{"id":"https://openalex.org/W2599499348","doi":null,"title":"The Dynamic Functions Of Bax Are Dependent On Key Structural And Regulatory Features","display_name":"The Dynamic Functions Of Bax Are Dependent On Key Structural And Regulatory Features","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2599499348","mag":"2599499348"},"language":"en","primary_location":{"id":"pmh:oai:stars.library.ucf.edu:etd-3291","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/2292","pdf_url":"https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=3291&context=etd","source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=3291&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069866985","display_name":"Rebecca J. Boohaker","orcid":"https://orcid.org/0000-0003-3387-1876","observed_orcids":["https://orcid.org/0000-0003-3387-1876"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rebecca J. Boohaker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3387-1876","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069866985"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.996999979019165},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6700000166893005},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cellular-respiration","display_name":"cellular respiration","score":0.7379999756813049},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.875},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.6779999732971191},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.718999981880188},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.574999988079071},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6579999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.335999995470047},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.699999988079071},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8259999752044678},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5069859027862549},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39289265871047974},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.1892164647579193}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:stars.library.ucf.edu:etd-3291","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/2292","pdf_url":"https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=3291&context=etd","source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},{"id":"mag:2599499348","doi":null,"is_oa":false,"landing_page_url":"https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=3291&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:stars.library.ucf.edu:etd-3291","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/2292","pdf_url":"https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=3291&context=etd","source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2599499348.pdf","grobid_xml":"https://content.openalex.org/works/W2599499348.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W42771847","https://openalex.org/W43675158","https://openalex.org/W80462140","https://openalex.org/W103053889","https://openalex.org/W1516954147","https://openalex.org/W1518293118","https://openalex.org/W1556295515","https://openalex.org/W1587050401","https://openalex.org/W1628370182","https://openalex.org/W1871308790","https://openalex.org/W1914973957","https://openalex.org/W1964483580","https://openalex.org/W1965392584","https://openalex.org/W1966078827","https://openalex.org/W1967701846","https://openalex.org/W1969439607","https://openalex.org/W1974034428","https://openalex.org/W1979354689","https://openalex.org/W1979995768","https://openalex.org/W1981021420","https://openalex.org/W1981961184","https://openalex.org/W1982628364","https://openalex.org/W1986053719","https://openalex.org/W1991303866","https://openalex.org/W1994611236","https://openalex.org/W1996271683","https://openalex.org/W1996554593","https://openalex.org/W1997608577","https://openalex.org/W1999317859","https://openalex.org/W2000289869","https://openalex.org/W2000894919","https://openalex.org/W2002321863","https://openalex.org/W2006864011","https://openalex.org/W2008597649","https://openalex.org/W2008845432","https://openalex.org/W2009183764","https://openalex.org/W2010069980","https://openalex.org/W2013319326","https://openalex.org/W2015805666","https://openalex.org/W2016363862","https://openalex.org/W2017675802","https://openalex.org/W2018439544","https://openalex.org/W2019262432","https://openalex.org/W2019843278","https://openalex.org/W2020911743","https://openalex.org/W2022821133","https://openalex.org/W2023671240","https://openalex.org/W2026873116","https://openalex.org/W2029667189","https://openalex.org/W2029744144","https://openalex.org/W2031213053","https://openalex.org/W2035266068","https://openalex.org/W2035687084","https://openalex.org/W2035736023","https://openalex.org/W2035768602","https://openalex.org/W2036274324","https://openalex.org/W2039108630","https://openalex.org/W2041592299","https://openalex.org/W2045838873","https://openalex.org/W2048582093","https://openalex.org/W2050477129","https://openalex.org/W2050668495","https://openalex.org/W2051136861","https://openalex.org/W2053534788","https://openalex.org/W2055063491","https://openalex.org/W2055923943","https://openalex.org/W2058593414","https://openalex.org/W2058608683","https://openalex.org/W2060039971","https://openalex.org/W2060079863","https://openalex.org/W2060785195","https://openalex.org/W2063154392","https://openalex.org/W2063250341","https://openalex.org/W2072451938","https://openalex.org/W2074077303","https://openalex.org/W2075983828","https://openalex.org/W2079781432","https://openalex.org/W2085006338","https://openalex.org/W2085419794","https://openalex.org/W2087591901","https://openalex.org/W2089605437","https://openalex.org/W2090632954","https://openalex.org/W2094924288","https://openalex.org/W2100304097","https://openalex.org/W2100621506","https://openalex.org/W2113278680","https://openalex.org/W2114974112","https://openalex.org/W2122662656","https://openalex.org/W2123243663","https://openalex.org/W2124221273","https://openalex.org/W2127036976","https://openalex.org/W2128347259","https://openalex.org/W2130714435","https://openalex.org/W2131189574","https://openalex.org/W2131785128","https://openalex.org/W2132055326","https://openalex.org/W2133475822","https://openalex.org/W2134979684","https://openalex.org/W2136073669","https://openalex.org/W2139487648","https://openalex.org/W2150419930","https://openalex.org/W2150680216","https://openalex.org/W2156826654","https://openalex.org/W2161605421","https://openalex.org/W2162378963","https://openalex.org/W2164323481","https://openalex.org/W2165250332","https://openalex.org/W2168587151","https://openalex.org/W2244063038","https://openalex.org/W2329173481","https://openalex.org/W2340836552","https://openalex.org/W2395167541","https://openalex.org/W2464112720"],"related_works":["https://openalex.org/W1997608577","https://openalex.org/W2980871781","https://openalex.org/W2040408804","https://openalex.org/W4234113515","https://openalex.org/W2171462241","https://openalex.org/W1974034428","https://openalex.org/W2140372706","https://openalex.org/W2164323481","https://openalex.org/W2098210382","https://openalex.org/W4388966433"],"abstract_inverted_index":{"Bax":[0,69,80,96,109,131,142,144,163,199,228,409,439,540],"is":[1,200,354,362,416,428,541],"an":[2,191,241,255,544],"essential":[3],"mediator":[4],"of":[5,79,125,135,162,172,182,202,207,212,218,227,271,282,286,292,309,405,408,423,438,451,455,478,490,495,546],"cell":[6,283,338,547],"fate.":[7],"Since":[8],"its":[9,27,168,358],"discovery":[10],"in":[11,43,66,84,95,113,130,143,174,178,299,315,321,381,388,396,448,481],"1985":[12],"as":[13,48,50,460,462,464],"a":[14,111,179,213,279,324,370,469,501],"protein":[15,366,512],"that":[16,106,158,252,374,410,487,539],"interacts":[17],"with":[18,244,349],"the":[19,64,77,114,196,216,222,237,265,272,307,344,364,406,421,435,444,449,452,476,488,491,506,511,530],"anti-apoptotic":[20],"protein,":[21,507],"Bcl-2,":[22],"key":[23],"elements":[24],"related":[25],"to":[26,33,116,221,296,391,418,429,433,474,516,554],"function,":[28],"structure":[29,437],"and":[30,59,68,89,150,153,250,258,277,303,311,317,367,384,440,519],"regulation":[31],"remains":[32,229],"be":[34,297,369,379,555],"determined.":[35,556],"To":[36,231],"this":[37,159,536],"end,":[38],"mitochondrial":[39,57,60,85,333],"metabolism":[40],"was":[41,63,101,164,275],"examined":[42],"non-apoptotic":[44,189,225],"Bax-deficient":[45,54],"HCT-116":[46],"cells":[47,107,146,176,314],"well":[49,463],"primary":[51],"hepatocytes":[52],"from":[53,514],"mice.":[55],"Although":[56],"density":[58],"DNA":[61],"content":[62],"same":[65],"Bax-containing":[67,175],"-deficient":[70,97,132,145],"cells,":[71,98],"MitoTracker":[72],"staining":[73],"patterns":[74],"differed,":[75],"suggesting":[