{"id":"https://openalex.org/W2597538342","doi":"https://doi.org/10.1172/jci.insight.91917","title":"LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn\u2019s disease patients","display_name":"LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn\u2019s disease patients","publication_year":2017,"publication_date":"2017-03-22","ids":{"openalex":"https://openalex.org/W2597538342","doi":"https://doi.org/10.1172/jci.insight.91917","mag":"2597538342","pmid":"https://pubmed.ncbi.nlm.nih.gov/28352666","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5358495"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.91917","doi":"https://doi.org/10.1172/jci.insight.91917","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.91917","pdf_url":"http://insight.jci.org/articles/view/91917/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/91917/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047477696","display_name":"Ta\u2010Chiang Liu","orcid":"https://orcid.org/0000-0002-2800-9360","observed_orcids":["https://orcid.org/0000-0002-2800-9360"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ta-Chiang Liu","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038009665","display_name":"Takeo Naito","orcid":"https://orcid.org/0000-0002-9744-7946","observed_orcids":["https://orcid.org/0000-0002-9744-7946"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Naito","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006849116","display_name":"Zhenqiu Liu","orcid":"https://orcid.org/0000-0002-5244-6894","observed_orcids":["https://orcid.org/0000-0002-5244-6894","https://orcid.org/0000-0003-1535-4322"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4405281400","display_name":"F. Widjaja Inflammatory Bowel Disease Institute","ror":"https://ror.org/049va9195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenqiu Liu","raw_affiliation_strings":["F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-1535-4322","affiliations":[{"raw_affiliation_string":"F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003270106","display_name":"Kelli L. VanDussen","orcid":"https://orcid.org/0000-0002-5810-0720","observed_orcids":["https://orcid.org/0000-0002-5810-0720"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelli L. VanDussen","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012807902","display_name":"Talin Haritunians","orcid":"https://orcid.org/0000-0002-9005-7750","observed_orcids":["https://orcid.org/0000-0002-9005-7750"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4405281400","display_name":"F. Widjaja Inflammatory Bowel Disease Institute","ror":"https://ror.org/049va9195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talin Haritunians","raw_affiliation_strings":["F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-9005-7750","affiliations":[{"raw_affiliation_string":"F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101419399","display_name":"Dalin Li","orcid":"https://orcid.org/0000-0003-4738-0074","observed_orcids":["https://orcid.org/0000-0003-4738-0074"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4405281400","display_name":"F. Widjaja Inflammatory Bowel Disease Institute","ror":"https://ror.org/049va9195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dalin Li","raw_affiliation_strings":["F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066039132","display_name":"Katsuya Endo","orcid":"https://orcid.org/0000-0002-6449-8392","observed_orcids":["https://orcid.org/0000-0002-6449-8392"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Endo","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016476726","display_name":"Yosuke Kawai","orcid":"https://orcid.org/0000-0003-0666-1224","observed_orcids":["https://orcid.org/0000-0003-0666-1224"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210136366","display_name":"Tohoku Medical Megabank Organization","ror":"https://ror.org/03zzyap02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210136366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Kawai","raw_affiliation_strings":["Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4210136366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025220924","display_name":"Masao Nagasaki","orcid":"https://orcid.org/0000-0002-4292-8785","observed_orcids":["https://orcid.org/0000-0002-4292-8785"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210136366","display_name":"Tohoku Medical Megabank Organization","ror":"https://ror.org/03zzyap02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210136366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Nagasaki","raw_affiliation_strings":["Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4210136366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043020113","display_name":"Yoshitaka Kinouchi","orcid":"https://orcid.org/0000-0002-3368-8855","observed_orcids":["https://orcid.org/0000-0002-3368-8855"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Kinouchi","raw_affiliation_strings":["Health Administration Center, Center for the Advancement of Higher Education, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Administration Center, Center for the Advancement of Higher Education, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035961257","display_name":"Dermot P.B. McGovern","orcid":"https://orcid.org/0000-0001-5621-759X","observed_orcids":["https://orcid.org/0000-0001-5621-759X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4405281400","display_name":"F. Widjaja Inflammatory Bowel Disease Institute","ror":"https://ror.org/049va9195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dermot P.B. McGovern","raw_affiliation_strings":["F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029930183","display_name":"Tooru Shimosegawa","orcid":"https://orcid.org/0000-0003-1255-5444","observed_orcids":["https://orcid.org/0000-0003-1255-5444"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tooru