{"id":"https://openalex.org/W2597345362","doi":"https://doi.org/10.1182/blood.v120.21.4836.4836","title":"Cynomolgus Monkey Invariant NKT (iNKT) Cells Recover Following Depletion by Treatment with the Anti-Invariant T Cell Receptor Antibody NKTT120","display_name":"Cynomolgus Monkey Invariant NKT (iNKT) Cells Recover Following Depletion by Treatment with the Anti-Invariant T Cell Receptor Antibody NKTT120","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2597345362","doi":"https://doi.org/10.1182/blood.v120.21.4836.4836","mag":"2597345362"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.4836.4836","doi":"https://doi.org/10.1182/blood.v120.21.4836.4836","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.4836.4836","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040627601","display_name":"Felix Scheuplein","orcid":"https://orcid.org/0000-0002-2691-0796","observed_orcids":["https://orcid.org/0000-0002-2691-0796"]},"institutions":[{"id":"https://openalex.org/I4210130256","display_name":"NKT Therapeutics (United States)","ror":"https://ror.org/040wa6e75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Felix Scheuplein","raw_affiliation_strings":["NKT Therapeutics, Waltham, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NKT Therapeutics, Waltham, MA, USA,","institution_ids":["https://openalex.org/I4210130256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042996646","display_name":"Susan E. MacDonald","orcid":"https://orcid.org/0000-0003-4335-1129","observed_orcids":["https://orcid.org/0000-0003-4335-1129"]},"institutions":[{"id":"https://openalex.org/I4210130256","display_name":"NKT Therapeutics (United States)","ror":"https://ror.org/040wa6e75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan Macdonald","raw_affiliation_strings":["NKT Therapeutics, Waltham, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NKT Therapeutics, Waltham, MA, USA,","institution_ids":["https://openalex.org/I4210130256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082907286","display_name":"Brandon M. Zeigler","orcid":"https://orcid.org/0000-0002-1258-7780","observed_orcids":["https://orcid.org/0000-0002-1258-7780"]},"institutions":[{"id":"https://openalex.org/I4210138245","display_name":"MPI Research (United States)","ror":"https://ror.org/03dqpq202","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138245"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brandon Zeigler","raw_affiliation_strings":["MPI Research, Mattawan, MI,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MPI Research, Mattawan, MI,","institution_ids":["https://openalex.org/I4210138245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069867697","display_name":"Elen LeBel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138245","display_name":"MPI Research (United States)","ror":"https://ror.org/03dqpq202","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138245"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elen LeBel","raw_affiliation_strings":["MPI Research, Mattawan, MI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MPI Research, Mattawan, MI, USA,","institution_ids":["https://openalex.org/I4210138245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039261127","display_name":"Abraham Thariath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130256","display_name":"NKT Therapeutics (United States)","ror":"https://ror.org/040wa6e75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abraham Thariath","raw_affiliation_strings":["NKT Therapeutics, Waltham, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NKT Therapeutics, Waltham, MA, USA,","institution_ids":["https://openalex.org/I4210130256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022073916","display_name":"Alemseged Truneh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130256","display_name":"NKT Therapeutics (United States)","ror":"https://ror.org/040wa6e75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alem Truneh","raw_affiliation_strings":["NKT Therapeutics, Waltham, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NKT