{"id":"https://openalex.org/W2601685387","doi":"https://doi.org/10.1038/s41536-017-0011-6","title":"A short discourse on vascular tissue engineering","display_name":"A short discourse on vascular tissue engineering","publication_year":2017,"publication_date":"2017-03-21","ids":{"openalex":"https://openalex.org/W2601685387","doi":"https://doi.org/10.1038/s41536-017-0011-6","mag":"2601685387","pmid":"https://pubmed.ncbi.nlm.nih.gov/29057097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5649630"},"language":"en","primary_location":{"id":"doi:10.1038/s41536-017-0011-6","doi":"https://doi.org/10.1038/s41536-017-0011-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41536-017-0011-6","pdf_url":"https://www.nature.com/articles/s41536-017-0011-6.pdf","source":{"id":"https://openalex.org/S2736947229","display_name":"npj Regenerative Medicine","issn_l":"2057-3995","issn":["2057-3995"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Regenerative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41536-017-0011-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007633044","display_name":"William Chang","orcid":"https://orcid.org/0000-0002-7707-9242","observed_orcids":["https://orcid.org/0000-0002-7707-9242"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William G. Chang","raw_affiliation_strings":["Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085748100","display_name":"Laura E. Niklason","orcid":"https://orcid.org/0000-0002-5156-504X","observed_orcids":["https://orcid.org/0000-0002-5156-504X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura E. Niklason","raw_affiliation_strings":["Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007633044"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":16.2536,"has_fulltext":true,"cited_by_count":151,"citation_normalized_percentile":{"value":0.9952973,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-tissue-engineering","display_name":"vascular tissue engineering","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.878000020980835},{"id":"https://openalex.org/keywords/organ-perfusion","display_name":"organ perfusion","score":0.6380000114440918},{"id":"https://openalex.org/keywords/synthetic-vascular-grafts","display_name":"synthetic vascular grafts","score":0.7620000243186951},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6340000033378601},{"id":"https://openalex.org/keywords/vascular-biology","display_name":"vascular biology","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.697587788105011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47583794593811035},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.4547927975654602},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4386111795902252},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.24944135546684265},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23960831761360168}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s41536-017-0011-6","doi":"https://doi.org/10.1038/s41536-017-0011-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41536-017-0011-6","pdf_url":"https://www.nature.com/articles/s41536-017-0011-6.pdf","source":{"id":"https://openalex.org/S2736947229","display_name":"npj Regenerative Medicine","issn_l":"2057-3995","issn":["2057-3995"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Regenerative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4567007","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5649630","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5649630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5649630","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Regen Med","raw_type":"Text"},{"id":"pmid:29057097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29057097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Regenerative medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ecc4208318c24c809359672ba18774b5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ecc4208318c24c809359672ba18774b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Regenerative Medicine, Vol 2, Iss 1, Pp 1-8 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41536-017-0011-6","doi":"https://doi.org/10.1038/s41536-017-0011-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41536-017-0011-6","pdf_url":"https://www.nature.com/articles/s41536-017-0011-6.pdf","source":{"id":"https://openalex.org/S2736947229","display_name":"npj Regenerative Medicine","issn_l":"2057-3995","issn":["2057-3995"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Regenerative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4766162534","display_name":"Investigating endothelial cell and glomerular anastomoses to advance kidney tissue engineering","funder_award_id":"K08EB018978","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8648704245","display_name":"Hyaluronan Coatings for Engineered Vessels","funder_award_id":"R01HL127386","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2601685387.pdf","grobid_xml":"https://content.openalex.org/works/W2601685387.