{"id":"https://openalex.org/W2602213899","doi":"https://doi.org/10.4155/ipk-2016-0021","title":"Pharmacokinetics of Next Generation Cyanide Antidote Sulfanegen in Rabbits","display_name":"Pharmacokinetics of Next Generation Cyanide Antidote Sulfanegen in Rabbits","publication_year":2017,"publication_date":"2017-03-30","ids":{"openalex":"https://openalex.org/W2602213899","doi":"https://doi.org/10.4155/ipk-2016-0021","mag":"2602213899"},"language":"en","primary_location":{"id":"doi:10.4155/ipk-2016-0021","doi":"https://doi.org/10.4155/ipk-2016-0021","is_oa":false,"landing_page_url":"https://doi.org/10.4155/ipk-2016-0021","pdf_url":null,"source":{"id":"https://openalex.org/S4210236014","display_name":"International Journal of Pharmacokinetics","issn_l":"2053-0846","issn":["2053-0846","2053-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016121331","display_name":"Michael W. Stutelberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177156846","display_name":"South Dakota State University","ror":"https://ror.org/015jmes13","country_code":"US","type":"education","lineage":["https://openalex.org/I177156846"]},{"id":"https://openalex.org/I2799572201","display_name":"Avera Health","ror":"https://ror.org/05nter171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799572201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W Stutelberg","raw_affiliation_strings":["Department of Chemistry & Biochemistry, South Dakota State University, Avera Health & Science Center 131, Box 2202, Brookings, SD, 57007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, South Dakota State University, Avera Health & Science Center 131, Box 2202, Brookings, SD, 57007, USA","institution_ids":["https://openalex.org/I177156846","https://openalex.org/I2799572201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012455369","display_name":"Alexandre R. Monteil","orcid":"https://orcid.org/0000-0002-9573-0713","observed_orcids":["https://orcid.org/0000-0002-9573-0713"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre R Monteil","raw_affiliation_strings":["Center for Drug Design, University of Minnesota, 516 Delaware Street SE, MN55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design, University of Minnesota, 516 Delaware Street SE, MN55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024721965","display_name":"Kumar G. Belani","orcid":"https://orcid.org/0000-0003-1784-136X","observed_orcids":["https://orcid.org/0000-0003-1784-136X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumar G Belani","raw_affiliation_strings":["Department of Anesthesiology, University of Minnesota, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Minnesota, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074112708","display_name":"Bryant Moeller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryant Moeller","raw_affiliation_strings":["Center for Drug Design, University of Minnesota, 516 Delaware Street SE, MN55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design, University of Minnesota, 516 Delaware Street SE, MN55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Harpreet Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harpreet Singh","raw_affiliation_strings":["Department of Anesthesiology, University of Minnesota, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Minnesota, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Navneet Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navneet Kaur","raw_affiliation_strings":["Department of Anesthesiology, University of Minnesota, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Minnesota, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Simranjit S Sra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simranjit S Sra","raw_affiliation_strings":["Department of Anesthesiology, University of Minnesota, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Minnesota, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113577694","display_name":"David S. Beebe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S Beebe","raw_affiliation_strings":["Department of Anesthesiology, University of Minnesota, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Minnesota, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105520322","display_name":"Steven E. Patterson","orcid":"https://orcid.org/0000-0002-4364-8558","observed_orcids":["https://orcid.org/0000-0002-4364-8558"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E Patterson","raw_affiliation_strings":["Center for Drug Design, University of Minnesota, 516 Delaware Street SE, MN55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design, University of Minnesota, 516 Delaware Street SE, MN55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041044560","display_name":"Brian A. Logue","orcid":"https://orcid.org/0000-0002-2400-9339","observed_orcids":["https://orcid.org/0000-0002-2400-9339"]},"institutions":[{"id":"https://openalex.org/I177156846","display_name":"South Dakota State University","ror":"https://ror.org/015jmes13","country_code":"US","type":"education","lineage":["https://openalex.org/I177156846"]},{"id":"https://openalex.org/I2799572201","display_name":"Avera Health","ror":"https://ror.org/05nter171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799572201"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A Logue","raw_affiliation_strings":["Department of Chemistry & Biochemistry, South Dakota State University, Avera Health & Science Center 131, Box 2202, Brookings, SD, 57007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, South Dakota State University, Avera Health & Science Center 131, Box 2202, Brookings, SD, 57007, USA","institution_ids":["https://openalex.org/I177156846","https://openalex.org/I2799572201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.03908981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"2","first_page":"105","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.1459999978542328,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyanide-antidote","display_name":"cyanide antidote","score":0.9620000123977661},{"id":"https://openalex.org/keywords/3-mercaptopyruvate-sulfurtransferase","display_name":"3-mercaptopyruvate sulfurtransferase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/thiocyanate","display_name":"thiocyanate","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cyanide-poisoning","display_name":"cyanide