Therapeutics, Waltham, MA, USA,","institution_ids":["https://openalex.org/I4210130256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083889976","display_name":"Robert D. Mashal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130256","display_name":"NKT Therapeutics (United States)","ror":"https://ror.org/040wa6e75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Mashal","raw_affiliation_strings":["NKT Therapeutics, Waltham, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NKT Therapeutics, Waltham, MA, USA,","institution_ids":["https://openalex.org/I4210130256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623635","display_name":"David G. Nathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Nathan","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020230031","display_name":"Robert G. Schaub","orcid":"https://orcid.org/0000-0003-2085-5914","observed_orcids":["https://orcid.org/0000-0003-2085-5914"]},"institutions":[{"id":"https://openalex.org/I4210130256","display_name":"NKT Therapeutics (United States)","ror":"https://ror.org/040wa6e75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Schaub","raw_affiliation_strings":["NKT Therapeutics, Waltham, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NKT Therapeutics, Waltham, MA, USA,","institution_ids":["https://openalex.org/I4210130256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022073916","https://openalex.org/A5039261127","https://openalex.org/A5040627601","https://openalex.org/A5042996646","https://openalex.org/A5069867697","https://openalex.org/A5082907286","https://openalex.org/A5083889976"],"corresponding_institution_ids":["https://openalex.org/I4210130256","https://openalex.org/I4210138245"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3095055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"21","first_page":"4836","last_page":"4836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inkt-cells","display_name":"invariant natural killer T cells","score":0.6290000081062317},{"id":"https://openalex.org/keywords/anti-tcr-antibody","display_name":"anti-TCR antibodies","score":0.628000020980835},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cd1d","display_name":"CD1d","score":0.527999997138977},{"id":"https://openalex.org/keywords/cdr3-loop","display_name":"CDR3 loop","score":0.7409999966621399},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.6690000295639038},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.48100000619888306},{"id":"https://openalex.org/keywords/innate-adaptive-immune-bridge","display_name":"innate-adaptive immune bridge","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2778607024","wikidata":"https://www.wikidata.org/wiki/Q4216825","display_name":"CD1D","level":5,"score":0.7363713383674622},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.7233485579490662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6112013459205627},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5966424942016602},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5651302337646484},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5522265434265137},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5350279808044434},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.49541962146759033},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.43907010555267334},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4217795133590698},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.366362988948822}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.4836.4836","doi":"https://doi.org/10.1182/blood.v120.21.4836.4836","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.4836.4836","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588948985","https://openalex.org/W2583491977","https://openalex.org/W2582529085","https://openalex.org/W7096962111","https://openalex.org/W2000643138","https://openalex.org/W976022473","https://openalex.org/W2584119965","https://openalex.org/W2983952034","https://openalex.org/W2584418414","https://openalex.org/W2406914216"],"abstract_inverted_index":{"Abstract":[0,1],"4836":[2],"Invariant":[3],"Natural":[4],"Killer":[5],"T":[6,14,