{"id":"https://openalex.org/W2602012817","doi":"https://doi.org/10.3390/ijms18030666","title":"Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response","display_name":"Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response","publication_year":2017,"publication_date":"2017-03-20","ids":{"openalex":"https://openalex.org/W2602012817","doi":"https://doi.org/10.3390/ijms18030666","mag":"2602012817","pmid":"https://pubmed.ncbi.nlm.nih.gov/28335522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5372678"},"language":"en","primary_location":{"id":"doi:10.3390/ijms18030666","doi":"https://doi.org/10.3390/ijms18030666","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18030666","pdf_url":"https://www.mdpi.com/1422-0067/18/3/666/pdf?version=1490091207","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/18/3/666/pdf?version=1490091207","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012818038","display_name":"Takahisa Kouwaki","orcid":"https://orcid.org/0000-0002-8842-4056","observed_orcids":["https://orcid.org/0000-0002-8842-4056"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Kouwaki","raw_affiliation_strings":["Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102946896","display_name":"Masaaki Okamoto","orcid":"https://orcid.org/0000-0001-7689-2939","observed_orcids":["https://orcid.org/0000-0001-7689-2939"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Okamoto","raw_affiliation_strings":["Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046865992","display_name":"Hirotake Tsukamoto","orcid":"https://orcid.org/0000-0003-3214-1652","observed_orcids":["https://orcid.org/0000-0003-3214-1652"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotake Tsukamoto","raw_affiliation_strings":["Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112454894","display_name":"Yoshimi Fukushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimi Fukushima","raw_affiliation_strings":["Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043184323","display_name":"Hiroyuki Oshiumi","orcid":"https://orcid.org/0000-0003-1567-8722","observed_orcids":["https://orcid.org/0000-0003-1567-8722"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroyuki Oshiumi","raw_affiliation_strings":["Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan","Japan Science and Technology Agency, PRESTO, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Japan Science and Technology Agency, PRESTO, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan","institution_ids":["https://openalex.org/I4210086780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043184323"],"corresponding_institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I96036126"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.1649,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.76984936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"18","issue":"3","first_page":"666","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/microvesicles","display_name":"microvesicles","score":0.9860000014305115},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/host-micrornas","display_name":"host microRNAs","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/rig-i-like-receptors","display_name":"RIG-I-like receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.847000002861023},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9610000252723694},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8754119873046875},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.7212108373641968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6979112029075623},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.666412353515625},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.6002533435821533},{"id":"https://openalex.org/C2776954689","wikidata":"https://www.wikidata.org/wiki/Q21100537","display_name":"RIG-I","level":4,"score":0.5827674865722656},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5710512399673462},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5274596214294434},{"id":"https://openalex.org/C188899842","wikidata":"https://www.wikidata.org/wiki/Q1483180","display_name":"Pathogen-associated molecular pattern","level":5,"score":0.49700644612312317},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4438480734825134},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.41870296001434326},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.416256844997406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41265660524368286},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4098614454269409},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.057572782039642334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D034443","descriptor_name":"RNA Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051192","descriptor_name":"Receptors, Pattern Recognition","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms18030666","doi":"https://doi.org/10.3390/ijms18030666","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18030666","pdf_url":"https://www.mdpi.com/1422-0067/18/3/666/pdf?version=1490091207","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5372678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5372678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:28335522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28335522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fcd3666ed3f240479ce13ddd8c3958d4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fcd3666ed3f240479ce13ddd8c3958d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 18, Iss 3, p 666 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms18030666","doi":"https://doi.org/10.3390/ijms18030666","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18030666","pdf_url":"https://www.mdpi.com/1422-0067/18/3/666/pdf?version=1490091207","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1887800256","display_name":"Novel interaction between virus and host innate immune system","funder_award_id":"15K08517","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4405369409","display_name":"The detrimental effect of soluble IL-6 receptor on CD4 T cell-mediated anti-tumor immune responses","funder_award_id":"26430165","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320323514","display_name":"Daiichi Sankyo Foundation of Life Science","ror":"https://ror.org/05j492n53"},{"id":"https://openalex.org/F4320325277","display_name":"Kao Foundation for Arts and Sciences","ror":"https://ror.org/016t1kc57"},{"id":"https://openalex.org/F4320327690","display_name":"Japan Diabetes Foundation","ror":"https://ror.org/002cfy541"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338111","display_name":"Precursory Research for Embryonic Science and Technology","ror":null},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2602012817.pdf","grobid_xml":"https://content.openalex.org/works/W2602012817.