{"id":"https://openalex.org/W2601465249","doi":"https://doi.org/10.1097/fjc.0000000000000482","title":"G Protein\u2013Coupled Receptor Signaling Through \u03b2-Arrestin\u2013Dependent Mechanisms","display_name":"G Protein\u2013Coupled Receptor Signaling Through \u03b2-Arrestin\u2013Dependent Mechanisms","publication_year":2017,"publication_date":"2017-03-21","ids":{"openalex":"https://openalex.org/W2601465249","doi":"https://doi.org/10.1097/fjc.0000000000000482","mag":"2601465249","pmid":"https://pubmed.ncbi.nlm.nih.gov/28328745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5591062"},"language":"en","primary_location":{"id":"doi:10.1097/fjc.0000000000000482","doi":"https://doi.org/10.1097/fjc.0000000000000482","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000000482","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2601465249"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5591062","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112053176","display_name":"Pierre\u2010Yves Jean\u2010Charles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pierre-Yves Jean-Charles","raw_affiliation_strings":["Medicine (Cardiology); and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine (Cardiology); and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035372885","display_name":"Suneet Kaur","orcid":"https://orcid.org/0000-0001-9271-8519","observed_orcids":["https://orcid.org/0000-0001-9271-8519"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Suneet Kaur","raw_affiliation_strings":["Medicine (Cardiology); and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine (Cardiology); and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063246729","display_name":"Sudha K. Shenoy","orcid":"https://orcid.org/0000-0002-2565-4663","observed_orcids":["https://orcid.org/0000-0002-2565-4663"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sudha K. Shenoy","raw_affiliation_strings":["Cell Biology, Duke University Medical Center, Durham, NC","Medicine (Cardiology); and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Medicine (Cardiology); and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035372885","https://openalex.org/A5063246729","https://openalex.org/A5112053176"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":1.4624,"has_fulltext":false,"cited_by_count":314,"citation_normalized_percentile":{"value":0.83350323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"70","issue":"3","first_page":"142","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-arrestin","display_name":"beta-arrestin","score":0.800000011920929},{"id":"https://openalex.org/keywords/beta-arrestin-1","display_name":"\u03b2-arrestin1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/beta-arrestin-2","display_name":"\u03b2-arrestin2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8700000047683716},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/g-protein-independent-signaling","display_name":"G protein-independent signaling","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.8619292974472046},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.8483932614326477},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8446900844573975},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7496128082275391},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.649194061756134},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.589165210723877},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.587713897228241},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5483081340789795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49141037464141846},{"id":"https://openalex.org/C33235085","wikidata":"https://www.wikidata.org/wiki/Q4355943","display_name":"G protein-coupled receptor kinase","level":4,"score":0.4831632971763611},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.4721149206161499},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.4336736798286438},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3695327937602997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3575841784477234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32992810010910034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17765921354293823}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/fjc.0000000000000482","doi":"https://doi.org/10.1097/fjc.0000000000000482","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000000482","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:28328745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28328745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5067843","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5591062","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5591062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5591062/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cardiovasc Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5067843","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5591062","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G262413973","display_name":"Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20","funder_award_id":"R01HL118369","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G278814654","display_name":"E3 