{"id":"https://openalex.org/W2600596998","doi":"https://doi.org/10.1042/cs100002p","title":"Asthmatic Bronchial Epithelium is More Susceptible to Oxidant \u2014 Induced Apoptosis (Introduced by ST Holgate)","display_name":"Asthmatic Bronchial Epithelium is More Susceptible to Oxidant \u2014 Induced Apoptosis (Introduced by ST Holgate)","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2600596998","doi":"https://doi.org/10.1042/cs100002p","mag":"2600596998"},"language":"en","primary_location":{"id":"doi:10.1042/cs100002p","doi":"https://doi.org/10.1042/cs100002p","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs100002p","pdf_url":null,"source":{"id":"https://openalex.org/S4210209534","display_name":"Clinical Science","issn_l":"0144-9664","issn":["0144-9664"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032192970","display_name":"Donna E. Davies","orcid":"https://orcid.org/0000-0002-5117-2991","observed_orcids":["https://orcid.org/0000-0002-5117-2991"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.E. Davies","raw_affiliation_strings":["School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008797235","display_name":"Fabio Bucchieri","orcid":"https://orcid.org/0000-0002-0209-8668","observed_orcids":["https://orcid.org/0000-0002-0209-8668"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. Bucchieri","raw_affiliation_strings":["School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112898681","display_name":"James Laurence Lordan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.L. Lordan","raw_affiliation_strings":["School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081302632","display_name":"Peter Hugo Howarth","orcid":"https://orcid.org/0000-0003-0619-7927","observed_orcids":["https://orcid.org/0000-0003-0619-7927"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.H. Howarth","raw_affiliation_strings":["School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043576559","display_name":"Ratko Djukanovi\u0107","orcid":"https://orcid.org/0000-0001-6039-5612","observed_orcids":["https://orcid.org/0000-0001-6039-5612"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Djukanovic","raw_affiliation_strings":["School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089020623","display_name":"Stephen T. Holgate","orcid":"https://orcid.org/0000-0003-2658-4617","observed_orcids":["https://orcid.org/0000-0003-2658-4617"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.T. Holgate","raw_affiliation_strings":["School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801388914"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":"s44","first_page":"2P","last_page":"2P"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bronchial-epithelium","display_name":"bronchial epithelium","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8009999990463257},{"id":"https://openalex.org/keywords/airway-epithelial-cells","display_name":"airway epithelial cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/asthma-pathogenesis","display_name":"asthma pathogenesis","score":0.5260000228881836},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.5410000085830688},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.6539999842643738},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.5370000004768372},{"id":"https://openalex.org/keywords/airway-mucus-hypersecretion","display_name":"airway mucus hypersecretion","score":0.7179999947547913},{"id":"https://openalex.org/keywords/airway-smooth-muscle-contraction","display_name":"airway smooth muscle contraction","score":0.6470000147819519},{"id":"https://openalex.org/keywords/airway-neutrophilia","display_name":"airway neutrophilia","score":0.5580000281333923},{"id":"https://openalex.org/keywords/airway-fibrosis","display_name":"airway fibrosis","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2992019943","wikidata":"https://www.wikidata.org/wiki/Q16917","display_name":"General hospital","level":2,"score":0.5636613368988037},{"id":"https://openalex.org/C2777012970","wikidata":"https://www.wikidata.org/wiki/Q2659932","display_name":"Respiratory