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1487837095","https://openalex.org/W1502104604","https://openalex.org/W1503339982","https://openalex.org/W1514540900","https://openalex.org/W1526700155","https://openalex.org/W1571387405","https://openalex.org/W1661544713","https://openalex.org/W1667782349","https://openalex.org/W1965147416","https://openalex.org/W1967953614","https://openalex.org/W1968138343","https://openalex.org/W1969002010","https://openalex.org/W1972776583","https://openalex.org/W1973646620","https://openalex.org/W1985844219","https://openalex.org/W1986321004","https://openalex.org/W1986360322","https://openalex.org/W1994344811","https://openalex.org/W1994391392","https://openalex.org/W1994942139","https://openalex.org/W1996997447","https://openalex.org/W1997571827","https://openalex.org/W2001567020","https://openalex.org/W2003220523","https://openalex.org/W2005884645","https://openalex.org/W2012420380","https://openalex.org/W2015312036","https://openalex.org/W2016131266","https://openalex.org/W2017857120","https://openalex.org/W2020717559","https://openalex.org/W2024206172","https://openalex.org/W2028248159","https://openalex.org/W2028575270","https://openalex.org/W2029339804","https://openalex.org/W2035027025","https://openalex.org/W2035844407","https://openalex.org/W2038236600","https://openalex.org/W2047703658","https://openalex.org/W2057784785","https://openalex.org/W2065821936","https://openalex.org/W2067706259","https://openalex.org/W2071019693","https://openalex.org/W2072109464","https://openalex.org/W2072203820","https://openalex.org/W2076361525","https://openalex.org/W2079007590","https://openalex.org/W2082448279","https://openalex.org/W2084770914","https://openalex.org/W2097217535","https://openalex.org/W2098259366","https://openalex.org/W2099610218","https://openalex.org/W2100665873","https://openalex.org/W2102097271","https://openalex.org/W2105275554","https://openalex.org/W2106684817","https://openalex.org/W2107008239","https://openalex.org/W2111560326","https://openalex.org/W2111695773","https://openalex.org/W2123614057","https://openalex.org/W2127517948","https://openalex.org/W2128340149","https://openalex.org/W2132127444","https://openalex.org/W2133845131","https://openalex.org/W2134994877","https://openalex.org/W2137649343","https://openalex.org/W2141137217","https://openalex.org/W2149826973","https://openalex.org/W2154171253","https://openalex.org/W2154322581","https://openalex.org/W2160098916","https://openalex.org/W2161208630","https://openalex.org/W2166796021","https://openalex.org/W2167056256","https://openalex.org/W2194401669","https://openalex.org/W2235539081","https://openalex.org/W2237018933","https://openalex.org/W2253555500","https://openalex.org/W2327541311","https://openalex.org/W2340514456","https://openalex.org/W2353041718","https://openalex.org/W2404612673","https://openalex.org/W2516639262","https://openalex.org/W2530674994","https://openalex.org/W2566233086"],"related_works":["https://openalex.org/W2516639262","https://openalex.org/W2005381457","https://openalex.org/W2072109464","https://openalex.org/W4397020663","https://openalex.org/W3109155990","https://openalex.org/W4404710987","https://openalex.org/W7165664976","https://openalex.org/W7151234981","https://openalex.org/W4411784609","https://openalex.org/W2911257203"],"abstract_inverted_index":{"The":[0],"innate":[1,36,132,150,168],"immune":[2,37,133,151,169],"system":[3],"plays":[4],"a":[5],"crucial":[6],"role":[7,163],"in":[8,74,79,121,166],"controlling":[9],"viral":[10,24,64,97],"infection.":[11],"Pattern":[12],"recognition":[13],"receptors":[14,19],"(PRRs),":[15],"such":[16],"as":[17],"Toll-like":[18],"and":[20,31,44,49,69,86,143],"RIG-I-like":[21],"receptors,":[22],"sense":[23],"components":[25],"called":[26],"pathogen-associated":[27],"molecular":[28],"patterns":[29],"(PAMPs)":[30],"trigger":[32],"signals":[33],"to":[34,66,103,117,128,146,161],"induce":[35],"responses.":[38,152,170],"Extracellular":[39],"vesicles":[40],"(EVs),":[41],"including":[42],"exosomes":[43],"microvesicles,":[45],"deliver":[46,63],"functional":[47],"RNA":[48,65,98],"mediate":[50],"intercellular":[51],"communications.":[52],"Recent":[53],"studies":[54],"have":[55],"revealed":[56],"that":[57,137],"EVs":[58,93,122,142,165],"released":[59,123],"from":[60,124],"virus-infected":[61,125],"cells":[62,68],"dendritic":[67],"macrophages,":[70],"thereby":[71],"activating":[72],"PRRs":[73],"recipient":[75,104],"cells,":[76,126],"which":[77],"results":[78],"the":[80,90,138,141,148,162],"expression":[81],"of":[82,108,130,164],"type":[83],"I":[84],"interferon":[85],"pro-inflammatory":[87],"cytokines.":[88],"On":[89],"other":[91],"hand,":[92],"transfer":[94],"not":[95],"only":[96],"but":[99],"also":[100],"host":[101,131,144],"microRNAs":[102,145],"cells.":[105],"Recently,":[106],"infection":[107],"hepatocytes":[109],"with":[110],"hepatitis":[111],"B":[112],"virus":[113,139],"(HBV)":[114],"was":[115],"shown":[116],"affect":[118],"microRNA":[119],"levels":[120],"leading":[127],"attenuation":[129],"response.":[134],"This":[135],"suggests":[136],"utilizes":[140],"counteract":[147],"antiviral":[149,167],"In":[153],"this":[154],"review,":[155],"we":[156],"summarize":[157],"recent":[158],"findings":[159],"related":[160]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-04-07T00:00:00"}