{"id":"https://openalex.org/W2600325565","doi":"https://doi.org/10.1177/0271678x17700913","title":"Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke","display_name":"Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke","publication_year":2017,"publication_date":"2017-03-27","ids":{"openalex":"https://openalex.org/W2600325565","doi":"https://doi.org/10.1177/0271678x17700913","mag":"2600325565","pmid":"https://pubmed.ncbi.nlm.nih.gov/28345479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125975"},"language":"en","primary_location":{"id":"doi:10.1177/0271678x17700913","doi":"https://doi.org/10.1177/0271678x17700913","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0271678x17700913","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X17700913","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X17700913","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016748099","display_name":"Richard J. Leigh","orcid":"https://orcid.org/0000-0002-8285-1815","observed_orcids":["https://orcid.org/0000-0002-8285-1815"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Leigh","raw_affiliation_strings":["National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002886384","display_name":"Linda Knutsson","orcid":"https://orcid.org/0000-0002-4263-113X","observed_orcids":["https://orcid.org/0000-0002-4263-113X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Linda Knutsson","raw_affiliation_strings":["Department of Medical Radiation Physics, Lund University, Lund, Sweden","Department of Radiology, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Radiation Physics, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049356393","display_name":"Jinyuan Zhou","orcid":"https://orcid.org/0000-0002-6684-7920","observed_orcids":["https://orcid.org/0000-0002-6684-7920"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinyuan Zhou","raw_affiliation_strings":["Department of Radiology, Johns Hopkins University, Baltimore, MD, USA","F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1298154867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033765540","display_name":"Peter C.M. van Zijl","orcid":"https://orcid.org/0000-0002-9706-1066","observed_orcids":["https://orcid.org/0000-0002-9706-1066"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter CM van Zijl","raw_affiliation_strings":["Department of Radiology, Johns Hopkins University, Baltimore, MD, USA","F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1298154867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033765540"],"corresponding_institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.5157,"has_fulltext":false,"cited_by_count":159,"citation_normalized_percentile":{"value":0.84594348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"38","issue":"9","first_page":"1500","last_page":"1516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-penumbra","display_name":"ischemic penumbra","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.722000002861023},{"id":"https://openalex.org/keywords/cerebral-blood-volume","display_name":"cerebral blood volume","score":0.8510000109672546},{"id":"https://openalex.org/keywords/penumbral-imaging","display_name":"penumbral imaging","score":0.8240000009536743},{"id":"https://openalex.org/keywords/oxygen-extraction-fraction","display_name":"oxygen extraction fraction","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ph","display_name":"pH","score":0.3630000054836273},{"id":"https://openalex.org/keywords/diffusion-coefficient","display_name":"diffusion coefficient","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mean-transit-time","display_name":"mean transit time","score":0.9990000128746033},{"id":"https://openalex.org/keywords/membrane-depolarization","display_name":"membrane depolarization","score":0.7839999794960022},{"id":"https://openalex.org/keywords/gray-and-white-matter","display_name":"gray and white matter","score":0.6890000104904175},{"id":"https://openalex.org/keywords/perfusion-threshold","display_name":"perfusion threshold","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C2780577055","wikidata":"https://www.wikidata.org/wiki/Q2069532","display_name":"Penumbra","level":3,"score":0.9933104515075684},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.712014377117157},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6346167325973511},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5366380214691162},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.49205583333969116},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.4904603660106659},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.46667444705963135},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4593949019908905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45474597811698914},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44537970423698