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1528545723","https://openalex.org/W1541371077","https://openalex.org/W1762724222","https://openalex.org/W1862237309","https://openalex.org/W1870346035","https://openalex.org/W1906558558","https://openalex.org/W1967293859","https://openalex.org/W1968445130","https://openalex.org/W1970600939","https://openalex.org/W1973620066","https://openalex.org/W1974753138","https://openalex.org/W1976852337","https://openalex.org/W1981030985","https://openalex.org/W1983210829","https://openalex.org/W1989704675","https://openalex.org/W1990793260","https://openalex.org/W1990973053","https://openalex.org/W1992112921","https://openalex.org/W1995012800","https://openalex.org/W1996481646","https://openalex.org/W1998510840","https://openalex.org/W2000151960","https://openalex.org/W2001863387","https://openalex.org/W2002348069","https://openalex.org/W2004181539","https://openalex.org/W2010748138","https://openalex.org/W2016701600","https://openalex.org/W2018599317","https://openalex.org/W2025962343","https://openalex.org/W2027966910","https://openalex.org/W2033951230","https://openalex.org/W2034877388","https://openalex.org/W2044967972","https://openalex.org/W2047126924","https://openalex.org/W2053566098","https://openalex.org/W2055101436","https://openalex.org/W2065321783","https://openalex.org/W2067072940","https://openalex.org/W2069270864","https://openalex.org/W2070213995","https://openalex.org/W2070619855","https://openalex.org/W2082013410","https://openalex.org/W2089004231","https://openalex.org/W2090028890","https://openalex.org/W2097993096","https://openalex.org/W2098902079","https://openalex.org/W2099361891","https://openalex.org/W2101228997","https://openalex.org/W2102075858","https://openalex.org/W2107291281","https://openalex.org/W2108813969","https://openalex.org/W2111338636","https://openalex.org/W2129477690","https://openalex.org/W2129956520","https://openalex.org/W2130223992","https://openalex.org/W2134569259","https://openalex.org/W2141126811","https://openalex.org/W2141507829","https://openalex.org/W2141642398","https://openalex.org/W2146787008","https://openalex.org/W2149165594","https://openalex.org/W2154837723","https://openalex.org/W2162249561","https://openalex.org/W2165116711","https://openalex.org/W2168539681","https://openalex.org/W2192349295","https://openalex.org/W2240295316","https://openalex.org/W2265387817","https://openalex.org/W2319562462","https://openalex.org/W2343770976","https://openalex.org/W2362125499","https://openalex.org/W2981029611"],"related_works":["https://openalex.org/W3165319164","https://openalex.org/W2034293958","https://openalex.org/W2169509558","https://openalex.org/W3020979935","https://openalex.org/W1969256502","https://openalex.org/W2001139094","https://openalex.org/W1497726858","https://openalex.org/W2089226558","https://openalex.org/W4366989156","https://openalex.org/W2147839061"],"abstract_inverted_index":{"Vascular":[0],"tissue":[1,37],"engineering":[2,38],"has":[3],"significant":[4],"potential":[5],"to":[6,41,78],"make":[7],"a":[8,12],"major":[9],"impact":[10],"on":[11,67],"wide":[13],"array":[14],"of":[15,39,90],"clinical":[16,68],"problems.":[17],"Continued":[18],"progress":[19],"in":[20,28,36],"understanding":[21],"basic":[22],"vascular":[23],"biology":[24],"will":[25,59,64,93],"be":[26,60,65,94],"invaluable":[27],"making":[29],"further":[30],"advancements.":[31],"Past":[32],"and":[33,51,54,73,87],"current":[34],"achievements":[35],"microvasculature":[40],"perfuse":[42],"organ":[43],"specific":[44],"constructs,":[45],"small":[46,72],"vessels":[47],"for":[48],"dialysis":[49],"grafts,":[50],"modified":[52],"synthetic":[53],"pediatric":[55],"large":[56],"caliber-vessel":[57],"grafts":[58],"discussed.":[61],"An":[62],"emphasis":[63],"placed":[66],"trial":[69],"results":[70],"with":[71],"large-caliber":[74],"vessel":[75],"grafts.":[76],"Challenges":[77],"achieving":[79],"engineered":[80,91],"constructs":[81],"that":[82],"satisfy":[83],"the":[84],"physiologic,":[85],"immunologic,":[86],"manufacturing":[88],"demands":[89],"vasculature":[92],"explored.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":13}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-04-07T00:00:00"}