wikidata.org/wiki/Q2386988","display_name":"Apelin","level":3,"score":0.5021162033081055},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45934683084487915},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.44939759373664856},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4058925211429596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4024239778518677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36825037002563477},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.337390273809433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2965887784957886},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24944528937339783},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22152921557426453},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000073296","descriptor_name":"Noncommunicable Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jsbmb.2017.03.019","doi":"https://doi.org/10.1016/j.jsbmb.2017.03.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsbmb.2017.03.019","pdf_url":null,"source":{"id":"https://openalex.org/S168421034","display_name":"The Journal of Steroid Biochemistry and Molecular Biology","issn_l":"0960-0760","issn":["0960-0760","1879-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The Journal of Steroid Biochemistry and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:28343901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28343901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of steroid biochemistry and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jsbmb.2017.03.019","doi":"https://doi.org/10.1016/j.jsbmb.2017.03.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsbmb.2017.03.019","pdf_url":null,"source":{"id":"https://openalex.org/S168421034","display_name":"The Journal of Steroid Biochemistry and Molecular Biology","issn_l":"0960-0760","issn":["0960-0760","1879-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The Journal of Steroid Biochemistry and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3201580287","display_name":"Role of Estrogen Receptor GPER for Toll-Like Receptor 4-Dependent Inflammatory Activation in Atherosclerosis","funder_award_id":"135874","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3653205400","display_name":"Molecular mechanisms of obesity-associated cardiovascular injury","funder_award_id":"122504","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3979134414","display_name":"Pathomechanisms of cardiovascular injury in obesity","funder_award_id":"108258","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8440112380","display_name":"Role of G Protein-Coupled Estrogen Receptor for Endothelial Function and Vascular Inflammation in Early Atherosclerosis","funder_award_id":"141501","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1771083324","https://openalex.org/W1820092961","https://openalex.org/W1905740399","https://openalex.org/W1965216303","https://openalex.org/W1969616726","https://openalex.org/W1972086601","https://openalex.org/W1974997758","https://openalex.org/W1980788978","https://openalex.org/W1981467972","https://openalex.org/W1983069289","https://openalex.org/W1983349129","https://openalex.org/W1983528779","https://openalex.org/W1988397302","https://openalex.org/W1997830617","https://openalex.org/W2002143964","https://openalex.org/W2002966121","https://openalex.org/W2005662241","https://openalex.org/W2019311111","https://openalex.org/W2025892985","https://openalex.org/W2033428497","https://openalex.org/W2035747909","https://openalex.org/W2067537589","https://openalex.org/W2068403201","https://openalex.org/W2068862678","https://openalex.org/W2074401185","https://openalex.org/W2075443461","https://openalex.org/W2076908209","https://openalex.org/W2077281334","https://openalex.org/W2079159302","https://openalex.org/W2084983662","https://openalex.org/W2096146170","https://openalex.org/W2098796887","https://openalex.org/W2101745219","https://openalex.org/W2107509703","https://openalex.org/W2108988373","https://openalex.org/W2111523997","https://openalex.org/W2114322110","https://openalex.org/W2115239727","https://openalex.org/W2116832131","https://openalex.org/W2117170436","https://openalex.org/W2119806364","https://openalex.org/W2120261914","https://openalex.org/W2122015809","https://openalex.org/W2124349235","https://openalex.org/W2132298206","https://openalex.org/W2136478511","https://openalex.org/W2147020292","https://openalex.org/W2149136975","https://openalex.org/W2149713530","https://openalex.org/W2150459982","https://openalex.org/W2154283765","https://openalex.org/W2164173624","https://openalex.org/W2168307852","https://openalex.org/W2196975609","https://openalex.org/W2228272997","https://openalex.org/W2239632319","https://openalex.org/W2243467818","https://openalex.org/W2289993018","https://openalex.org/W2315512556","https://openalex.org/W2341885640","https://openalex.org/W2411335118","https://openalex.org/W2471332471","https://openalex.org/W2517653246","https://openalex.org/W2547446918","https://openalex.org/W2551434251","https://openalex.org/W2561992980","https://openalex.org/W4232868044"],"related_works":["https://openalex.org/W2742815579","https://openalex.org/W2972881652","https://openalex.org/W2743716581","https://openalex.org/W2547191059","https://openalex.org/W2563268632","https://openalex.org/W2228272997","https://openalex.org/W2508264310","https://openalex.org/W2022671309","https://openalex.org/W2899188664","https://openalex.org/W91254163"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-07T00:00:00"}