{"id":"https://openalex.org/W2601807661","doi":null,"title":"Loss of function mutations in dipeptidyl peptidase 6 in Alzheimer disease and Frontotemporal dementia: a novel pathway in neurodegeneration","display_name":"Loss of function mutations in dipeptidyl peptidase 6 in Alzheimer disease and Frontotemporal dementia: a novel pathway in neurodegeneration","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2601807661","mag":"2601807661"},"language":"en","primary_location":{"id":"pmh:oai:eprints.whiterose.ac.uk:111133","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/111133/3/Lippiat_Loss%20of%20function.pdf","pdf_url":"http://eprints.whiterose.ac.uk/111133/3/Lippiat_Loss%20of%20function.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Proceedings Paper"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059991915","display_name":"Rita Cacace","orcid":"https://orcid.org/0000-0002-0180-3687","observed_orcids":["https://orcid.org/0000-0002-0180-3687"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Cacace, R","raw_affiliation_strings":["KU Leuven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000196240","display_name":"Tine Van den Bossche","orcid":"https://orcid.org/0000-0002-7004-6130","observed_orcids":["https://orcid.org/0000-0002-7004-6130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Van den Bossche, T","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003763959","display_name":"Jonathan D. Lippiat","orcid":"https://orcid.org/0000-0003-3748-7345","observed_orcids":["https://orcid.org/0000-0003-3748-7345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lippiat, J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107870055","display_name":"Jonathan Janssens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janssens, J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039155418","display_name":"Greet De Baets","orcid":"https://orcid.org/0000-0001-8844-800X","observed_orcids":["https://orcid.org/0000-0001-8844-800X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De Baets, G","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041038663","display_name":"Sebastiaan Engelborghs","orcid":"https://orcid.org/0000-0003-0304-9785","observed_orcids":["https://orcid.org/0000-0003-0304-9785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Engelborghs, S","raw_affiliation_strings":["Clinical sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080487735","display_name":"Anne Sieben","orcid":"https://orcid.org/0000-0003-1278-6605","observed_orcids":["https://orcid.org/0000-0003-1278-6605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sieben, A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073952660","display_name":"Mathieu Vandenbulcke","orcid":"https://orcid.org/0000-0001-9765-1499","observed_orcids":["https://orcid.org/0000-0001-9765-1499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vandenbulcke, M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042147303","display_name":"Peter De Rijk","orcid":"https://orcid.org/0000-0001-8558-9288","observed_orcids":["https://orcid.org/0000-0001-8558-9288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"de Rijk, P","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087199511","display_name":"Elise Cuyvers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cuyvers, E","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062913819","display_name":"Caroline Van Cauwenberghe","orcid":"https://orcid.org/0000-0002-3438-6031","observed_orcids":["https://orcid.org/0000-0002-3438-6031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Van Cauwenberghe, C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032536867","display_name":"Caroline Robberecht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robberecht, C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112295011","display_name":"Lubina Dillen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dillen, L","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013881555","display_name":"C\u00e9line Merlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merlin, C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002750221","display_name":"Nathalie Geerts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geerts, N","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071341444","display_name":"Rik R. Vandenberghe","orcid":"https://orcid.org/0000-0001-6237-2502","observed_orcids":["https://orcid.org/0000-0001-6237-2502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vandenberghe, R","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085198119","display_name":"J. C. Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin, J-J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111674825","display_name":"PP De Deyn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De Deyn, PP","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031589452","display_name":"Joost W. H. Schymkowitz","orcid":"https://orcid.org/0000-0003-2020-0168","observed_orcids":["https://orcid.org/0000-0003-2020-0168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schymkowitz, J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033862949","display_name":"Stuart R. Maudsley","orcid":"https://orcid.org/0000-0002-1868-184X","observed_orcids":["https://orcid.org/0000-0002-1868-184X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maudsley, S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088006851","display_name":"Marc Cruts","orcid":"https://orcid.org/0000-0002-1338-992X","observed_orcids":["https://orcid.org/0000-0002-1338-992X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cruts, M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060034564","display_name":"Julie van der Zee","orcid":"https://orcid.org/0000-0003-4381-8040","observed_orcids":["https://orcid.org/0000-0003-4381-8040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"van der Zee, J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015407411","display_name":"Kristel Sleegers","orcid":"https://orcid.org/0000-0002-0283-2332","observed_orcids":["https://orcid.org/0000-0002-0283-2332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sleegers, K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039639102","display_name":"Christine Van Broeckhoven","orcid":"https://orcid.org/0000-0003-0183-7665","observed_orcids":["https://orcid.org/0000-0003-0183-7665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Van Broeckhoven, C","raw_affiliation_strings":["Pathologic Biochemistry and Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathologic Biochemistry and Physiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30614806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpp6","display_name":"DPP6","score":0.8859999775886536},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.9390000104904175},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":1.0},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9769999980926514},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.8846480846405029},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8054807186126709},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6207892894744873},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5591012835502625},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5537689924240112},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4723580777645111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4574649930000305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26704102754592896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21159446239471436}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.whiterose.ac.uk:111133","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/111133/3/Lippiat_Loss%20of%20function.pdf","pdf_url":"http://eprints.whiterose.ac.uk/111133/3/Lippiat_Loss%20of%20function.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Proceedings Paper"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:124411","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/loss-of-function-mutations-in-dipeptidyl-peptidase-6-in-alzheimer-disease-and-frontotemporal-dementia-a-novel-pathway-in-neurodegeneration(c3a6dd98-cd0b-4718-8612-6e4941c606c5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2921105624","https://openalex.org/W1978475692","https://openalex.org/W2478390407","https://openalex.org/W7074005870","https://openalex.org/W2089836526","https://openalex.org/W6926286295","https://openalex.org/W2068163638","https://openalex.org/W7202170921","https://openalex.org/W7030483397","https://openalex.org/W4379054533"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-04-07T00:00:00"}