23,33,42,63,68,117,650,665,680],"(iNKT)":[7],"cells":[8,34,64,74,97,104,107,118,169,217,235,255,284,353,369,422,448,461,475,501,553,560],"are":[9,105],"a":[10,76,109,140,153,164,188,304,327,382,405],"small":[11],"subset":[12],"of":[13,21,98,116,126,199,214,221,231,250,252,256,267,279,282,290,297,307,337,395,401,408,462,496,516,529,566,710,714],"lymphocytes":[15,425],"(ranging":[16],"from":[17,236],"0.01":[18],"\u2013":[19],"0.1%":[20],"CD3+":[22],"cells)":[24],"that":[25,191,247,312,332,547,558],"share":[26,114],"surface":[27],"markers":[28],"and":[29,35,124,145,180,240,340,359,393,417,423,432,437,480,491,505,557,574],"functional":[30],"characteristics":[31],"with":[32,89,108,196,223,347,454],"natural":[36],"killer":[37],"(NK)":[38],"cells.":[39],"Unlike":[40],"other":[41,424,460],"cells,":[43],"they":[44,137],"recognize":[45],"glycolipid":[46],"antigens":[47],"presented":[48,128],"by":[49,264,301,488,570],"the":[50,99,130,143,197,253,257,268,274,295,321,334,338,341,365,372,389,459,463,477,481,503,506,527],"MHC":[51],"class-I-like":[52],"protein":[53],"CD1d":[54],"rather":[55],"than":[56],"peptide":[57],"antigens.":[58],"In":[59,273,364,443],"contrast":[60],"to":[61,156,162,173,226,387,472,533],"most":[62],"which":[65,86],"express":[66,75],"diverse":[67],"cell":[69,292,315,397,540],"receptor":[70],"(TCR)":[71],"sequences,":[72],"iNKT":[73,103,168,216,234,254,283,291,314,352,368,396,421,447,474,500,539,552,559,621],"unique,":[77],"highly":[78],"conserved,":[79],"semi-invariant":[80],"TCR-\u03b1":[81],"chain":[82],"(V\u03b124-J\u03b118":[83],"in":[84,94,176,182,218,294,303,320,354,371,384,458,476,502,518,554],"humans),":[85],"preferentially":[87],"pairs":[88],"specific":[90],"TCR-\u03b2":[91],"chains":[92],"(V\u03b211":[93],"humans).":[95],"Like":[96],"innate":[100,144],"immune":[101,147,166],"system,":[102],"rapid-onset":[106],"universal":[110],"receptor.":[111],"They":[112,149],"also":[113],"properties":[115],"like":[119,132],"requiring":[120],"thymic":[121],"positive":[122],"selection":[123],"recognition":[125,190],"antigen":[127],"on":[129,526,538],"MHC-I":[131],"molecule":[133],"CD1d.":[134],"As":[135,495],"such,":[136],"serve":[138],"as":[139,262],"bridge":[141],"between":[142,391],"adaptive":[146],"systems.":[148,185],"can":[150,549,561],"play":[151],"either":[152],"pro-inflammatory":[154],"role":[155,161,289],"enhance":[157],"or":[158],"an":[159,211,248,277],"immuno-regulatory":[160],"attenuate":[163],"developing":[165],"response.":[167],"have":[170,325,469,511],"been":[171,470],"shown":[172,546],"be":[174,534],"involved":[175],"mediating":[177],"tissue":[178,536],"injury":[179],"inflammation":[181,193,319],"multiple":[183],"organ":[184],"There":[186],"is":[187,194,299,531],"growing":[189],"chronic":[192],"associated":[195],"pathophysiology":[198],"Sickle":[200],"Cell":[201],"Disease":[202],"(SCD).":[203],"Wallace":[204],"et":[205],"al.":[206],"(Blood":[207,309],"114:667,":[208,310],"2009)":[209,311],"found":[210,246],"increased":[212],"ratio":[213],"activated":[215,261],"peripheral":[219,232,373],"blood":[220,233],"patients":[222,239,259],"SCD":[224,238,258,298,308,322],"compared":[225],"normal":[227],"volunteers.":[228],"Our":[229],"study":[230,383,544],"5":[237,490,592],"10":[241,478,599,607],"unaffected":[242],"African":[243],"American":[244],"volunteers":[245],"average":[249,278],"50.5%":[251],"were":[260,413,426,449,486],"indicated":[263],"up":[265],"regulation":[266],"lymphocyte":[269],"activation":[270,293],"marker":[271],"CD69.":[272,286],"healthy":[275],"controls":[276],"only":[280],"8.9%":[281],"expressed":[285],"A":[287],"key":[288],"pathology":[296],"supported":[300],"studies":[302],"mouse":[305],"model":[306],"suggest":[313],"depletion":[316,537],"could":[317],"reduce":[318],"patient.":[323],"We":[324,380],"developed":[326],"humanized":[328],"monoclonal":[329],"antibody":[330],"(NKTT120)":[331],"binds":[333],"CDR3":[335],"loop":[336],"human":[339,355],"old-world":[342],"non-human":[343,555],"primate":[344],"invariant":[345],"TCR":[346],"high":[348],"specificity.":[349],"NKTT120":[350,576],"depletes":[351],"iTCR":[356],"transgenic":[357,366