{"id":"https://openalex.org/W2601783147","doi":"https://doi.org/10.20944/preprints201703.0125.v1","title":"Peptidylarginine Deiminases as Mediators of Microvesicular Release - Novel Therapeutic Interventions","display_name":"Peptidylarginine Deiminases as Mediators of Microvesicular Release - Novel Therapeutic Interventions","publication_year":2017,"publication_date":"2017-03-16","ids":{"openalex":"https://openalex.org/W2601783147","doi":"https://doi.org/10.20944/preprints201703.0125.v1","mag":"2601783147"},"language":"en","primary_location":{"id":"doi:10.20944/preprints201703.0125.v1","doi":"https://doi.org/10.20944/preprints201703.0125.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201703.0125.v1","pdf_url":"https://www.preprints.org/manuscript/201703.0125/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/manuscript/201703.0125/v1/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081374351","display_name":"Sigrun Lange","orcid":"https://orcid.org/0000-0002-7193-3102","observed_orcids":["https://orcid.org/0000-0002-7193-3102"]},"institutions":[{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I94951947","display_name":"University of Westminster","ror":"https://ror.org/04ycpbx82","country_code":"GB","type":"education","lineage":["https://openalex.org/I94951947"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sigrun Lange","raw_affiliation_strings":["Department of Biomedical Sciences, University of Westminster, 115, New Cavendish Street, W1W 6UW, UK;","University College London School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Westminster, 115, New Cavendish Street, W1W 6UW, UK;","institution_ids":["https://openalex.org/I94951947"]},{"raw_affiliation_string":"University College London School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK;","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014242103","display_name":"Sharad Kholia","orcid":"https://orcid.org/0000-0001-6488-8334","observed_orcids":["https://orcid.org/0000-0001-6488-8334"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sharad Kholia","raw_affiliation_strings":["Department of Medical Sciences, Molecular Biotechnology Center, Corso Dogliotti 14, University of Turin, Turin, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Molecular Biotechnology Center, Corso Dogliotti 14, University of Turin, Turin, Italy;","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073191723","display_name":"Uchini S. Kosgodage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126193024","display_name":"London Metropolitan University","ror":"https://ror.org/00ae33288","country_code":"GB","type":"education","lineage":["https://openalex.org/I126193024"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Uchini Kosgodage","raw_affiliation_strings":["Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK;","institution_ids":["https://openalex.org/I126193024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012975235","display_name":"Mariya Hristova","orcid":"https://orcid.org/0000-0002-5017-5744","observed_orcids":["https://orcid.org/0000-0002-5017-5744"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mariya Hristova","raw_affiliation_strings":["Institute for Women's Health, University College London, 74 Huntley Street, London WC1N 6HX, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Women's Health, University College London, 74 Huntley Street, London WC1N 6HX, UK;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Reta Lila Weston Research Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reta Lila Weston Research Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK;","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029330042","display_name":"Jameel M. Inal","orcid":"https://orcid.org/0000-0002-7200-0363","observed_orcids":["https://orcid.org/0000-0002-7200-0363"]},"institutions":[{"id":"https://openalex.org/I126193024","display_name":"London Metropolitan University","ror":"https://ror.org/00ae33288","country_code":"GB","type":"education","lineage":["https://openalex.org/I126193024"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jameel M Inal","raw_affiliation_strings":["Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK;"],"raw_orcid":"https://orcid.org/0000-0002-7200-0363","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK;","institution_ids":["https://openalex.org/I126193024"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5081374351"],"corresponding_institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253","https://openalex.org/I94951947"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptidylarginine-deiminase","display_name":"peptidylarginine