{"id":"https://openalex.org/W2600550865","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.13506","title":"Breast cancer: Draining lymph node of vaccination site targeted by adjuvant GM-CSF in an autologous vaccine","display_name":"Breast cancer: Draining lymph node of vaccination site targeted by adjuvant GM-CSF in an autologous vaccine","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2600550865","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.13506","mag":"2600550865"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.13506","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.13506","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.13506","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074450620","display_name":"E Garc\u00eda-Giralt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145299","display_name":"Clinique Hartmann","ror":"https://ror.org/04z27mz17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Garcia-Giralt","raw_affiliation_strings":["Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210145299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033238766","display_name":"Eduardo Lasalvia-Prisco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145299","display_name":"Clinique Hartmann","ror":"https://ror.org/04z27mz17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Lasalvia-Prisco","raw_affiliation_strings":["Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210145299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010760587","display_name":"Silvia Cucchi","orcid":"https://orcid.org/0009-0004-5934-3101","observed_orcids":["https://orcid.org/0009-0004-5934-3101"]},"institutions":[{"id":"https://openalex.org/I4210145299","display_name":"Clinique Hartmann","ror":"https://ror.org/04z27mz17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Cucchi","raw_affiliation_strings":["Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210145299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053765620","display_name":"Marta Aghazarian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145299","display_name":"Clinique Hartmann","ror":"https://ror.org/04z27mz17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Aghazarian","raw_affiliation_strings":["Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210145299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110812961","display_name":"J. Larra\u00f1aga","orcid":"https://orcid.org/0000-0003-4708-6609","observed_orcids":["https://orcid.org/0000-0003-4708-6609"]},"institutions":[{"id":"https://openalex.org/I4210145299","display_name":"Clinique Hartmann","ror":"https://ror.org/04z27mz17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Larra\u00f1aga","raw_affiliation_strings":["Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210145299"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Brent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145299","display_name":"Clinique Hartmann","ror":"https://ror.org/04z27mz17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Brent","raw_affiliation_strings":["Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210145299"]}]},{"author_position":"last","author":{"id":null,"display_name":"D. Walton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145299","display_name":"Clinique Hartmann","ror":"https://ror.org/04z27mz17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145299"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Walton","raw_affiliation_strings":["Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De Cancerologie Hartmann, Neuilly Sur Seine, France; Pharmablood, North Miami Beach, FL; Interdoctors, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210145299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210145299"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"13506","last_page":"13506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gm-csf-adjuvant","display_name":"GM-CSF adjuvant","score":0.8309999704360962},{"id":"https://openalex.org/keywords/draining-lymph-nodes","display_name":"draining lymph nodes","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7039999961853027},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.44999998807907104},{"id":"https://openalex.org/keywords/hr-her2-breast-cancer","display_name":"hormone receptor-positive HER2-negative breast cancer","score":0.7279999852180481},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9059387445449829},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6618923544883728},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.609370231628418},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6051996946334839},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.6035056114196777},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5860275626182556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.491240918636322},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4731907844543457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44669127464294434},{"id":"https://openalex.org/C2780212769","wikidata":"https://www.wikidata.org/wiki/Q776290","display_name":"Sentinel