{"id":"https://openalex.org/W2598058902","doi":null,"title":"Suppression of Pulmonary Innate Immunity by Pneumoviruses","display_name":"Suppression of Pulmonary Innate Immunity by Pneumoviruses","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2598058902","mag":"2598058902"},"language":"en","primary_location":{"id":"pmh:oai:engagedscholarship.csuohio.edu:etdarchive-1935","doi":null,"is_oa":true,"landing_page_url":"https://engagedscholarship.csuohio.edu/etdarchive/936","pdf_url":"https://engagedscholarship.csuohio.edu/etdarchive/936","source":{"id":"https://openalex.org/S4306400889","display_name":"EngagedScholarship @ Cleveland State University (Cleveland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102607778","host_organization_name":"Cleveland State University","host_organization_lineage":["https://openalex.org/I102607778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETD Archive","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://engagedscholarship.csuohio.edu/etdarchive/936","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089594599","display_name":"Jayeeta Dhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jayeeta Dhar","raw_affiliation_strings":["Cleveland State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland State University","institution_ids":["https://openalex.org/I102607778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089594599"],"corresponding_institution_ids":["https://openalex.org/I102607778"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pneumovirus","display_name":"pneumovirus","score":0.8529999852180481},{"id":"https://openalex.org/keywords/type-i-interferon-suppression","display_name":"type I interferon suppression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/interferon-signaling-pathway","display_name":"interferon pathway","score":0.578000009059906},{"id":"https://openalex.org/keywords/nonstructural-proteins","display_name":"non-structural proteins","score":0.8989999890327454},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.7720000147819519},{"id":"https://openalex.org/keywords/irf3","display_name":"IRF3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stat2","display_name":"STAT2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.7639999985694885},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oasl","display_name":"OASL","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ifitm1","display_name":"IFITM1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/isg20","display_name":"ISG20","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ido","display_name":"IDO","score":0.9300000071525574},{"id":"https://openalex.org/keywords/paramyxoviridae","display_name":"Paramyxoviridae","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7802621126174927},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4655526280403137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3334053158760071},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2760447561740875},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1454387605190277}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:engagedscholarship.csuohio.edu:etdarchive-1935","doi":null,"is_oa":true,"landing_page_url":"https://engagedscholarship.csuohio.edu/etdarchive/936","pdf_url":"https://engagedscholarship.csuohio.edu/etdarchive/936","source":{"id":"https://openalex.org/S4306400889","display_name":"EngagedScholarship @ Cleveland State University (Cleveland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102607778","host_organization_name":"Cleveland State University","host_organization_lineage":["https://openalex.org/I102607778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETD Archive","raw_type":"text"},{"id":"pmh:oai:etd.ohiolink.edu:csu1479673989904175","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1479673989904175","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1479673989904175","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=csu1479673989904175","raw_type":"text"},{"id":"mag:2598058902","doi":null,"is_oa":false,"landing_page_url":"https://engagedscholarship.csuohio.edu/etdarchive/936/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:engagedscholarship.csuohio.edu:etdarchive-1935","doi":null,"is_oa":true,"landing_page_url":"https://engagedscholarship.csuohio.edu/etdarchive/936","pdf_url":"https://engagedscholarship.csuohio.edu/etdarchive/936","source":{"id":"https://openalex.org/S4306400889","display_name":"EngagedScholarship @ Cleveland State University (Cleveland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102607778","host_organization_name":"Cleveland State University","host_organization_lineage":["https://openalex.org/I102607778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETD Archive","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2598058902.pdf","grobid_xml":"https://content.openalex.org/works/W2598058902.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W149003669","https://openalex.org/W1570950275","https://openalex.org/W1785948735","https://openalex.org/W1965591672","https://openalex.org/W1965892231","https://openalex.org/W1966164449","https://openalex.org/W1970319521","https://openalex.org/W1978527132","https://openalex.org/W1981536815","https://openalex.org/W1985661552","https://openalex.org/W1986358021","https://openalex.org/W1989926440","https://openalex.org/W1990167513","https://openalex.org/W1990464397","https://openalex.org/W1993897877","https://openalex.org/W2000871561","https://openalex.org/W2001375348","https://openalex.org/W2001758956","https://openalex.org/W2004773897","https://openalex.org/W2004995275","https://openalex.org/W2005043758","https://openalex.org/W2013035173","https://openalex.org/W2014581157","https://openalex.org/W2015321393","https://openalex.org/W2018637841","https://openalex.org/W2019108023