poisoning","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8069999814033508},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.5740000009536743},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.6460000276565552},{"id":"https://openalex.org/keywords/sulfur-donors","display_name":"sulfur donors","score":0.6179999709129333},{"id":"https://openalex.org/keywords/one-compartment-model","display_name":"one-compartment model","score":0.6340000033378601},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2779365888","wikidata":"https://www.wikidata.org/wiki/Q194168","display_name":"Antidote","level":3,"score":0.9218850135803223},{"id":"https://openalex.org/C2778455166","wikidata":"https://www.wikidata.org/wiki/Q55076544","display_name":"Cyanide","level":2,"score":0.879602313041687},{"id":"https://openalex.org/C2780506445","wikidata":"https://www.wikidata.org/wiki/Q883082","display_name":"Cyanide poisoning","level":3,"score":0.76999831199646},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.744461178779602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6966490149497986},{"id":"https://openalex.org/C2776294642","wikidata":"https://www.wikidata.org/wiki/Q77747995","display_name":"Thiocyanate","level":2,"score":0.6536120176315308},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5741080045700073},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.5036837458610535},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.4246731698513031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30733364820480347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21117907762527466},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1634143888950348},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14965716004371643}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4155/ipk-2016-0021","doi":"https://doi.org/10.4155/ipk-2016-0021","is_oa":false,"landing_page_url":"https://doi.org/10.4155/ipk-2016-0021","pdf_url":null,"source":{"id":"https://openalex.org/S4210236014","display_name":"International Journal of Pharmacokinetics","issn_l":"2053-0846","issn":["2053-0846","2053-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmacokinetics","raw_type":"journal-article"},{"id":"pmh:oai:openprairie.sdstate.edu:chem_pubs-1073","doi":null,"is_oa":false,"landing_page_url":"https://openprairie.sdstate.edu/chem_pubs/67","pdf_url":null,"source":{"id":"https://openalex.org/S4377196457","display_name":"Open PRAIRIE (South Dakota State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177156846","host_organization_name":"South Dakota State University","host_organization_lineage":["https://openalex.org/I177156846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry and Biochemistry Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W120883060","https://openalex.org/W1752933235","https://openalex.org/W1966666013","https://openalex.org/W1985390573","https://openalex.org/W1988987892","https://openalex.org/W1991375597","https://openalex.org/W1994237675","https://openalex.org/W2002565670","https://openalex.org/W2012076539","https://openalex.org/W2017801064","https://openalex.org/W2023226752","https://openalex.org/W2027526965","https://openalex.org/W2030271509","https://openalex.org/W2033623607","https://openalex.org/W2051475428","https://openalex.org/W2053831974","https://openalex.org/W2057487372","https://openalex.org/W2058687959","https://openalex.org/W2063759396","https://openalex.org/W2065398955","https://openalex.org/W2066369900","https://openalex.org/W2072234641","https://openalex.org/W2073265380","https://openalex.org/W2092175186","https://openalex.org/W2095304362","https://openalex.org/W2100078302","https://openalex.org/W2107204360","https://openalex.org/W2112453730","https://openalex.org/W2115588508","https://openalex.org/W2118909497","https://openalex.org/W2125163391","https://openalex.org/W2126671869","https://openalex.org/W2128454891","https://openalex.org/W2144215775","https://openalex.org/W2151968663","https://openalex.org/W2165073658","https://openalex.org/W2252539153","https://openalex.org/W2427085028","https://openalex.org/W2566345335","https://openalex.org/W4366066231"],"related_works":["https://openalex.org/W2118909497","https://openalex.org/W2427085028","https://openalex.org/W2974689431","https://openalex.org/W2605915925","https://openalex.org/W2328403855","https://openalex.org/W2165073658","https://openalex.org/W2115588508","https://openalex.org/W7208790769","https://openalex.org/W2031569296","https://openalex.org/W2319213781"],"abstract_inverted_index":{"Aim:":[0],"Sulfanegen":[1,17],"has":[2],"been":[3],"shown":[4],"to":[5,28,41,53,72,134,150],"be":[6,151],"an":[7],"effective":[8],"next":[9],"generation":[10],"cyanide":[11,19,27,57,159],"antidote":[12],"in":[13,48,89],"multiple":[14],"animal":[15],"studies.":[16],"detoxifies":[18],"by":[20],"acting":[21],"as":[22,63],"a":[23,68],"sulfur":[24,75],"donor,":[25,76],"converting":[26],"thiocyanate":[29],"through":[30],"the":[31,43,73,108,117,136,143,155],"enzyme":[32],"3-mercaptopyruvate":[33],"(3-MP)":[34],"sulfurtransferase.":[35],"The":[36],"current":[37,54],"study":[38],"was":[39,113,120,132],"performed":[40],"determine":[42],"PK":[44,137,144],"behavior":[45,138],"of":[46,87,93,105,111,139,146,158],"sulfanegen":[47,61,66,88,98,147],"rabbits":[49],"and":[50,103,130],"compare":[51],"it":[52],"US":[55],"FDA-approved":[56],"therapeutics.":[58],"Methods:":[59],"Plasma":[60],"concentrations,":[62],"3-MP":[64,94,106,112],"(i.e.,":[65],"is":[67],"prodrug":[69],"that":[70],"converts":[71],"active":[74],"3-MP,":[77],"upon":[78],"administration),":[79],"were":[80,148],"monitored":[81],"using":[82],"LC\u2013MS/MS":[83],"following":[84,97],"intramuscular":[85],"administration":[86],"rabbits.":[90],"Results:":[91],"Concentrations":[92],"rapidly":[95],"increased":[96],"administration,":[99],"indicating":[100],"rapid":[101,156],"absorption":[102],"distribution":[104,129],"throughout":[107],"body.":[109],"Elimination":[110],"also":[114],"relatively":[115],"rapid;":[116],"calculated":[118],"half-life":[119],"approximately":[121],"114":[122],"min.":[123],"A":[124],"one-compartment":[125],"model":[126],"with":[127],"first-order":[128],"elimination":[131],"used":[133],"describe":[135],"3-MP.":[140],"Conclusion:":[141],"Overall,":[142],"characteristics":[145],"found":[149],"well":[152],"suited":[153],"for":[154],"treatment":[157],"poisoning.":[160]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}