{"id":"https://openalex.org/W2602117339","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e15635","title":"Multimodality salvage therapy for anal cancer failing standard chemoradiation","display_name":"Multimodality salvage therapy for anal cancer failing standard chemoradiation","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W2602117339","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e15635","mag":"2602117339"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2009.27.15_suppl.e15635","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e15635","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2009.27.15_suppl.e15635","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113446641","display_name":"Y. N. You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. N. You","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031323337","display_name":"David W. Larson","orcid":"https://orcid.org/0000-0001-9177-4586","observed_orcids":["https://orcid.org/0000-0001-9177-4586"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. W. Larson","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005306368","display_name":"Eric J. Dozois","orcid":"https://orcid.org/0000-0002-2290-4735","observed_orcids":["https://orcid.org/0000-0002-2290-4735"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. J. Dozois","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077947383","display_name":"Heidi Nelson","orcid":"https://orcid.org/0000-0003-0710-8332","observed_orcids":["https://orcid.org/0000-0003-0710-8332"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Nelson","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Antpack Filho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Antpack Filho","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113118521","display_name":"K. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Klein","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091023123","display_name":"Robert Clell Miller","orcid":"https://orcid.org/0000-0001-8932-2732","observed_orcids":["https://orcid.org/0000-0001-8932-2732","https://orcid.org/0000-0002-9373-5203"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. C. Miller","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"15_suppl","first_page":"e15635","last_page":"e15635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anal-cancer","display_name":"anal cancer","score":0.800000011920929},{"id":"https://openalex.org/keywords/anal-squamous-cell-carcinoma","display_name":"anal squamous cell carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/recurrent-cancer","display_name":"recurrent cancer","score":0.5249999761581421},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/intraoperative-radiotherapy","display_name":"intraoperative radiotherapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/abdominoperineal-resection","display_name":"abdominoperineal resection","score":0.9929999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.734000027179718},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.878000020980835},{"id":"https://openalex.org/keywords/perineal-wound-complications","display_name":"perineal wound complications","score":0.7940000295639038},{"id":"https://openalex.org/keywords/intestinal-obstruction","display_name":"intestinal obstruction","score":0.921999990940094},{"id":"https://openalex.org/keywords/hydronephrosis","display_name":"hydronephrosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/treatment-morbidity","display_name":"treatment morbidity","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9764593839645386},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6899828910827637},{"id":"https://openalex.org/C2779840525","wikidata":"https://www.wikidata.org/wiki/Q484827","display_name":"Anal cancer","level":3,"score":0.6668059825897217},{"id":"https://openalex.org/C2781171867","wikidata":"https://www.wikidata.org/wiki/Q3933360","display_name":"Abdominoperineal