{"id":"https://openalex.org/W2599262829","doi":null,"title":"Effects of Polycyclic Aromatic Hydrocarbons, Metals and Polycyclic Aromatic Hydrocarbon/Metal Mixtures on Rat Corpus Luteal Cells and Placental Cell Line, JEG-3","display_name":"Effects of Polycyclic Aromatic Hydrocarbons, Metals and Polycyclic Aromatic Hydrocarbon/Metal Mixtures on Rat Corpus Luteal Cells and Placental Cell Line, JEG-3","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2599262829","mag":"2599262829"},"language":"en","primary_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/3390","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/3390","pdf_url":"http://hdl.handle.net/10012/3390","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10012/3390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065481633","display_name":"Julie Ann Nykamp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julie Ann Nykamp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065481633"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.20810000598430634,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxygenated-pahs","display_name":"oxygenated PAHs","score":0.7409999966621399},{"id":"https://openalex.org/keywords/9-10-phenanthrenequinone","display_name":"9,10-phenanthrenequinone","score":0.9319999814033508},{"id":"https://openalex.org/keywords/metal-co-contamination","display_name":"metal co-contamination","score":0.652999997138977},{"id":"https://openalex.org/keywords/mercury","display_name":"mercury","score":0.734000027179718},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9539999961853027},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.6880000233650208},{"id":"https://openalex.org/keywords/nickel","display_name":"nickel","score":0.8169999718666077},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9049999713897705},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9070000052452087},{"id":"https://openalex.org/keywords/jeg-3-cells","display_name":"JEG-3 cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/progesterone-synthesis","display_name":"progesterone secretion","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lh-stimulation","display_name":"LH stimulation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8640000224113464},{"id":"https://openalex.org/keywords/membrane-integrity","display_name":"membrane integrity","score":0.8830000162124634},{"id":"https://openalex.org/keywords/metabolic-activity","display_name":"metabolic activity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/biotic-ligand-model","display_name":"biotic ligand model","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2779033964","wikidata":"https://www.wikidata.org/wiki/Q407212","display_name":"Polycyclic aromatic hydrocarbon","level":2,"score":0.8216350078582764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5514760613441467},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.550836980342865},{"id":"https://openalex.org/C2777207669","wikidata":"https://www.wikidata.org/wiki/Q43648","display_name":"Hydrocarbon","level":2,"score":0.5147719383239746},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.4183559715747833},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22919690608978271}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/3390","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/3390","pdf_url":"http://hdl.handle.net/10012/3390","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},{"id":"mag:2599262829","doi":null,"is_oa":false,"landing_page_url":"https://uwspace.uwaterloo.ca/handle/10012/3390","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/3390","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/3390","pdf_url":"http://hdl.handle.net/10012/3390","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2599262829.pdf","grobid_xml":"https://content.openalex.org/works/W2599262829.grobid-xml"},"referenced_works_count":378,"referenced_works":["https://openalex.org/W15909306","https://openalex.org/W54608552","https://openalex.org/W67988900","https://openalex.org/W198065351","https://openalex.org/W217158524","https://openalex.org/W574632868","https://openalex.org/W896176044","https://openalex.org/W1488035356","https://openalex.org/W1