425},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.43132591247558594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3626570403575897},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3374796211719513},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3358614146709442},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.32699406147003174},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14619994163513184},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.09024810791015625}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1177/0271678x17700913","doi":"https://doi.org/10.1177/0271678x17700913","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0271678x17700913","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X17700913","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5675707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125975","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6125975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cereb Blood Flow Metab","raw_type":"Text"},{"id":"pmid:28345479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28345479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:50f43fbe-89d8-4b4b-b1d8-4bc21eb27813","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/50f43fbe-89d8-4b4b-b1d8-4bc21eb27813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1559-7016","raw_type":"contributiontojournal/systematicreview"}],"best_oa_location":{"id":"doi:10.1177/0271678x17700913","doi":"https://doi.org/10.1177/0271678x17700913","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0271678x17700913","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X17700913","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2959002857","display_name":"US-China Collaborative Research on Stroke Imaging","funder_award_id":"R01NS083435","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4237977461","display_name":"Resource for Quantitative Functional FMRI","funder_award_id":"P41EB015909","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2600325565.pdf"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W146867948","https://openalex.org/W346087094","https://openalex.org/W1504494046","https://openalex.org/W1599159471","https://openalex.org/W1688941701","https://openalex.org/W1896426626","https://openalex.org/W1897928980","https://openalex.org/W1944705852","https://openalex.org/W1957534325","https://openalex.org/W1963778885","https://openalex.org/W1965655136","https://openalex.org/W1968022331","https://openalex.org/W1969295152","https://openalex.org/W1969824218","https://openalex.org/W1970148403","https://openalex.org/W1970632050","https://openalex.org/W1972190491","https://openalex.org/W1973256430","https://openalex.org/W1973913902","https://openalex.org/W1974483939","https://openalex.org/W1974774291","https://openalex.org/W1979483144","https://openalex.org/W1979949380","https://openalex.org/W1980357202","https://openalex.org/W1981009092","https://openalex.org/W1981401772","https://openalex.org/W1982255086","https://openalex.org/W1983064182","https://openalex.org/W1988619721","https://openalex.org/W1990814258","https://openalex.org/W1990870045","https://openalex.org/W1994757115","https://openalex.org/W1996802760","https://openalex.org/W1998604986","https://openalex.org/W1998684439","https://openalex.org/W1998916449","https://openalex.org/W1999917076","https://openalex.org/W2005412294","https://openalex.org/W2005826846","https://openalex.org/W2006134358","https://openalex.org/W2006188334","https://openalex.org/W2006767153","https://openalex.org/W2006916002","https://openalex.org/W2007192266","https://openalex.org/W2008033930","https://openalex.org/W2009283203","https://openalex.org/W2009412483","https://openalex.org/W2009904478","https://openalex.org/W2010127368","https://openalex.org/W2012678826","https://openalex.org/W2014690342","https://openalex.org/W2016294888","https://openalex.org/W2017009049","https://openalex.org/W2017201352","https://openalex.org/W2017501282","https://openalex.org/W2023537572","https://openalex.org/W2031987811","https://openalex.org/W2032809525","https://openalex.org/W2035809927","https://openalex.org/W2037399775","https://openalex.org/W2040490831","https://openalex.org/W2043151182","https://openalex.org/W2047541454","https://openalex.org/W2047966126","https://openalex.org/W2050188772","https://openalex.org/W2052305732","https://openalex.org/W2052453732","https://openalex.org/W2053759106","https://openalex.org/W2057767329","https://openalex.org/W2060124415","https://openalex.org/W2064533924","https://openalex.org/W2065393358","https://openalex.org/W2065999262","https://openalex.org/W2066122082","https://openalex.org/W2067365590","https://openalex.org/W2068648364","https://openalex.org/W2069539816","https://openalex.org/W2069929255","https://openalex.org/W2070231190","https://