{"id":"https://openalex.org/W2602005834","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.5011","title":"KRAS and EGFR mutations to distinguish adenocarcinomas and squamous cell carcinomas of the cervix.","display_name":"KRAS and EGFR mutations to distinguish adenocarcinomas and squamous cell carcinomas of the cervix.","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W2602005834","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.5011","mag":"2602005834"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.30.15_suppl.5011","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.5011","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.5011","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032378308","display_name":"Alexi A. Wright","orcid":"https://orcid.org/0000-0002-9776-7114","observed_orcids":["https://orcid.org/0000-0002-9776-7114"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexi A. Wright","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027134730","display_name":"Michelle S. Hirsch","orcid":"https://orcid.org/0000-0002-8767-8564","observed_orcids":["https://orcid.org/0000-0002-8767-8564"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle S. Hirsch","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068721624","display_name":"Nikhil Wagle","orcid":"https://orcid.org/0000-0003-3332-9438","observed_orcids":["https://orcid.org/0000-0003-3332-9438"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Wagle","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043053884","display_name":"Brooke E. Howitt","orcid":"https://orcid.org/0000-0002-0309-6680","observed_orcids":["https://orcid.org/0000-0002-0309-6680"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke E Howitt","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007760528","display_name":"Emanuele Palescandolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuele Palescandolo","raw_affiliation_strings":["Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088965709","display_name":"Laura E. MacConaill","orcid":"https://orcid.org/0000-0002-0220-4715","observed_orcids":["https://orcid.org/0000-0002-0220-4715"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura E. MacConaill","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004172458","display_name":"Paul Van Hummelen","orcid":"https://orcid.org/0000-0002-4801-8600","observed_orcids":["https://orcid.org/0000-0002-4801-8600"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Van Hummelen","raw_affiliation_strings":["Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028095610","display_name":"Melina Shoni","orcid":"https://orcid.org/0000-0001-6015-8764","observed_orcids":["https://orcid.org/0000-0001-6015-8764"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melina Shoni","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063875415","display_name":"William C. Hahn","orcid":"https://orcid.org/0000-0003-2840-9791","observed_orcids":["https://orcid.org/0000-0003-2840-9791"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C Hahn","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058249824","display_name":"Ursula A. Matulonis","orcid":"https://orcid.org/0000-0002-3103-6992","observed_orcids":["https://orcid.org/0000-0002-3103-6992"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ursula A Matulonis","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"15_suppl","first_page":"5011","last_page":"5011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-adenocarcinoma","display_name":"cervical adenocarcinoma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cervical-squamous-cell-carcinoma","display_name":"cervical squamous cell carcinoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9769999980926514},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5400000214576721},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6639999747276306},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8563365936279297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7352484464645386},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6962619423866272},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.587610125541687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5399880409240723},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5197141170501709},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46099853515625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4571511745452881},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4094451665878296},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3304366171360016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3167555332183838},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.24994125962257385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18532639741897583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08828148245811462},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08376297354698181}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2012.30.15_suppl.5011","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.5011","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.5011","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038045035","https://openalex.org/W1483878487","https://openalex.org/W4312139838","https://openalex.org/W6957861857","https://openalex.org/W2043385216","https://openalex.org/W4312306353","https://openalex.org/W3134835226","https://openalex.org/W6991105558","https://openalex.org/W2117156908","https://openalex.org/W2939856162"],"abstract_inverted_index":{"5011":[0],"Background:":[1],"Cervical":[2],"adenocarcinomas":[3],"(AC)":[4],"have":[5,31],"higher":[6,124],"rates":[7,125],"of":[8,36,46,117,146,150,162,168,175,183,211,244,278],"recurrence":[9],"and":[10,19,44,52,104,181,237],"distant":[11],"metastasis,":[12],"compared":[13,128],"with":[14,67,120,129,229],"squamous":[15],"cell":[16],"carcinomas":[17],"(SCC),":[18],"decreased":[20],"survival":[21],"in":[22,49,92,114,126,143,159,179,195,215,226,235,239,256],"advanced":[23],"disease.":[24],"Yet,":[25],"tailored":[26],"treatments":[27],"for":[28,59,190],"cervical":[29,50,68,118,196,216,230],"cancers":[30],"not":[32],"emerged.":[33],"The":[34,173],"aim":[35],"this":[37,203,219,257],"study":[38],"was":[39],"to":[40,54,208,274],"compare":[41],"the":[42,151,184,205,245],"frequency":[43],"type":[45],"somatic":[47],"mutations":[48,91,111,140,156,214,234],"AC":[51,169,182,240],"SCC":[53,127,152,180,197],"identify":[55],"novel":[56],"therapeutic":[57,188],"targets":[58],"both":[60],"subtypes.":[61],"Methods:":[62],"Tumors":[63],"from":[64],"61":[65],"patients":[66,228],"cancer":[69,94],"(36":[70],"AC,":[71,147],"25":[72],"SCC)":[73],"underwent":[74],"genomic":[75,177,265,279],"profiling":[76,266],"by":[77],"OncoMap,":[78],"a":[79,121],"multiplexed":[80],"mass":[81],"spectrometric":[82],"genotyping":[83],"technology":[84],"that":[85,221,242],"interrogates":[86],"more":[87,263],"than":[88],"400":[89],"known":[90],"33":[93],"genes.":[95],"Results:":[96],"Overall,":[97],"31/61":[98],"(50.8%)":[99],"tumors":[100],"harbored":[101],"candidate":[102],"mutations,":[103],"6/61":[105],"(9.8%)":[106],"had":[107],"\u22652":[108],"mutations.":[109],"PIK3CA":[110,238],"were":[112,141,157],"present":[113,142,158],"21/64":[115],"(34.4%)":[116],"cancers,":[119],"trend":[122],"towards":[123],"ACC":[130],"(21/25":[131],"or":[132,136],"48.0%":[133],"vs.":[134],"9/27":[135],"33.3%,":[137],"p=0.10).":[138],"KRAS":[139,236],"6/31":[144],"(16.7%)":[145],"but":[148,166,202],"none":[149,167],"(0%;":[153,170],"0/25).":[154],"EGFR":[155,193,213],"9/25":[160],"(36.0%)":[161],"SCC,":[163],"including":[164],"G719S,":[165],"0/31).":[171],"Conclusions:":[172],"identification":[174],"distinct":[176],"alterations":[178],"cervix":[185],"suggest":[186,241],"different":[187],"rationales":[189],"each":[191],"subtype.":[192,258],"amplification":[194],"has":[198],"been":[199],"previously":[200],"reported,":[201],"is":[204],"first":[206],"identification,":[207],"our":[209],"knowledge,":[210],"activating":[212,233],"SCC.":[217,231],"Together,":[218],"suggests":[220],"EGFR-inhibitors":[222],"might":[223],"be":[224,254],"useful":[225],"selected":[227],"Similarly,":[232],"inhibition":[243],"MAPK":[246],"pathway":[247,252],"(MEK":[248],"inhibitors)":[249],"and/or":[250],"PI3K":[251],"may":[253],"beneficial":[255],"Future":[259],"studies":[260],"should":[261],"include":[262],"comprehensive":[264],"strategies,":[267],"such":[268],"as":[269],"targeted":[270],"massively":[271],"parallel":[272],"sequencing,":[273],"detect":[275],"multiple":[276],"types":[277],"alterations.":[280]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2017-04-07T00:00:00"}