495032438","https://openalex.org/W1525236685","https://openalex.org/W1526320464","https://openalex.org/W1542603018","https://openalex.org/W1546537221","https://openalex.org/W1550604239","https://openalex.org/W1551058707","https://openalex.org/W1552368341","https://openalex.org/W1554683290","https://openalex.org/W1570572659","https://openalex.org/W1595502468","https://openalex.org/W1672896294","https://openalex.org/W1855309623","https://openalex.org/W1867124507","https://openalex.org/W1876993892","https://openalex.org/W1896820448","https://openalex.org/W1908586502","https://openalex.org/W1922443931","https://openalex.org/W1958574545","https://openalex.org/W1964400951","https://openalex.org/W1965139535","https://openalex.org/W1965205115","https://openalex.org/W1965575986","https://openalex.org/W1965817517","https://openalex.org/W1966699296","https://openalex.org/W1967184405","https://openalex.org/W1967427213","https://openalex.org/W1967495709","https://openalex.org/W1967921288","https://openalex.org/W1968577485","https://openalex.org/W1968624316","https://openalex.org/W1969175677","https://openalex.org/W1969877792","https://openalex.org/W1970222071","https://openalex.org/W1970507028","https://openalex.org/W1970695981","https://openalex.org/W1970701286","https://openalex.org/W1970723200","https://openalex.org/W1972692298","https://openalex.org/W1974410673","https://openalex.org/W1975023855","https://openalex.org/W1975237339","https://openalex.org/W1975282457","https://openalex.org/W1976308669","https://openalex.org/W1976347620","https://openalex.org/W1976416147","https://openalex.org/W1976935051","https://openalex.org/W1977819021","https://openalex.org/W1978368163","https://openalex.org/W1978785653","https://openalex.org/W1980144224","https://openalex.org/W1980149512","https://openalex.org/W1981763058","https://openalex.org/W1982788047","https://openalex.org/W1983365254","https://openalex.org/W1983445383","https://openalex.org/W1983577269","https://openalex.org/W1983583030","https://openalex.org/W1984065308","https://openalex.org/W1984953670","https://openalex.org/W1986075945","https://openalex.org/W1986170848","https://openalex.org/W1986906463","https://openalex.org/W1987480766","https://openalex.org/W1987481333","https://openalex.org/W1987814107","https://openalex.org/W1987842531","https://openalex.org/W1988193262","https://openalex.org/W1988657514","https://openalex.org/W1988713440","https://openalex.org/W1990757599","https://openalex.org/W1991273560","https://openalex.org/W1991312422","https://openalex.org/W1991402805","https://openalex.org/W1992415335","https://openalex.org/W1992502261","https://openalex.org/W1993218028","https://openalex.org/W1993279572","https://openalex.org/W1993473210","https://openalex.org/W1994057070","https://openalex.org/W1995660669","https://openalex.org/W1996706809","https://openalex.org/W1997044988","https://openalex.org/W1997308064","https://openalex.org/W1997763620","https://openalex.org/W1997976703","https://openalex.org/W1998460663","https://openalex.org/W1999217401","https://openalex.org/W1999417857","https://openalex.org/W1999419061","https://openalex.org/W1999716098","https://openalex.org/W2001465433","https://openalex.org/W2002386517","https://openalex.org/W2003413174","https://openalex.org/W2004031738","https://openalex.org/W2004266212","https://openalex.org/W2005226698","https://openalex.org/W2006255055","https://openalex.org/W2006431779","https://openalex.org/W2006728665","https://openalex.org/W2007129212","https://openalex.org/W2008198395","https://openalex.org/W2010094123","https://openalex.org/W2010437988","https://openalex.org/W2011085435","https://openalex.org/W2011284056","https://openalex.org/W2011606516","https://openalex.org/W2012018827","https://openalex.org/W2012108207","https://openalex.org/W2012557536","https://openalex.org/W2012587757","https://openalex.org/W2012983503","https://openalex.org/W2014523058","https://openalex.org/W2014682090","https://openalex.org/W2014791202","https://openalex.org/W2014837680","https://openalex.org/W2015398376","https://openalex.org/W2015982086","https://openalex.org/W2016332747","https://openalex.org/W2016341678","https://openalex.org/W2017093116","https://openalex.org/W2017