Shimosegawa","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034412681","display_name":"Yoichi Kakuta","orcid":"https://orcid.org/0000-0002-7042-009X","observed_orcids":["https://orcid.org/0000-0002-7042-009X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoichi Kakuta","raw_affiliation_strings":["Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7042-009X","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052310284","display_name":"Thaddeus S. Stappenbeck","orcid":"https://orcid.org/0000-0002-6023-3901","observed_orcids":["https://orcid.org/0000-0002-6023-3901"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thaddeus S. Stappenbeck","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034412681","https://openalex.org/A5047477696","https://openalex.org/A5052310284"],"corresponding_institution_ids":["https://openalex.org/I201537933","https://openalex.org/I204465549"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":4.7074,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95411165,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"2","issue":"6","first_page":"e91917","last_page":"e91917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/atg16l1","display_name":"ATG16L1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.6110000014305115},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.703000009059906},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.628000020980835},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8230000138282776},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6010000109672546},{"id":"https://openalex.org/keywords/ileal-resection","display_name":"ileal resection","score":0.7839999794960022},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nod2","display_name":"NOD2","score":0.8769999742507935},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C187092789","wikidata":"https://www.wikidata.org/wiki/Q4654662","display_name":"ATG16L1","level":4,"score":0.9635896682739258},{"id":"https://openalex.org/C2776145723","wikidata":"https://www.wikidata.org/wiki/Q2004084","display_name":"Paneth cell","level":3,"score":0.9252909421920776},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6548522710800171},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.630933403968811},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5811424255371094},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.46800199151039124},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4615914821624756},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4399794936180115},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43497806787490845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3320685923099518},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32517707347869873},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3160632848739624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24566036462783813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14882993698120117},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019879","descriptor_name":"Paneth Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci.insight.91917","doi":"https://doi.org/10.1172/jci.insight.91917","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.91917","pdf_url":"http://insight.jci.org/articles/view/91917/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5358495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5358495","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:28352666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28352666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-11888","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/10894","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.91917","doi":"https://doi.org/10.1172/jci.insight.91917","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.91917","pdf_url":"http://insight.jci.org/articles/view/91917/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3910398444","display_name":"Gene-microbiota interaction of inflammatory bowel disease","funder_award_id":"15K15284","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4113360374","display_name":"DEFINING OF CROHN'S DISEASE SUBTYPES USING GENETICS AND METAGENOMICS","funder_award_id":"R56DK095820","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5383521319","display_name":"DEFINING THE BASIS OF EPITHELIAL DEFECTS IN CROHN'S DISEASE PATIENTS","funder_award_id":"K01DK109081","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6095632310","display_name":"Genome-wide association study of inflammatory bowel disease using population optimized array and reference panel in Japanese","funder_award_id":"15H04805","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G611383016","display_name":null,"funder_award_id":"TR000448","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G6796664046","display_name":null,"funder_award_id":"274415","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"},{"id":"https://openalex.org/G725115302","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000115080","display_name":null,"funder_award_id":"TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000871445","display_name":"Determining genomic and host-environment contributions to IBD phenotypes","funder_award_id":"U01DK062413","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2597538342.pdf","grobid_xml":"https://content.openalex.org/works/W2597538342.