{"id":"https://openalex.org/W2601839635","doi":null,"title":"Influence of in utero inflammation on diaphragm function in preterm lambs","display_name":"Influence of in utero inflammation on diaphragm function in preterm lambs","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2601839635","mag":"2601839635"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:publications/38441301-f291-4afd-b361-891880c30c05","doi":null,"is_oa":false,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/38441301-f291-4afd-b361-891880c30c05","pdf_url":null,"source":{"id":"https://openalex.org/S4306402523","display_name":"UWA Profiles and Research Repository (University of Western Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Karisnan, K 2015, 'Influence of in utero inflammation on diaphragm function in preterm lambs', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047540546","display_name":"Kanakeswary Karisnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kanakeswary Karisnan","raw_affiliation_strings":["School of Anatomy, Physiology and Human Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Anatomy, Physiology and Human Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5047540546"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diaphragm-function","display_name":"diaphragm function","score":0.8149999976158142},{"id":"https://openalex.org/keywords/preterm-lambs","display_name":"preterm lambs","score":0.8320000171661377},{"id":"https://openalex.org/keywords/chorioamnionitis","display_name":"chorioamnionitis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9319999814033508},{"id":"https://openalex.org/keywords/intra-amniotic-inflammation","display_name":"intra-amniotic inflammation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/respiratory-muscle-weakness","display_name":"respiratory muscle weakness","score":0.44600000977516174},{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia","display_name":"bronchopulmonary dysplasia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fetal-lung-development","display_name":"fetal lung development","score":0.5720000267028809},{"id":"https://openalex.org/keywords/fetal-breathing-movements","display_name":"fetal breathing movements","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.7346303462982178},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6578025221824646},{"id":"https://openalex.org/C164292776","wikidata":"https://www.wikidata.org/wiki/Q5271779","display_name":"Diaphragm (acoustics)","level":3,"score":0.5676342248916626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49380525946617126},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4252583682537079},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.32921797037124634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2981436252593994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26636549830436707},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.24089473485946655},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12106075882911682},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08664438128471375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C157138929","wikidata":"https://www.wikidata.org/wiki/Q570","display_name":"Loudspeaker","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:publications/38441301-f291-4afd-b361-891880c30c05","doi":null,"is_oa":false,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/38441301-f291-4afd-b361-891880c30c05","pdf_url":null,"source":{"id":"https://openalex.org/S4306402523","display_name":"UWA Profiles and Research Repository (University of Western Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Karisnan, K 2015, 'Influence of in utero inflammation on diaphragm function in preterm lambs', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2601839635","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/files/8148709/Karisnan_Kanakeswary_2015.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W24239069","https://openalex.org/W1523709841","https://openalex.org/W1749029280","https://openalex.org/W1836375302","https://openalex.org/W1966259045","https://openalex.org/W1976608207","https://openalex.org/W1990613641","https://openalex.org/W1992036272","https://openalex.org/W1993197717","https://openalex.org/W1994565268","https://openalex.org/W2010323888","https://openalex.org/W2010973636","https://openalex.org/W2015920478","https://openalex.org/W2022650586","https://openalex.org/W2025653977","https://openalex.org/W2032138306","https://openalex.org/W2032592339","https://openalex.org/W2043991526","https://openalex.org/W2046619780","https://openalex.org/W2052207154","https://openalex.org/W2065172724","https://openalex.org/W2066001832","https://openalex.org/W2076302905","https://openalex.org/W2078575750","https://openalex.org/W2083937009","https://openalex.org/W2104414181","https://openalex.org/W2105027118","https://openalex.org/W2115492098","https://openalex.org/W2116241595","https://openalex.org/W2123893661","https://openalex.org/W2127510146","https://openalex.org/W2127808488","https://openalex.org/W2128635872","https://openalex.org/W2128678605","https://openalex.org/W2133140259","https://openalex.org/W2133762721","https://openalex.org/W2134590871","https://openalex.org/W2137640454","https://openalex.org/W2146070073","https://openalex.org