{"id":"https://openalex.org/W2601706262","doi":"https://doi.org/10.1200/jco.2017.35.6_suppl.275","title":"Modes of action of low-dose cabazitaxel in combination with the antiangiogenic and antitumoral pigment epithelium-derived factor in prostate cancer.","display_name":"Modes of action of low-dose cabazitaxel in combination with the antiangiogenic and antitumoral pigment epithelium-derived factor in prostate cancer.","publication_year":2017,"publication_date":"2017-02-20","ids":{"openalex":"https://openalex.org/W2601706262","doi":"https://doi.org/10.1200/jco.2017.35.6_suppl.275","mag":"2601706262"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.6_suppl.275","doi":"https://doi.org/10.1200/jco.2017.35.6_suppl.275","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.6_suppl.275","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066792434","display_name":"Thomas Nelius","orcid":"https://orcid.org/0000-0001-8858-5602","observed_orcids":["https://orcid.org/0000-0001-8858-5602"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Nelius","raw_affiliation_strings":["Texas Tech University Health Sciences Center, Lubbock, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Health Sciences Center, Lubbock, TX;","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012414813","display_name":"Courtney Jarvis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Jarvis","raw_affiliation_strings":["Texas Tech University Health Sciences Center, Lubbock, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Health Sciences Center, Lubbock, TX;","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002277031","display_name":"St\u00e9phanie Filleur","orcid":"https://orcid.org/0000-0002-3420-5536","observed_orcids":["https://orcid.org/0000-0002-3420-5536"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Filleur","raw_affiliation_strings":["Texas Tech University Health Sciences Center, Lubbock, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Health Sciences Center, Lubbock, TX;","institution_ids":["https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I926076166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"6_suppl","first_page":"275","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cabazitaxel","display_name":"cabazitaxel","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pigment-epithelium-derived-factor","display_name":"pigment epithelium-derived factor","score":0.921999990940094},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.7620000243186951},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9480000138282776},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.671999990940094},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9729999899864197},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5989999771118164},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.45399999618530273},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2778971682","wikidata":"https://www.wikidata.org/wiki/Q412963","display_name":"Cabazitaxel","level":5,"score":0.974789023399353},{"id":"https://openalex.org/C52237779","wikidata":"https://www.wikidata.org/wiki/Q18030441","display_name":"PEDF","level":3,"score":0.8497815132141113},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.8201615810394287},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.666063129901886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6566184759140015},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5493068099021912},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.522100567817688},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.5188911557197571},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5151764154434204},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.5028047561645508},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45181185007095337},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3714570105075836},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3250278830528259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3123956322669983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1897585093975067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17642274498939514},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.06822681427001953},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.6_suppl.275","doi":"https://doi.org/10.1200/jco.2017.35.6_suppl.275","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.6_suppl.275","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2892061579","https://openalex.org/W2800869553","https://openalex.org/W2890970659","https://openalex.org/W2481125971","https://openalex.org/W1980583758","https://openalex.org/W2334947147","https://openalex.org/W2071201073","https://openalex.org/W7077179829","https://openalex.org/W2590146621","https://openalex.org/W2319939324"],"abstract_inverted_index":{"275":[0],"Background:":[1],"Despite":[2],"the":[3,11,41,58,64,72,128,133,137,146,187,206,221,243,252,258,286,291,294,299,302,306],"approval":[4],"of":[5,46,66,136,190,205,242,293,301],"several":[6],"new":[7],"agents,":[8],"taxanes":[9],"remain":[10],"main":[12],"alternative":[13],"treatment":[14],"for":[15],"castration-refractory":[16],"metastatic":[17],"prostate":[18],"cancer":[19],"(mCRPC).":[20],"In":[21,57,192,223],"a":[22,34,231,274],"previous":[23],"work,":[24],"we":[25,61,194],"have":[26,62],"demonstrated":[27,195,264],"that":[28,85,164,196,251,265],"cabazitaxel":[29,68,170,201,269],"is":[30],"more":[31,215,240],"efficient":[32,216],"in":[33,39,49,55,132,157,219,288,305],"low-dose":[35,67,268],"setting":[36],"than":[37,217,248],"docetaxel":[38],"inhibiting":[40],"proliferation":[42],"and":[43,51,74,116,124,167,297],"inducing":[44],"apoptosis":[45],"CRPC":[47,81],"cells":[48,83,94,245],"vitro,":[50,224],"delaying":[52,220],"tumor":[53,140,177,227,244,259,303],"growth":[54],"vivo.":[56],"present":[59],"study,":[60],"investigated":[63],"efficacy":[65,175],"when":[69],"combined":[70,138,198],"with":[71,199,267],"anti-angiogenic":[73],"anti-tumoral":[75],"Pigment":[76],"Epithelium-Derived":[77],"Factor":[78],"(PEDF).":[79],"Methods:":[80],"CL1":[82],"(LNCaP-derivative)":[84],"express":[86],"PEDF":[87,174,197,266],"or":[88],"control":[89],"plasmid":[90],"were":[91,95,105],"used.":[92],"Tumor":[93,151],"injected":[96],"s.c.":[97],"into":[98,107],"C.B.17-SCID":[99],"mice.":[100],"After":[101],"two":[102],"weeks,":[103],"mice":[104],"randomized":[106],"groups:":[108],"1)":[109],"Placebo;":[110],"2)":[111],"Docetaxel:":[112],"5mg/kg":[113,200],"i.p.":[114,120],"d4;":[115],"3)":[117],"Cabazitazel":[118],"5-1-0.5-0.1mg/kg":[119],"d4,":[121],"d1-7,":[122],"d2,":[123],"daily.":[125],"To":[126],"investigate":[127],"molecular":[129],"mechanisms":[130],"involved":[131],"anti-tumor":[134,307],"effect":[135],"treatment,":[139],"cell":[141,152,228],"migration":[142,229],"was":[143,154,180,209],"measured":[144],"using":[145],"inverted":[147],"Boyden":[148],"chamber":[149],"assay.":[150],"phagocytosis":[153,241],"also":[155,210,283],"assessed":[156],"CL1-RAW264.7":[158],"macrophages":[159,247,256],"co-cultures.":[160],"Results:":[161],"We":[162],"showed":[163],"while":[165],"0.5":[166],"0.1":[168],"mg/kg":[169],"did":[171],"not":[172],"improve":[173],"on":[176,285],"growth,":[178],"1mg/kg":[179],"extremely":[181],"toxic,":[182],"killing":[183],"1/2":[184],"animals":[185],"within":[186,257],"first":[188],"week":[189],"treatment.":[191],"contrast,":[193],"lead":[202],"to":[203,212,235,278],"stabilization":[204],"disease.":[207,222],"PEDF/cabazitaxel":[208,225,238],"found":[211],"be":[213,271],"drastically":[214],"PEDF/docetaxel":[218,249],"inhibited":[226],"at":[230],"superior":[232],"level":[233],"compared":[234],"PEDF/docetaxel.":[236],"Finally,":[237],"induced":[239],"by":[246],"suggesting":[250],"combination":[253,277,295],"may":[254],"target":[255],"microenvironment.":[260],"Conclusions:":[261],"Our":[262,281],"data":[263],"could":[270],"used":[272],"as":[273],"novel":[275],"therapeutic":[276],"treat":[279],"CRPC.":[280],"results":[282],"emphasize":[284],"importance":[287],"closely":[289],"evaluating":[290],"cytotoxicity":[292],"tested":[296],"investigating":[298],"role":[300],"microenvironment":[304],"effect.":[308]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2017-04-07T00:00:00"}