deiminase","score":0.968999981880188},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8899999856948853},{"id":"https://openalex.org/keywords/protein-deimination","display_name":"protein deimination","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cytoskeletal-proteins","display_name":"cytoskeletal proteins","score":0.8980000019073486},{"id":"https://openalex.org/keywords/pad-inhibitors","display_name":"PAD inhibitors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cl-amidine","display_name":"Cl-amidine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6290000081062317},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ipsc-models","display_name":"iPSC models","score":0.6399999856948853},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C48632299","wikidata":"https://www.wikidata.org/wiki/Q68581","display_name":"Citrullination","level":5,"score":0.8375296592712402},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5279870629310608},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5273699760437012},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.49499768018722534},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.467459499835968},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4132902920246124},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40252697467803955},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38148146867752075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37329089641571045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3308359384536743},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24002805352210999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1402028501033783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09393876791000366},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints201703.0125.v1","doi":"https://doi.org/10.20944/preprints201703.0125.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201703.0125.v1","pdf_url":"https://www.preprints.org/manuscript/201703.0125/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints201703.0125.v1","doi":"https://doi.org/10.20944/preprints201703.0125.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201703.0125.v1","pdf_url":"https://www.preprints.org/manuscript/201703.0125/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2601783147.pdf","grobid_xml":"https://content.openalex.org/works/W2601783147.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W98840032","https://openalex.org/W1075551552","https://openalex.org/W1606241038","https://openalex.org/W1848563179","https://openalex.org/W1884970356","https://openalex.org/W1966202673","https://openalex.org/W1967259165","https://openalex.org/W1968179127","https://openalex.org/W1969002010","https://openalex.org/W1971310354","https://openalex.org/W1972423412","https://openalex.org/W1974354099","https://openalex.org/W1974926560","https://openalex.org/W1975689733","https://openalex.org/W1976845082","https://openalex.org/W1977191190","https://openalex.org/W1979405618","https://openalex.org/W1979510976","https://openalex.org/W1980111352","https://openalex.org/W1980325059","https://openalex.org/W1982525225","https://openalex.org/W1983275829","https://openalex.org/W1985596848","https://openalex.org/W1985928588","https://openalex.org/W1988327113","https://openalex.org/W1989763054","https://openalex.org/W1990038772","https://openalex.org/W1991965941","https://openalex.org/W1995357368","https://openalex.org/W1996075048","https://openalex.org/W1997499946","https://openalex.org/W2000667628","https://openalex.org/W2003909308","https://openalex.org/W2005699747","https://openalex.org/W2009299099","https://openalex.org/W2009676595","https://openalex.org/W2010651946","https://openalex.org/W2015117562","https://openalex.org/W2017680929","https://openalex.org/W2028622306","https://openalex.org/W2029617457","https://openalex.org/W2032784036","https://openalex.org/W2034147064","https://openalex.org/W2039313867","https://openalex.org/W2040465412","https://openalex.org/W2040856340","https://openalex.org/W2041060250","https://openalex.org/W2047159195","https://openalex.org/W2053500132","https://openalex.org/W2055313665","https://openalex.org/W2057259507","https://openalex.org/W2057443097","https://openalex.org/W2057896776","https://openalex.org/W2057910472","https://openalex.org/W2065894198","https://openalex.org/W2067476102","https://openalex.org/W2069437848","https://openalex.org/W2070973339","https://openalex.org/W2071700927","https://openalex.org/W2074253758","https://openalex.org/W2077120971","https://openalex.org/W2082962986