555211","https://openalex.org/W2017715427","https://openalex.org/W2017780934","https://openalex.org/W2017808300","https://openalex.org/W2018526118","https://openalex.org/W2019065245","https://openalex.org/W2020077166","https://openalex.org/W2020226114","https://openalex.org/W2020263041","https://openalex.org/W2020443564","https://openalex.org/W2020820653","https://openalex.org/W2023300047","https://openalex.org/W2024050037","https://openalex.org/W2024136927","https://openalex.org/W2025532522","https://openalex.org/W2025796457","https://openalex.org/W2026302267","https://openalex.org/W2026576808","https://openalex.org/W2027276053","https://openalex.org/W2027736004","https://openalex.org/W2028506074","https://openalex.org/W2029082288","https://openalex.org/W2029225755","https://openalex.org/W2029525590","https://openalex.org/W2029994257","https://openalex.org/W2031302504","https://openalex.org/W2032194748","https://openalex.org/W2032615313","https://openalex.org/W2032793821","https://openalex.org/W2033085616","https://openalex.org/W2033296044","https://openalex.org/W2034040852","https://openalex.org/W2034328371","https://openalex.org/W2034597881","https://openalex.org/W2035585204","https://openalex.org/W2036495761","https://openalex.org/W2036839645","https://openalex.org/W2037382710","https://openalex.org/W2037541581","https://openalex.org/W2037809316","https://openalex.org/W2038345750","https://openalex.org/W2038690423","https://openalex.org/W2038778551","https://openalex.org/W2038909854","https://openalex.org/W2040650056","https://openalex.org/W2040914101","https://openalex.org/W2043475823","https://openalex.org/W2043549608","https://openalex.org/W2044112975","https://openalex.org/W2044136163","https://openalex.org/W2044353176","https://openalex.org/W2044774901","https://openalex.org/W2044899507","https://openalex.org/W2044939514","https://openalex.org/W2045020165","https://openalex.org/W2045169475","https://openalex.org/W2045252266","https://openalex.org/W2045414486","https://openalex.org/W2045549483","https://openalex.org/W2045621472","https://openalex.org/W2046638467","https://openalex.org/W2047083811","https://openalex.org/W2047558574","https://openalex.org/W2047687549","https://openalex.org/W2048649932","https://openalex.org/W2048923023","https://openalex.org/W2049084155","https://openalex.org/W2050189770","https://openalex.org/W2050610995","https://openalex.org/W2050767860","https://openalex.org/W2051617705","https://openalex.org/W2052147623","https://openalex.org/W2052751122","https://openalex.org/W2053032644","https://openalex.org/W2053927934","https://openalex.org/W2054364786","https://openalex.org/W2054545372","https://openalex.org/W2054577044","https://openalex.org/W2057095899","https://openalex.org/W2057366309","https://openalex.org/W2057605282","https://openalex.org/W2058521416","https://openalex.org/W2060040712","https://openalex.org/W2061819574","https://openalex.org/W2061950383","https://openalex.org/W2062116068","https://openalex.org/W2062199032","https://openalex.org/W2062531915","https://openalex.org/W2062834865","https://openalex.org/W2063108561","https://openalex.org/W2063766586","https://openalex.org/W2063846535","https://openalex.org/W2064707684","https://openalex.org/W2065210744","https://openalex.org/W2067204762","https://openalex.org/W2067299698","https://openalex.org/W2067693504","https://openalex.org/W2069352109","https://openalex.org/W2069413351","https://openalex.org/W2069513152","https://openalex.org/W2071245122","https://openalex.org/W2072428298","https://openalex.org/W2072550971","https://openalex.org/W2073496517","https://openalex.org/W2073625728","https://openalex.org/W2074276424","https://openalex.org/W2074372134","https://openalex.org/W2074655523","https://openalex.org/W2074723821","https://openalex.org/W2074964502","https://openalex.org/W2075751493","https://openalex.org/W2076184158","https://openalex.org/W2076945242","https://openalex.org/W2077743415","https://openalex.org/W2078194160","https://openalex.org/W2078442772","https://openalex.org/W2078878879","https://openalex.org/W2079282623","https://openalex.org/W2079428859","https://openalex.org/W2079547148","https://openalex.org/W2079691945","https://openalex.org/W2079