{"id":"https://openalex.org/W2597350731","doi":"https://doi.org/10.1093/biolreprod/83.s1.118","title":"Transcriptomics of Human Preplacental Trophoblast Development.","display_name":"Transcriptomics of Human Preplacental Trophoblast Development.","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W2597350731","doi":"https://doi.org/10.1093/biolreprod/83.s1.118","mag":"2597350731"},"language":"en","primary_location":{"id":"doi:10.1093/biolreprod/83.s1.118","doi":"https://doi.org/10.1093/biolreprod/83.s1.118","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biolreprod/83.s1.118","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008270331","display_name":"Paul Robson","orcid":"https://orcid.org/0000-0002-0191-3958","observed_orcids":["https://orcid.org/0000-0002-0191-3958"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Paul Robson","raw_affiliation_strings":["Genome Institute of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Singapore","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003982146","display_name":"Wishva B. Herath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wishva Herath","raw_affiliation_strings":["Genome Institute of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Singapore","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101108417","display_name":"Lili Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lili Sun","raw_affiliation_strings":["Genome Institute of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Singapore","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039384527","display_name":"Wenlong Luo","orcid":"https://orcid.org/0009-0000-3294-9665","observed_orcids":["https://orcid.org/0009-0000-3294-9665"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wenlong Luo","raw_affiliation_strings":["Genome Institute of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Singapore","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037550701","display_name":"Mikael Huss","orcid":"https://orcid.org/0000-0003-0839-2451","observed_orcids":["https://orcid.org/0000-0003-0839-2451"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mikael Huss","raw_affiliation_strings":["Genome Institute of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Singapore","institution_ids":["https://openalex.org/I66068411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I66068411"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"Suppl_1","first_page":"118","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0723000019788742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trophoblast-differentiation","display_name":"trophoblast differentiation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/placental-development","display_name":"placental development","score":0.6000000238418579},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cdx2","display_name":"CDX2","score":0.7429999709129333},{"id":"https://openalex.org/keywords/gata-factors","display_name":"GATA transcription factors","score":0.6919999718666077},{"id":"https://openalex.org/keywords/msx2","display_name":"Msx2","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cgas","display_name":"cGAS","score":0.5730000138282776},{"id":"https://openalex.org/keywords/hypoxia-response","display_name":"hypoxia response","score":0.8489999771118164},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mesenchymal-epithelial-transition","display_name":"mesenchymal-epithelial transition","score":0.8270000219345093},{"id":"https://openalex.org/keywords/monoallelic-expression","display_name":"monoallelic expression","score":0.9110000133514404},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.9670000076293945},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9235124588012695},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.676449179649353},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5786350965499878},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5653306245803833},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.45865485072135925},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.44077837467193604},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.43795284628868103},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4315989315509796},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.42744433879852295},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42160671949386597},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4208661913871765},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2945634424686432},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.27332204580307007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23263585567474365},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/biolreprod/83.s1.118","doi":"https://doi.org/10.1093/biolreprod/83.s1.118","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biolreprod/83.s1.118","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3022905671","https://openalex.org/W2772563973","https://openalex.org/W2120832598","https://openalex.org/W3127295823","https://openalex.org/W2805157403","https://openalex.org/W1564013432","https://openalex.org/W1987114178","https://openalex.org/W2009473720","https://openalex.org/W2979364001","https://openalex.org/W2074137603"],"abstract_inverted_index":{"Human":[0],"embryonic":[1],"stem":[2],"cells":[3],"(hESCs)":[4],"readily":[5],"give":[6],"rise":[7],"to":[8,21,69,134,183,193,220],"placental":[9],"cell":[10,25,222],"types":[11,26],"derived":[12,48],"from":[13,201,229],"the":[14,22,28,45,50,74,90,113,142,156,160,164,173,178,186,210,246,252],"developing":[15,29],"embryo.":[16],"This":[17,37,86,216],"provides":[18],"experimental":[19],"access":[20],"earliest":[23],"extraembryonic":[24,52],"of":[27,79,98,101,118,130,144,148,159,172,203,207,251],"human":[30,253],"embryo":[31],"that":[32,147],"would":[33],"otherwise":[34],"be":[35],"inaccessible.":[36],"is":[38],"an":[39],"invaluable":[40],"research":[41],"tool":[42],"particularly":[43],"considering":[44],"biological":[46],"novelties":[47],"in":[49,56,58,89,135,170],"primate":[51],"tissues":[53],"which":[54],"remain":[55],"accessible":[57],"other":[59],"animal":[60],"models.":[61],"Here":[62],"we":[63,152,189],"first":[64,179],"define":[65],"a":[66,99,127,241],"robust":[67],"protocol":[68],"differentiation":[70,131,208],"hESCs":[71],"uniformly":[72],"along":[73],"trophoblast":[75,102,165],"lineage":[76],"by":[77,84],"inhibition":[78],"FGF":[80],"signaling":[81],"and":[82,92,110,112,231,249],"induction":[83],"BMP4.":[85],"treatment":[87],"results":[88],"immediate":[91],"dramatic":[93],"up-regulation":[94,143],"(within":[95,115],"4":[96],"hrs)":[97,117],"suite":[100],"transcription":[103],"factors":[104],"(eg.":[105],"CDX2,":[106],"GATA3,":[107],"GATA2,":[108],"MSX2,":[109],"TFAPA2)":[111],"down-regulation":[114],"8":[116],"key":[119],"pluripotency":[120],"factors.":[121],"BeadArray":[122],"gene":[123],"expression":[124,137,226],"profiling":[125],"through":[126],"time":[128,205],"course":[129],"reveals":[132],"similarities":[133],"vivo":[136],"dynamics":[138],"with,":[139],"for":[140,155],"instance,":[141],"CGA":[145],"preceding":[146],"CGB.":[149],"In":[150,236],"addition,":[151],"provide":[153,240],"evidence":[154],"hard":[157],"wiring":[158],"hypoxic":[161],"response":[162],"within":[163,177],"developmental":[166],"genetic":[167],"regulatory":[168],"network,":[169],"anticipation":[171],"low":[174],"oxygen":[175],"environment":[176],"trimester":[180],"placenta.":[181],"Finally,":[182],"fully":[184],"explore":[185],"preplacental":[187,254],"transcriptome":[188],"have":[190],"employed":[191],"RNA-seq":[192],"generate":[194],">60":[195],"million":[196],"50":[197],"base,":[198],"strand-specific":[199],"reads":[200],"each":[202],"5":[204],"points":[206],"using":[209],"ABI":[211],"SOLiD3+":[212],"NextGen":[213],"sequencing":[214],"system.":[215],"data":[217,239],"identifies":[218],"mesenchymal":[219],"epithelial":[221],"splicing":[223],"transitions,":[224],"monoallelic":[225],"presumably":[227],"resulting":[228],"imprinting,":[230],"many":[232],"novel":[233],"transcribed":[234],"regions.":[235],"sum,":[237],"our":[238],"resource":[242],"enabling":[243],"insight":[244],"into":[245],"molecular":[247],"control":[248],"characterization":[250],"trophoblast.":[255],"(platform)":[256]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-03-23T00:00:00"}
