{"id":"https://openalex.org/W2602190189","doi":null,"title":"Starch nanoparticles: modifications, toxicity, and drug loading","display_name":"Starch nanoparticles: modifications, toxicity, and drug loading","publication_year":2015,"publication_date":"2015-04-30","ids":{"openalex":"https://openalex.org/W2602190189","mag":"2602190189"},"language":"en","primary_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/9301","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/9301","pdf_url":"http://hdl.handle.net/10012/9301","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10012/9301","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101474157","display_name":"Ziyi Sun","orcid":"https://orcid.org/0009-0004-8391-8323","observed_orcids":["https://orcid.org/0009-0004-8391-8323","https://orcid.org/0009-0000-7731-2545"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ziyi Sun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-8391-8323","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101474157"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/starch-nanoparticles","display_name":"starch nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5899999737739563},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8019999861717224},{"id":"https://openalex.org/keywords/drug-loading","display_name":"drug loading","score":0.6650000214576721},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6470000147819519},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cationic-nanoparticles","display_name":"cationic nanoparticles","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dna-delivery","display_name":"DNA delivery","score":0.9739999771118164},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.8009999990463257},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.718999981880188},{"id":"https://openalex.org/keywords/biodegradable-nanocarriers","display_name":"biodegradable nanocarriers","score":0.871999979019165},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.585638165473938},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5824283957481384},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5673158764839172},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.48065435886383057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36898350715637207},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3296559453010559},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32654696702957153},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24284249544143677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22838953137397766},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.18235838413238525},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10549727082252502}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/9301","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/9301","pdf_url":"http://hdl.handle.net/10012/9301","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master Thesis"},{"id":"mag:2602190189","doi":null,"is_oa":false,"landing_page_url":"https://uwspace.uwaterloo.ca/bitstream/10012/9301/1/Sun_Ziyi.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/9301","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/9301","pdf_url":"http://hdl.handle.net/10012/9301","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2602190189.pdf","grobid_xml":"https://content.openalex.org/works/W2602190189.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W989326842","https://openalex.org/W1496281810","https://openalex.org/W1508537511","https://openalex.org/W1540602576","https://openalex.org/W1865814132","https://openalex.org/W1888210475","https://openalex.org/W1906718334","https://openalex.org/W1963797031","https://openalex.org/W1966257337","https://openalex.org/W1969250416","https://openalex.org/W1970807882","https://openalex.org/W1974061482","https://openalex.org/W1974913887","https://openalex.org/W1975825403","https://openalex.org/W1976385056","https://openalex.org/W1979024093","https://openalex.org/W1980447828","https://openalex.org/W1983405869","https://openalex.org/W1986212912","https://openalex.org/W1988681998","https://openalex.org/W1989230986","https://openalex.org/W1994390268","https://openalex.org/W1994405704","https://openalex.org/W1995285206","https://openalex.org/W1995588997","https://openalex.org/W1996285277","https://openalex.org/W1996453161","https://openalex.org/W1997011294","https://openalex.org/W1997598938","https://openalex.org/W1998697301","https://openalex.org/W2001364537","https://openalex.org/W2001995867","https://openalex.org/W2005926406","https://openalex.org/W2006495855","https://openalex.org/W2010655741","https://openalex.org/W2012528391","https://openalex.org/W2013470095","https://openalex.org/W2016046385","https://openalex.org/W2023380754","https://openalex.org/W2024825858","https://openalex.org/W2025372180","https://openalex.org/W2029398755","https://openalex.org/W2030855909","https://openalex.org/W2031808379","https://openalex.org/W2032760352","https://openalex.org/W2034791362","https://openalex.org/W2037831947","https://openalex.org/W2040188256","https://openalex.org/W2040795847","https://openalex.org/W2041827925","https://openalex.org/W2044952691","https://openalex.org/W2045501299","https://openalex.org/W2046422929","https://openalex.org/W2055483349","https://openalex.org/W2055656861","https://openalex.org/W2056171928","https://openalex.org/W2057776973","https://openalex.org/W2058984075","https://openalex.org/W2059343461","https://openalex.org/W2060875558","https