{"id":"https://openalex.org/W2598530935","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.9596","title":"Predictors of hand-foot syndrome (HFS) in randomised double-blind, placebo-controlled trial of pyridoxine for prevention of capecitabine induced HFS.","display_name":"Predictors of hand-foot syndrome (HFS) in randomised double-blind, placebo-controlled trial of pyridoxine for prevention of capecitabine induced HFS.","publication_year":2015,"publication_date":"2015-05-20","ids":{"openalex":"https://openalex.org/W2598530935","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.9596","mag":"2598530935"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2015.33.15_suppl.9596","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.9596","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.9596","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052352446","display_name":"Yoon Sim Yap","orcid":"https://orcid.org/0000-0002-0347-5066","observed_orcids":["https://orcid.org/0000-0002-0347-5066"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yoon Sim Yap","raw_affiliation_strings":["National Cancer Centre Singapore, Division of Medical Oncology, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Centre Singapore, Division of Medical Oncology, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016521205","display_name":"Li\u2010Lian Kwok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Li-Lian Kwok","raw_affiliation_strings":["National Cancer Centre Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Centre Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023818239","display_name":"Raymond Chee-Hui Ng","orcid":"https://orcid.org/0000-0002-0272-7399","observed_orcids":["https://orcid.org/0000-0002-0272-7399"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Raymond C.H. Ng","raw_affiliation_strings":["National Cancer Centre Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Centre Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110551700","display_name":"Nan Soon Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nan Soon Wong","raw_affiliation_strings":["Natl Cancer Centre Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Cancer Centre Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113618205","display_name":"Soo Kien Lo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Soo Kien Lo","raw_affiliation_strings":["National Cancer Centre Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Centre Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060485249","display_name":"Wen Yee Chay","orcid":"https://orcid.org/0000-0002-3482-0176","observed_orcids":["https://orcid.org/0000-0002-3482-0176"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wen Yee Chay","raw_affiliation_strings":["National Cancer Centre, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108573701","display_name":"John Whay-Kuang Chia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"John Whay Kuang Chia","raw_affiliation_strings":["Natl Cancer Centre, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Cancer Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072779566","display_name":"Chee Kian Tham","orcid":"https://orcid.org/0000-0002-1733-7844","observed_orcids":["https://orcid.org/0000-0002-1733-7844"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chee Kian Tham","raw_affiliation_strings":["National Cancer Centre, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082318299","display_name":"Si Li Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Si Li Tan","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084106587","display_name":"Vanessa Zuan Yu Mok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Vanessa Zuan Yu Mok","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014871175","display_name":"Jeffrey King Xin Koh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jeffrey King Xin Koh","raw_affiliation_strings":["Department of Pathology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033794495","display_name":"Marie Chiew Shia Loh","orcid":"https://orcid.org/0000-0003-3626-8466","observed_orcids":["https://orcid.org/0000-0003-3626-8466"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Marie Loh","raw_affiliation_strings":["Oncology Research Institute, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research Institute, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022940367","display_name":"Han Chong Toh","orcid":"https://orcid.org/0000-0003-0642-3453","observed_orcids":["https://orcid.org/0000-0003-0642-3453"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Han Chong Toh","raw_affiliation_strings":["Natl Cancer Centre, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Cancer Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111935346","display_name":"Wen Hsin Koo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wen Hsin Koo","raw_affiliation_strings":["National Cancer Centre Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Centre Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572531","display_name":"Richie Chuan Teck Soong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Richie Chuan Teck Soong","raw_affiliation_strings":["National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":null,"display_name":"SuPin Choo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"SuPin Choo","raw_affiliation_strings":["Division of Medical Oncology, National Cancer Centre, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, National Cancer Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"15_suppl","first_page":"9596","last_page":"9596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hand-foot-syndrome","display_name":"hand-foot