{"id":"https://openalex.org/W2600564254","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15061","title":"Phase II trial of nemorubicin hydrochloride (N) in combination with cisplatin (cDDP) administered by intra-hepatic artery (IHA) in patients (pts) with hepatocellular carcinoma (HCC): Final results.","display_name":"Phase II trial of nemorubicin hydrochloride (N) in combination with cisplatin (cDDP) administered by intra-hepatic artery (IHA) in patients (pts) with hepatocellular carcinoma (HCC): Final results.","publication_year":2013,"publication_date":"2013-05-20","ids":{"openalex":"https://openalex.org/W2600564254","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15061","mag":"2600564254"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.15_suppl.e15061","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15061","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15061","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110290403","display_name":"Francesco Izzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Izzo","raw_affiliation_strings":["National Cancer Institute of Naples, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute of Naples, Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035318279","display_name":"Thomas Joseph Vogl","orcid":"https://orcid.org/0000-0001-5218-1075","observed_orcids":["https://orcid.org/0000-0001-5218-1075"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas J. Vogl","raw_affiliation_strings":["Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032842440","display_name":"Gennaro Gadaleta\u2010Caldarola","orcid":"https://orcid.org/0000-0001-7120-8747","observed_orcids":["https://orcid.org/0000-0001-7120-8747"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gennaro Gadaleta-Caldarola","raw_affiliation_strings":["National Cancer Institute Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051430596","display_name":"Mark Ross Middleton","orcid":"https://orcid.org/0000-0003-0167-1685","observed_orcids":["https://orcid.org/0000-0003-0167-1685"]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark R. Middleton","raw_affiliation_strings":["Churchill Hospital Cancer Center, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Churchill Hospital Cancer Center, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077826150","display_name":"Juan W. Valle","orcid":"https://orcid.org/0000-0002-1999-0863","observed_orcids":["https://orcid.org/0000-0002-1999-0863","https://orcid.org/0000-0002-7964-8402"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Juan W. Valle","raw_affiliation_strings":["University of Manchester, Manchester Academic Health Science Centre; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester, Manchester Academic Health Science Centre; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055262652","display_name":"Renate Hammerstingl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Renate Hammerstingl","raw_affiliation_strings":["Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062612530","display_name":"Cosmo Damiano Gadaleta","orcid":"https://orcid.org/0000-0003-2398-691X","observed_orcids":["https://orcid.org/0000-0003-2398-691X"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cosmo D. Gadaleta","raw_affiliation_strings":["National Cancer Institute Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063907460","display_name":"Marcella Martignoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marcella Martignoni","raw_affiliation_strings":["CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090305968","display_name":"Anna Petroccione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Petroccione","raw_affiliation_strings":["CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051480361","display_name":"Mariangela Mariani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariangela Mariani","raw_affiliation_strings":["CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084831912","display_name":"Cristina Davite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Davite","raw_affiliation_strings":["CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLInical Organization for Strategies & Solutions (CLIOSS), NMS Group, Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044401066","display_name":"Francesco Fiore","orcid":"https://orcid.org/0000-0003-4877-1149","observed_orcids":["https://orcid.org/0000-0003-4877-1149"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Fiore","raw_affiliation_strings":["National Cancer Institute of Naples, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute of Naples, Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"15_suppl","first_page":"e15061","last_page":"e15061"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/dna-intercalators","display_name":"DNA intercalators","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cyp3a4-metabolism","display_name":"CYP3A4 metabolism","score":0.7419999837875366},{"id":"https://openalex.org/keywords/portal-vein-thrombosis","display_name":"portal vein