","https://openalex.org/W2022291234","https://openalex.org/W2023492411","https://openalex.org/W2023594156","https://openalex.org/W2028571879","https://openalex.org/W2029317398","https://openalex.org/W2030747794","https://openalex.org/W2032408099","https://openalex.org/W2034772880","https://openalex.org/W2035509260","https://openalex.org/W2038698914","https://openalex.org/W2040313539","https://openalex.org/W2041769542","https://openalex.org/W2042486230","https://openalex.org/W2045812944","https://openalex.org/W2049923099","https://openalex.org/W2050899039","https://openalex.org/W2050963689","https://openalex.org/W2051874642","https://openalex.org/W2062490839","https://openalex.org/W2062964316","https://openalex.org/W2066425910","https://openalex.org/W2067240517","https://openalex.org/W2068518836","https://openalex.org/W2069968343","https://openalex.org/W2073143025","https://openalex.org/W2075254766","https://openalex.org/W2076971119","https://openalex.org/W2078646756","https://openalex.org/W2090461035","https://openalex.org/W2091006367","https://openalex.org/W2092230550","https://openalex.org/W2094232612","https://openalex.org/W2096879687","https://openalex.org/W2096886486","https://openalex.org/W2097160006","https://openalex.org/W2099610218","https://openalex.org/W2100223188","https://openalex.org/W2104898251","https://openalex.org/W2107380548","https://openalex.org/W2107491018","https://openalex.org/W2114884151","https://openalex.org/W2117492670","https://openalex.org/W2120949068","https://openalex.org/W2124036003","https://openalex.org/W2127322768","https://openalex.org/W2128966128","https://openalex.org/W2135275823","https://openalex.org/W2138677670","https://openalex.org/W2141137217","https://openalex.org/W2143671051","https://openalex.org/W2144275393","https://openalex.org/W2146648517","https://openalex.org/W2147533489","https://openalex.org/W2149643442","https://openalex.org/W2159779332","https://openalex.org/W2160063406","https://openalex.org/W2161818718","https://openalex.org/W2168026897","https://openalex.org/W2317416690","https://openalex.org/W2345488562","https://openalex.org/W2411085167"],"related_works":["https://openalex.org/W7018683117","https://openalex.org/W2077714772","https://openalex.org/W6945936352","https://openalex.org/W6981632169","https://openalex.org/W2605133850","https://openalex.org/W7098560636","https://openalex.org/W7033580897","https://openalex.org/W7100811548","https://openalex.org/W7010681258","https://openalex.org/W7038357504"],"abstract_inverted_index":{"Pneumonia":[0],"Virus":[1,8],"of":[2,27,51,92,97,115,134,147,157,167,174,186,231,270,308,321],"Mice":[3],"(PVM)":[4],"and":[5,70,181,208,223,262],"Respiratory":[6],"Syncytial":[7],"(RSV)":[9],"are":[10,79],"negative":[11],"sense,":[12],"single-stranded,":[13],"enveloped":[14],"RNA":[15],"viruses":[16],"from":[17,273],"Pneumovirus":[18,257,302,340],"genus,":[19,258],"Paramyxoviridae":[20],"family.":[21],"RSV":[22,48,55,71,86,191,222,233,263,304],"is":[23,40,153,286,313],"the":[24,95,120,154,158,187,250,255,266,274,282,318,322,338],"leading":[25],"cause":[26],"respiratory":[28,35],"diseases":[29],"in":[30,37,138,239],"infants.":[31],"PVM":[32,39,69,101,108,128,168,261,279,285],"causes":[33],"similar":[34,196],"illness":[36],"mice.":[38],"used":[41],"as":[42,65,177],"an":[43,66],"animal":[44,290],"model":[45,291],"to":[46,81,118,198,226,248,280,296,316,331],"study":[47,211,305],"pathogenesis":[49],"because":[50],"its":[52],"similarity":[53],"with":[54,144,306],"infection.":[56,303],"Viral":[57],"infection":[58],"induces":[59],"type":[60],"I":[61],"interferon":[62],"(IFN)":[63],"response":[64],"antiviral":[67,219,229],"strategy.":[68],"both":[72,259],"have":[73,105,162],"two":[74],"non-structural":[75],"(NS)":[76],"proteins":[77,130,166,193,235],"that":[78,107,127,164,217,225,292],"known":[80],"be":[82],"IFN":[83,93,98,116,139,159,200,275,283,324],"antagonists.":[84],"While":[85],"can":[87,109,169,236],"target":[88,111,171,319],"different":[89,112],"signaling":[90,113,271],"components":[91,114,272],"pathway,":[94],"mechanism":[96,253],"suppression":[99,185,252],"for":[100,183,254,260,337],"was":[102],"unknown.":[103],"We":[104,161],"identified":[106,163,213],"also":[110,170,314],"pathway":[117,140,201,276],"circumvent":[119],"host":[121,188],"immune":[122,189,334],"system.":[123,190],"Our":[124,210],"observations":[125,245],"showed":[126],"NS":[129,165,192,234],"facilitate":[131],"proteasome-mediated":[132],"degradation":[133],"RIG-I,":[135,205],"IRF3,":[136,206],"STAT2":[137],"by":[141,202,264,278],"direct":[142],"interactions":[143],"them.":[145],"Production":[146],"several":[148],"Interferon":[149],"Stimulated":[150],"Genes":[151],"(ISGs)":[152],"distal":[155],"part":[156],"pathway.":[160,325],"a":[172,195,240,287],"few":[173],"them":[175],"such":[176],"TRAFD1,":[178],"IFITM1,":[179],"ISG20,":[180],"IDO":[182],"complete":[184,251],"play":[194],"role":[197],"suppress":[199,281],"targeting":[203],"TBK1,":[204],"IRF7,":[207],"STAT2.":[209],"has":[212,218],"one":[214,307],"ISG,":[215],"OASL,":[216,232,312],"properties":[220],"against":[221,301],"documented":[224],"counteract":[227],"this":[228],"property":[230],"degrade":[237],"OASL":[238],"proteasome-dependent":[241],"way.":[242],"These":[243],"above":[244],"help":[246,294,329],"us":[247,295,330],"delineate":[249,332],"whole":[256,339],"providing":[265],"first":[267],"experimental":[268],"evidence":[269],"targeted":[277],"response.":[284],"clinically":[288],"relevant":[289],"will":[293],"find":[297],"new":[298,333],"therapeutic":[299],"strategies":[300,336],"those":[309],"important":[310,315],"ISGs,":[311],"uncover":[317],"substrates":[320],"entire":[323],"Together":[326],"these":[327],"findings":[328],"modulatory":[335],"genus.":[341]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-04-07T00:00:00"}