{"id":"https://openalex.org/W2598067950","doi":null,"title":"The relationship between relative solvent accessibility and evolutionary rate in protein evolution","display_name":"The relationship between relative solvent accessibility and evolutionary rate in protein evolution","publication_year":2011,"publication_date":"2011-03-23","ids":{"openalex":"https://openalex.org/W2598067950","mag":"2598067950"},"language":"en","primary_location":{"id":"mag:2598067950","doi":null,"is_oa":false,"landing_page_url":"http://absimage.aps.org/image/MAR11/MWS_MAR11-2010-000695.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764664775","display_name":"Bulletin of the American Physical Society","issn_l":"0003-0503","issn":["0003-0503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bulletin of the American Physical Society","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070411498","display_name":"Claus O. Wilke","orcid":"https://orcid.org/0000-0002-7470-9261","observed_orcids":["https://orcid.org/0000-0002-7470-9261"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claus O. Wilke","raw_affiliation_strings":["University of Texas at Austin"],"raw_orcid":"https://orcid.org/0000-0002-7470-9261","affiliations":[{"raw_affiliation_string":"University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070411498"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2011","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.11829999834299088,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relative-solvent-accessibility","display_name":"relative solvent accessibility","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.6980000138282776},{"id":"https://openalex.org/keywords/evolutionary-rates","display_name":"evolutionary rates","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.546999990940094},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8769999742507935},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.644401490688324},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5767051577568054},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.550621509552002},{"id":"https://openalex.org/C2992240565","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Protein evolution","level":3,"score":0.49439573287963867},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4873095750808716},{"id":"https://openalex.org/C2994376932","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Amino acid residue","level":4,"score":0.48036178946495056},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4595576226711273},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.4334242343902588},{"id":"https://openalex.org/C91852762","wikidata":"https://www.wikidata.org/wiki/Q3307742","display_name":"Fitness landscape","level":3,"score":0.42523249983787537},{"id":"https://openalex.org/C12426560","wikidata":"https://www.wikidata.org/wiki/Q189569","display_name":"Basis (linear algebra)","level":2,"score":0.41964587569236755},{"id":"https://openalex.org/C3019152653","wikidata":"https://www.wikidata.org/wiki/Q186290","display_name":"Linear relationship","level":2,"score":0.4183495044708252},{"id":"https://openalex.org/C2986302931","wikidata":"https://www.wikidata.org/wiki/Q764759","display_name":"Positive selection","level":3,"score":0.4165351986885071},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3880290985107422},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3799583315849304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3751780390739441},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.33233642578125},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.28571146726608276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24238142371177673},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.167371928691864},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15750637650489807},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.15458542108535767},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.15400797128677368},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.148484468460083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0915052592754364},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.07363149523735046},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2598067950","doi":null,"is_oa":false,"landing_page_url":"http://absimage.aps.org/image/MAR11/MWS_MAR11-2010-000695.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764664775","display_name":"Bulletin of the American Physical Society","issn_l":"0003-0503","issn":["0003-0503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bulletin of the American Physical Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1508885706","https://openalex.org/W1930635754","https://openalex.org/W1964580362","https://openalex.org/W1966990745","https://openalex.org/W1982565368","https://openalex.org/W1983501050","https://openalex.org/W1990581095","https://openalex.org/W1991301739","https://openalex.org/W1993900316","https://openalex.org/W1999669514","https://openalex.org/W2003235560","https://openalex.org/W2008708467","https://openalex.org/W2025304263","https://openalex.org/W2038898901","https://openalex.org/W2039790548","https://openalex.org/W2041658859","https://openalex.org/W2041938888","https://openalex.org/W2042548693","https://openalex.org/W2045994733","https://openalex.org/W2050735926","https://openalex.org/W2051085340","https://openalex.org/W2060690425","https://openalex.org/W2061181383","https://openalex.org/W2062018285","https://openalex.org/W2086719212","https://openalex.org/W2096413602","https://openalex.org/W2105000219","https://openalex.org/W2109083660","https://openalex.org/W2110335151","https://openalex.org/W2111878373","https://openalex.org/W2111909811","https://openalex.org/W2122376908","https://openalex.org/W2131768361","https://openalex.org/W2132926880","https://openalex.org/W2135753651","https://openalex.org/W2139348052","https://openalex.org/W2139774535","https://openalex.org/W2141789570","https://openalex.org/W2145406188","https://openalex.org/W2147126179","https://openalex.org/W2150300758","https://openalex.org/W2157650375","https://openalex.org/W2160156676","https://openalex.org/W2165187711","https://openalex.org/W2168172687","https://openalex.org/W2169546600","https://openalex.org/W2170203686","https://openalex.org/W2906676080","https://openalex.org/W3182520187"],"related_works":["https://openalex.org/W2259266639","https://openalex.org/W2153261051","https://openalex.org/W2135753651","https://openalex.org/W1890232178","https://openalex.org/W1886080132","https://openalex.org/W2116137622","https://openalex.org/W2766925510","https://openalex.org/W2167676468","https://openalex.org/W2122376908","https://openalex.org/W2807954510"],"abstract_inverted_index":{"Recent":[0],"work":[1],"with":[2,62],"Saccharomyces":[3],"cerevisiae":[4],"shows":[5],"a":[6,34,65,84],"linear":[7,41],"relationship":[8],"between":[9],"the":[10,16,22,26,78,87,111,127],"evolutionary":[11,105,140],"rate":[12],"of":[13,21,89,113,120,139],"sites":[14],"and":[15,64,95],"relative":[17],"solvent":[18],"accessibility":[19],"(RSA)":[20],"corresponding":[23],"residues":[24],"in":[25,57],"folded":[27],"protein.":[28],"Here,":[29],"we":[30],"aim":[31],"to":[32,76,110],"develop":[33,83],"mathematical":[35],"model":[36,56,68,85,99],"that":[37,46,49,97,104,130],"can":[38],"reproduce":[39,77],"this":[40,98,121],"relationship.":[42,80],"We":[43,81,102],"first":[44],"demonstrate":[45],"two":[47],"models":[48],"both":[50],"seem":[51],"reasonable":[52],"choices":[53],"(a":[54],"simple":[55],"which":[58],"selection":[59],"strength":[60],"correlates":[61],"RSA":[63],"more":[66],"complex":[67],"based":[69],"on":[70,86],"RSA-dependent":[71],"amino":[72,92,114,132],"acid":[73,93,133],"distributions)":[74],"fail":[75],"observed":[79,90],"then":[82],"basis":[88],"site-specific":[91],"distributions":[94,134],"show":[96],"behaves":[100],"appropriately.":[101],"conclude":[103],"rates":[106],"are":[107],"directly":[108],"linked":[109],"distribution":[112],"acids":[115],"at":[116],"individual":[117],"sites.":[118],"Because":[119],"link,":[122],"any":[123],"future":[124],"insight":[125],"into":[126],"biophysical":[128],"mechanisms":[129],"determine":[131],"will":[135],"improve":[136],"our":[137],"understanding":[138],"rates.":[141]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-07T00:00:00"}
