{"id":"https://openalex.org/W2599712971","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.tps11120","title":"Identification and validation of an assay predictive of response and prognosis following anthracycline-based chemotherapy for early breast cancer.","display_name":"Identification and validation of an assay predictive of response and prognosis following anthracycline-based chemotherapy for early breast cancer.","publication_year":2013,"publication_date":"2013-05-20","ids":{"openalex":"https://openalex.org/W2599712971","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.tps11120","mag":"2599712971"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.15_suppl.tps11120","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.tps11120","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.tps11120","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056014309","display_name":"Jude M. Mulligan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jude M. Mulligan","raw_affiliation_strings":["Almac Diagnostics, Craigavon, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics, Craigavon, United Kingdom","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108545528","display_name":"Laura A. Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura A. Hill","raw_affiliation_strings":["Almac Diagnostics, Craigavon, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics, Craigavon, Northern Ireland","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015203574","display_name":"Steve Deharo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve Deharo","raw_affiliation_strings":["Almac Diagnostics, Craigavon, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics, Craigavon, Northern Ireland","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108197098","display_name":"Katherine E. Keating","orcid":"https://orcid.org/0009-0009-3273-9380","observed_orcids":["https://orcid.org/0009-0009-3273-9380"]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katherine E. Keating","raw_affiliation_strings":["Almac Diagnostics Ltd., Craigavon, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics Ltd., Craigavon, Northern Ireland","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108767531","display_name":"Olaide Y. Raji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olaide Raji","raw_affiliation_strings":["Almac Diagnostics, Craigavon, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics, Craigavon, Northern Ireland","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091724252","display_name":"Fionnuala A. McDyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fionnuala A. McDyer","raw_affiliation_strings":["Almac Diagnostics, Craigavon, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics, Craigavon, Northern Ireland","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053522042","display_name":"Jacqueline A. James","orcid":"https://orcid.org/0000-0002-6945-6060","observed_orcids":["https://orcid.org/0000-0002-6945-6060"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jacqueline James","raw_affiliation_strings":["Queen's University Belfast, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's University Belfast, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067880138","display_name":"Gareth W. Irwin","orcid":"https://orcid.org/0000-0002-2499-5896","observed_orcids":["https://orcid.org/0000-0002-2499-5896"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth Irwin","raw_affiliation_strings":["Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Boyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Boyle","raw_affiliation_strings":["Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112560732","display_name":"Jennifer E. Quinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer E. Quinn","raw_affiliation_strings":["Queen's University Belfast, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's University Belfast, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014851181","display_name":"Paul B. Mullan","orcid":"https://orcid.org/0000-0003-1479-7084","observed_orcids":["https://orcid.org/0000-0003-1479-7084"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul B. Mullan","raw_affiliation_strings":["Queen's University Belfast, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's University Belfast, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112822738","display_name":"Colin R. James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin R. James","raw_affiliation_strings":["Queen's University Belfast, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's University Belfast, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045420024","display_name":"Manuel Salto\u2010Tellez","orcid":"https://orcid.org/0000-0001-8586-282X","observed_orcids":["https://orcid.org/0000-0001-8586-282X"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Manuel Salto-Tellez","raw_affiliation_strings":["Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109387546","display_name":"Timothy S. Davison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy S. Davison","raw_affiliation_strings":["Almac Diagnostics, Craigavon, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics, Craigavon, Northern Ireland","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Patrick Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick Johnston","raw_affiliation_strings":["Centre for Cancer Research and Cell Biology, Queen's University of  Belfast, Belfast, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Research and Cell Biology, Queen's University of  Belfast, Belfast, Northern Ireland","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016908886","display_name":"Fergus J. Couch","orcid":"https://orcid.org/0000-0001-9417-9985","observed_orcids":["https://orcid.org/0000-0001-9417-9985"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fergus J. Couch","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103575071","display_name":"Denis Paul Harkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137931","display_name":"Almac (United Kingdom)","ror":"https://ror.org/03prym056","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210137931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Paul