],"mice":[358],"cynomolgus":[360,385],"monkeys":[361,386],"(Macaca":[362],"fascicularis).":[363],"mice,":[367],"reappear":[370],"circulation":[374],"within":[375,451],"weeks":[376],"after":[377,563],"complete":[378],"depletion.":[379,398,564],"conducted":[381],"explore":[388],"relationship":[390],"dose":[392,407,445,484,509,521],"duration":[394],"Each":[399],"group":[400,485],"animals":[402,522],"(n=3)":[403],"received":[404],"single":[406],"NKTT120.":[409],"The":[410,514],"dosing":[411,436],"groups":[412,510],"10,":[414],"30,":[415],"100":[416,504,603,611,617],"300":[418,507,605,613,619],"ug/kg,":[419],"respectively.":[420,494],"monitored":[427],"24,":[428],"48,":[429],"72,":[430],"96":[431],"168":[433],"hours":[434,453],"following":[435],"weekly":[438],"thereafter":[439],"using":[440],"flow":[441],"cytometry.":[442],"all":[444],"groups,":[446],"depleted":[450],"24":[452],"no":[455],"significant":[456],"changes":[457],"lymphocytic":[464],"series.":[465],"No":[466],"adverse":[467],"events":[468],"noted":[471],"date.":[473],"ug/kg":[479,483,508,600,602,604,606,608,610,612,614,616,618,620],"30":[482,601,609,615],"recovered":[487],"week":[489,492,497],"7":[493,596],"12":[498],"post-dosing,":[499],"not":[512],"recovered.":[513],"kinetics":[515],"recovery":[517],"these":[519],"higher":[520],"will":[523],"shed":[524],"light":[525],"impact":[528],"what":[530],"expected":[532],"full":[535],"recovery.":[541],"Overall,":[542],"our":[543],"has":[545],"we":[548],"safely":[550],"deplete":[551],"primates":[556],"recover":[562],"Percent":[565],"Cells":[567],"(Mean\u00b1SD)":[568],"Estimated":[569],"FACS":[571],"Analysis":[572],"Before":[573],"Following":[575,581],"IV":[577],"Administration":[578],"Shows":[579],"Recovery":[580],"Depletion":[582],"Lymphocyte":[583],"Profiles":[584],"Pre":[585],"Sample":[586],"Day":[587],"1":[588],"Post":[589,593,597],"Dose":[590,594,598],"Week":[591,595],"Cells*":[622],"0.29\u00b10.17":[623],"0.02\u00b10.03":[624],"0":[625,626,627,630,631,633],"0.14\u00b10.12":[628],"0.01\u00b10.005":[629],"0.05\u00b10.01":[632],"0.01\u00b10.01":[634],"NK":[635],"Cells**":[636,666,681,695],"11.6\u00b13.9":[637],"8.1\u00b11.8":[638],"8.5\u00b12.1":[639],"7.8\u00b14":[640],"11.1\u00b12.5":[641],"11.4\u00b12.6":[642],"16.2\u00b14.3":[643],"8.9\u00b13.1":[644],"14.3\u00b14.3":[645],"13.2\u00b13.1":[646],"9.2\u00b14.1":[647],"13.2\u00b12.5":[648],"Mature":[649],"cells**":[651],"73.1\u00b15.5":[652],"69.6\u00b14":[653],"70\u00b17.5":[654],"75.9\u00b14.3":[655],"65.1\u00b13.6":[656],"70.6\u00b14.5":[657],"67.4\u00b15.1":[658],"78.2\u00b15.7":[659],"66.5\u00b14.4":[660],"72.3\u00b14.9":[661],"80.8\u00b16.3":[662],"69.3\u00b13.2":[663],"CD8":[664],"26.0\u00b14.7":[667],"22.1\u00b14.2":[668],"20.7\u00b12.8":[669],"27.8\u00b13.5":[670],"22.4\u00b14.1":[671],"26.2\u00b15.5":[672],"24.1\u00b16.3":[673],"31.8\u00b13.7":[674],"26.5\u00b16.1":[675],"25.4\u00b15.8":[676],"32.7\u00b15.1":[677],"27.2\u00b16.9":[678],"CD4":[679],"42.0\u00b14":[682],"44.3\u00b17.9":[683],"45.2\u00b15.2":[684],"43.2\u00b11.5":[685],"38.3\u00b14.1":[686],"41.1\u00b16.9":[687],"39.5\u00b11.7":[688],"40.9\u00b12.6":[689],"35.4\u00b13.3":[690],"43.2\u00b17.7":[691],"42.2\u00b10.7":[692],"37.4\u00b15.4":[693],"B":[694],"3.4\u00b12.1":[696],"8.9\u00b12.4":[697],"6.8\u00b11.6":[698],"5.1\u00b11":[699],"8.5\u00b15.1":[700],"7\u00b11.1":[701],"7.4\u00b12.9":[702],"4.3\u00b10.6":[703],"7.8\u00b14.9":[704],"5.5\u00b11.5":[705],"2.4\u00b10.2":[706],"6.1\u00b13.5":[707],"*":[708],"%":[709,713],"CD3":[711],"**":[712],"Lymphocytes":[715],"Disclosures:":[716],"Scheuplein:":[717],"NKT":[718,731,738],"Therapeutics:":[719,724,732,739,743,748,753,758,761],"Employment,":[720,725,744,754,762],"Equity":[721,726,745,750,755,763],"Ownership.":[722,727,746,751,756,764],"Macdonald:NKT":[723],"Zeigler:MPI":[728],"Research:":[729,736],"Employment;":[730,737],"Research":[733,740],"Funding.":[734,741],"LeBel:MPI":[735],"Thariath:NKT":[742],"Truneh:NKT":[747],"Consultancy,":[749],"Mashal:NKT":[752],"Nathan:NKT":[757],"Consultancy.":[759],"Schaub:NKT":[760]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-03-23T00:00:00"}