://openalex.org/W2061510929","https://openalex.org/W2065337815","https://openalex.org/W2065462876","https://openalex.org/W2065858691","https://openalex.org/W2066842507","https://openalex.org/W2070464059","https://openalex.org/W2071404078","https://openalex.org/W2074427729","https://openalex.org/W2078628247","https://openalex.org/W2081938664","https://openalex.org/W2082511916","https://openalex.org/W2082545995","https://openalex.org/W2082575848","https://openalex.org/W2083763442","https://openalex.org/W2086924462","https://openalex.org/W2087214651","https://openalex.org/W2090091324","https://openalex.org/W2093325598","https://openalex.org/W2095694204","https://openalex.org/W2102897174","https://openalex.org/W2111163976","https://openalex.org/W2120915183","https://openalex.org/W2122833589","https://openalex.org/W2122995651","https://openalex.org/W2125211711","https://openalex.org/W2130977758","https://openalex.org/W2138281910","https://openalex.org/W2149984051","https://openalex.org/W2151609134","https://openalex.org/W2154482941","https://openalex.org/W2161806809","https://openalex.org/W2161836547","https://openalex.org/W2162994503","https://openalex.org/W2165072611","https://openalex.org/W2170529786","https://openalex.org/W2320622646","https://openalex.org/W2321877594"],"related_works":["https://openalex.org/W1474188169","https://openalex.org/W2612731147","https://openalex.org/W2323345483","https://openalex.org/W4401582996","https://openalex.org/W2807292124","https://openalex.org/W2727861587","https://openalex.org/W4312431235","https://openalex.org/W2989099166","https://openalex.org/W2066538086","https://openalex.org/W4304690961"],"abstract_inverted_index":{"Nanoparticles":[0],"as":[1,198],"drug":[2,50,127,185,279,286],"delivery":[3,51,90,216,249],"vehicles":[4,217,240],"have":[5,230],"been":[6,231],"well":[7],"tested":[8,332],"and":[9,31,75,91,128,156,177,244,255,271,282,290,307,320,333],"transferred":[10],"into":[11],"clinical":[12,193],"practice":[13],"in":[14,106,140,174,358],"the":[15,98,107,132,151,154,162,165,175,199,204,223,236,251,265,283,295,315,322,327,354,359],"past":[16],"few":[17],"decades.":[18],"The":[19,57,111,278],"success":[20],"of":[21,94,114,134,137,145,153,208,238,285,294,326,347,356],"most":[22],"nanocarriers":[23,229],"is":[24,136,148,167,211,241,268],"attributed":[25,168],"to":[26,53,87,118,149,169,203,213,218,222,233,247,269,292,335,338],"their":[27,54],"biocompatibility,":[28,73],"controlled":[29],"release":[30,93],"unique":[32],"size-dependent":[33],"properties.":[34],"In":[35,81],"this":[36,146],"regard,":[37],"I":[38],"proposed":[39],"that":[40,122,293],"starch":[41],"nanoparticles":[42],"(SNPs)":[43],"might":[44],"be":[45,85,124,180,257,336],"a":[46,190,261,303,339],"good":[47,72],"candidate":[48],"for":[49,78,126,164,275,309,353],"due":[52],"excellent":[55],"biocompatibility.":[56],"crosslinked":[58],"SNPs":[59,83,99,115,252,274,300,317],"supplied":[60],"by":[61,182,302],"EcoSynthetix":[62,101],"Inc.":[63],"are":[64,102,116,253],"nanogel-like":[65],"materials":[66,121],"with":[67],"many":[68],"potential":[69],"advantages,":[70],"including":[71],"biodegradability,":[74],"high":[76],"capacity":[77],"loading":[79,186],"drugs.":[80,95],"addition,":[82],"can":[84,123,179,256],"engineered":[86],"achieve":[88],"targeted":[89,215],"sustained":[92],"So":[96],"far":[97],"from":[100],"only":[103],"used":[104,125],"commercially":[105,259],"paper":[108],"coating":[109],"industry.":[110],"chemical":[112],"modifications":[113],"expected":[117],"generate":[119],"new":[120,345],"gene":[129,341],"delivery.":[130,311],"Since":[131],"safety":[133],"nanomaterial":[135],"great":[138,351],"concern":[139],"biomedical":[141],"applications,":[142],"one":[143],"objective":[144,267],"research":[147],"study":[150],"toxicity":[152,166,221],"unmodified":[155],"modified":[157],"SNPs.":[158],"Through":[159],"my":[160],"research,":[161],"reason":[163],"free":[170,296],"crosslinker":[171],"molecules":[172],"present":[173],"sample,":[176],"they":[178],"removed":[181],"washing.":[183],"For":[184],"study,":[187],"doxorubicin":[188],"(Dox),":[189],"highly":[191],"effective":[192],"anticancer":[194],"drug,":[195],"was":[196,318,330],"chosen":[197],"model":[200],"drug.":[201,297],"Due":[202],"significant":[205],"side":[206],"effects":[207],"Dox,":[209,235],"it":[210],"important":[212],"develop":[214],"decrease":[219],"its":[220],"healthy":[224],"tissues.":[225],"While":[226],"several":[227],"biocompatible":[228],"developed":[232,301],"deliver":[234],"synthesis":[237],"these":[239,248],"often":[242],"complicated":[243],"expensive.":[245],"Compared":[246],"platforms,":[250],"renewable":[254],"produced":[258],"on":[260],"large":[262],"scale.":[263],"Therefore,":[264],"second":[266],"synthesize":[270],"characterize":[272],"carboxyl-modified":[273],"Dox":[276],"loading.":[277],"loading/release":[280],"kinetics":[281],"efficacy":[284],"complex":[287],"were":[288,305,331],"studied":[289],"compared":[291],"Finally,":[298],"cationic":[299,316],"co-worker":[304],"evaluated":[306],"utilized":[308],"DNA":[310,312],"adsorption":[313],"onto":[314],"investigated,":[319],"then":[321],"cellular":[323],"uptake":[324],"efficiency":[325],"DNA/SNPs":[328],"complexes":[329],"formed":[334],"comparable":[337],"commercial":[340],"transfection":[342],"agent.":[343],"This":[344],"generation":[346],"SNP":[348],"platform":[349],"holds":[350],"promise":[352],"treatment":[355],"cancer":[357],"future.":[360]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2017-04-07T00:00:00"}