833868","https://openalex.org/W2079930867","https://openalex.org/W2079975801","https://openalex.org/W2080823735","https://openalex.org/W2081337319","https://openalex.org/W2081745487","https://openalex.org/W2082189835","https://openalex.org/W2083301613","https://openalex.org/W2084735151","https://openalex.org/W2085503509","https://openalex.org/W2085572387","https://openalex.org/W2086034235","https://openalex.org/W2089245773","https://openalex.org/W2089483136","https://openalex.org/W2089616792","https://openalex.org/W2089837853","https://openalex.org/W2090252458","https://openalex.org/W2090990681","https://openalex.org/W2091337015","https://openalex.org/W2092071477","https://openalex.org/W2092085709","https://openalex.org/W2092273192","https://openalex.org/W2092535926","https://openalex.org/W2092605227","https://openalex.org/W2092959030","https://openalex.org/W2093010210","https://openalex.org/W2094259718","https://openalex.org/W2094952821","https://openalex.org/W2095454851","https://openalex.org/W2096227359","https://openalex.org/W2096693727","https://openalex.org/W2097045992","https://openalex.org/W2097620122","https://openalex.org/W2097775321","https://openalex.org/W2099617073","https://openalex.org/W2099750936","https://openalex.org/W2100617131","https://openalex.org/W2101477213","https://openalex.org/W2101650864","https://openalex.org/W2102319964","https://openalex.org/W2102324667","https://openalex.org/W2104088220","https://openalex.org/W2105932182","https://openalex.org/W2111542946","https://openalex.org/W2114710924","https://openalex.org/W2114911435","https://openalex.org/W2115162201","https://openalex.org/W2115255735","https://openalex.org/W2115888129","https://openalex.org/W2118450434","https://openalex.org/W2118646067","https://openalex.org/W2118718951","https://openalex.org/W2118932410","https://openalex.org/W2119685625","https://openalex.org/W2120593960","https://openalex.org/W2121646452","https://openalex.org/W2121697486","https://openalex.org/W2122031662","https://openalex.org/W2122412289","https://openalex.org/W2122887522","https://openalex.org/W2123273404","https://openalex.org/W2123739878","https://openalex.org/W2124629939","https://openalex.org/W2126214612","https://openalex.org/W2127697202","https://openalex.org/W2127754721","https://openalex.org/W2129091668","https://openalex.org/W2130125915","https://openalex.org/W2131482708","https://openalex.org/W2131520908","https://openalex.org/W2131671483","https://openalex.org/W2132949900","https://openalex.org/W2134136300","https://openalex.org/W2134817040","https://openalex.org/W2135903629","https://openalex.org/W2136704539","https://openalex.org/W2137367185","https://openalex.org/W2138016026","https://openalex.org/W2138901393","https://openalex.org/W2139305993","https://openalex.org/W2139328007","https://openalex.org/W2140272554","https://openalex.org/W2140968862","https://openalex.org/W2141955100","https://openalex.org/W2142273232","https://openalex.org/W2142284699","https://openalex.org/W2143504734","https://openalex.org/W2144634347","https://openalex.org/W2147279428","https://openalex.org/W2147322409","https://openalex.org/W2147491228","https://openalex.org/W2147993424","https://openalex.org/W2149719174","https://openalex.org/W2150311131","https://openalex.org/W2151634687","https://openalex.org/W2152629654","https://openalex.org/W2152920631","https://openalex.org/W2153051064","https://openalex.org/W2154385453","https://openalex.org/W2154835083","https://openalex.org/W2154876851","https://openalex.org/W2155598851","https://openalex.org/W2157811049","https://openalex.org/W2158379438","https://openalex.org/W2158714788","https://openalex.org/W2159127121","https://openalex.org/W2159403020","https://openalex.org/W2163187840","https://openalex.org/W2163300496","https://openalex.org/W2164943060","https://openalex.org/W2165139205","https://openalex.org/W2166005059","https://openalex.org/W2166469094","https://openalex.org/W2167386768","https://openalex.org/W2167689499","https://openalex.org/W2168283268","https://openalex.org/W2168899269","https://openalex.org/W2170327826","https://openalex.org/W2170415938","https://openalex.org/W2174898918","https://openalex.org/W2177511165","https://openalex.org/W2182396