{"id":"https://openalex.org/W2597989406","doi":null,"title":"The Anatomic Connectome and Functional Dissection of the Caenorhabditis elegans First-stage Larvae (L1) Motor Circuit","display_name":"The Anatomic Connectome and Functional Dissection of the Caenorhabditis elegans First-stage Larvae (L1) Motor Circuit","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2597989406","mag":"2597989406"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/70415","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70415","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8f8a7f44-98e6-4acd-b06c-c287456ebefe/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/8f8a7f44-98e6-4acd-b06c-c287456ebefe/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063448115","display_name":"Sihui Asuka Guan","orcid":"https://orcid.org/0000-0003-4276-2671","observed_orcids":["https://orcid.org/0000-0003-4276-2671"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sihui Asuka Guan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4276-2671","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063448115"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/first-stage-larvae","display_name":"first-stage larvae","score":0.8629999756813049},{"id":"https://openalex.org/keywords/undulation","display_name":"undulation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/motor-circuits","display_name":"motor circuits","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cholinergic-motor-neurons","display_name":"cholinergic motor neurons","score":0.9390000104904175},{"id":"https://openalex.org/keywords/gabaergic-motor-neurons","display_name":"GABAergic motor neurons","score":1.0},{"id":"https://openalex.org/keywords/body-wall-musculature","display_name":"body wall muscle","score":0.7009999752044678},{"id":"https://openalex.org/keywords/muscle-innervation","display_name":"muscle innervation","score":0.640999972820282},{"id":"https://openalex.org/keywords/locomotor-development","display_name":"locomotor development","score":0.6629999876022339},{"id":"https://openalex.org/keywords/sensorimotor-development","display_name":"sensorimotor development","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.8838119506835938},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8323482275009155},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6612765789031982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.502147912979126},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.4780322015285492},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.4731016159057617},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3799206018447876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16164541244506836},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.14589402079582214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10611358284950256}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/70415","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70415","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8f8a7f44-98e6-4acd-b06c-c287456ebefe/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2597989406","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/70415/2/Guan_Sihui_201511_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/70415","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/70415","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8f8a7f44-98e6-4acd-b06c-c287456ebefe/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2597989406.pdf","grobid_xml":"https://content.openalex.org/works/W2597989406.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W14730294","https://openalex.org/W181689146","https://openalex.org/W191855840","https://openalex.org/W1537949732","https://openalex.org/W1563576581","https://openalex.org/W1588629441","https://openalex.org/W1589286039","https://openalex.org/W1664536148","https://openalex.org/W1669755322","https://openalex.org/W1764067125","https://openalex.org/W1788465141","https://openalex.org/W1904905451","https://openalex.org/W1944127002","https://openalex.org/W1956608331","https://openalex.org/W1964697727","https://openalex.org/W1965259272","https://openalex.org/W1968335909","https://openalex.org/W1969947576","https://openalex.org/W1977215035","https://openalex.org/W1978862241","https://openalex.org/W1980143518","https://openalex.org/W1981024652","https://openalex.org/W1982508615","https://openalex.org/W1983853047","https://openalex.org/W1986006829","https://openalex.org/W1986768021","https://openalex.org/W1987446232","https://openalex.org/W1988156076","https://openalex.org/W1989032179","https://openalex.org/W1990762857","https://openalex.org/W1993673892","https://openalex.org/W1997349799","https://openalex.org/W2000261863","https://openalex.org/W2002716043","https://openalex.org/W2002972805","https://openalex.org/W2003154381","https://openalex.org/W2004905041","https://openalex.org/W2006374456","https://openalex.org/W2006615800","https://openalex.org/W2013878893","https://openalex.org/W2016910258","https://openalex.org/W2024004316","https://openalex.org/W2024642025","https://openalex.