/W2148044501","https://openalex.org/W2152591620","https://openalex.org/W2153444851","https://openalex.org/W2156098713","https://openalex.org/W2162878054","https://openalex.org/W2262491734","https://openalex.org/W2337858082","https://openalex.org/W2402697586","https://openalex.org/W2408404578"],"related_works":["https://openalex.org/W3174108047","https://openalex.org/W2946176883","https://openalex.org/W2971915831","https://openalex.org/W2774690779","https://openalex.org/W1902806012","https://openalex.org/W2135432484","https://openalex.org/W2164778729","https://openalex.org/W4410305565","https://openalex.org/W7096936742","https://openalex.org/W3032629747"],"abstract_inverted_index":{"[Truncated]":[0],"Despite":[1],"recent":[2],"major":[3,76],"advances":[4],"in":[5,85,125,169,223,250,276,284,425,455],"neonatal":[6],"care,":[7],"preterm":[8,22,57,126,130,192,225,252,278,312,408,419,456],"birth":[9,23],"remains":[10],"the":[11,31,34,38,62,65,107,179,199,224,232,241,251,257,267,273,277,290,319,336,342,372,393,418,441,469],"leading":[12,153],"cause":[13],"of":[14,21,29,33,64,136,141,178,191,235,243,266,318,330,338,341,365,395,443,464],"postnatal":[15],"morbidity":[16],"and":[17,97,104,148,158,181,254,287,302,345,370,401,409,446],"mortality.":[18],"The":[19,78,263,294,315,353,386,434],"complications":[20],"arise":[24],"from":[25,471],"immature":[26,151],"organ":[27],"systems":[28],"which":[30],"dysfunction":[32,430],"respiratory":[35,46,68,108,159,208],"system":[36,47,109],"is":[37,59,73,80,122,184,202,217,227],"most":[39,203],"common":[40],"clinical":[41],"problem.":[42],"Infants":[43],"require":[44],"developed":[45,124],"to":[48,61,139,154,188,205,239,255,271,283,288,308,323,332,391,405,424,439],"sustain":[49],"independent":[50],"ventilation":[51],"after":[52,281,361,378],"birth.":[53],"Respiratory":[54],"failure":[55],"among":[56],"infant":[58,226],"due":[60,138],"underdevelopment":[63],"lungs,":[66],"however":[67],"muscle":[69,111],"weakness":[70,359,454],"and/or":[71],"fatigue":[72,157],"also":[74],"a":[75,362,379],"contributor.":[77],"diaphragm":[79,96,155,221,253,280,313,344,351,358,411,420,453,470],"important":[81],"for":[82],"lung":[83,101],"development":[84],"utero":[86,170,285,426],"as":[87,115,117,174,211],"fetal":[88,171,182,279,343],"breathing":[89,137],"movements":[90],"that":[91,201,298,357,371,417,462],"are":[92],"mainly":[93],"driven":[94],"by":[95,167,229],"intercostal":[98],"contraction,":[99],"stimulate":[100],"cellular":[102],"proliferation":[103],"growth.":[105],"Thus,":[106],"(including":[110],"pump":[112],"\u2013":[113,120],"diaphragm,":[114],"well":[116],"gas":[118],"exchanger":[119],"lungs)":[121],"poorly":[123],"infants.":[127],"In":[128],"addition,":[129],"infants":[131],"face":[132],"an":[133],"increased":[134],"work":[135],"lack":[140],"surfactant":[142],"proteins,":[143],"highly":[144],"compliant":[145],"chest":[146],"wall":[147],"noncompliant,":[149],"structurally":[150],"lungs":[152],"weakness,":[156],"failure.":[160],"Diaphragm":[161],"function":[162,222,249],"may":[163],"be":[164,375],"compromised":[165],"further":[166],"adverse":[168],"exposures":[172,349],"such":[173,210],"inflammation.":[175],"Chorioamnionitis,":[176],"inflammation":[177,246,286,427,472],"placental":[180],"membranes,":[183],"associated":[185],"with":[186],"up":[187],"70":[189],"%":[190],"births":[193],"at":[194,328],"<":[195],"28":[196],"week":[197],"gestation,":[198],"group":[200],"likely":[204],"develop":[206],"chronic":[207,380],"illness,":[209],"bronchopulmonary":[212],"dysplasia":[213],"(BPD).":[214],"Notably,":[215],"little":[216],"known":[218],"on":[219,247,407,449],"how":[220,325],"affected":[228],"chorioamnionitis.":[230],"Therefore,":[231],"overall":[233],"aim":[234,437],"this":[236],"thesis":[237],"was":[238,297,416,421,438,461],"investigate":[240,392,440],"impact":[242],"chorioamnionitis":[244],"induced":[245,428,452,473],"contractile":[248,429,474],"elucidate":[256,289],"molecular":[258,292],"mechanism":[259],"underlying":[260,291],"functional":[261,274,339],"alteration.":[262],"specific":[264,316],"aims":[265,317,389],"first":[268],"study":[269,295,321,354,388,414,436,459],"were":[270,322,356,390],"establish":[272],"changes":[275],"exposure":[282,307,331,367,382,398],"mechanisms.":[293],"hypothesis":[296,415,460],"acute":[299,396],"2":[300],"d":[301,304,400,403],"7":[303,402],"intra-amniotic":[305],"(IA)":[306],"lipopolysaccharide":[309],"(LPS)":[310],"impairs":[311],"function.":[314,412],"second":[320],"assess":[324],"gestational":[326],"age":[327],"time":[329],"IA":[333,450],"LPS":[334,366,381,384,397,451],"determines":[335],"extent":[337],"impairment":[340],"whether":[346],"weekly":[347],"inflammatory":[348],"exacerbate":[350],"dysfunction.":[352,475],"hypotheses":[355],"persists":[360],"long":[363],"duration":[364],"(21":[368],"d)":[369],"effects":[373],"would":[374],"more":[376,422],"pronounced":[377],"(weekly":[383],"injections).":[385],"third":[387],"effect":[394],"(2":[399],"prior":[404],"delivery)":[406],"term":[410,432],"This":[413,458],"vulnerable":[423],"than":[431],"diaphragm.":[433],"fourth":[435],"role":[442],"IL-1":[444,465],"signalling":[445,466],"oxidative":[447],"stress":[448],"lambs.":[457],"blockade":[463],"will":[467],"protect":[468]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-04-07T00:00:00"}