866","https://openalex.org/W2256057330","https://openalex.org/W2468038875","https://openalex.org/W2487384206","https://openalex.org/W2573551505","https://openalex.org/W2769263730","https://openalex.org/W4252432538"],"related_works":["https://openalex.org/W2568613940","https://openalex.org/W2738537890","https://openalex.org/W2968119090","https://openalex.org/W2152468739","https://openalex.org/W3108530761","https://openalex.org/W3216431229","https://openalex.org/W2009651637","https://openalex.org/W2923420926","https://openalex.org/W2783181211","https://openalex.org/W2744407350"],"abstract_inverted_index":{"Polycyclic":[0],"aromatic":[1],"hydrocarbons":[2],"(PAHs)":[3],"are":[4,51,63,78],"ubiquitous":[5],"environmental":[6],"contaminants":[7],"that":[8,21,115,177,510],"can":[9,34],"be":[10,25,35,627],"modified":[11,785],"to":[12,24,37,80,143,210,219,308,368,393,452,470,491,556,611,626,716,720,783],"oxygenated":[13],"PAH":[14],"(oxyPAHs)":[15],"derivatives.":[16],"It":[17],"is":[18,98],"well":[19],"known":[20,99],"oxyPAHs":[22,704],"tend":[23],"much":[26],"more":[27,234,706],"reactive":[28,46],"than":[29,239,708,719],"their":[30,101,150,208,342,417,709,792],"parent":[31,151,710],"compounds.":[32,711],"Toxicity":[33],"attributed":[36],"direct":[38],"interaction":[39],"with":[40,200,331,338,387,449,507,516,524,550,579,629],"target":[41],"molecules":[42],"or":[43,104,155,334,385,389,409],"generation":[44,735],"of":[45,54,106,237,244,312,328,361,383,405,456,460,476,489,534,538,547,553,562,574,582,615,757,765,776],"oxygen":[47],"species":[48],"(ROS).":[49],"Metals":[50,712],"another":[52],"class":[53],"contaminant":[55],"found":[56],"ubiquitously":[57],"throughout":[58],"the":[59,68,73,195,310,454,464,474,487,551,569,580,583,597,613,724,737,763,774,781],"environment.":[60],"Some":[61],"metals":[62,87,204,247,313,787],"toxic":[64,707],"at":[65],"levels":[66],"below":[67],"1:1":[69],"ratio":[70],"predicted":[71],"by":[72,167],"biotic":[74],"ligand":[75],"model":[76],"and":[77,88,145,169,213,225,264,279,295,301,314,320,341,347,363,372,396,407,423,435,486,527,591,666,698,729,788],"thought":[79],"manifest":[81],"toxicity":[82,209,238,245,367,715],"through":[83],"ROS":[84,186,318,424,436,734],"generation.":[85],"Often":[86],"PAHs":[89,315],"occur":[90],"as":[91],"co-contaminants":[92],"in":[93,108,125,139,162,187,248,283,324,377,399,413,430,473,495,499,568,671,750,767],"industrialized":[94],"environments,":[95],"yet":[96],"little":[97],"about":[100],"potential":[102,560,793],"co-toxicity":[103],"mechanisms":[105],"action":[107,457],"mammalian":[109],"reproductive":[110,752,797],"function.":[111],"\\nPreviously,":[112],"we":[113],"described":[114],"a":[116,233,496,520,607,659,759,770],"PAH,":[117],"9,":[118],"10-phenanthrenequinone":[119],"(PHEQ),":[120],"inhibited":[121,166,515],"LH-stimulated":[122,159,321,420,432],"progesterone":[123,160,322,421,433,500,512,548],"secretion":[124,422,434,513,549],"dispersed":[126],"rat":[127],"corpus":[128],"luteal":[129],"(CL)":[130],"cells":[131,141,164,250,340,379,401,415,472,493,673],"(Nykamp":[132],"et":[133],"al.,":[134],"2001).":[135],"Viability":[136,190],"was":[137,165,232,251,288,514,529,606,736],"decreased":[138],"CL":[140,163,188,212,249,325,339,400,414,471,492],"exposed":[142],"PHEQ":[144,168,333,364,388,408,517,528,557,616,630,675,728],"1,2-dihydroxy-anthraquinone":[146],"(1,2-dhATQ),":[147],"but":[148,171,179],"not":[149,172,180,530,542],"compounds":[152],"phenanthrene":[153],"(PHE)":[154],"anthracene":[156],"(ANT).":[157],"Similarly,":[158],"production":[161,323,437,501,756],"1,2-dhATQ,":[170],"PHE.":[173],"Further":[174],"investigation":[175],"revealed":[176],"PHEQ,":[178],"PHE,":[181],"ANT":[182],"nor":[183],"1,2-dhATQ":[184,335,410],"generated":[185],"cells.":[189,215,285,326],"experiments":[191],"were":[192,205,222,281,298,306,336,402,411,428,447,632,705],"repeated":[193],"using":[194],"choriocarcinoma":[196],"cell":[197,702,744],"line":[198],"JEG-3":[199,214,284,378,618,672],"similar":[201],"results.":[202],"\\nVarious":[203],"assessed":[206],"for":[207,246,261,274,291,416,438,444,458,762,773,791],"both":[211,369,431,445,525,701],"The":[216,242,532,559,621,754],"endpoints":[217],"used":[218,380,746],"measure":[220],