{"id":"https://openalex.org/W2602170127","doi":null,"title":"Doubling the rate of neurologic development in Down syndrome: a pilot study.","display_name":"Doubling the rate of neurologic development in Down syndrome: a pilot study.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2602170127","mag":"2602170127","pmid":"https://pubmed.ncbi.nlm.nih.gov/29108172"},"language":"en","primary_location":{"id":"pmid:29108172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29108172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Issues in law & medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066081122","display_name":"Patrick James Baggot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick James Baggot","raw_affiliation_strings":["Obstetrician/Gynecologist in Private Practice, Los Angeles CA. pjbaggot@hotmail.com","Obstetrician/Gynecologist in Private Practice, Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrician/Gynecologist in Private Practice, Los Angeles CA. pjbaggot@hotmail.com","institution_ids":[]},{"raw_affiliation_string":"Obstetrician/Gynecologist in Private Practice, Los Angeles CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032984698","display_name":"Rocel Medina Baggot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rocel Medina Baggot","raw_affiliation_strings":["Obstetrician/Gynecologist in Private Practice, Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrician/Gynecologist in Private Practice, Los Angeles CA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2642172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"2","first_page":"125","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11632","display_name":"Family and Disability Support Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":1.0},{"id":"https://openalex.org/keywords/neurologic-development","display_name":"neurologic development","score":0.7680000066757202},{"id":"https://openalex.org/keywords/developmental-rate","display_name":"developmental rate","score":0.39100000262260437},{"id":"https://openalex.org/keywords/crawling","display_name":"crawling","score":0.39399999380111694},{"id":"https://openalex.org/keywords/catch-up-growth","display_name":"catch-up growth","score":0.5519999861717224},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5031654238700867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4304613471031189},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.41256043314933777}],"mesh":[{"descriptor_ui":"D002657","descriptor_name":"Child Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018479","descriptor_name":"Early Intervention, Educational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:29108172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29108172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Issues in law & medicine","raw_type":"Journal Article"},{"id":"mag:2602170127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29108172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W319895346","https://openalex.org/W1584356369","https://openalex.org/W1963722545","https://openalex.org/W1969584505","https://openalex.org/W1977747998","https://openalex.org/W1986490928","https://openalex.org/W1993100830","https://openalex.org/W1998063406","https://openalex.org/W2002102608","https://openalex.org/W2007326167","https://openalex.org/W2015600814","https://openalex.org/W2017976379","https://openalex.org/W2018635339","https://openalex.org/W2035969575","https://openalex.org/W2040580760","https://openalex.org/W2065297036","https://openalex.org/W2072672328","https://openalex.org/W2107713038","https://openalex.org/W2131946259","https://openalex.org/W2134953810","https://openalex.org/W2137361753","https://openalex.org/W2156139994","https://openalex.org/W2158318714","https://openalex.org/W2184786628","https://openalex.org/W4240544774"],"related_works":["https://openalex.org/W2473469147","https://openalex.org/W2056222491","https://openalex.org/W7057344424","https://openalex.org/W7055891329","https://openalex.org/W2758091748","https://openalex.org/W7065504825","https://openalex.org/W6912089297","https://openalex.org