{"id":"https://openalex.org/W2601189503","doi":null,"title":"Delivery and activity of toxic effector domains from contact-dependent growth inhibition systems in Escherichia coli","display_name":"Delivery and activity of toxic effector domains from contact-dependent growth inhibition systems in Escherichia coli","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2601189503","mag":"2601189503"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt1918d6vn","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1918d6vn","pdf_url":"https://escholarship.org/uc/item/1918d6vn","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/1918d6vn","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084778900","display_name":"Julia L. E. Willett","orcid":"https://orcid.org/0000-0002-0524-8289","observed_orcids":["https://orcid.org/0000-0002-0524-8289"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julia L. E. Willett","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0524-8289","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084778900"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.19059999287128448,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/contact-dependent-growth-inhibition","display_name":"contact-dependent growth inhibition","score":1.0},{"id":"https://openalex.org/keywords/toxin-translocation","display_name":"toxin translocation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/interbacterial-competition","display_name":"bacterial competition","score":0.7099999785423279},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.6489999890327454},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.65326988697052},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6404518485069275},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5333027839660645},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5277484059333801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5140169858932495},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.47471702098846436},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.46282440423965454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4546636939048767},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39637482166290283},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.36192092299461365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2905830144882202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2842315137386322},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26686224341392517},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.15975594520568848}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt1918d6vn","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1918d6vn","pdf_url":"https://escholarship.org/uc/item/1918d6vn","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt1918d6vn","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/1918d6vn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Willett, Julia Laura Elizabeth. (2016). Delivery and activity of toxic effector domains from contact-dependent growth inhibition systems in Escherichia coli. 0035: Molecular, Cellular &amp; Developmental Biology. Retrieved from: http://www.escholarship.org/uc/item/1918d6vn","raw_type":"dissertation"},{"id":"mag:2601189503","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1918d6vn","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt1918d6vn","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1918d6vn","pdf_url":"https://escholarship.org/uc/item/1918d6vn","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1337336788","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1144085","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G572199456","display_name":"Control of beta-Sheet Self-Assembly through Chemical Crosslinks","funder_award_id":"1058825","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2601189503.pdf","grobid_xml":"https://content.openalex.org/works/W2601189503.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966688540","https://openalex.org/W3003565807","https://openalex.org/W2767236814","https://openalex.org/W4224847260","https://openalex.org/W2173219694","https://openalex.org/W2159502479","https://openalex.org/W2991440516","https://openalex.org/W1544967679","https://openalex.org/W4255923498","https://openalex.org/W2800790547"],"abstract_inverted_index":{"Bacteria":[0],"are":[1,77,99,108],"ubiquitous":[2],"in":[3,17,150,211,242,263,326,331],"nature":[4],"and":[5,12,66,94,140,164,180,236],"have":[6],"evolved":[7],"a":[8,26,84,112,158,200,230,268,292,304],"variety":[9,113],"of":[10,54,61,83,110,114,120,124,173,177,185,205,228,240,247,261,286,311,323,329],"communication":[11],"competition":[13,28,167],"systems":[14,107,179,188,313],"to":[15,91,134,161,191,274],"survive":[16],"dense,":[18],"complex":[19],"environments.":[20,152],"Contact-dependent":[21],"growth":[22,69,135],"inhibition":[23,136],"(CDI)":[24],"is":[25,31,37,64,224],"microbial":[27],"system":[29],"that":[30,105,132,145,189,254,307],"widespread":[32],"throughout":[33],"Gram-negative":[34],"bacteria.":[35,74],"CDI":[36,106,148,178,312,330],"mediated":[38],"by":[39,81,137,297],"the":[40,47,52,92,129,238,284,287,327],"CdiB/CdiA":[41],"two-partner":[42],"secretion":[43,187],"system,":[44],"which":[45,89,223],"displays":[46],"large":[48],"CdiA":[49,62],"exoprotein":[50],"on":[51,219],"surface":[53],"CDI+":[55,75],"inhibitor":[56],"cells.":[57],"The":[58],"C-terminal":[59],"domain":[60],"(CdiA-CT)":[63],"toxic":[65,130],"inhibits":[67],"cell":[68,142],"after":[70,259],"delivery":[71,123,260],"into":[72,126,208],"target":[73,127,141,209,257],"cells":[76,210,258],"protected":[78],"from":[79,233],"auto-inhibition":[80],"expression":[82],"cognate":[85],"immunity":[86],"protein":[87],"(CdiI),":[88],"binds":[90],"CdiA-CT":[93,138,206,299],"inactivates":[95],"toxicity.":[96],"CdiA-CT/CdiI":[97,271],"pairs":[98],"highly":[100],"divergent":[101],"across":[102],"species,":[103],"indicating":[104],"capable":[109],"deploying":[111],"toxins.This":[115],"thesis":[116],"explores":[117,251],"several":[118],"aspects":[119],"CDI,":[121],"including":[122],"CdiA-CTs":[125],"cells,":[128],"activities":[131],"lead":[133],"domains,":[139],"stress":[143],"responses":[144,253],"may":[146],"influence":[147],"populations":[149],"natural":[151],"In":[153,214,276],"Chapter":[154,212,215,249,264,277,301,332],"I,":[155],"we":[156,217,266,279,319],"provide":[157],"general":[159],"introduction":[160],"both":[162],"diffusible":[163],"contact-dependent":[165],"bacterial":[166,195],"systems.":[168],"This":[169],"provides":[170],"an":[171],"overview":[172],"our":[174],"current":[175],"knowledge":[176],"also":[181],"highlights":[182],"key":[183],"features":[184],"other":[186],"contribute":[190],"population":[192],"dynamics":[193],"within":[194],"communities.":[196],"We":[197],"then":[198],"present":[199,267],"genetic":[201,252],"study":[202,269],"characterizing":[203,270],"pathways":[204],"translocation":[207,227],"II.":[213],"III,":[216],"focus":[218],"one":[220],"protein,":[221],"YciB,":[222],"required":[225,294],"for":[226,295],"CdiA-CTo11EC869,":[229],"DNase":[231],"toxin":[232],"E.":[234,243],"coli,":[235],"examine":[237],"role":[239,285],"YciB":[241],"coli":[244],"physiology":[245],"outside":[246],"CDI.":[248],"IV":[250],"occur":[255],"inside":[256],"CdiA-CTo11EC869;":[262],"V,":[265],"modules":[272],"related":[273],"CdiA-CT/CdiIo11EC869.":[275],"VI,":[278],"discuss":[280,320],"unpublished":[281],"work":[282],"examining":[283],"translation":[288],"factor":[289],"EF-Tu":[290],"as":[291,314],"co-factor":[293],"activity":[296],"numerous":[298],"toxins.":[300],"VII":[302],"describes":[303],"collaborative":[305],"project":[306],"utilized":[308],"principle":[309],"components":[310],"synthetic":[315],"biology":[316],"tools.":[317],"Finally,":[318],"research":[321],"questions":[322],"significant":[324],"interest":[325],"field":[328],"VIII.":[333]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-04-07T00:00:00"}