org/W2026466572","https://openalex.org/W2027261517","https://openalex.org/W2031012150","https://openalex.org/W2034180599","https://openalex.org/W2035289053","https://openalex.org/W2040312196","https://openalex.org/W2041664896","https://openalex.org/W2042630054","https://openalex.org/W2045538700","https://openalex.org/W2050152611","https://openalex.org/W2053253879","https://openalex.org/W2055435981","https://openalex.org/W2056128846","https://openalex.org/W2057522454","https://openalex.org/W2058615553","https://openalex.org/W2061603242","https://openalex.org/W2062849434","https://openalex.org/W2064363302","https://openalex.org/W2064499073","https://openalex.org/W2064739762","https://openalex.org/W2069280878","https://openalex.org/W2070803237","https://openalex.org/W2073191414","https://openalex.org/W2073389632","https://openalex.org/W2074071999","https://openalex.org/W2074400859","https://openalex.org/W2074683128","https://openalex.org/W2074821443","https://openalex.org/W2074911271","https://openalex.org/W2075299328","https://openalex.org/W2078498925","https://openalex.org/W2078529500","https://openalex.org/W2082288734","https://openalex.org/W2083585583","https://openalex.org/W2084076889","https://openalex.org/W2091599503","https://openalex.org/W2091723337","https://openalex.org/W2092236011","https://openalex.org/W2098186057","https://openalex.org/W2098923623","https://openalex.org/W2102329408","https://openalex.org/W2106149898","https://openalex.org/W2108024591","https://openalex.org/W2109234881","https://openalex.org/W2112196515","https://openalex.org/W2112357421","https://openalex.org/W2115682148","https://openalex.org/W2116086925","https://openalex.org/W2118123933","https://openalex.org/W2120339844","https://openalex.org/W2122107405","https://openalex.org/W2122163057","https://openalex.org/W2123004503","https://openalex.org/W2124140792","https://openalex.org/W2126578880","https://openalex.org/W2127183925","https://openalex.org/W2129968729","https://openalex.org/W2130088507","https://openalex.org/W2130413520","https://openalex.org/W2133351202","https://openalex.org/W2141320069","https://openalex.org/W2151834825","https://openalex.org/W2154389993","https://openalex.org/W2157127963","https://openalex.org/W2158454314","https://openalex.org/W2159240874","https://openalex.org/W2160938187","https://openalex.org/W2169109050","https://openalex.org/W2169554936","https://openalex.org/W2212274541","https://openalex.org/W2240145697","https://openalex.org/W2318825297","https://openalex.org/W2334963168","https://openalex.org/W2336622581","https://openalex.org/W2340199301","https://openalex.org/W2394504301","https://openalex.org/W2409484183","https://openalex.org/W2411128509","https://openalex.org/W2415997936","https://openalex.org/W2463734860","https://openalex.org/W2465207083","https://openalex.org/W4232143967"],"related_works":["https://openalex.org/W3044984143","https://openalex.org/W2892302865","https://openalex.org/W7098480267","https://openalex.org/W2004991950","https://openalex.org/W4211062256","https://openalex.org/W2003154381","https://openalex.org/W4298055477","https://openalex.org/W2006615800","https://openalex.org/W4240267565","https://openalex.org/W4307297749"],"abstract_inverted_index":{"During":[0],"development,":[1],"neural":[2,18],"networks":[3],"exhibits":[4],"anatomic":[5],"and":[6,47,80,100,104,121,134],"functional":[7],"modifications":[8],"yet":[9,64],"the":[10,29,37,65,81,89,105],"activity":[11],"patterns":[12],"change":[13],"remains":[14],"poorly":[15],"understood.":[16],"The":[17],"circuit":[19],"controlling":[20],"locomotion":[21],"of":[22,31,91,144],"C.":[23,76],"elegans":[24,77],"undergoes":[25],"major":[26],"reconstructions":[27],"at":[28],"end":[30],"first-larval":[32],"(L1)":[33],"stage.":[34],"In":[35],"adults,":[36],"ventral/dorsal":[38],"body":[39],"wall":[40],"muscles":[41,56,122],"are":[42,57,95],"symmetrically":[43],"innervated":[44],"by":[45],"cholinergic":[46,93],"GABAergic":[48,106],"motor":[49],"neurons":[50],"(MNs).":[51],"Cholinergic":[52],"MNs":[53,94,107,120],"innervating":[54],"ventral":[55,101,110],"not":[58],"derived":[59],"during":[60,147],"early":[61],"L1":[62,75,124],"stage,":[63],"animals":[66],"can":[67],"still":[68],"generate":[69],"undulation.":[70,127],"This":[71,113],"study":[72],"addressed":[73],"how":[74],"produces":[78],"undulation":[79],"mechanism":[82],"underlying":[83],"muscle":[84,102,111],"innervations.":[85],"We":[86],"demonstrated":[87],"that":[88],"activities":[90],"dorsal":[92,99],"required":[96],"for":[97],"both":[98],"contraction,":[103],"mediate":[108],"only":[109],"relaxation.":[112],"indicated":[114],"a":[115],"differential":[116],"synaptic":[117],"wiring":[118],"between":[119,132],"in":[123],"to":[125,139],"permit":[126],"Through":[128],"this":[129],"comparative":[130],"analysis":[131],"juvenile":[133],"adult":[135],"locomotion,":[136],"we":[137],"hope":[138],"provide":[140],"insights":[141],"on":[142],"principles":[143],"behavioral":[145],"adaptation":[146],"sensorimotor":[148],"development.":[149]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-04-07T00:00:00"}