/W2993703812","https://openalex.org/W2084109161","https://openalex.org/W2101304698"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recently,":[1],"Von":[2,30],"Tetzchner":[3],"and":[4,39,72,80,93,110,114,132,140,259,262,271,289,309,328,336],"colleagues":[5],"completed":[6],"the":[7,14,19,294,331],"first":[8,172],"study":[9,32,57,70,281],"in":[10,112,217,299],"three":[11],"decades":[12],"of":[13,16,21,163,182,274,286,296,306,326,333],"method":[15,256],"Institutes":[17],"for":[18,205],"Achievement":[20],"Human":[22,208],"Potential":[23],"(IAHP.)":[24],"They":[25],"found":[26],"no":[27,236],"benefit.":[28,238],"Because":[29],"Tetzchner's":[31],"had":[33,150,175],"few":[34],"patients":[35,104],"(17-18),":[36],"many":[37],"diagnoses,":[38],"numerous":[40],"(13)":[41],"different":[42],"outcome":[43,75],"measures,":[44],"these":[45,221],"flaws":[46],"may":[47],"have":[48,235],"obscured":[49],"a":[50,68,73,135,244,283,302,323],"treatment":[51],"benefit":[52],"with":[53,157,225],"excessive":[54],"variance.":[55,101],"This":[56,154,280],"was":[58,88,98,118,142,191],"designed":[59],"to":[60,90,99,107,120,124,130,171,232,318,322],"correct":[61],"those":[62],"flaws.":[63],"One":[64],"diagnosis":[65],"(Down":[66],"syndrome),":[67],"larger":[69],"(218),":[71],"single":[74],"measure":[76],"were":[77,105,128],"used":[78,119],"before":[79,92],"after":[81,94],"(the":[82],"IAHP":[83,147,206,255],"developmental":[84],"profile).":[85],"Each":[86],"child":[87],"compared":[89],"himself,":[91],"treatment.":[95],"The":[96,126,180,188,196,239,254],"goal":[97],"minimize":[100],"METHODS:":[102],"Study":[103],"encouraged":[106],"crawl":[108],"early":[109],"engage":[111],"movement":[113],"balance":[115],"exercises.":[116],"Patterning":[117],"help":[121],"children":[122,127,149,174],"learn":[123],"crawl.":[125],"taught":[129],"read":[131],"count":[133],"from":[134,168],"very":[136],"young":[137],"age.":[138],"Nutrition":[139],"physiology":[141],"also":[143],"addressed.":[144],"RESULTS:":[145],"Before":[146],"treatment,":[148,167],"neurologic":[151,183,297],"age/chronologic":[152],"age=0.55.":[153],"is":[155,215,250,263,276,282,315,338],"consistent":[156,224],"standard":[158],"median":[159],"Down":[160,300],"syndrome":[161],"IQs":[162],"about":[164],"40.":[165],"After":[166],"initial":[169],"exam":[170],"follow-up,":[173],"delta":[176],"NA/CA":[177],"=":[178],"1.43.":[179],"rate":[181,295],"progress":[184,298],"more":[185],"than":[186],"doubled.":[187],"p":[189,192],"value":[190],"<":[193],"10-15.":[194],"DISCUSSION:":[195],"animal":[197],"literature":[198,210],"on":[199,341],"environmental":[200],"studies":[201],"provides":[202],"strong":[203],"foundation":[204],"methods.":[207],"adoption":[209],"demonstrates":[211,243],"substantial":[212],"catch-up":[213],"recovery":[214],"possible":[216],"humans.":[218],"While":[219],"surprising,":[220],"results":[222],"are":[223],"scientific":[226],"literature.":[227],"CONCLUSION:":[228],"Conventional":[229],"methods,":[230],"according":[231],"von":[233],"Tetzchner,":[234],"proven":[237],"evidence":[240],"presented":[241],"here":[242,317],"strong,":[245],"clinically":[246],"significant":[247],"benefit,":[248],"which":[249],"highly":[251,264],"statistically":[252],"significant.":[253],"enhances":[257],"development":[258],"cognitive":[260],"performance,":[261],"cost":[265],"effective":[266],"since":[267],"1)":[268],"it":[269,320,345],"works":[270],"2)":[272],"most":[273],"therapy":[275],"done":[277],"by":[278],"parents.":[279],"verbatim":[284],"reprint":[285],"Baggot":[287,290],"PJ":[288],"RM":[291],"(2016),":[292],"Doubling":[293],"syndrome:":[301],"pilot":[303],"study,":[304],"Journal":[305,332],"American":[307,334],"Physicians":[308,335],"Surgeons,":[310],"21":[311],"(2):":[312],"41-46.":[313],"It":[314],"reprinted":[316],"make":[319],"available":[321],"wider":[324],"audience":[325],"physicians":[327],"scientists,":[329],"as":[330],"Surgeons":[337],"not":[339,350],"indexed":[340],"Pubmed.":[342],"For":[343],"metanalyses,":[344],"should":[346],"be":[347],"counted":[348],"once,":[349],"twice.":[351]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}