thrombosis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.7919999957084656},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.3700000047683716},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.5809999704360962},{"id":"https://openalex.org/keywords/unresectable-liver-cancer","display_name":"unresectable liver cancer","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9202718138694763},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5660569667816162},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5411862730979919},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5402263402938843},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5377901196479797},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5208802223205566},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.4101712703704834},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3882342576980591},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.22878959774971008}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.15_suppl.e15061","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15061","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15061","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2279375955","https://openalex.org/W2252998021","https://openalex.org/W2529709090","https://openalex.org/W6993048580","https://openalex.org/W3097455342","https://openalex.org/W2036766163","https://openalex.org/W1988566953","https://openalex.org/W7097204842","https://openalex.org/W1994513787","https://openalex.org/W2109321344"],"abstract_inverted_index":{"e15061":[0],"Background:":[1],"N":[2,34,298],"is":[3],"a":[4,89,310],"novel":[5],"DNA-intercalator,":[6],"mainly":[7],"metabolized":[8],"in":[9,38,50,136,162,176,192,250,289,293,304,320,323],"liver":[10],"by":[11,36],"CYP3A4":[12],"enzyme":[13],"and":[14,31,69,97,131,138,147,171,175,184,207,229,247,263,281,307],"showing":[15],"synergic":[16],"antitumor":[17],"activity":[18,303],"with":[19,40,194,299,309],"cDDP.":[20],"The":[21,47,155,188,218,267,285],"objective":[22],"of":[23,33,91,115,122,158,297],"this":[24],"study":[25,48],"was":[26,49,83,108,160,190,287],"to":[27,42,110,124],"evaluate":[28,111],"the":[29,112,223,242],"efficacy":[30,224],"toxicity":[32,96],"administered":[35],"IHA":[37,295],"combination":[39],"cDDP":[41,300],"unresectable":[43],"HCC":[44,52],"pts.":[45],"Methods:":[46],"two":[51],"pt":[53],"populations:":[54],"advanced":[55],"risk":[56,71],"(ARP)":[57],"(CLIP":[58,73],"2,":[59],"bilirubin":[60,75,264],"\u2264":[61,76],"2.5":[62],"mg/dL,":[63],"portal":[64],"vein":[65],"thrombosis":[66],"[PVT]":[67],"admitted)":[68],"intermediate":[70],"(IRP)":[72],"0-1,":[74],"1.5":[77],"x":[78],"ULN,":[79],"no":[80,98],"PVT).":[81],"Treatment":[82],"repeated":[84],"every":[85],"4-6":[86],"wks":[87],"for":[88],"maximum":[90],"6":[92],"courses,":[93],"if":[94],"acceptable":[95],"disease":[99,212],"progression":[100],"occurred.":[101],"A":[102],"single-arm,":[103],"Simon\u2019s":[104],"Minimax":[105],"two-stage":[106],"design":[107],"adopted":[109],"primary":[113],"endpoint":[114],"tumour":[116],"response":[117],"(WHO":[118],"criteria,":[119],"critical":[120],"numbers":[121],"responses":[123,203,210],"reject":[125],"H0were":[126],"\u2265":[127,132,274],"6/29":[128],"evaluable":[129,134,197,237],"pts":[130,135,144,150,198],"11/33":[133],"ARP":[137,143,164,193,290,308],"IRP,":[139],"respectively).":[140],"Results:":[141],"Thirty-seven":[142],"(27":[145],"evaluable)":[146,152],"42":[148],"IRP":[149,177,219,306],"(33":[151],"were":[153,252,276],"enrolled.":[154],"median":[156],"number":[157],"cycles":[159],"3":[161,216,233],"both":[163,305],"(range":[165,178],"1-13;":[166],"dose":[167,180],"400":[168],"mcg/m2":[169,182],"nemorubicin":[170,183],"60":[172,185],"mg/m2":[173,186],"cDDP)":[174],"1-6;":[179],"600":[181],"cDDP).":[187],"trial":[189,286,327],"successful":[191,288],"8":[195,208],"successes/27":[196],"(RR":[199],"30%):":[200],"7":[201],"partial":[202],"(PR),":[204],"1":[205],"downstaging":[206],"minor":[209],"(MR)/":[211],"stabilization":[213],"(SD)":[214],">":[215,232],"months.":[217],"did":[220],"not":[221,292],"meet":[222],"criteria:2":[225],"CR,":[226],"5":[227],"PR":[228],"13":[230],"MR/SD":[231],"months":[234],"(7":[235],"responses/33":[236],"pts;":[238],"RR":[239],"21%).":[240],"Overall,":[241],"main":[243],"Grade":[244,273],"3-4":[245],"hematological":[246],"biochemical":[248],"toxicities":[249],"ARP/IRP":[251],"thrombocytopenia":[253],"(28/58%),":[254],"neutropenia":[255],"(26/60%),":[256],"aspartate":[257],"aminotransferase":[258,261],"(25/31%),":[259],"alanine":[260],"(14/23%)":[262],"increase":[265],"(17/21%).":[266],"most":[268],"frequent":[269],"adverse":[270],"events":[271],"(any":[272],"20%)":[275],"fatigue":[277],"(38%),":[278],"nausea":[279],"(35/29%),":[280],"vomiting":[282],"(24/26%).":[283],"Conclusions:":[284],"but":[291],"IRP;":[294],"infusion":[296],"showed":[301],"promising":[302],"well":[311],"tolerated":[312],"regimen.":[313],"These":[314],"encouraging":[315],"results":[316],"warrant":[317],"further":[318],"investigation":[319],"HCC,":[321],"specially":[322],"multinodular":[324],"type.":[325],"Clinical":[326],"information:":[328],"2005-000731-26.":[329]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-04-07T00:00:00"}