syndrome","score":0.8870000243186951},{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pyridoxine","display_name":"pyridoxine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.5049999952316284},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.9890000224113464},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5870000123977661},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8410000205039978},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6119999885559082},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.6330000162124634},{"id":"https://openalex.org/keywords/time-to-onset","display_name":"time to onset","score":0.5270000100135803},{"id":"https://openalex.org/keywords/east-asian-patients","display_name":"East Asian patients","score":0.5960000157356262},{"id":"https://openalex.org/keywords/vitamin-b12-supplementation","display_name":"vitamin B12 supplementation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/folate-receptor-1","display_name":"folate receptor 1","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.9222328066825867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9175398349761963},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.705998420715332},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6962131261825562},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5949243307113647},{"id":"https://openalex.org/C2776514930","wikidata":"https://www.wikidata.org/wiki/Q423746","display_name":"Pyridoxine","level":2,"score":0.5083536505699158},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4490969777107239},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4238497018814087},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.39841949939727783},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3468458652496338},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.31956395506858826},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23849788308143616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05899125337600708},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2015.33.15_suppl.9596","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.9596","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.9596","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2734832333","https://openalex.org/W2097407622","https://openalex.org/W4243263385","https://openalex.org/W2806279625","https://openalex.org/W2949678063","https://openalex.org/W1975198395","https://openalex.org/W1761218107","https://openalex.org/W2078034281","https://openalex.org/W1950923865","https://openalex.org/W2032738724"],"abstract_inverted_index":{"9596":[0],"Background:":[1],"Hand-foot":[2],"syndrome":[3],"(HFS)is":[4],"a":[5,96,338],"common":[6],"side":[7],"effect":[8],"of":[9,28,46,55,98,101,122,129,141,155,169,187,217,252,265,302,330,341],"capecitabine,":[10,102],"although":[11],"East":[12],"Asian":[13],"patients":[14,34,143,157,171,226,234],"appear":[15],"to":[16,24,44,87,145,167,215,230,278],"have":[17],"better":[18],"tolerability.":[19],"Methods:":[20],"This":[21],"study":[22,119],"aimed":[23],"evaluate":[25],"the":[26,42,118,138,196,206,275,328],"incidence":[27],"grade":[29,47,123,218,266,303,331],"\u2265":[30,48,124,149,219,267,304,332],"2":[31,49,125,150,220,268,305,333],"HFS":[32,126,151,221,306],"in":[33,80,109,153,195,205,225,233,318],"receiving":[35,164,178],"pyridoxine":[36,90,165,197],"versus":[37,111],"placebo":[38,93,179,207,236,279],"(primary":[39],"objective),":[40],"compare":[41],"time":[43,214],"onset":[45,216,329],"HFS,":[50,56],"and":[51,60,77,107,199,292],"identify":[52],"biomarkers":[53],"predictive":[54],"including":[57],"baseline":[58,243,293],"folate":[59,245,296,336],"vitamin":[61],"B12":[62],"levels,":[63],"plus":[64],"genetic":[65],"polymorphisms":[66],"(secondary":[67],"objectives).":[68],"Patients":[69,114],"starting":[70,185],"capecitabine":[71,188],"single-agent":[72],"chemotherapy":[73],"for":[74,95,249],"breast,":[75],"colorectal":[76],"other":[78],"cancers":[79],"National":[81],"Cancer":[82],"Centre":[83],"Singapore":[84],"were":[85,115,297],"randomized":[86],"receive":[88],"concurrent":[89],"(200mg)":[91],"or":[92,127,326],"daily":[94],"maximum":[97],"8":[99],"cycles":[100],"with":[103,262,299,313],"stratification":[104],"by":[105],"gender":[106],"use":[108],"adjuvant/neoadjuvant":[110],"palliative":[112],"setting.":[113],"withdrawn":[116],"from":[117],"upon":[120],"development":[121],"cessation":[128],"capecitabine.":[130],"Results:":[131],"The":[132,183,212],"trial":[133,344],"was":[134,189,222,260,337],"terminated":[135],"before":[136],"reaching":[137],"original":[139],"target":[140],"296":[142],"due":[144],"slow":[146],"accrual.":[147],"Grade":[148],"occurred":[152],"33":[154],"105":[156],"(31.4%,":[158],"95%":[159,173,254,283],"CI:":[160,174,255,284],"22.6%":[161],"-":[162,176],"40.3%)":[163],"compared":[166,229,277],"39":[168],"103":[170],"(37.9%,":[172],"28.5%":[175],"47.2%)":[177],"(p":[180,209,237],"=":[181,210,238,258,287],"0.329).":[182],"median":[184,213],"dose":[186,290],"1000mg/m2":[190],"(range":[191,201],"793-1250":[192],"mg/m2)":[193,203],"bid":[194,204],"arm,":[198],"1011mg/m2":[200],"845-1250":[202],"arm":[208],"0.667).":[211],"not":[223,272,309,323],"reached":[224],"on":[227,235,307],"pyridoxine,":[228],"174":[231],"days":[232],"0.677).":[239],"On":[240],"multivariate":[241,310],"analysis,":[242],"serum":[244],"(odds":[246,280],"ratio":[247,281],"1.27":[248],"every":[250],"increase":[251],"5nmol/l;":[253],"1.10-1.47;":[256],"p":[257,286],".001)":[259],"associated":[261,298],"increased":[263,300],"risk":[264,276,301],"HFS.":[269,334,342],"Pyridoxine":[270,321],"did":[271,322],"significantly":[273,324],"decrease":[274],"0.50;":[282],"0.24-1.03;":[285],"0.061).":[288],"Initial":[289],"intensity":[291],"red":[294],"cell":[295],"univariate,":[308],"analysis.":[311],"Genotyping":[312],"Zhonghua":[314],"SNP":[315],"arrays":[316],"is":[317],"progress.":[319],"Conclusions:":[320],"prevent":[325],"delay":[327],"Serum":[335],"significant":[339],"predictor":[340],"Clinical":[343],"information:":[345],"NCT00486213.":[346]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-04-07T00:00:00"}