Ligases and Deubiquitinases in GPCR Down Regulation","funder_award_id":"R01HL080525","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3461390556","display_name":"George M. O'Brien Kidney Research Core Centers","funder_award_id":"P30DK096493","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":214,"referenced_works":["https://openalex.org/W67378539","https://openalex.org/W176630383","https://openalex.org/W195223799","https://openalex.org/W973428835","https://openalex.org/W1193047888","https://openalex.org/W1503765703","https://openalex.org/W1519384361","https://openalex.org/W1581533309","https://openalex.org/W1602123692","https://openalex.org/W1606541986","https://openalex.org/W1718009280","https://openalex.org/W1820617636","https://openalex.org/W1909516796","https://openalex.org/W1922891700","https://openalex.org/W1927020399","https://openalex.org/W1963569632","https://openalex.org/W1963638079","https://openalex.org/W1964332360","https://openalex.org/W1964684914","https://openalex.org/W1965194214","https://openalex.org/W1967767166","https://openalex.org/W1968490749","https://openalex.org/W1969154199","https://openalex.org/W1970793561","https://openalex.org/W1971418008","https://openalex.org/W1971965185","https://openalex.org/W1976147218","https://openalex.org/W1976412816","https://openalex.org/W1977548660","https://openalex.org/W1978310995","https://openalex.org/W1978387124","https://openalex.org/W1979103781","https://openalex.org/W1982822910","https://openalex.org/W1983074420","https://openalex.org/W1983789860","https://openalex.org/W1984448003","https://openalex.org/W1984474706","https://openalex.org/W1984849052","https://openalex.org/W1984867385","https://openalex.org/W1986177696","https://openalex.org/W1987060427","https://openalex.org/W1988966858","https://openalex.org/W1989978497","https://openalex.org/W1990660812","https://openalex.org/W1992041054","https://openalex.org/W1994161105","https://openalex.org/W1995150983","https://openalex.org/W1996013683","https://openalex.org/W1996193406","https://openalex.org/W1996564506","https://openalex.org/W1996987808","https://openalex.org/W1998343474","https://openalex.org/W2001051671","https://openalex.org/W2001626986","https://openalex.org/W2006268283","https://openalex.org/W2006419043","https://openalex.org/W2012571494","https://openalex.org/W2012628363","https://openalex.org/W2012961239","https://openalex.org/W2016060470","https://openalex.org/W2019166246","https://openalex.org/W2020909272","https://openalex.org/W2021193175","https://openalex.org/W2022260308","https://openalex.org/W2022294588","https://openalex.org/W2023629636","https://openalex.org/W2024625315","https://openalex.org/W2025217136","https://openalex.org/W2025472785","https://openalex.org/W2027651093","https://openalex.org/W2027832797","https://openalex.org/W2030205627","https://openalex.org/W2036683613","https://openalex.org/W2037276555","https://openalex.org/W2037535929","https://openalex.org/W2038410772","https://openalex.org/W2039435520","https://openalex.org/W2041229150","https://openalex.org/W2043606146","https://openalex.org/W2049253479","https://openalex.org/W2051301625","https://openalex.org/W2052060549","https://openalex.org/W2052694810","https://openalex.org/W2053071903","https://openalex.org/W2053996795","https://openalex.org/W2054573680","https://openalex.org/W2054610585","https://openalex.org/W2054872731","https://openalex.org/W2055712181","https://openalex.org/W2056955262","https://openalex.org/W2059220343","https://openalex.org/W2059334078","https://openalex.org/W2061286602","https://openalex.org/W2063811814","https://openalex.org/W2065227956","https://openalex.org/W2067856993","https://openalex.org/W2071001120","https://openalex.org/W2071159103","https://openalex.org/W2075536398","https://openalex.org/W2077936290","https://openalex.org/W2078748771","https://openalex.org/W2078762484","https://openalex.org/W2080192851","https://openalex.org/W2082817154","https://openalex.org/W2082956345","https://openalex.org/W2083776958","https://openalex.org/W2085775776","https://openalex.org/W2086041680","https://openalex.org/W2087276894","https://openalex.org/W2087663632","https://openalex.org/W2089357523","https://openalex.org/W2090455515","https://openalex.org/W2091366475","https://openalex.org/W2092322021","https://openalex.org/W2092493326","https://openalex.org/W2094587282","https://openalex.org/W2094843483","https://openalex.org/W2095014491","https://openalex.org/W2095374622","https://openalex.org/W2096986888","https://openalex.org/W2097829102","https://openalex.org/W2099039944","https://openalex.org/W2099152902","https://openalex.org/W2099817260","https://openalex.org/W2100576913","https://openalex.org/W2107704792","https://openalex.org/W2108281249","https://openalex.org/W2109680608","https://openalex.org/W2109685426","https://openalex.org/W2109771867","https://openalex.org/W2111373319","https://openalex.org/W2112412740","https://openalex.org/W2112482916","https://openalex.org/W2115957792","https://openalex.org/W2116679480","https://openalex.org/W2118579624","https://openalex.org/W2119199305","https://openalex.org/W2121279599","