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1014257459","https://openalex.org/W1175815497","https://openalex.org/W1487785114","https://openalex.org/W1656401266","https://openalex.org/W1877302225","https://openalex.org/W1878830193","https://openalex.org/W1961855149","https://openalex.org/W1967200174","https://openalex.org/W1970090376","https://openalex.org/W1979309473","https://openalex.org/W1980475824","https://openalex.org/W1982252191","https://openalex.org/W1984813184","https://openalex.org/W1987836935","https://openalex.org/W1991724593","https://openalex.org/W1998324306","https://openalex.org/W2000111822","https://openalex.org/W2001944800","https://openalex.org/W2002636911","https://openalex.org/W2005706799","https://openalex.org/W2005928313","https://openalex.org/W2011197968","https://openalex.org/W2011933109","https://openalex.org/W2015747379","https://openalex.org/W2018846024","https://openalex.org/W2021178651","https://openalex.org/W2025949276","https://openalex.org/W2028062821","https://openalex.org/W2028536701","https://openalex.org/W2032760411","https://openalex.org/W2032782331","https://openalex.org/W2038463151","https://openalex.org/W2047208232","https://openalex.org/W2048030072","https://openalex.org/W2049655097","https://openalex.org/W2052545263","https://openalex.org/W2065031087","https://openalex.org/W2069388628","https://openalex.org/W2069781093","https://openalex.org/W2070032768","https://openalex.org/W2077334432","https://openalex.org/W2093916547","https://openalex.org/W2096290681","https://openalex.org/W2096701144","https://openalex.org/W2096853390","https://openalex.org/W2097121808","https://openalex.org/W2099662390","https://openalex.org/W2104750799","https://openalex.org/W2106779017","https://openalex.org/W2107418647","https://openalex.org/W2110321953","https://openalex.org/W2112635226","https://openalex.org/W2113486346","https://openalex.org/W2113548010","https://openalex.org/W2113975063","https://openalex.org/W2119591540","https://openalex.org/W2124046782","https://openalex.org/W2128724486","https://openalex.org/W2133728642","https://openalex.org/W2140896211","https://openalex.org/W2140908681","https://openalex.org/W2141793177","https://openalex.org/W2143625465","https://openalex.org/W2153685214","https://openalex.org/W2158132545","https://openalex.org/W2158507534","https://openalex.org/W2161215353","https://openalex.org/W2161633633","https://openalex.org/W2163013660","https://openalex.org/W2165347734","https://openalex.org/W2168647393","https://openalex.org/W2186788028","https://openalex.org/W2208085400","https://openalex.org/W2264133902","https://openalex.org/W2268619028","https://openalex.org/W2417400945","https://openalex.org/W2464146806","https://openalex.org/W2473954287","https://openalex.org/W2570178861","https://openalex.org/W3029052526","https://openalex.org/W4210972027","https://openalex.org/W6640980657"],"related_works":["https://openalex.org/W2105502028","https://openalex.org/W2113975063","https://openalex.org/W2140908681","https://openalex.org/W2314078347","https://openalex.org/W2096853390","https://openalex.org/W2341154183","https://openalex.org/W2002773051","https://openalex.org/W2023101660","https://openalex.org/W2530571498","https://openalex.org/W2081521541"],"abstract_inverted_index":{"BACKGROUND.":[0],"Morphological":[1],"patterns":[2],"of":[3,30,52,113,203,236,285],"Paneth":[4,31,66,85,115,131,155,177,241,251,262],"cells":[5,116],"are":[6,17,39],"a":[7,49,81,101],"prognostic":[8],"biomarker":[9],"in":[10,34,44,69,117,158,189,254,268],"Western":[11,102,123,147,191,247],"Crohn\u2019s":[12,292],"disease":[13],"(CD)":[14],"patients,":[15],"and":[16,22,129,205,224,228,238,246,290,293,302],"associated":[18,58,136,153,259],"with":[19,59,137,154,176,209,219,260],"autophagy-associated":[20],"ATG16L1":[21,149,237],"NOD2":[23],"variants.":[24],"We":[25,47,78,232],"hypothesized":[26],"that":[27],"genetic":[28],"determinants":[29],"cell":[32,67,86,95,132,156,178,242,252,263],"phenotype":[33,87,133,253,264],"other":[35,206],"ethnic":[36],"CD":[37,60,72,103,119,124,160,192,221,256],"cohorts":[38],"distinct":[40],"but":[41],"also":[42,135,258,265],"involved":[43],"autophagy.":[45,261],"METHODS.":[46],"performed":[48,80],"hypothesis-driven":[50],"analysis":[51,202],"56":[53,167],"single":[54],"nucleotide":[55],"polymorphisms":[56],"(SNPs)":[57],"susceptibility":[61,222],"or":[62],"known":[63,220],"to":[64,100,122,146,226],"affect":[65],"function":[68],"110":[70],"Japanese":[71,118,159,245,255,269],"patients":[73],"who":[74],"underwent":[75],"ileal":[76],"resection.":[77],"subsequently":[79],"genome-wide":[82],"association":[83,175],"analysis.":[84],"was":[88,120,134,151,195],"determined":[89],"by":[90],"defensin-5":[91],"immunofluorescence.":[92],"Selected":[93],"genotype\u2013Paneth":[94],"defect":[96,157,179,243],"correlations":[97],"were":[98,257],"compared":[99],"cohort":[104,193],"(":[105,125,140,161,180,197],"n":[106],"=":[107,127,142,163,182,199],"164).":[108],"RESULTS.":[109],"The":[110],"average":[111],"percentage":[112],"abnormal":[114,130],"similar":[121],"P":[126,141,162,181,198,210],"0.87),":[128],"early":[138],"recurrence":[139],"0.013).":[143],"In":[144],"contrast":[145],"CD,":[148],"T300A":[150],"not":[152,196],"0.20).":[164],"Among":[165],"the":[166,190,283],"selected":[168],"SNPs,":[169],"only":[170],"LRRK2":[171,204,239],"M2397T":[172],"showed":[173,217],"significant":[174],"3.62":[183],"\u00d7":[184,214],"10":[185,215],"\u20134":[186,216],"),":[187],"whereas":[188],"it":[194],"0.76).":[200],"Pathway":[201],"candidate":[207],"genes":[208,223],"less":[211],"than":[212],"5":[213],"connections":[218],"links":[225],"autophagy":[227],"TNF-\u03b1":[229],"networks.":[230],"CONCLUSIONS.":[231],"found":[233],"dichotomous":[234],"effects":[235],"on":[240],"between":[244],"CD.":[248,270],"Genes":[249],"affecting":[250],"predicted":[266],"prognosis":[267],"FUNDING.":[271],"Helmsley":[272],"Charitable":[273],"Trust,":[274],"Doris":[275],"Duke":[276],"Foundation":[277,295],"(grant":[278],"2014103),":[279],"Japan":[280],"Society":[281],"for":[282],"Promotion":[284],"Science":[286],"(KAKENHI":[287],"grants":[288],"JP15H04805":[289],"JP15K15284),":[291],"Colitis":[294],"grant":[296],"274415,":[297],"NIH":[298],"(grants":[299],"1R56DK095820,":[300],"K01DK109081,":[301],"UL1":[303],"TR000448).":[304]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-07T00:00:00"}