"viability":[221],"metabolic":[223,230,262,293,345,370,394,717],"activity":[224,231,263,294,346,371,395,718],"membrane":[226,240,275,296,348,373,397,721],"integrity.":[227,241,276,374,722],"In":[228],"general,":[229],"sensitive":[235],"indicator":[236],"order":[243],"Hg2+":[252,265,278,292,386],">":[253,255,257,259,268,270,272],"Cd2+":[254,269],"Zn2+":[256,267],"Ni2+":[258,273],"Cu2+":[260,271,280,287,362,384,406,526,730],"\u2248":[266],"Only":[277],"tested":[282,412],"While":[286],"non-toxic,":[289],"EC50s":[290],"integrity":[297,349,398],"20":[299],"mM":[300],"23":[302],"mM,":[303],"respectively.":[304],"\\nExperiments":[305],"designed":[307],"study":[309,784],"mixtures":[311,354,360,440,459,790],"on":[316,344,419,617,795],"viability,":[317],"production,":[319],"Mixtures":[327,404],"each":[329],"metal":[330],"either":[332],"incubated":[337],"effect":[343,418,614],"assessed.":[350],"Generally,":[351],"most":[352,598],"metal/oxyPAH":[353,789],"displayed":[355],"only":[356,381,727],"additive":[357],"toxicity.":[358,733,742,777],"However,":[359],"showed":[365,713],"synergistic":[366,442,732],"Mixture":[375],"studies":[376],"combinations":[382,725],"1,2-dhATQ.":[390],"Similar":[391],"results":[392,779],"observed.":[403,531],"production.":[425],"Additive":[426],"effects":[427,443],"observed":[429],"Cu2+/1,2-dhATQ":[439],"while":[441,511],"parameters":[446],"seen":[448],"Cu2+/PHEQ.":[450],"\\nEfforts":[451],"determine":[453,612],"site":[455],"Cu2+/PHEQ":[461,554,563],"involved":[462],"adding":[463],"cholesterol":[465,468],"analogue,":[466],"22-OH":[467],"(22-OHC)":[469],"absence":[475],"LH.":[477,504],"Cytochrome":[478],"P450":[479,586],"side-chain":[480],"cleavage":[481,589],"(CYP450scc)":[482],"enzyme":[483,590],"operates":[484],"constitutively":[485],"addition":[488,518,552],"22-OHC":[490,508],"resulting":[494],"5-fold":[497],"increase":[498],"without":[502],"added":[503],"Kinetic":[505],"assays":[506],"show":[509,543],"alone,":[519],"further":[521],"significant":[522,545],"reduction":[523],"use":[533],"forskolin,":[535],"an":[536],"activator":[537],"adenylate":[539],"cyclase,":[540],"did":[541],"any":[544,566],"enhancement":[546],"compared":[555],"alone.":[558],"targets":[561],"mixture":[564],"include":[565],"step":[567],"steroidogenic":[570,592],"cascade":[571],"from":[572],"activation":[573],"protein":[575],"kinase":[576],"A":[577],"onward":[578],"proteins":[581],"mitochondria,":[584],"cytochrome":[585],"side":[587],"chain":[588,603],"acute":[593],"regulatory":[594],"protein,":[595,652],"being":[596],"likely.":[599],"\\nDifferential":[600],"display":[601],"polymerase":[602,679],"reaction":[604],"(ddPCR)":[605],"molecular":[608],"approach":[609],"taken":[610],"gene":[619],"expression.":[620],"genes":[622,670],"whose":[623],"expression":[624],"appeared":[625],"up-regulated":[628],"exposure":[631,676],"serine":[633],"protease":[634],"inhibitor,":[635],"Alu":[636],"repeat":[637],"sequence,":[638],"heterogeneous":[639,686],"ribonuclear":[640,687],"ribonucleoprotein":[641,688],"C":[642,689],"(hnRNP":[643,690],"C),":[644,691],"eukaryotic":[645,653,692],"translation":[646,654,693],"initiation":[647,694],"factor":[648,656,695],"3":[649],"(eIF3),":[650],"nucleoporin-like":[651],"elongation":[655],"1a1":[657],"(eEF1":[658],"1),":[660],"autophagy-linked":[661],"FYVE":[662],"domain":[663],"(Alfy),":[664],"spectrin,":[665],"proteasome.":[667],"Apparent":[668],"down-regulated":[669],"after":[674],"included":[677],"poly(ADP-ribose)":[678],"10":[680],"(PARP10),":[681],"polyglutamine":[682],"binding":[683],"protein-1":[684],"(PQBP-1),":[685],"5A":[696],"(eIF5A),":[697],"keratin.":[699],"\\nIn":[700],"types,":[703],"greater":[714],"Of":[723],"tested,":[726],"exhibited":[731],"likely":[738],"mechanism":[739],"behind":[740],"PHEQ/Cu2+":[741],"Both":[743],"types":[745],"represent":[747],"critical":[748,760],"roles":[749],"human":[751,796],"health.":[753,798],"proper":[755],"progesterone,":[758],"hormone":[761],"maintenance":[764],"pregnancy":[766],"mammals,":[768],"represents":[769],"unique":[771],"endpoint":[772],"assessment":[775],"These":[778],"illustrate":[780],"need":[782],"oxyPAHs,":[786],"impact":[794]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-04-07T00:00:00"}