resection","level":4,"score":0.6192419528961182},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5802128911018372},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.5395641922950745},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5137368440628052},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.41562551259994507},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33654505014419556},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31019914150238037},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.19572314620018005},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.19158217310905457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13597899675369263}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2009.27.15_suppl.e15635","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e15635","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2009.27.15_suppl.e15635","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068875986","https://openalex.org/W2412695364","https://openalex.org/W2614128040","https://openalex.org/W2802663647","https://openalex.org/W2410445800","https://openalex.org/W2414779843","https://openalex.org/W2157438140","https://openalex.org/W2780923912","https://openalex.org/W1977129112","https://openalex.org/W75930335"],"abstract_inverted_index":{"e15635":[0],"Background:":[1],"Most":[2],"squamous":[3],"cell":[4],"carcinomas":[5],"of":[6],"the":[7,95,230],"anal":[8],"canal":[9],"(SCC)":[10],"respond":[11],"to":[12,146,229,292],"chemoradiation,":[13,40,276],"but":[14],"effective":[15],"therapy":[16,47],"for":[17,51,216,285],"locally-invasive(T4)":[18],"or":[19,66,148,198,264],"recurrent":[20,67,265],"disease":[21,68,124,134,179,223],"that":[22,125,135],"fails":[23],"standard":[24,129,139,269],"chemoradiation":[25,130,140],"and/or":[26],"salvage":[27,153],"abdominoperineal":[28],"resection":[29,43,279],"(APR)":[30],"has":[31],"not":[32],"been":[33],"clearly":[34],"delineated.":[35],"A":[36,58],"multimodality":[37,273],"approach":[38,274],"including":[39,61],"extended":[41,277],"pelvic":[42,178,278],"and":[44,54,72,88,92,101,166,171,214,221,280],"intraoperative":[45],"radiation":[46,169],"(IORT)":[48],"was":[49,74,78,180,193,206],"assessed":[50],"survival":[52,80,204],"impact":[53],"treatment":[55],"morbidity.morbidities.":[56],"Methods:":[57],"prospective":[59],"registry":[60],"26":[62],"patients":[63,163,217,234,261],"with":[64,121,218,262],"locally-invasive":[65,123],"treated":[69],"between":[70],"1993":[71],"2007":[73],"reviewed.":[75],"Primary":[76],"endpoint":[77],"overall":[79,203],"(OS),":[81],"obtained":[82],"from":[83],"prospectively":[84],"collected":[85],"patient":[86],"questionnaires":[87],"medical":[89],"record":[90],"review,":[91],"analyzed":[93],"by":[94],"Kaplan-Meier":[96],"method.":[97],"Short":[98],"(60-day":[99],"postoperative)":[100],"long-term":[102,236],"(median":[103,116],"followup:":[104],"1.6":[105],"years;":[106],"5.3":[107],"years":[108,145,159],"among":[109],"survivors)":[110],"complications":[111,226,237],"were":[112],"assessed.":[113],"Results:":[114],"Patients":[115],"age:":[117],"51":[118],"years)":[119],"presented":[120],"(1)":[122],"persisted":[126],"despite":[127],"initial":[128,138],"(n=10,":[131,141],"39%),":[132],"(2)":[133],"recurred":[136],"after":[137,151],"39%;":[142],"median":[143,157],"1.7":[144,207],"recurrence),":[147],"(3)":[149],"re-recurrence":[150],"a":[152,272,283],"APR":[154],"(n=6,":[155],"23%;":[156],"1.3":[158],"since":[160],"APR).":[161],"All":[162],"received":[164,173],"chemotherapy":[165],"external":[167],"beam":[168],"preoperatively,":[170],"19%":[172],"additional":[174],"postoperative":[175],"chemoradiation.":[176],"Gross":[177],"completely":[181],"resected":[182],"in":[183,186,189,241,249,253,256],"all":[184],"(R0":[185],"73%;":[187],"R1":[188],"27%).":[190],"IORT":[191,281],"(750\u20133250cGy)":[192],"delivered":[194],"at":[195],"single":[196],"(92%)":[197],"two":[199],"sites":[200],"(8%).":[201],"Median":[202],"(OS)":[205],"years.":[208],"Five-year":[209],"OS":[210],"were:":[211],"50%,":[212],"10%,":[213],"22%":[215],"locally-invasive,":[219],"recurrent,":[220],"re-recurrent":[222],"respectively.":[224],"Short-term":[225],"predominantly":[227],"related":[228],"perineal":[231,246],"wound.":[232],"Fifteen":[233],"reported":[235],"(>grade3):":[238],"bowel":[239],"obstruction":[240],"8":[242],"(1":[243],"requiring":[244],"operation),":[245],"wound":[247],"fistula/non-healing":[248],"9,":[250],"leg":[251],"paresthesia":[252],"5,":[254],"hydronephrosis":[255],"3.":[257],"Conclusions:":[258],"For":[259],"select":[260],"locally-persistent":[263],"SCC":[266],"who":[267],"fail":[268],"primary":[270],"treatment,":[271],"involving":[275],"offers":[282],"chance":[284],"improved":[286],"survival.":[287],"No":[288],"significant":[289],"financial":[290],"relationships":[291],"disclose.":[293]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2017-04-07T00:00:00"}