{"id":"https://openalex.org/W2598677342","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15145","title":"HER2 expression and response to neoadjuvant chemoradiotherapy in esophagogastric adenocarcinoma.","display_name":"HER2 expression and response to neoadjuvant chemoradiotherapy in esophagogastric adenocarcinoma.","publication_year":2013,"publication_date":"2013-05-20","ids":{"openalex":"https://openalex.org/W2598677342","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15145","mag":"2598677342"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.15_suppl.e15145","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15145","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15145","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112062560","display_name":"Lizette Vila Duckworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lizette Vila Duckworth","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ellie Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellie Chan","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083228573","display_name":"Ahmad Alkhasawneh","orcid":"https://orcid.org/0000-0002-1343-2035","observed_orcids":["https://orcid.org/0000-0002-1343-2035"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad Alkhasawneh","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054434791","display_name":"Tania Zuluaga Toro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tania Zuluaga-Toro","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101967569","display_name":"Xiaomin Lu","orcid":"https://orcid.org/0000-0001-6798-2668","observed_orcids":["https://orcid.org/0000-0001-6798-2668"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaomin Lu","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032632922","display_name":"Steven J. Hughes","orcid":"https://orcid.org/0000-0002-5688-6942","observed_orcids":["https://orcid.org/0000-0002-5688-6942","https://orcid.org/0000-0001-5637-1669"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Hughes","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020154592","display_name":"Thomas J. George","orcid":"https://orcid.org/0000-0002-6249-9180","observed_orcids":["https://orcid.org/0000-0002-6249-9180"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. George","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"15_suppl","first_page":"e15145","last_page":"e15145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.24979999661445618,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.9589999914169312},{"id":"https://openalex.org/keywords/esophagogastric-adenocarcinoma","display_name":"esophagogastric adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.8259999752044678},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5730000138282776},{"id":"https://openalex.org/keywords/esophagectomy","display_name":"esophagectomy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-response-prediction","display_name":"tumor response prediction","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9071117639541626},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.6484510898590088},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6298646330833435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6284904479980469},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.606839120388031},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5941511392593384},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.5331600904464722},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.49756529927253723},{"id":"https://openalex.org/C2777297899","wikidata":"https://www.wikidata.org/wiki/Q298191","display_name":"Esophagectomy","level":4,"score":0.49640733003616333},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.48209884762763977},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.4799083173274994},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3521384596824646},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.3026617467403412},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2976987957954407},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2959752082824707},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.18242153525352478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.15_suppl.e15145","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15145","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.e15145","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2209957364","https://openalex.org/W2136373821","https://openalex.org/W2593671610","https://openalex.org/W2118346118","https://openalex.org/W2972470166","https://openalex.org/W7142265281","https://openalex.org/W2588423206","https://openalex.org/W2769255961","https://openalex.org/W3124578085","https://openalex.org/W2594444174"],"abstract_inverted_index":{"e15145":[0],"Background:":[1],"Targeting":[2],"HER2":[3,22,34,97,166,180,203,221,229,247,259,273],"overexpression":[4,35,260],"with":[5,14,52,96,131,185,205,279,299],"trastuzumab":[6],"in":[7,24,36,171,226,234,249,264],"metastatic":[8],"esophagogastric":[9],"adenocarcinoma":[10],"(EGA)":[11],"improves":[12],"survival":[13],"clinical":[15],"trials":[16],"currently":[17],"examining":[18],"the":[19,31,62,227,243,254],"impact":[20],"of":[21,33,40,64,195,245],"inhibition":[23],"early":[25,293],"stage":[26,140,296],"disease.":[27],"This":[28,48,270,288],"study":[29,241],"analyzed":[30,130],"pattern":[32],"matched-pair":[37,208],"tumor":[38,79,94,162],"samples":[39,209,267],"patients":[41],"(pts)":[42],"undergoing":[43],"neoadjuvant":[44,56,237],"chemoradiotherapy":[45],"(chemoRT).":[46],"Methods:":[47],"analysis":[49,189],"included":[50],"pts":[51,127,147],"EGA":[53,250],"who":[54,70],"underwent":[55],"chemoRT":[57,278],"followed":[58],"by":[59,277],"esophagectomy":[60],"at":[61],"University":[63],"Florida":[65],"from":[66],"2001":[67],"to":[68,164,211,236,256],"2011":[69],"did":[71,182,190],"not":[72,160,183,191,252],"receive":[73],"anti-HER2":[74],"therapy.":[75],"Demographics,":[76],"risk":[77],"factors,":[78],"features,":[80],"and":[81,117,218,284,294],"outcome":[82],"data":[83],"were":[84,120,129,139],"analyzed.":[85],"Central":[86],"blinded":[87],"IHC":[88],"was":[89,168],"performed":[90],"on":[91],"paraffin":[92],"embedded":[93],"specimens":[95],"expression":[98,167,181,204,222,230,248],"scored":[99],"as":[100],"negative":[101],"(-)":[102],"(0,":[103],"1+),":[104],"indeterminate":[105],"(2+)":[106],"or":[107,143,159,200,214],"positive":[108],"(+)":[109],"(3+).":[110],"Descriptive":[111],"statistics,":[112],"Chi-square":[113],"exact":[114],"test,":[115],"uni":[116],"multivariate":[118],"analyses":[119],"used":[121],"for":[122,291],"statistical":[123],"analyses.":[124],"Results:":[125],"49":[126],"(41M/8F)":[128],"median":[132],"age":[133],"65":[134],"years":[135],"(39-87).":[136],"Most":[137],"tumors":[138],"II":[141,176],"(55%)":[142],"III":[144],"(43%).":[145],"9/49":[146],"(18%)":[148],"had":[149,156],"pathologic":[150],"complete":[151],"response":[152,235,255],"(pCR),":[153],"another":[154],"10/49":[155],"near":[157],"pCR":[158,213],"enough":[161],"(NET)":[163],"examine.":[165],"more":[169,262],"common":[170],"lower":[172],"stages":[173],"(stage":[174],"I,":[175],"vs":[177],"III).":[178],"Baseline":[179],"correlate":[184],"treatment":[186,202,220,266,286],"response.":[187],"Univariate":[188],"show":[192],"significant":[193],"correlation":[194],"age,":[196],"stage,":[197],"smoking,":[198],"pre":[199,217,283],"post":[201,219,265,285],"survival.":[206],"For":[207],"failing":[210],"achieve":[212],"NET":[215],"(n=30),":[216],"profiles":[223],"are":[224],"presented":[225],"Table.":[228],"appears":[231],"UP":[232],"regulated":[233],"chemoRT.":[238,257],"Conclusions:":[239],"Our":[240],"demonstrated":[242],"degree":[244],"pre-treatment":[246],"does":[251],"predict":[253],"However,":[258],"is":[261],"frequent":[263],"without":[268],"pCR.":[269],"suggests":[271],"that":[272],"may":[274],"be":[275],"upregulated":[276],"unreliable":[280],"concordance":[281],"between":[282],"samples.":[287],"has":[289],"implications":[290],"both":[292],"advanced":[295],"therapeutic":[297],"interventions":[298],"targeted":[300],"therapies.":[301],"[Table:":[302],"see":[303],"text]":[304]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-04-07T00:00:00"}