Harkin","raw_affiliation_strings":["Almac Diagnostics, Craigavon, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Diagnostics, Craigavon, Northern Ireland","institution_ids":["https://openalex.org/I4210137931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088266020","display_name":"Richard D. Kennedy","orcid":"https://orcid.org/0000-0003-4737-6163","observed_orcids":["https://orcid.org/0000-0003-4737-6163"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard D. Kennedy","raw_affiliation_strings":["Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland","institution_ids":["https://openalex.org/I126231945"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"15_suppl","first_page":"TPS11120","last_page":"TPS11120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.2628999948501587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-anemia-brca-pathway","display_name":"Fanconi anemia/BRCA pathway","score":0.9290000200271606},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/anthracycline-based-chemotherapy","display_name":"anthracycline chemotherapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8550000190734863},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8970000147819519},{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8399999737739563},{"id":"https://openalex.org/keywords/brca-mutations","display_name":"BRCA mutations","score":0.7699999809265137},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.9190000295639038},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.375}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7921930551528931},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.780139684677124},{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.7776387929916382},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.7025517821311951},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6745001673698425},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6682226061820984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6184327602386475},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.581169605255127},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5586392879486084},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46435546875},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4473492503166199},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4390738606452942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11842620372772217},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.08302134275436401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0623127818107605}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.15_suppl.tps11120","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.tps11120","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.tps11120","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097539177","https://openalex.org/W2225069272","https://openalex.org/W1973736220","https://openalex.org/W2944411768","https://openalex.org/W2315229232","https://openalex.org/W2158501247","https://openalex.org/W2406243607","https://openalex.org/W3208876955","https://openalex.org/W1989643385","https://openalex.org/W2246144684"],"abstract_inverted_index":{"TPS11120":[0],"Background:":[1],"Currently":[2],"there":[3],"is":[4],"no":[5],"biomarker":[6],"to":[7,40,48,70,154],"predict":[8],"specific":[9],"benefit":[10,60],"from":[11,61,130,174],"DNA-damaging":[12,41,156],"anthracycline":[13,159],"and":[14,36,91,96,160,189,244,252,262],"cyclophosphamide-based":[15],"chemotherapy":[16,157,258],"in":[17,30,38,137,222,259],"the":[18,22,52,56,78,106,112,138,150,193,238,260],"clinic.":[19,139],"Loss":[20],"of":[21,33,51,58,77,111,147,166,178,211,220,237,250],"Fanconi":[23],"anemia/BRCA":[24],"(FA/BRCA)":[25],"DNA-damage":[26],"response":[27,119,153,251],"pathway":[28,240],"occurs":[29],"approximately":[31],"25%":[32],"breast":[34,181],"cancer":[35,182],"results":[37],"sensitivity":[39],"agents.":[42],"We":[43,170],"therefore":[44],"developed":[45,124,243],"an":[46,163,175],"assay":[47,122,151,200,216,233],"detect":[49],"loss":[50,76,110,236],"FA/BRCA":[53,79,113,239],"pathway,":[54],"for":[55],"purpose":[57],"predicting":[59],"chemotherapy.":[62,228],"Methods:":[63],"21":[64],"FA":[65],"patient":[66],"samples":[67,95,136,173],"were":[68],"analyzed":[69],"identify":[71,127],"genetic":[72],"processes":[73,108],"associated":[74],"with":[75,162,185,207],"pathway.":[80,114],"Unsupervised":[81],"hierarchical":[82],"clustering":[83],"was":[84,100,103,123,217],"then":[85],"performed":[86],"using":[87],"60":[88],"BRCA1/2":[89],"mutant":[90],"47":[92],"sporadic":[93],"tumor":[94],"a":[97,142,208,248],"molecular":[98,107],"subgroup":[99,129],"identified":[101],"that":[102,125,234],"defined":[104],"by":[105],"representing":[109],"A":[115],"44-gene":[116],"DNA":[117,255],"Damage":[118],"deficient":[120],"(DDRD)":[121],"could":[126],"this":[128],"formalin":[131],"fixed,":[132],"paraffin":[133],"embedded":[134],"(FFPE)":[135],"Results:":[140],"In":[141],"publicly":[143],"available":[144],"independent":[145,176],"cohort":[146,177],"204":[148],"patients,":[149],"predicted":[152,202],"neoadjuvant":[155,261],"(5-fluorouracil,":[158],"cyclophosphamide)":[161],"odds":[164],"ratio":[165,210],"4.01,":[167],"(95%":[168,213],"Cl:1.69-9.54).":[169],"also":[171],"analysed":[172],"114":[179],"node-negative":[180],"patients":[183,223],"treated":[184],"adjuvant":[186,263],"5-fluorouracil,":[187],"epirubicin":[188],"cyclophosphamide":[190],"treatment":[191],"at":[192],"Northern":[194],"Ireland":[195],"Cancer":[196],"Centre.":[197],"The":[198,215],"DDRD":[199],"significantly":[201],"5-year":[203],"relapse":[204],"free":[205],"survival":[206,221],"hazard":[209],"0.27":[212],"Cl:0.10-0.83).":[214],"not":[218,226],"predictive":[219],"who":[224],"did":[225],"receive":[227],"Conclusions:":[229],"An":[230],"FFPE":[231],"tissue-based":[232],"detects":[235],"has":[241],"been":[242],"independently":[245],"validated":[246],"as":[247],"predictor":[249],"prognosis":[253],"following":[254],"damaging":[256],"anthracycline/cyclophosphamide-based":[257],"settings.":[264]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-04-07T00:00:00"}