https://openalex.org/W2122456701","https://openalex.org/W2122773218","https://openalex.org/W2123895632","https://openalex.org/W2124874841","https://openalex.org/W2124963164","https://openalex.org/W2125103083","https://openalex.org/W2125365369","https://openalex.org/W2126988283","https://openalex.org/W2128670872","https://openalex.org/W2130536801","https://openalex.org/W2130632774","https://openalex.org/W2131863923","https://openalex.org/W2135319033","https://openalex.org/W2135453228","https://openalex.org/W2138226936","https://openalex.org/W2143227312","https://openalex.org/W2144744785","https://openalex.org/W2151312020","https://openalex.org/W2151526347","https://openalex.org/W2153588568","https://openalex.org/W2154128178","https://openalex.org/W2155425053","https://openalex.org/W2155547273","https://openalex.org/W2155977502","https://openalex.org/W2156753857","https://openalex.org/W2157687771","https://openalex.org/W2158321076","https://openalex.org/W2159377192","https://openalex.org/W2160536323","https://openalex.org/W2160829003","https://openalex.org/W2161802386","https://openalex.org/W2165488941","https://openalex.org/W2166748873","https://openalex.org/W2167741185","https://openalex.org/W2170605386","https://openalex.org/W2171777264","https://openalex.org/W2171820798","https://openalex.org/W2177829001","https://openalex.org/W2189059614","https://openalex.org/W2233128761","https://openalex.org/W2253416145","https://openalex.org/W2257788161","https://openalex.org/W2261301267","https://openalex.org/W2263460445","https://openalex.org/W2278392058","https://openalex.org/W2290512328","https://openalex.org/W2294105046","https://openalex.org/W2298382229","https://openalex.org/W2302828574","https://openalex.org/W2303462194","https://openalex.org/W2310131378","https://openalex.org/W2317013688","https://openalex.org/W2326555481","https://openalex.org/W2331805617","https://openalex.org/W2331876349","https://openalex.org/W2334307909","https://openalex.org/W2344538922","https://openalex.org/W2398014928","https://openalex.org/W2403185436","https://openalex.org/W2413409105","https://openalex.org/W2413893340","https://openalex.org/W2428830558","https://openalex.org/W2432792594","https://openalex.org/W2460366155","https://openalex.org/W2464567435","https://openalex.org/W2468767034","https://openalex.org/W2505532605","https://openalex.org/W2510897743","https://openalex.org/W2529251769","https://openalex.org/W2536583888","https://openalex.org/W2549673336","https://openalex.org/W2552979079","https://openalex.org/W2559256288","https://openalex.org/W2614496215","https://openalex.org/W4245103782","https://openalex.org/W6683423354"],"related_works":["https://openalex.org/W1933410007","https://openalex.org/W4231883275","https://openalex.org/W1986508513","https://openalex.org/W4306406967","https://openalex.org/W2950778246","https://openalex.org/W2091073917","https://openalex.org/W2253416145","https://openalex.org/W1989787741","https://openalex.org/W3021278062","https://openalex.org/W3134655212"],"abstract_inverted_index":{"\u03b2-arrestin1":[0],"(or":[1,5],"arrestin2)":[2],"and":[3,48,118,145],"\u03b2-arrestin2":[4],"arrestin3)":[6],"are":[7],"ubiquitously":[8],"expressed":[9],"cytosolic":[10],"adaptor":[11],"proteins":[12],"that":[13,36,56,84,112],"were":[14,68],"originally":[15],"discovered":[16],"for":[17],"their":[18],"inhibitory":[19],"role":[20],"in":[21],"G":[22,29,75,86],"protein-coupled":[23],"receptor":[24],"(GPCR)":[25],"signaling":[26,54,63,103,114,140],"through":[27,123],"heterotrimeric":[28],"proteins.":[30],"However,":[31],"further":[32],"biochemical":[33],"characterization":[34],"revealed":[35],"\u03b2-arrestins":[37,67,144],"do":[38],"not":[39],"just":[40],"\"block\"":[41],"the":[42,96,128,147],"activated":[43],"GPCRs,":[44],"but":[45,89],"trigger":[46],"endocytosis":[47],"kinase":[49,131],"activation":[50,77,88],"leading":[51],"to":[52,71],"specific":[53],"pathways":[55,64,141],"can":[57],"be":[58,72],"localized":[59],"on":[60],"endosomes.":[61],"The":[62,80],"initiated":[65],"by":[66,78,143],"also":[69],"found":[70],"independent":[73],"of":[74,82,99,150],"protein":[76,87],"GPCRs.":[79],"discovery":[81],"ligands":[83],"blocked":[85],"promoted":[90],"\u03b2-arrestin":[91],"binding,":[92],"or":[93],"vice-versa,":[94],"suggested":[95],"exciting":[97],"possibility":[98],"selectively":[100],"activating":[101],"intracellular":[102],"pathways.":[104],"In":[105,134],"addition,":[106],"it":[107],"is":[108,115,132],"becoming":[109],"increasingly":[110],"evident":[111],"\u03b2-arrestin-dependent":[113,151],"extremely":[116],"diverse":[117],"provokes":[119],"distinct":[120],"cellular":[121],"responses":[122],"different":[124],"GPCRs":[125],"even":[126],"when":[127],"same":[129],"effector":[130],"involved.":[133],"this":[135],"review,":[136],"we":[137],"summarize":[138],"various":[139],"mediated":[142],"highlight":[146],"physiologic":[148],"effects":[149],"signaling.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":40},{"year":2025,"cited_by_count":64},{"year":2024,"cited_by_count":51},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":38},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2017-04-07T00:00:00"}