{"id":"https://openalex.org/W2600940366","doi":"https://doi.org/10.1038/cdd.2017.24","title":"\u2018Hints\u2019 in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death","display_name":"\u2018Hints\u2019 in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death","publication_year":2017,"publication_date":"2017-03-03","ids":{"openalex":"https://openalex.org/W2600940366","doi":"https://doi.org/10.1038/cdd.2017.24","mag":"2600940366","pmid":"https://pubmed.ncbi.nlm.nih.gov/28362726","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5384029"},"language":"en","primary_location":{"id":"doi:10.1038/cdd.2017.24","doi":"https://doi.org/10.1038/cdd.2017.24","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cdd.2017.24","pdf_url":"https://www.nature.com/articles/cdd201724.pdf","source":{"id":"https://openalex.org/S152938505","display_name":"Cell Death and Differentiation","issn_l":"1350-9047","issn":["1350-9047","1476-5403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Differentiation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/cdd201724.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087750213","display_name":"Shiqiao Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiqiao Qiu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China","Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Department of Stomatology, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082216696","display_name":"Feiyue Xing","orcid":"https://orcid.org/0000-0003-0014-3565","observed_orcids":["https://orcid.org/0000-0003-0014-3565"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feiyue Xing","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China","Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082216696"],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":{"value":5790,"currency":"USD","value_usd":5790},"fwci":0.694,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.58126628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"24","issue":"4","first_page":"588","last_page":"596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pore-forming-proteins","display_name":"pore-forming proteins","score":0.8190000057220459},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.8140000104904175},{"id":"https://openalex.org/keywords/gasdermin-e","display_name":"gasdermin E","score":0.9150000214576721},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.6850000023841858},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/secondary-necrosis","display_name":"secondary necrosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/caspase-cleavage","display_name":"caspase cleavage","score":0.8330000042915344},{"id":"https://openalex.org/keywords/plasma-membrane-targeting","display_name":"plasma membrane targeting","score":0.5009999871253967},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.9855028390884399},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.8921157717704773},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.876874566078186},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.826583981513977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7943374514579773},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.5806931853294373},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5558331608772278},{"id":"https://openalex.org/C2779004061","wikidata":"https://www.wikidata.org/wiki/Q5247322","display_name":"Death domain","level":4,"score":0.5012967586517334},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.49424150586128235},{"id":"https://openalex.org/C2776550021","wikidata":"https://www.wikidata.org/wiki/Q18033276","display_name":"RIPK1","level":5,"score":0.47262904047966003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4430626332759857},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4216381013393402},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.41830840706825256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4058302044868469},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25258365273475647},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17628365755081177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1174367368221283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000094524","descriptor_name":"Gasdermins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028044","descriptor_name":"Phosphate-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/cdd.2017.24","doi":"https://doi.org/10.1038/cdd.2017.24","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cdd.2017.24","pdf_url":"https://www.nature.com/articles/cdd201724.pdf","source":{"id":"https://openalex.org/S152938505","display_name":"Cell Death and Differentiation","issn_l":"1350-9047","issn":["1350-9047","1476-5403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Differentiation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4246815","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5384029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5384029","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5384029","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Differ","raw_type":"Text"},{"id":"pmid:28362726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28362726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death and differentiation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/cdd.2017.24","doi":"https://doi.org/10.1038/cdd.2017.24","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cdd.2017.24","pdf_url":"https://www.nature.com/articles/cdd201724.pdf","source":{"id":"https://openalex.org/S152938505","display_name":"Cell Death and Differentiation","issn_l":"1350-9047","issn":["1350-9047","1476-5403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Differentiation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7834155793","display_name":"Jagged-1\u5728Th17\u7ec6\u80de\u5206\u5316\u4e2d\u7684\u4f5c\u7528\u53ca\u5176\u673a\u5236","funder_award_id":"30971465","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7839961951","display_name":null,"funder_award_id":"81172824","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2600940366.pdf","grobid_xml":"https://content.openalex.org/works/W2600940366.