76,157],"existence":[78],"-dependent":[81],"functional":[82],"differences":[83],"physiology.":[86],"Oxygen":[87],"consumption":[88,152],"cellular":[90,120],"ATP":[91,118,148,183],"levels":[92],"were":[93,411],"reduced":[94,126,154],"while":[99,352],"glycolysis":[100],"increased.":[102],"These":[103],"results":[104],"suggest":[105],"lacking":[108],"have":[110,210],"deficiency":[112],"ability":[115],"generate":[117],"through":[119],"respiration,":[121],"supported":[122],"by":[123,337,472],"detection":[124],"citrate":[127],"synthase":[128],"activity":[129,361,450],"cells.":[133,398],"Expression":[134,171],"either":[136],"full":[137],"length":[138],"or":[139,224],"C-terminal":[140,169,238,492],"truncated":[141],"rescued":[147],"synthesis":[149],"oxygen":[151],"glycolytic":[155],"activity,":[156],"metabolic":[160],"function":[161],"not":[165],"dependent":[166],"upon":[167],"helix.":[170],"BCL-2":[173],"resulted":[177],"subsequent":[180],"loss":[181],"measured,":[184],"implying":[185],"that,":[186],"even":[187],"under":[188],"conditions,":[190],"antagonistic":[192],"interaction":[193],"exists":[194],"between":[195],"two":[197],"proteins.":[198],"composed":[201],"nine":[203],"alpha-helices.":[204],"While":[205,399],"three":[206],"these":[208,304],"helices":[209],"features":[211],"trans-membrane":[214],"region,":[215],"contribution":[217],"each":[219],"domain":[220,243],"apoptotic":[223,288],"functions":[226],"unknown.":[230],"examine":[232],"this,":[233],"we":[234],"focused":[235],"on":[236,264,356],"alpha-9":[239,273,493],"helix,":[240],"amphipathic":[242],"putative":[245],"membrane":[246,334,341,346],"binding":[247],"iv":[248],"properties":[249],"discovered":[251],"it":[253,295],"has":[254,385,550],"inherent":[256],"membrane-binding":[257],"cytotoxic":[259,360],"capacity.":[260],"A":[261],"peptide":[262],"based":[263,355],"last":[266],"twenty":[267],"amino":[268],"acids":[269],"(CT20p)":[270],"helix":[274,494,532],"synthesized":[276],"proved":[278],"potent":[280],"inducer":[281,545],"death":[284,308,339,394,548],"independent":[285],"any":[287],"stimuli.":[289],"The":[290],"solubility":[291],"CT20p":[293,330,353],"allowed":[294],"encapsulated":[298,380],"polymeric":[300],"nanoparticles":[301,383],"(NPs),":[302],"CT20p-NPs":[305],"caused":[306,331],"colon":[310],"breast":[312,326],"cancer":[313,327,397],"vitro":[316],"induced":[318],"tumor":[319,328],"regression":[320],"vivo,":[322],"using":[323],"murine":[325],"model.":[329],"increased":[332],"potential":[335,386],"followed":[336],"via":[340,524],"rupture,":[342],"without":[343],"characteristic":[345],"asymmetry":[347],"associated":[348],"apoptosis.":[350],"Hence,":[351],"Bax,":[357,496],"innate":[359],"unlike":[363],"parent":[365],"could":[368],"powerful":[371,470],"anti-cancer":[372],"agent":[373],"bypasses":[375],"drug":[376],"resistance,":[377],"can":[378],"tumor-targeted":[382],"application":[387],"combination":[389],"therapies":[390],"activate":[392],"multiple":[393],"pathways":[395],"previous":[400],"work":[401,485,537],"revealed":[402,486],"novel":[403],"aspects":[404],"biology":[407],"unrecognized,":[412],"new":[413],"structural":[414,445],"information":[415],"needed":[417],"fully":[419],"elucidate":[420],"complexity":[422],"Bax\u2019s":[424],"function.":[425],"One":[426],"approach":[427],"use":[430],"computational":[431,466],"modeling":[432],"assess":[434],"solved":[436],"provide":[441],"insight":[442],"into":[443],"components":[446],"involved":[447],"protein.":[453],"Use":[454],"molecular":[456],"dynamics":[457],"simulators":[458],"such":[459],"GROMACS,":[461],"other":[465],"tools":[467],"provides":[468],"means":[471],"which":[473,497],"test":[475],"feasibility":[477],"certain":[479],"modifications":[480],"defined":[482],"parameters.":[483],"Such":[484],"removal":[489],"normally":[498],"resides":[499],"within":[500],"hydrophobic":[502],"pocket,":[503],"significantly":[504],"destabilized":[505],"perhaps":[508],"explaining":[509],"how":[510,529],"transitions":[513],"soluble":[515],"membrane-bound":[517],"form":[518],"maintain":[520],"energy":[521],"v":[522],"production":[523],"aerobic":[525],"respiration":[526],"or,":[527],"conversely,":[528],"C-terminus":[531],"conveys":[533],"cytotoxicity.":[534],"Collectively,":[535],"reveals":[538],"more":[542],"than":[543],"but":[549],"complex":[551],"activities":[552],"yet":[553]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-04-07T00:00:00"}