{"id":"https://openalex.org/W2601625670","doi":"https://doi.org/10.1080/15265161.2017.1284934","title":"Should Patients Be Required to Undergo Standard Chemotherapy Before Being Eligible for Novel Phase I Immunotherapy Clinical Trials?","display_name":"Should Patients Be Required to Undergo Standard Chemotherapy Before Being Eligible for Novel Phase I Immunotherapy Clinical Trials?","publication_year":2017,"publication_date":"2017-03-22","ids":{"openalex":"https://openalex.org/W2601625670","doi":"https://doi.org/10.1080/15265161.2017.1284934","mag":"2601625670","pmid":"https://pubmed.ncbi.nlm.nih.gov/28328380"},"language":"en","primary_location":{"id":"doi:10.1080/15265161.2017.1284934","doi":"https://doi.org/10.1080/15265161.2017.1284934","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15265161.2017.1284934","pdf_url":null,"source":{"id":"https://openalex.org/S41709181","display_name":"The American Journal of Bioethics","issn_l":"1526-5161","issn":["1526-5161","1536-0075"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Bioethics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063179700","display_name":"Benjamin S. Wilfond","orcid":"https://orcid.org/0000-0002-2671-9860","observed_orcids":["https://orcid.org/0000-0002-2671-9860"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]},{"id":"https://openalex.org/I4405272236","display_name":"Treuman Katz Center for Pediatric Bioethics and Palliative Care","ror":"https://ror.org/03tdtdp62","country_code":"US","type":"education","lineage":["https://openalex.org/I4405272236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin S. Wilfond","raw_affiliation_strings":["a Treuman Katz Center for Pediatric Bioethics and Seattle Children's Research Institute","Treuman Katz Center for Pediatric Bioethics and Seattle Children's Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Treuman Katz Center for Pediatric Bioethics and Seattle Children's Research Institute","institution_ids":["https://openalex.org/I4405262941","https://openalex.org/I4405272236"]},{"raw_affiliation_string":"Treuman Katz Center for Pediatric Bioethics and Seattle Children's Research Institute","institution_ids":["https://openalex.org/I4405262941","https://openalex.org/I4405272236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063002543","display_name":"Christian Morales","orcid":"https://orcid.org/0000-0001-9117-8418","observed_orcids":["https://orcid.org/0000-0001-9117-8418"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210092215","display_name":"Johns Hopkins Berman Institute of Bioethics","ror":"https://ror.org/00gzx6s15","country_code":"US","type":"facility","lineage":["https://openalex.org/I145311948","https://openalex.org/I4210092215"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christian Morales","raw_affiliation_strings":["b Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics","Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210092215"]},{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210092215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074502941","display_name":"Holly A. Taylor","orcid":"https://orcid.org/0000-0001-6811-9356","observed_orcids":["https://orcid.org/0000-0001-6811-9356"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210092215","display_name":"Johns Hopkins Berman Institute of Bioethics","ror":"https://ror.org/00gzx6s15","country_code":"US","type":"facility","lineage":["https://openalex.org/I145311948","https://openalex.org/I4210092215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly A. Taylor","raw_affiliation_strings":["b Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics","Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210092215"]},{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Berman Institute of Bioethics","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210092215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063002543"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210092215"],"apc_list":null,"apc_paid":null,"fwci":0.2463,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59262272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"4","first_page":"66","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13147","display_name":"Ethics and bioethics in healthcare","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/standard-chemotherapy","display_name":"standard chemotherapy","score":0.7639999985694885},{"id":"https://openalex.org/keywords/clinical-trial-eligibility-criteria","display_name":"inclusion and exclusion criteria","score":0.7350000143051147},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.3490000069141388},{"id":"https://openalex.org/keywords/clinical-trial-ethics","display_name":"clinical trial ethics","score":0.3959999978542328},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6982185244560242},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6763341426849365},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6739063262939453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.633720874786377},{"id":"https://openalex.org/C188084074","wikidata":"https://www.wikidata.org/wiki/Q194294","display_name":"Bioethics","level":2,"score":0.5260113477706909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47353336215019226},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45684751868247986},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1239490807056427},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.10342273116111755},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/15265161.2017.1284934","doi":"https://doi.org/10.1080/15265161.2017.1284934","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15265161.2017.1284934","pdf_url":null,"source":{"id":"https://openalex.org/S41709181","display_name":"The American Journal of Bioethics","issn_l":"1526-5161","issn":["1526-5161","1536-0075"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Bioethics","raw_type":"journal-article"},{"id":"pmid:28328380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28328380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of bioethics : AJOB","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1354486225","display_name":"TRAINING IN HEALTH SERVICES RESEARCH","funder_award_id":"T32HS000029","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"}],"funders":[{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1965938576","https://openalex.org/W2115261608"],"related_works":["https://openalex.org/W2602346878","https://openalex.org/W2570689942","https://openalex.org/W2020352568","https://openalex.org/W69355984","https://openalex.org/W1617701162","https://openalex.org/W4243430318","https://openalex.org/W2109967225","https://openalex.org/W2395824271","https://openalex.org/W6979077824","https://openalex.org/W2397602119"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}