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1550684847","https://openalex.org/W1582335305","https://openalex.org/W1797701563","https://openalex.org/W1811981061","https://openalex.org/W1864325817","https://openalex.org/W1882905539","https://openalex.org/W1973496622","https://openalex.org/W1983254279","https://openalex.org/W1984520240","https://openalex.org/W1985970823","https://openalex.org/W1986960525","https://openalex.org/W1994127646","https://openalex.org/W1994988658","https://openalex.org/W2001212240","https://openalex.org/W2003251187","https://openalex.org/W2003605139","https://openalex.org/W2011013726","https://openalex.org/W2012347074","https://openalex.org/W2013642338","https://openalex.org/W2015414808","https://openalex.org/W2016988352","https://openalex.org/W2027902565","https://openalex.org/W2029340310","https://openalex.org/W2029861821","https://openalex.org/W2038976751","https://openalex.org/W2039586060","https://openalex.org/W2045897279","https://openalex.org/W2048136172","https://openalex.org/W2055547672","https://openalex.org/W2055727949","https://openalex.org/W2059246452","https://openalex.org/W2059627714","https://openalex.org/W2066328430","https://openalex.org/W2066491869","https://openalex.org/W2068619092","https://openalex.org/W2079501367","https://openalex.org/W2080827095","https://openalex.org/W2085006338","https://openalex.org/W2101667253","https://openalex.org/W2109265522","https://openalex.org/W2120454965","https://openalex.org/W2141504650","https://openalex.org/W2143102054","https://openalex.org/W2156458099","https://openalex.org/W2157521429","https://openalex.org/W2160821224","https://openalex.org/W2169678859","https://openalex.org/W2172160537","https://openalex.org/W2175794645","https://openalex.org/W2280790887","https://openalex.org/W2418806051","https://openalex.org/W2431987552","https://openalex.org/W2461756806","https://openalex.org/W2461915818","https://openalex.org/W2462773201","https://openalex.org/W2469002912","https://openalex.org/W2517997111","https://openalex.org/W2564122215"],"related_works":["https://openalex.org/W3217082586","https://openalex.org/W2509409496","https://openalex.org/W2418806051","https://openalex.org/W4281556855","https://openalex.org/W2980560502","https://openalex.org/W4291703651","https://openalex.org/W7212261179","https://openalex.org/W2586409557","https://openalex.org/W4390663946","https://openalex.org/W4417151996"],"abstract_inverted_index":{"Pyroptosis":[0],"is":[1],"a":[2,22,29,92,153],"lytic":[3,168],"form":[4],"of":[5,64,73,77,126,167,172],"cell":[6,66,87,97,117,132,174],"death":[7,98,118],"distinguished":[8],"from":[9],"apoptosis,":[10],"ferroptosis,":[11],"necrosis,":[12],"necroptosis,":[13],"NETosis,":[14],"oncosis,":[15],"pyronecrosis":[16],"and":[17,61,124,141,165],"autophagy.":[18],"Proinflammatory":[19],"caspases":[20],"cleave":[21],"gasdermin":[23,105,147],"D":[24],"(GSDMD)":[25],"protein":[26],"to":[27,47,51,69,95,151],"generate":[28],"31":[30],"kDa":[31],"N-terminal":[32,111],"domain.":[33],"The":[34,146],"cleavage":[35],"relieves":[36],"the":[37,41,48,59,70,74,78,82,127,162],"intramolecular":[38],"inhibition":[39],"on":[40],"gasdermin-N":[42],"domain,":[43],"which":[44],"then":[45],"moves":[46],"plasma":[49,79],"membrane":[50,80],"exhibit":[52],"pore-forming":[53,83,155],"activity.":[54],"Thus,":[55],"GSDMD":[56,89,135],"acts":[57],"as":[58,176,178],"final":[60],"direct":[62],"executor":[63],"pyroptotic":[65,86],"death.":[67],"Owing":[68],"selective":[71],"targeting":[72],"inner":[75],"leaflet":[76],"with":[81],"that":[84],"determines":[85],"death,":[88,133,175],"could":[90],"be":[91,152],"potential":[93,180],"target":[94],"control":[96],"or":[99,169],"extracellular":[100],"bacterial":[101],"infections.":[102],"Intriguingly,":[103],"other":[104],"family":[106],"members":[107],"also":[108],"share":[109],"similar":[110],"domains,":[112],"but":[113],"they":[114],"present":[115],"different":[116],"programs.":[119],"Herein,":[120],"we":[121],"summarize":[122],"features":[123],"functions":[125],"novel":[128,154,159],"player":[129],"proteins":[130],"in":[131,182],"including":[134],"triggering":[136],"pyroptosis,":[137],"Gsdma3/GSDMA":[138],"initiating":[139],"autophagy/apoptosis":[140],"DFNA5":[142],"inducing":[143],"apoptosis/secondary":[144],"necrosis.":[145],"N":[148],"terminus":[149],"appears":[150],"protein.":[156],"This":[157],"provides":[158],"insight":[160],"into":[161],"underlying":[163],"roles":[164],"mechanisms":[166],"nonlytic":[170],"forms":[171],"programmed":[173],"well":[177],"their":[179],"applications":[181],"inflammation-associated":[183],"diseases.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-04-07T00:00:00"}