Medicine","level":2,"score":0.5577225089073181},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.44665098190307617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4311240613460541},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.42086270451545715},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.29362183809280396},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10957679152488708},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10930129885673523},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1042/cs100002p","doi":"https://doi.org/10.1042/cs100002p","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs100002p","pdf_url":null,"source":{"id":"https://openalex.org/S4210209534","display_name":"Clinical Science","issn_l":"0144-9664","issn":["0144-9664"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2156063437","https://openalex.org/W7017342968","https://openalex.org/W2010225757","https://openalex.org/W1972837952","https://openalex.org/W2124542794","https://openalex.org/W2009922537","https://openalex.org/W2081818128","https://openalex.org/W2937714454","https://openalex.org/W174056243","https://openalex.org/W7028106518"],"abstract_inverted_index":{"Conference":[0],"Abstract|":[1],"February":[2,288],"01":[3],"2001":[4,341],"Asthmatic":[5,269],"Bronchial":[6,270],"Epithelium":[7,271],"is":[8,272,334],"More":[9,273],"Susceptible":[10,274],"to":[11,275,363],"Oxidant":[12,276],"\u2014":[13,277],"Induced":[14,278],"Apoptosis":[15,279],"(Introduced":[16,280],"by":[17,45,79,113,147,181,215,281],"ST":[18,282],"Holgate)":[19],"D.E.":[20,22,257],"Davies;":[21],"Davies":[23],"1School":[24,58,92,126,160,194],"of":[25,28,59,62,93,96,127,130,161,164,195,198],"Medicine,":[26,60,94,128,162,196],"Division":[27,61,95,129,163,197],"Respiratory":[29,63,97,131,165,199],"Cell":[30,64,98,132,166,200],"and":[31,65,99,133,167,201,345],"Molecular":[32,66,100,134,168,202],"Biology,":[33,67,101,135,169,203],"Southampton":[34,68,102,136,170,204],"General":[35,69,103,137,171,205],"Hospital,":[36,70,104,138,172,206],"Southampton,":[37,71,105,139,173,207],"SO16":[38,72,106,140,174,208],"6YD,":[39,73,107,141,175,209],"UK":[40,74,108,142,176,210],"Search":[41,75,109,143,177,211,311,318,329,331],"for":[42,76,110,144,178,212],"other":[43,77,111,145,179,213],"works":[44,78,112,146,180,214],"this":[46,80,114,148,182,216,364],"author":[47,81,115,149,183,217],"on:":[48,82,116,150,184,218],"This":[49,83,117,151,185,219,332],"Site":[50,84,118,152,186,220],"PubMed":[51,85,119,153,187,221],"Google":[52,86,120,154,188,222],"Scholar":[53,87,121,155,189,223],"F.":[54,56,259],"Bucchieri;":[55],"Bucchieri":[57],"J.L.":[88,90,261],"Lordan;":[89],"Lordan":[91],"P.H.":[122,124,263],"Howarth;":[123],"Howarth":[125],"R.":[156,158,265],"Djukanovic;":[157],"Djukanovic":[159],"S.T.":[190,192,267],"Holgate":[191,193],"Clin":[224,284],"Sci":[225,285],"(Lond)":[226,286],"(2001)":[227],"100":[228,290],"(s44):":[229,291],"2P.":[230,292],"https://doi.org/10.1042/cs100002P":[231,294],"Views":[232,234],"Icon":[233,247,252],"Article":[235,350],"contents":[236],"Figures":[237],"&":[238],"tables":[239],"Video":[240],"Audio":[241],"Supplementary":[242],"Data":[243],"Peer":[244],"Review":[245],"Share":[246,248],"Twitter":[249],"LinkedIn":[250],"Cite":[251,253],"Get":[254],"Permissions":[255],"Citation":[256],"Davies,":[258],"Bucchieri,":[260],"Lordan,":[262],"Howarth,":[264],"Djukanovic,":[266],"Holgate;":[268],"Holgate).":[283],"1":[287],"2001;":[289],"doi:":[293],"Download":[295],"citation":[296],"file:":[297],"Ris":[298],"(Zotero)":[299],"Reference":[300],"Manager":[301],"EasyBib":[302],"Bookends":[303],"Mendeley":[304],"Papers":[305],"EndNote":[306],"RefWorks":[307],"BibTex":[308],"toolbar":[309,314],"search":[310,315,316,324],"Dropdown":[312],"Menu":[313],"input":[317,319],"auto":[320],"suggest":[321],"filter":[322],"your":[323],"All":[325],"ContentAll":[326],"JournalsClinical":[327],"Science":[328],"Advanced":[330],"content":[333],"only":[335],"available":[336],"as":[337],"a":[338],"PDF.":[339],"\u00a9":[340],"The":[342],"Biochemical":[343],"Society":[344],"the":[346],"Medical":[347],"Research":[348],"Society2001":[349],"PDF":[351],"first":[352],"page":[353],"preview":[354],"Close":[355],"Modal":[356],"You":[357],"do":[358],"not":[359],"currently":[360],"have":[361],"access":[362],"content.":[365]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}