{"id":"https://openalex.org/W2600317898","doi":"https://doi.org/10.1002/aoc.3752","title":"Synthesis and use of dioxime ligands for treatment of leukemia and colon cancer cells","display_name":"Synthesis and use of dioxime ligands for treatment of leukemia and colon cancer cells","publication_year":2017,"publication_date":"2017-03-27","ids":{"openalex":"https://openalex.org/W2600317898","doi":"https://doi.org/10.1002/aoc.3752","mag":"2600317898"},"language":"en","primary_location":{"id":"doi:10.1002/aoc.3752","doi":"https://doi.org/10.1002/aoc.3752","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aoc.3752","pdf_url":null,"source":{"id":"https://openalex.org/S134627157","display_name":"Applied Organometallic Chemistry","issn_l":"0268-2605","issn":["0268-2605","1099-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Organometallic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023303575","display_name":"\u0130lknur Babahan","orcid":"https://orcid.org/0000-0002-1336-671X","observed_orcids":["https://orcid.org/0000-0002-1336-671X","https://orcid.org/0000-0001-6081-4899"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]},{"id":"https://openalex.org/I83909951","display_name":"Morgan State University","ror":"https://ror.org/017d8gk22","country_code":"US","type":"education","lineage":["https://openalex.org/I83909951"]}],"countries":["TR","US"],"is_corresponding":true,"raw_author_name":"Ilknur Babahan","raw_affiliation_strings":["Department of Chemistry, Adnan Menderes University, Faculty of Science, 09010 Aydin, Turkey","Department of Chemistry, Morgan State University, Baltimore, Maryland, 21251 U.S.A"],"raw_orcid":"https://orcid.org/0000-0001-6081-4899","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Adnan Menderes University, Faculty of Science, 09010 Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]},{"raw_affiliation_string":"Department of Chemistry, Morgan State University, Baltimore, Maryland, 21251 U.S.A","institution_ids":["https://openalex.org/I83909951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016593665","display_name":"Ali \u00d6zmen","orcid":"https://orcid.org/0000-0003-4364-4853","observed_orcids":["https://orcid.org/0000-0003-4364-4853"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ali \u00d6zmen","raw_affiliation_strings":["Department of Biology, Adnan Menderes University, Faculty of Science, 09010 Aydin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Adnan Menderes University, Faculty of Science, 09010 Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038160973","display_name":"Kadir Aslan","orcid":"https://orcid.org/0000-0002-7617-0175","observed_orcids":["https://orcid.org/0000-0002-7617-0175"]},"institutions":[{"id":"https://openalex.org/I83909951","display_name":"Morgan State University","ror":"https://ror.org/017d8gk22","country_code":"US","type":"education","lineage":["https://openalex.org/I83909951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kadir Aslan","raw_affiliation_strings":["Department of Chemistry, Morgan State University, Baltimore, Maryland, 21251 U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-7617-0175","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Morgan State University, Baltimore, Maryland, 21251 U.S.A","institution_ids":["https://openalex.org/I83909951"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016593665","https://openalex.org/A5023303575"],"corresponding_institution_ids":["https://openalex.org/I76806599","https://openalex.org/I83909951"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.3617,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61969242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12458","display_name":"Organometallic Compounds Synthesis and Characterization","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dioxime-ligands","display_name":"dioxime ligands","score":0.9629999995231628},{"id":"https://openalex.org/keywords/thiosemicarbazones","display_name":"thiosemicarbazones","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nickel-ii-complexes","display_name":"nickel(II) complexes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cu-ii-complexes","display_name":"copper(II) complexes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cobalt-ii-complexes","display_name":"cobalt(II) complexes","score":1.0},{"id":"https://openalex.org/keywords/template-effect","display_name":"template effect","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anticancer-metal-complexes","display_name":"anticancer metal complexes","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9430532455444336},{"id":"https://openalex.org/C92381491","wikidata":"https://www.wikidata.org/wiki/Q5747409","display_name":"Heteronuclear