openalex.org/W2070896918","https://openalex.org/W2072418533","https://openalex.org/W2073869238","https://openalex.org/W2074034549","https://openalex.org/W2076663249","https://openalex.org/W2077151306","https://openalex.org/W2078610221","https://openalex.org/W2080129640","https://openalex.org/W2080190646","https://openalex.org/W2080644144","https://openalex.org/W2088711041","https://openalex.org/W2089363873","https://openalex.org/W2090005971","https://openalex.org/W2092767384","https://openalex.org/W2093409635","https://openalex.org/W2096971175","https://openalex.org/W2100862858","https://openalex.org/W2102964293","https://openalex.org/W2107741047","https://openalex.org/W2108812972","https://openalex.org/W2110035983","https://openalex.org/W2112571673","https://openalex.org/W2113057422","https://openalex.org/W2119542322","https://openalex.org/W2121854361","https://openalex.org/W2123351961","https://openalex.org/W2123894485","https://openalex.org/W2126717340","https://openalex.org/W2127176859","https://openalex.org/W2131777016","https://openalex.org/W2137777323","https://openalex.org/W2137859715","https://openalex.org/W2139621750","https://openalex.org/W2140099191","https://openalex.org/W2140365873","https://openalex.org/W2141827300","https://openalex.org/W2150276788","https://openalex.org/W2152705022","https://openalex.org/W2153664287","https://openalex.org/W2156896333","https://openalex.org/W2160826774","https://openalex.org/W2162789506","https://openalex.org/W2163904986","https://openalex.org/W2168094470","https://openalex.org/W2169545732","https://openalex.org/W2171058244","https://openalex.org/W2191520969","https://openalex.org/W2203834727","https://openalex.org/W2292308933","https://openalex.org/W2293425673","https://openalex.org/W2340979175","https://openalex.org/W2414049679","https://openalex.org/W2442033361","https://openalex.org/W2442289071","https://openalex.org/W2469502808","https://openalex.org/W2544578848","https://openalex.org/W4253130475","https://openalex.org/W4293084779"],"related_works":["https://openalex.org/W2069012429","https://openalex.org/W1547269951","https://openalex.org/W2356786671","https://openalex.org/W7125274856","https://openalex.org/W2361609135","https://openalex.org/W4205768837","https://openalex.org/W2046708241","https://openalex.org/W2071964105","https://openalex.org/W7097881134","https://openalex.org/W2391665583"],"abstract_inverted_index":{"We":[0],"review":[1],"the":[2,29,86,110,114,163],"hemodynamic,":[3],"metabolic":[4],"and":[5,12,81,97,130,139,142,149,187],"cellular":[6],"parameters":[7,27,160],"affected":[8,39,95],"during":[9],"early":[10],"ischemia":[11],"their":[13],"changes":[14],"as":[15],"a":[16,89,93,169,203],"function":[17],"of":[18,33,50,55,88,113,172],"approximate":[19],"cerebral":[20,131],"blood":[21,132],"flow":[22],"(":[23,134,183,191],"CBF)":[24],"thresholds.":[25],"These":[26],"underlie":[28],"current":[30],"practical":[31,155],"definition":[32,66],"an":[34],"ischemic":[35],"penumbra,":[36],"namely":[37,178],"metabolically":[38,94],"but":[40,58],"still":[41],"viable":[42],"brain":[43],"tissue.":[44],"Such":[45],"tissue":[46],"is":[47,165],"at":[48],"risk":[49],"infarction":[51],"under":[52],"continuing":[53],"conditions":[54],"reduced":[56],"CBF,":[57],"can":[59,79],"be":[60,68,123],"rescued":[61],"through":[62],"timely":[63],"intervention.":[64],"This":[65],"will":[67,196],"useful":[69],"in":[70,161,168,202],"clinical":[71,105],"diagnosis":[72],"only":[73],"if":[74],"imaging":[75,157,194],"techniques":[76],"exist":[77],"that":[78,99,108],"rapidly,":[80],"with":[82,144],"sufficient":[83],"accuracy,":[84],"visualize":[85],"existence":[87],"mismatch":[90],"between":[91],"such":[92],"area":[96],"regions":[98],"have":[100],"suffered":[101],"cell":[102],"depolarization.":[103],"Unfortunately,":[104],"data":[106],"show":[107],"defining":[109],"outer":[111,150],"boundary":[112],"penumbra":[115],"based":[116],"solely":[117],"on":[118],"perfusion-related":[119],"thresholds":[120,127],"may":[121],"not":[122],"sufficiently":[124],"accurate.":[125],"Also,":[126],"for":[128,137,146],"CBF":[129,174,176],"volume":[133],"CBV)":[135],"differ":[136],"white":[138],"gray":[140],"matter":[141],"evolve":[143],"time":[145,190],"both":[147],"inner":[148],"penumbral":[151,156],"boundaries.":[152],"As":[153],"such,":[154],"would":[158],"involve":[159],"which":[162],"physiology":[164],"immediately":[166],"displayed":[167],"manner":[170],"independent":[171],"baseline":[173],"or":[175],"threshold,":[177],"pH,":[179],"oxygen":[180],"extraction":[181],"fraction":[182],"OEF),":[184],"diffusion":[185],"constant":[186],"mean":[188],"transit":[189],"MTT).":[192],"Suitable":[193],"technologies":[195],"need":[197],"to":[198],"meet":[199],"this":[200],"requirement":[201],"10-20":[204],"min":[205],"exam.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}