lymph node","level":4,"score":0.4414432644844055},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.4318888187408447},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.353149950504303},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14375117421150208}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.13506","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.13506","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.13506","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2531751707","https://openalex.org/W4225016278","https://openalex.org/W1625334896","https://openalex.org/W2086271857","https://openalex.org/W2539097455","https://openalex.org/W4255655213","https://openalex.org/W2120009493","https://openalex.org/W2240502175","https://openalex.org/W178166036","https://openalex.org/W2372606164"],"abstract_inverted_index":{"13506":[0],"Background:":[1],"We":[2],"have":[3,146],"reported":[4],"the":[5,13,47,51,55,72,77,83,116,141,220],"sensitization":[6,225,299],"against":[7],"Tumor":[8],"Associated":[9],"Antigens":[10],"(TAA)":[11],"and":[12,54,70,113,163,170,232,240,264,274,300],"tumor":[14,65,301],"antiprogressive":[15,302],"effect":[16,303],"of":[17,111,242,248,312,321],"Autologous":[18],"Thermostable":[19],"Hemoderivative-Cancer":[20],"Vaccine":[21],"(ATH-CV)":[22],"in":[23,177,246],"breast":[24,157,296],"cancer":[25,158],"patients":[26],"(E.":[27],"Garcia-Giralt":[28],"et":[29,126,132],"al":[30,127,133],"ASCO,":[31],"2006).":[32,137],"Systemic":[33],"immune":[34,44,92,102,118],"response":[35,45,93],"elicited":[36],"by":[37,41,50,226,306],"TAA":[38],"is":[39,76,94,108,317],"started":[40],"a":[42,64,67,99,109,150],"locoregional":[43,91,117,151],"at":[46,206,219],"microenvironment":[48],"constituted":[49],"antigens":[52,60],"source":[53,61],"draining":[56,73],"lymph":[57,74,79,243],"node.":[58],"The":[59],"can":[62],"be":[63],"or":[66,82,89,105],"vaccination":[68,207],"site":[69,208],"respectively,":[71],"node":[75,80,244],"sentinel":[78],"(SLN)":[81],"Sentinel":[84],"Immunized":[85],"Node":[86],"(SIN).":[87],"Tolerogenic":[88],"protective":[90,123],"decisional":[95],"because":[96],"it":[97],"starts":[98],"corresponding":[100],"systemic":[101],"response,":[103],"tolerogenic":[104,121],"protective.":[106],"GM-CSF":[107,148,205,307],"conditioner":[110],"SLN":[112],"SIN,":[114],"switching":[115],"responses":[119],"from":[120],"to":[122,139,192,327],"(ML":[124],"Disis":[125],"Blood,":[128],"1996;":[129],"AJ":[130],"Cochran":[131],"Nat":[134],"Rev":[135],"Immunology,":[136],"Therefore,":[138],"optimize":[140],"ATH-CV":[142,203,298],"antitumoral":[143],"effect,":[144],"we":[145],"explored":[147],"as":[149,308,319],"adjuvant.":[152,310],"Methods:":[153],"Thirty":[154],"six":[155],"M1":[156],"patients,":[159],"ER+,HER":[160],"2-,":[161],"hormone":[162],"chemotherapy":[164],"resistant,":[165],"performance":[166],"status":[167],"=":[168],"2,":[169],"CA":[171,284],"15\u20133":[172,285],"rising":[173],"level,":[174],"were":[175,185,291,304],"included":[176],"this":[178],"prospective,":[179],"IRB-approved":[180],"phase":[181],"I/II":[182],"trial.":[183],"Patients":[184],"3-group":[186],"(G)":[187],"randomized":[188],"(12":[189],"each),":[190],"submitted":[191],"different":[193],"treatments:":[194],"G1,":[195,260,270],"no":[196],"additional":[197],"oncology":[198],"treatment;":[199],"G2,":[200,262,272],"ATH-CV;":[201],"G3,":[202,265,275],"plus":[204],"150":[209],"\u03bcg/day,":[210],"5":[211,258],"days.":[212],"Statistic":[213],"assessment":[214],"(Student\u2019s":[215],"t-test)":[216],"was":[217],"performed":[218],"30-day":[221],"end":[222],"point:":[223],"ATH":[224],"Delayed":[227],"Type":[228],"Hypersensibility":[229],"test":[230,256],"(DTH)":[231],"Lymphocyte":[233],"Proliferative":[234],"Assay":[235],"(LPA);":[236],"PSA":[237],"serum":[238],"level":[239],"immunophenotyping":[241],"cells":[245,316],"biopsies":[247],"SIN":[249,313],"scintigraphy-localized.":[250],"Results:":[251],"Significant":[252],"differences":[253],"(p<0.05):":[254],"DTH":[255],">":[257,268],"mm:":[259],"0/12;":[261,271],"3/12":[263],"6/12.":[266],"LPA":[267],"2.0:":[269],"4/12":[273],"7/12.":[276],"Immunophenotyping:":[277],"MHC-II+CD83+":[278],"(Mature":[279],"Dendritic":[280],"Cells):G3>G2>G1.":[281],"30":[282],"days":[283],"increase:":[286],"G1>G2>G3.":[287],"No":[288,323],"relevant":[289],"toxicities":[290],"evidenced.":[292],"Conclusions:":[293],"In":[294],"advanced":[295],"cancer,":[297],"potentiated":[305],"local":[309],"Increase":[311],"mature":[314],"dendritic":[315],"suggested":[318],"mechanism":[320],"action.":[322],"significant":[324],"financial":[325],"relationships":[326],"disclose.":[328]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-04-07T00:00:00"}