molecule","level":3,"score":0.8180630207061768},{"id":"https://openalex.org/C504270822","wikidata":"https://www.wikidata.org/wiki/Q744","display_name":"Nickel","level":2,"score":0.6924368739128113},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6560268998146057},{"id":"https://openalex.org/C515602321","wikidata":"https://www.wikidata.org/wiki/Q740","display_name":"Cobalt","level":2,"score":0.5990611910820007},{"id":"https://openalex.org/C83591994","wikidata":"https://www.wikidata.org/wiki/Q416105","display_name":"Semicarbazone","level":2,"score":0.5236746668815613},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.5152531266212463},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.49039220809936523},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4667380750179291},{"id":"https://openalex.org/C121349320","wikidata":"https://www.wikidata.org/wiki/Q285851","display_name":"Vicinal","level":2,"score":0.43023431301116943},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.34155869483947754},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.2954009771347046},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.19468355178833008},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08795985579490662},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06242090463638306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061120182275772095}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/aoc.3752","doi":"https://doi.org/10.1002/aoc.3752","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aoc.3752","pdf_url":null,"source":{"id":"https://openalex.org/S134627157","display_name":"Applied Organometallic Chemistry","issn_l":"0268-2605","issn":["0268-2605","1099-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Organometallic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1600909042","https://openalex.org/W1964001990","https://openalex.org/W1964469129","https://openalex.org/W1966234818","https://openalex.org/W1974926012","https://openalex.org/W1978633893","https://openalex.org/W1988327708","https://openalex.org/W1996887660","https://openalex.org/W2003734715","https://openalex.org/W2013852447","https://openalex.org/W2017810787","https://openalex.org/W2020365578","https://openalex.org/W2024494256","https://openalex.org/W2038535177","https://openalex.org/W2039593231","https://openalex.org/W2041223644","https://openalex.org/W2048985070","https://openalex.org/W2055605644","https://openalex.org/W2056498672","https://openalex.org/W2059441265","https://openalex.org/W2061127672","https://openalex.org/W2064618474","https://openalex.org/W2069315270","https://openalex.org/W2070537451","https://openalex.org/W2072609433","https://openalex.org/W2084427728","https://openalex.org/W2085055018","https://openalex.org/W2091796741","https://openalex.org/W2093558545","https://openalex.org/W2094579447","https://openalex.org/W2164114492","https://openalex.org/W2319596329","https://openalex.org/W2345350529","https://openalex.org/W2588033600","https://openalex.org/W2595776066","https://openalex.org/W2599998404","https://openalex.org/W2603283362","https://openalex.org/W2949513956","https://openalex.org/W2952345979","https://openalex.org/W2953271720","https://openalex.org/W4234505122"],"related_works":["https://openalex.org/W1988327708","https://openalex.org/W2917203895","https://openalex.org/W3013584989","https://openalex.org/W2000297535","https://openalex.org/W2072609433","https://openalex.org/W3004585068","https://openalex.org/W4213209047","https://openalex.org/W1967452657","https://openalex.org/W2164114492","https://openalex.org/W2535985626"],"abstract_inverted_index":{"Two":[0],"new":[1],"vicinal":[2],"dioxime":[3],"ligands":[4],"containing":[5,59],"thiosemicarbazone":[6],"units":[7],"(L1H2":[8],"and":[9,13,26,31,40,51,88,93,101,114,119,127,129],"L2H2)":[10],"were":[11,53,79],"synthesized":[12],"characterized":[14],"using":[15,66],"1H":[16],"NMR,":[17,19],"13C":[18],"heteronuclear":[20],"multiple":[21],"quantum":[22],"correlation,":[23],"mass,":[24],"infrared":[25],"UV\u2013visible":[27],"spectroscopies,":[28],"elemental":[29],"analysis":[30],"magnetic":[32],"susceptibility":[33],"measurements.":[34],"In":[35],"addition,":[36],"homotrinuclear":[37],"nickel(II),":[38],"copper(II)":[39],"cobalt(II)":[41],"complexes":[42,78],"with":[43,108],"a":[44,60,67],"metal\u2010to\u2010ligand":[45],"ratio":[46],"of":[47,56,124],"3:2":[48],"for":[49,90],"L1H2":[50],"L2H2":[52],"prepared.":[54],"Synthesis":[55],"nickel(II)":[57,70],"complex":[58,71],"BF2+":[61],"bridge":[62],"was":[63],"carried":[64],"out":[65],"precursor":[68],"hydrogen\u2010bridged":[69],"via":[72],"the":[73,104],"template":[74],"effect.":[75],"All":[76],"metal\u2013ligand":[77],"tested":[80],"against":[81],"two":[82],"human":[83],"cancer":[84],"cell":[85],"lines":[86],"(HL\u201060":[87],"HT\u201029)":[89],"their":[91],"antiproliferative":[92,106],"apoptotic":[94],"activities.":[95],"The":[96],"results":[97],"showed":[98],"that":[99],"[Co(L2H)2(H2O)2]":[100,118],"[Ni(L2H)2]":[102,120],"exhibited":[103],"strongest":[105],"activity":[107],"IpC50":[109],"values":[110],"ranging":[111],"between":[112],"5":[113],"10":[115],"\u03bcM,":[116],"while":[117],"both":[121],"induced":[122],"necrosis":[123],"HT\u201029":[125],"cells":[126],"60":[128],"65%":[130],"apoptosis":[131],"in":[132],"HL\u201060":[133],"cells,":[134],"respectively.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-04-07T00:00:00"}