","https://openalex.org/W2085178413","https://openalex.org/W2086233696","https://openalex.org/W2086412028","https://openalex.org/W2087695031","https://openalex.org/W2090175640","https://openalex.org/W2095013356","https://openalex.org/W2096355575","https://openalex.org/W2098613848","https://openalex.org/W2099067892","https://openalex.org/W2103433150","https://openalex.org/W2108550450","https://openalex.org/W2113269521","https://openalex.org/W2113473876","https://openalex.org/W2113942339","https://openalex.org/W2119061919","https://openalex.org/W2124339684","https://openalex.org/W2125110523","https://openalex.org/W2125676079","https://openalex.org/W2125883523","https://openalex.org/W2128338277","https://openalex.org/W2131827320","https://openalex.org/W2132140599","https://openalex.org/W2133494286","https://openalex.org/W2137388630","https://openalex.org/W2139610636","https://openalex.org/W2143472860","https://openalex.org/W2147465745","https://openalex.org/W2154344198","https://openalex.org/W2155417259","https://openalex.org/W2155651511","https://openalex.org/W2157102136","https://openalex.org/W2159254316","https://openalex.org/W2161083956","https://openalex.org/W2161392725","https://openalex.org/W2162889000","https://openalex.org/W2162968791","https://openalex.org/W2165962539","https://openalex.org/W2167212772","https://openalex.org/W2170087857","https://openalex.org/W2172165524","https://openalex.org/W2172339454","https://openalex.org/W2205293062","https://openalex.org/W2218209996","https://openalex.org/W2222334012","https://openalex.org/W2253090940","https://openalex.org/W2278207783","https://openalex.org/W2303765968","https://openalex.org/W2315799534","https://openalex.org/W2325622993","https://openalex.org/W2326949971","https://openalex.org/W2335498371","https://openalex.org/W2336718835","https://openalex.org/W2405647747","https://openalex.org/W4255309504"],"related_works":["https://openalex.org/W4229674319","https://openalex.org/W2133494286","https://openalex.org/W2624137608","https://openalex.org/W7097128238","https://openalex.org/W3126883505","https://openalex.org/W3101060465","https://openalex.org/W1861427073","https://openalex.org/W2987132107","https://openalex.org/W2965859976","https://openalex.org/W2519719248"],"abstract_inverted_index":{"Extracellular":[0],"vesicle":[1],"(EV)":[2],"release,":[3],"which":[4],"occurs":[5],"in":[6,31,54,60,76,109,142,148,171],"most":[7],"eukaryotic":[8],"cells,":[9,66,112],"has":[10],"recently":[11],"been":[12],"associated":[13,39],"with":[14,40],"peptidylarginine":[15],"deiminase":[16],"(PAD)-driven":[17],"protein":[18,155],"deimination.":[19,33,156],"Evidence":[20],"points":[21],"to":[22,58,68,91,118,162,188],"the":[23,184],"involvement":[24],"of":[25,86,98,124,153],"deiminated":[26],"cytoskeletal":[27],"proteins":[28],"and":[29,36,46,84,94,136],"changes":[30],"histone":[32],"Both":[34],"PADs":[35,135],"EVs":[37],"are":[38],"various":[41],"pathologies":[42],"including":[43],"cancers,":[44],"autoimmune":[45],"neurodegenerative":[47,77,87,146,190],"diseases.":[48],"The":[49],"elevated":[50,72],"PAD":[51,73,140,160],"expression":[52,74],"observed":[53,63,75],"cancers":[55],"may":[56,79],"contribute":[57],"increase":[59],"EV":[61,82,88,107,165,178],"shedding":[62,83],"from":[64],"cancer":[65,69,111,172],"contributing":[67,90],"progression.":[70,192],"Similarly,":[71],"diseases":[78],"cause":[80],"increased":[81,154],"spread":[85],"cargo,":[89],"disease":[92,191],"progression":[93],"pathologies.":[95],"Pharmacological":[96],"inhibition":[97],"PAD-mediated":[99],"deimination":[100],"using":[101,139,158],"pan-PAD":[102],"inhibitor":[103],"Cl-amidine,":[104],"reduced":[105],"cellular":[106],"release":[108],"prostate":[110],"rendering":[113],"them":[114],"significantly":[115],"more":[116],"susceptible":[117],"chemotherapeutic":[119],"drugs.":[120],"Studies":[121],"on":[122],"models":[123,150],"central":[125],"nervous":[126],"system":[127],"damage":[128],"have":[129],"demonstrated":[130],"critical":[131],"functional":[132],"roles":[133],"for":[134,167],"neuroprotective":[137],"effects":[138],"inhibitors":[141,161],"vivo,":[143],"while":[144],"human":[145],"iPSC":[147],"vitro":[149],"showed":[151],"evidence":[152],"Besides":[157],"refined":[159],"selectively":[163],"manipulate":[164],"biogenesis":[166,179],"novel":[168],"combination":[169],"therapies":[170],"treatment,":[173],"we":[174],"also":[175],"speculate":[176],"how":[177],"could":[180],"be":[181],"targeted":[182],"via":[183],"newly":[185],"identified":[186],"PAD-pathway":[187],"ameliorate":[189]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}
